ES2351971T3 - Uso de una combinación de sustancias de la síntesis de la porfirina, salicilatos y antioxidantes en la fototerapia de enfermedades de la piel y/o de las articulaciones. - Google Patents
Uso de una combinación de sustancias de la síntesis de la porfirina, salicilatos y antioxidantes en la fototerapia de enfermedades de la piel y/o de las articulaciones. Download PDFInfo
- Publication number
- ES2351971T3 ES2351971T3 ES03815354T ES03815354T ES2351971T3 ES 2351971 T3 ES2351971 T3 ES 2351971T3 ES 03815354 T ES03815354 T ES 03815354T ES 03815354 T ES03815354 T ES 03815354T ES 2351971 T3 ES2351971 T3 ES 2351971T3
- Authority
- ES
- Spain
- Prior art keywords
- combination
- synthesis
- treatment
- psoriasis
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000011282 treatment Methods 0.000 claims description 29
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- 229960002749 aminolevulinic acid Drugs 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
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- 229960001860 salicylate Drugs 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 6
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
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- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
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- 101000642224 Apomastus schlingeri U1-cyrtautoxin-As1d Proteins 0.000 description 1
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- 108090000695 Cytokines Proteins 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical class [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
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- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
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- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
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- 239000006210 lotion Substances 0.000 description 1
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- 150000002823 nitrates Chemical class 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 239000011591 potassium Chemical class 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 230000003014 reinforcing effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
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- 239000011734 sodium Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
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- 230000008961 swelling Effects 0.000 description 1
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- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
- 229910052725 zinc Chemical class 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10301917A DE10301917B4 (de) | 2003-01-17 | 2003-01-17 | Verwendung von Substanzen der Porphyrinsynthese bei der Phototherapie von Haut- oder Gelenkerkrankungen des Menschen oder von Säugetieren |
| DE10301917 | 2003-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2351971T3 true ES2351971T3 (es) | 2011-02-14 |
Family
ID=32602752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03815354T Expired - Lifetime ES2351971T3 (es) | 2003-01-17 | 2003-12-23 | Uso de una combinación de sustancias de la síntesis de la porfirina, salicilatos y antioxidantes en la fototerapia de enfermedades de la piel y/o de las articulaciones. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070099878A1 (https=) |
| EP (1) | EP1583525B1 (https=) |
| JP (1) | JP2006514072A (https=) |
| AT (1) | ATE479431T1 (https=) |
| AU (1) | AU2003300499A1 (https=) |
| CY (1) | CY1110957T1 (https=) |
| DE (2) | DE10301917B4 (https=) |
| DK (1) | DK1583525T3 (https=) |
| ES (1) | ES2351971T3 (https=) |
| PT (1) | PT1583525E (https=) |
| RU (1) | RU2336078C2 (https=) |
| SI (1) | SI1583525T1 (https=) |
| WO (1) | WO2004064827A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005019628A1 (de) * | 2005-04-26 | 2006-11-09 | Technische Universität Braunschweig | Formulierung zur dermalen Anwendung |
| DE102011117364A1 (de) * | 2011-10-29 | 2013-05-02 | Merck Patent Gmbh | Hautaufheller in der Phototherapie |
| DE202013003573U1 (de) | 2013-04-16 | 2013-06-04 | Gerhard Saalmann | Ganzkörper-Belichtungseinheit |
| RU2712806C1 (ru) * | 2019-05-20 | 2020-01-31 | Федеральное государственное бюджетное учреждение "Государственный научный центр лазерной медицины имени О.К. Скобелкина Федерального медико-биологического агентства" | Способ лечения больных перипротезной инфекцией после эндопротезирования сустава |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145686A (en) * | 1982-02-03 | 1992-09-08 | Efamol Limited | Topical pharmaceutical compositions |
| IL68965A (en) * | 1983-06-13 | 1987-02-27 | Rafa Labor Ltd | Topical pharmaceutical preparation comprising acetylsalicylic acid for the treatment of dermatological disorders |
| US4647453A (en) * | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
| US5368841A (en) * | 1993-02-11 | 1994-11-29 | The General Hospital Corporation | Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides |
| DE4320871C2 (de) * | 1993-06-24 | 1995-05-04 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen mit einem Gehalt an delta-Aminolävulinsäure |
| WO1996006602A1 (en) | 1993-08-27 | 1996-03-07 | Noven Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR THE ADMINISTRATION OF δ-AMINOLEVULINIC ACID AND PHARMACEUTICAL EQUIVALENTS THEREOF |
| DE4440112A1 (de) * | 1994-11-11 | 1996-05-15 | Jan H Dr Wilkens | Bestrahlungsanordnung zur Behandlung von Hauterkrankungen |
| US5530157A (en) * | 1995-02-16 | 1996-06-25 | Scios Nova Inc. | Anti-inflammatory benzoic acid derivatives |
| HU225148B1 (en) * | 1995-03-10 | 2006-07-28 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using |
| US5942534A (en) * | 1996-10-10 | 1999-08-24 | The General Hospital Corporation | Photodynamic therapy for the treatment of osteoarthritis |
| RU2145247C1 (ru) * | 1998-04-10 | 2000-02-10 | Жаров Владимир Павлович | Фотоматричное терапевтическое устройство для лечения протяженных патологий |
| AU4645099A (en) * | 1998-07-09 | 2000-02-01 | Yoram Harth | Apparatus and method for efficient high energy photodynamic therapy of acne vulgaris and seborrhea |
| DE19852245A1 (de) * | 1998-11-12 | 2000-05-18 | Asat Ag Applied Science & Tech | 5-Aminolävulinsäure-Nanoemulsion |
| DE10003620A1 (de) * | 2000-01-28 | 2001-08-02 | Asat Ag Applied Science & Tech | 5-Aminolävulinsäure-Formulierung in nichtwässrigen Lösungsmitteln |
| ATE297188T1 (de) * | 2000-09-08 | 2005-06-15 | Vivier Canada Inc | Stabilisierte ascorbinsäure-lösungen |
| DE10063076A1 (de) * | 2000-12-18 | 2002-06-27 | Medac Klinische Spezialpraep | Verwendung von 5-Aminolävulinsäure zur Restenose-Prophylaxe |
| US20030082101A1 (en) * | 2001-06-11 | 2003-05-01 | Cavalier Discovery | Accelerators for increasing the rate of formation of free radicals and reactive oxygen species |
| US6723750B2 (en) * | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
| US20040048842A1 (en) * | 2002-09-10 | 2004-03-11 | Mcmillan Kathleen | Method of treating skin disorders |
-
2003
- 2003-01-17 DE DE10301917A patent/DE10301917B4/de not_active Expired - Fee Related
- 2003-12-23 JP JP2004566721A patent/JP2006514072A/ja active Pending
- 2003-12-23 DE DE50313052T patent/DE50313052D1/de not_active Expired - Lifetime
- 2003-12-23 EP EP03815354A patent/EP1583525B1/de not_active Expired - Lifetime
- 2003-12-23 PT PT03815354T patent/PT1583525E/pt unknown
- 2003-12-23 AT AT03815354T patent/ATE479431T1/de active
- 2003-12-23 US US10/542,355 patent/US20070099878A1/en not_active Abandoned
- 2003-12-23 WO PCT/DE2003/004254 patent/WO2004064827A1/de not_active Ceased
- 2003-12-23 DK DK03815354.0T patent/DK1583525T3/da active
- 2003-12-23 ES ES03815354T patent/ES2351971T3/es not_active Expired - Lifetime
- 2003-12-23 SI SI200331911T patent/SI1583525T1/sl unknown
- 2003-12-23 AU AU2003300499A patent/AU2003300499A1/en not_active Abandoned
- 2003-12-23 RU RU2005127035/15A patent/RU2336078C2/ru not_active IP Right Cessation
-
2010
- 2010-12-01 CY CY20101101103T patent/CY1110957T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1583525B1 (de) | 2010-09-01 |
| JP2006514072A (ja) | 2006-04-27 |
| US20070099878A1 (en) | 2007-05-03 |
| RU2336078C2 (ru) | 2008-10-20 |
| AU2003300499A1 (en) | 2004-08-13 |
| PT1583525E (pt) | 2010-12-07 |
| RU2005127035A (ru) | 2006-01-27 |
| DK1583525T3 (da) | 2011-01-03 |
| WO2004064827A1 (de) | 2004-08-05 |
| DE10301917A1 (de) | 2004-07-29 |
| CY1110957T1 (el) | 2015-06-11 |
| SI1583525T1 (sl) | 2011-01-31 |
| EP1583525A1 (de) | 2005-10-12 |
| DE10301917B4 (de) | 2007-02-01 |
| ATE479431T1 (de) | 2010-09-15 |
| DE50313052D1 (de) | 2010-10-14 |
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