ES2339113T3 - Plasmido vegf inducible por la hipoxia para una enfermedad isquemica. - Google Patents

Plasmido vegf inducible por la hipoxia para una enfermedad isquemica. Download PDF

Info

Publication number
ES2339113T3
ES2339113T3 ES04713771T ES04713771T ES2339113T3 ES 2339113 T3 ES2339113 T3 ES 2339113T3 ES 04713771 T ES04713771 T ES 04713771T ES 04713771 T ES04713771 T ES 04713771T ES 2339113 T3 ES2339113 T3 ES 2339113T3
Authority
ES
Spain
Prior art keywords
prtp801
vegf
plasmid
seq
baselineskip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04713771T
Other languages
English (en)
Spanish (es)
Inventor
Minhyung Lee
Sung Wan Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Application granted granted Critical
Publication of ES2339113T3 publication Critical patent/ES2339113T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/001Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES04713771T 2003-02-21 2004-02-23 Plasmido vegf inducible por la hipoxia para una enfermedad isquemica. Expired - Lifetime ES2339113T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44896103P 2003-02-21 2003-02-21
US448961P 2003-02-21

Publications (1)

Publication Number Publication Date
ES2339113T3 true ES2339113T3 (es) 2010-05-17

Family

ID=32927484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04713771T Expired - Lifetime ES2339113T3 (es) 2003-02-21 2004-02-23 Plasmido vegf inducible por la hipoxia para una enfermedad isquemica.

Country Status (9)

Country Link
US (2) US7638322B2 (enExample)
EP (1) EP1594549B1 (enExample)
JP (1) JP4652325B2 (enExample)
KR (1) KR101077689B1 (enExample)
AT (1) ATE456380T1 (enExample)
CA (1) CA2516727C (enExample)
DE (1) DE602004025328D1 (enExample)
ES (1) ES2339113T3 (enExample)
WO (1) WO2004076633A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101094617B1 (ko) 2004-08-16 2011-12-15 사일런스 테라퓨틱스 아게 알티피801 억제제의 치료적 용도
DOP2007000015A (es) 2006-01-20 2007-08-31 Quark Biotech Inc Usos terapéuticos de inhibidores de rtp801
GB2450840B (en) * 2006-05-11 2010-12-29 Quark Pharmaceuticals Inc Screening Systems Utilizing RTP801
WO2007141796A2 (en) 2006-06-09 2007-12-13 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of rtp801l
JP2010518880A (ja) 2007-02-26 2010-06-03 クアーク・ファーマスーティカルス、インコーポレイテッド Rtp801のインヒビター及びその疾患の治療における使用
US8614311B2 (en) 2007-12-12 2013-12-24 Quark Pharmaceuticals, Inc. RTP801L siRNA compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
US6548633B1 (en) * 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides

Also Published As

Publication number Publication date
WO2004076633A2 (en) 2004-09-10
DE602004025328D1 (de) 2010-03-18
US7638322B2 (en) 2009-12-29
KR20050103302A (ko) 2005-10-28
KR101077689B1 (ko) 2011-10-27
US20110015257A1 (en) 2011-01-20
JP2006518604A (ja) 2006-08-17
ATE456380T1 (de) 2010-02-15
JP4652325B2 (ja) 2011-03-16
US20070149467A1 (en) 2007-06-28
US7998941B2 (en) 2011-08-16
EP1594549A4 (en) 2008-01-23
CA2516727C (en) 2014-02-04
WO2004076633A3 (en) 2005-06-02
CA2516727A1 (en) 2004-09-10
EP1594549B1 (en) 2010-01-27
EP1594549A2 (en) 2005-11-16

Similar Documents

Publication Publication Date Title
ES2384553T3 (es) Utilización de secuencias de adn de estructura triple para la transferencia de secuencias nucleotídicas
ES2821655T5 (es) Vectores de ADN no integrantes para la modificación genética de células
US8859747B2 (en) Promoters exhibiting endothelial cell specificity and methods of using same
JPH11506302A (ja) 組織特異的低酸素で調節される治療用構築物
JP2002502608A (ja) 血管新生促進因子である血管内皮細胞成長因子:vegfの変異体
CN114555809A (zh) 组合癌症免疫疗法
US7998941B2 (en) Hypoxia inducible VEGF plasmid for ischemic disease
JP2001522224A (ja) 遺伝子治療における使用のための非免疫原性プロドラッグおよび選択マーカー
ES2425321T3 (es) Promotores que muestran especificidad por células endoteliales y métodos de utilización de los mismos
Boulikas Status of gene therapy in 1997: molecular mechanisms, disease targets, and clinical applications
CA2406687A1 (en) Chimeric promoters for controlling expression in muscle cells
AU2001270614B2 (en) Chimeric promoters for controlling expression in smooth muscle cells
JP2006502726A (ja) 改善された免疫療法
US20090305977A1 (en) Method for treating peripheral arterial disease with zinc finger proteins
US6165754A (en) Method of expressing an exogenous nucleic acid
AU2002226400B2 (en) Sequences upstream of the carp gene, vectors containing them and uses thereof
ES2248849T3 (es) Generacion de moleculas replicantes "in vivo".
AU2003215871A1 (en) Expression cassette for persistence of expression of a gene of interest in muscle cells
JP2003501362A (ja) 脈管形成インヒビターとしてのc−cam
JP2004500879A (ja) 腎の調節エレメントおよびそれらの使用方法
KR20230003557A (ko) 스펙트린 융합 도메인을 갖는 소형화 디스트로핀 및 그의 용도
CA2355228A1 (en) Bone sialoprotein based toxic gene therapy for the treatment of calcified tumors and tissues
Gros Gene therapy: Present situation and future prospects
AU2004207999A1 (en) Ires
Wynd Adenovirus-enhanced Receptor-mediated Transgene Delivery to Hepatocytes: Role of the Core Factor VIII Promoter and HNF-1 on Transgene Expression