ES2325260T3 - Utilizacion de esfingolipidos para reducir los niveles de triacilglicerol y colesterol en el plasma. - Google Patents
Utilizacion de esfingolipidos para reducir los niveles de triacilglicerol y colesterol en el plasma. Download PDFInfo
- Publication number
- ES2325260T3 ES2325260T3 ES04703544T ES04703544T ES2325260T3 ES 2325260 T3 ES2325260 T3 ES 2325260T3 ES 04703544 T ES04703544 T ES 04703544T ES 04703544 T ES04703544 T ES 04703544T ES 2325260 T3 ES2325260 T3 ES 2325260T3
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- Prior art keywords
- sphingolipid
- food
- cholesterol
- sphingolipids
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
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- 230000036470 plasma concentration Effects 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
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| NL1022442A NL1022442C2 (nl) | 2003-01-20 | 2003-01-20 | Toepassing van lipide ter verbetring van de opname van nutrienten en (farmaceutisch) actieve stoffen. |
| NL1022442 | 2003-01-20 | ||
| EP03078141 | 2003-10-06 | ||
| EP03078141 | 2003-10-06 |
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| ES2325260T3 true ES2325260T3 (es) | 2009-08-31 |
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| ES04703544T Expired - Lifetime ES2325260T3 (es) | 2003-01-20 | 2004-01-20 | Utilizacion de esfingolipidos para reducir los niveles de triacilglicerol y colesterol en el plasma. |
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| EP (1) | EP1585508B1 (enExample) |
| JP (1) | JP2006516280A (enExample) |
| AT (1) | ATE427106T1 (enExample) |
| DE (1) | DE602004020316D1 (enExample) |
| ES (1) | ES2325260T3 (enExample) |
| WO (1) | WO2004064820A2 (enExample) |
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| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| DE602004020316D1 (de) | 2003-01-20 | 2009-05-14 | Tno | Die verwendung von sphingolipiden zur senkung der cholesterin- und triglyzeridspiegel im plasma. |
| US20050196461A1 (en) * | 2004-01-14 | 2005-09-08 | Udell Ronald G. | Ceramide formulations suitable for oral administration |
| AU2005220692A1 (en) * | 2004-03-16 | 2005-09-22 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | The use of sphingolipids in the treatment and prevention of type 2 diabetes mellitus, insulin resistance and Metabolic Syndrome |
| JP4359204B2 (ja) * | 2004-03-19 | 2009-11-04 | 花王株式会社 | 皮膚保湿用食品 |
| EP1618876A1 (en) * | 2004-07-19 | 2006-01-25 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Use of sphingolipids for prevention and treatment of atherosclerosis |
| US7648714B2 (en) | 2004-08-05 | 2010-01-19 | Kao Corporation | Food for skin moisture retention |
| DE102004052697A1 (de) * | 2004-10-29 | 2006-05-04 | Haehner, Thomas, Dr. | Pharmazeutische Zubereitungen zur Behandlung von Folgen des Alkoholmissbrauchs, Hepatitis, Pankreatitis, Alzheimererkrankung, Morbus Parkinson, Diabetes, toxischen Nierenerkrankungen, Reperfusionsschäden, der Arteriosklerose sowie als Antidote gegen Umweltgifte und Medikamentenintoxikation |
| EP1830829B1 (en) | 2004-11-30 | 2012-01-04 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Sphingolipids in treatment and prevention of hepatic steatosis |
| JP4040069B2 (ja) * | 2005-08-09 | 2008-01-30 | 株式会社ミツカングループ本社 | 脳機能改善用組成物 |
| JP4040070B2 (ja) * | 2005-08-22 | 2008-01-30 | 株式会社ミツカングループ本社 | 筋肉損傷抑制組成物 |
| JP2008013579A (ja) * | 2005-08-22 | 2008-01-24 | Mitsukan Group Honsha:Kk | 筋肉損傷抑制組成物 |
| US20100048928A1 (en) * | 2005-09-22 | 2010-02-25 | Snow Brand Milk Products Co., Ltd | Medicine, Food and Drink or Feed Containing Sphingomyelin |
| EP1815745A1 (en) | 2006-02-03 | 2007-08-08 | Friesland Brands B.V. | Cholesterol-lowering dairy products and methods for their preparation |
| ES2431142T3 (es) * | 2006-04-07 | 2013-11-25 | Megmilk Snow Brand Co., Ltd. | Inhibidor de acumulación de grasa para el tratamiento de síndrome metabólico |
| TWI589228B (zh) | 2009-04-23 | 2017-07-01 | S A Corman | 降低膽固醇含量之奶產品 |
| WO2010131718A1 (ja) * | 2009-05-13 | 2010-11-18 | 丸大食品株式会社 | 鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び／又は抗高脂血症剤 |
| WO2013119857A1 (en) | 2012-02-07 | 2013-08-15 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| EP2906576B1 (en) | 2012-10-12 | 2019-09-11 | The Brigham and Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| JP2016013083A (ja) * | 2014-07-01 | 2016-01-28 | 花王株式会社 | 麺つゆ |
| JP6232008B2 (ja) * | 2015-03-19 | 2017-11-15 | 国立大学法人北海道大学 | 酸化抑制剤及びこれを用いた油脂含有飲食品 |
| US20170044516A1 (en) | 2015-08-11 | 2017-02-16 | Industrial Technology Research Institute | Biochemistry reactive material and device for eliminating electronegative low-density lipoprotein (ldl) and method for treating blood or plasma ex vivo to eliminate electronegative low-density lipoprotein therein |
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| FR2492259A1 (fr) | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| JPS61152632A (ja) * | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
| JPS6344842A (ja) | 1986-08-12 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
| US4952567A (en) * | 1988-05-09 | 1990-08-28 | City Of Hope | Inhibition of lipogenesis |
| IT1235162B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
| US5190876A (en) * | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
| US5231090A (en) * | 1990-07-30 | 1993-07-27 | University Of Miami | Treatment for hypercholesterolemia |
| BR9106744A (pt) | 1990-08-13 | 1993-07-20 | Univ Duke | Processo para induzir diferenciacao celular,preparacao farmaceutica,composicao e uso de um composto |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5232837A (en) * | 1991-08-05 | 1993-08-03 | Emory University | Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
| US5374616A (en) * | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
| US6190894B1 (en) * | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
| US5478860A (en) * | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
| US5830853A (en) * | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6773719B2 (en) * | 1994-03-04 | 2004-08-10 | Esperion Luv Development, Inc. | Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias |
| US20020182250A1 (en) * | 1995-09-06 | 2002-12-05 | Goro Hori | Lipid metabolism improving agent |
| AU7374396A (en) | 1995-09-29 | 1997-04-17 | Georgetown University | Use of sphingosylphosphorylcholine as a wound-healing agent |
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-
2004
- 2004-01-20 DE DE602004020316T patent/DE602004020316D1/de not_active Expired - Lifetime
- 2004-01-20 AT AT04703544T patent/ATE427106T1/de not_active IP Right Cessation
- 2004-01-20 ES ES04703544T patent/ES2325260T3/es not_active Expired - Lifetime
- 2004-01-20 WO PCT/NL2004/000048 patent/WO2004064820A2/en not_active Ceased
- 2004-01-20 US US10/542,845 patent/US7968529B2/en not_active Expired - Fee Related
- 2004-01-20 EP EP04703544A patent/EP1585508B1/en not_active Revoked
- 2004-01-20 JP JP2006500735A patent/JP2006516280A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1585508A2 (en) | 2005-10-19 |
| US7968529B2 (en) | 2011-06-28 |
| WO2004064820A2 (en) | 2004-08-05 |
| EP1585508B1 (en) | 2009-04-01 |
| JP2006516280A (ja) | 2006-06-29 |
| WO2004064820A3 (en) | 2004-09-30 |
| US20060189575A1 (en) | 2006-08-24 |
| ATE427106T1 (de) | 2009-04-15 |
| DE602004020316D1 (de) | 2009-05-14 |
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