ES2316968T3 - Nuevos derivados de aminopiridina utilizados como antagonistas de mglur5. - Google Patents
Nuevos derivados de aminopiridina utilizados como antagonistas de mglur5. Download PDFInfo
- Publication number
- ES2316968T3 ES2316968T3 ES04717193T ES04717193T ES2316968T3 ES 2316968 T3 ES2316968 T3 ES 2316968T3 ES 04717193 T ES04717193 T ES 04717193T ES 04717193 T ES04717193 T ES 04717193T ES 2316968 T3 ES2316968 T3 ES 2316968T3
- Authority
- ES
- Spain
- Prior art keywords
- pyridin
- amine
- methyl
- phenylethynyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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Landscapes
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0304901A GB0304901D0 (en) | 2003-03-04 | 2003-03-04 | Novel aminopyridine derivatives as mGIuR5 antagonists |
| GB0304901 | 2003-03-04 | ||
| GB0316430A GB0316430D0 (en) | 2003-07-14 | 2003-07-14 | Aminopyridine derivatives |
| GB0316430 | 2003-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2316968T3 true ES2316968T3 (es) | 2009-04-16 |
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| ES04717193T Expired - Lifetime ES2316968T3 (es) | 2003-03-04 | 2004-03-04 | Nuevos derivados de aminopiridina utilizados como antagonistas de mglur5. |
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| EP (2) | EP1603877B1 (enExample) |
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| GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2006115895A2 (en) * | 2005-04-22 | 2006-11-02 | Merck & Co., Inc. | Phenyl ethyne compounds |
| WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
| DE102005062987A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| MX2009002684A (es) * | 2006-09-11 | 2009-06-05 | Novartis Ag | Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropico. |
| MX2013010698A (es) | 2011-03-18 | 2014-02-17 | Novartis Ag | Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson. |
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| JPS6028963A (ja) * | 1983-07-27 | 1985-02-14 | Takeda Chem Ind Ltd | 置換ビニル誘導体 |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| DE10009000A1 (de) | 2000-02-25 | 2001-08-30 | Basf Ag | Verfahren zur Herstellung substituierter Indole |
| MXPA03004862A (es) | 2000-12-04 | 2005-02-14 | Hoffmann La Roche | Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato. |
-
2004
- 2004-03-04 CA CA002517083A patent/CA2517083A1/en not_active Abandoned
- 2004-03-04 JP JP2006506343A patent/JP2006519251A/ja active Pending
- 2004-03-04 ES ES04717193T patent/ES2316968T3/es not_active Expired - Lifetime
- 2004-03-04 AT AT04717193T patent/ATE415390T1/de not_active IP Right Cessation
- 2004-03-04 SI SI200431006T patent/SI1603877T1/sl unknown
- 2004-03-04 PT PT04717193T patent/PT1603877E/pt unknown
- 2004-03-04 DK DK04717193T patent/DK1603877T3/da active
- 2004-03-04 EP EP04717193A patent/EP1603877B1/en not_active Expired - Lifetime
- 2004-03-04 EP EP08018437A patent/EP2028180A1/en not_active Withdrawn
- 2004-03-04 RU RU2005130647/04A patent/RU2330020C2/ru not_active IP Right Cessation
- 2004-03-04 WO PCT/IB2004/000745 patent/WO2004078728A1/en not_active Ceased
- 2004-03-04 UA UAA200508498A patent/UA81464C2/xx unknown
- 2004-03-04 DE DE602004017966T patent/DE602004017966D1/de not_active Expired - Lifetime
- 2004-03-04 PL PL04717193T patent/PL1603877T3/pl unknown
- 2004-03-04 AU AU2004218180A patent/AU2004218180B2/en not_active Ceased
-
2005
- 2005-09-02 US US11/225,490 patent/US7205411B2/en not_active Expired - Fee Related
-
2007
- 2007-03-13 US US11/717,860 patent/US20080004316A1/en not_active Abandoned
-
2009
- 2009-02-26 CY CY20091100218T patent/CY1108837T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1108837T1 (el) | 2014-07-02 |
| RU2330020C2 (ru) | 2008-07-27 |
| PL1603877T3 (pl) | 2009-05-29 |
| PT1603877E (pt) | 2009-02-11 |
| EP2028180A1 (en) | 2009-02-25 |
| DE602004017966D1 (de) | 2009-01-08 |
| JP2006519251A (ja) | 2006-08-24 |
| DK1603877T3 (da) | 2009-03-09 |
| RU2005130647A (ru) | 2006-04-10 |
| US20060030601A1 (en) | 2006-02-09 |
| US7205411B2 (en) | 2007-04-17 |
| SI1603877T1 (sl) | 2009-04-30 |
| EP1603877A1 (en) | 2005-12-14 |
| AU2004218180B2 (en) | 2009-11-12 |
| US20080004316A1 (en) | 2008-01-03 |
| UA81464C2 (en) | 2008-01-10 |
| WO2004078728A1 (en) | 2004-09-16 |
| ATE415390T1 (de) | 2008-12-15 |
| CA2517083A1 (en) | 2004-09-16 |
| EP1603877B1 (en) | 2008-11-26 |
| AU2004218180A1 (en) | 2004-09-16 |
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