PT1603877E - Novos derivados de aminopiridina como antagonistas de mglur5 - Google Patents
Novos derivados de aminopiridina como antagonistas de mglur5 Download PDFInfo
- Publication number
- PT1603877E PT1603877E PT04717193T PT04717193T PT1603877E PT 1603877 E PT1603877 E PT 1603877E PT 04717193 T PT04717193 T PT 04717193T PT 04717193 T PT04717193 T PT 04717193T PT 1603877 E PT1603877 E PT 1603877E
- Authority
- PT
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- Prior art keywords
- amine
- methylpyridin
- mmol
- compounds
- alkyl
- Prior art date
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- 239000005557 antagonist Substances 0.000 title claims description 7
- 150000003927 aminopyridines Chemical class 0.000 title abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 51
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- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 claims abstract description 15
- 230000002265 prevention Effects 0.000 claims abstract description 7
- -1 C 1 -C 6 -alkoxy Chemical group 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- 150000002431 hydrogen Chemical group 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 6
- 125000005026 carboxyaryl group Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 150000004677 hydrates Chemical class 0.000 claims description 6
- 239000012453 solvate Substances 0.000 claims description 6
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- OEJKHVWZFQTQNL-UHFFFAOYSA-N 2-[2-(3-chlorophenyl)ethynyl]-4,6-dimethylpyridin-3-amine Chemical compound CC1=CC(C)=C(N)C(C#CC=2C=C(Cl)C=CC=2)=N1 OEJKHVWZFQTQNL-UHFFFAOYSA-N 0.000 claims description 4
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- NCYCMSJKPSBNNU-UHFFFAOYSA-N 2-[2-(5-chloropyridin-3-yl)ethynyl]-6-methylpyridin-3-amine Chemical compound CC1=CC=C(N)C(C#CC=2C=C(Cl)C=NC=2)=N1 NCYCMSJKPSBNNU-UHFFFAOYSA-N 0.000 claims description 4
- SBZBJEIGHFTLIR-UHFFFAOYSA-N 6-methyl-2-(2-pyridin-3-ylethynyl)pyridin-3-amine Chemical compound CC1=CC=C(N)C(C#CC=2C=NC=CC=2)=N1 SBZBJEIGHFTLIR-UHFFFAOYSA-N 0.000 claims description 4
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0304901A GB0304901D0 (en) | 2003-03-04 | 2003-03-04 | Novel aminopyridine derivatives as mGIuR5 antagonists |
| GB0316430A GB0316430D0 (en) | 2003-07-14 | 2003-07-14 | Aminopyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1603877E true PT1603877E (pt) | 2009-02-11 |
Family
ID=32964064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04717193T PT1603877E (pt) | 2003-03-04 | 2004-03-04 | Novos derivados de aminopiridina como antagonistas de mglur5 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7205411B2 (enExample) |
| EP (2) | EP1603877B1 (enExample) |
| JP (1) | JP2006519251A (enExample) |
| AT (1) | ATE415390T1 (enExample) |
| AU (1) | AU2004218180B2 (enExample) |
| CA (1) | CA2517083A1 (enExample) |
| CY (1) | CY1108837T1 (enExample) |
| DE (1) | DE602004017966D1 (enExample) |
| DK (1) | DK1603877T3 (enExample) |
| ES (1) | ES2316968T3 (enExample) |
| PL (1) | PL1603877T3 (enExample) |
| PT (1) | PT1603877E (enExample) |
| RU (1) | RU2330020C2 (enExample) |
| SI (1) | SI1603877T1 (enExample) |
| UA (1) | UA81464C2 (enExample) |
| WO (1) | WO2004078728A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2006115895A2 (en) * | 2005-04-22 | 2006-11-02 | Merck & Co., Inc. | Phenyl ethyne compounds |
| WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
| DE102005062987A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| MX2009002684A (es) * | 2006-09-11 | 2009-06-05 | Novartis Ag | Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropico. |
| MX2013010698A (es) | 2011-03-18 | 2014-02-17 | Novartis Ag | Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6028963A (ja) * | 1983-07-27 | 1985-02-14 | Takeda Chem Ind Ltd | 置換ビニル誘導体 |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| DE10009000A1 (de) | 2000-02-25 | 2001-08-30 | Basf Ag | Verfahren zur Herstellung substituierter Indole |
| MXPA03004862A (es) | 2000-12-04 | 2005-02-14 | Hoffmann La Roche | Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato. |
-
2004
- 2004-03-04 CA CA002517083A patent/CA2517083A1/en not_active Abandoned
- 2004-03-04 JP JP2006506343A patent/JP2006519251A/ja active Pending
- 2004-03-04 ES ES04717193T patent/ES2316968T3/es not_active Expired - Lifetime
- 2004-03-04 AT AT04717193T patent/ATE415390T1/de not_active IP Right Cessation
- 2004-03-04 SI SI200431006T patent/SI1603877T1/sl unknown
- 2004-03-04 PT PT04717193T patent/PT1603877E/pt unknown
- 2004-03-04 DK DK04717193T patent/DK1603877T3/da active
- 2004-03-04 EP EP04717193A patent/EP1603877B1/en not_active Expired - Lifetime
- 2004-03-04 EP EP08018437A patent/EP2028180A1/en not_active Withdrawn
- 2004-03-04 RU RU2005130647/04A patent/RU2330020C2/ru not_active IP Right Cessation
- 2004-03-04 WO PCT/IB2004/000745 patent/WO2004078728A1/en not_active Ceased
- 2004-03-04 UA UAA200508498A patent/UA81464C2/xx unknown
- 2004-03-04 DE DE602004017966T patent/DE602004017966D1/de not_active Expired - Lifetime
- 2004-03-04 PL PL04717193T patent/PL1603877T3/pl unknown
- 2004-03-04 AU AU2004218180A patent/AU2004218180B2/en not_active Ceased
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2005
- 2005-09-02 US US11/225,490 patent/US7205411B2/en not_active Expired - Fee Related
-
2007
- 2007-03-13 US US11/717,860 patent/US20080004316A1/en not_active Abandoned
-
2009
- 2009-02-26 CY CY20091100218T patent/CY1108837T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1108837T1 (el) | 2014-07-02 |
| RU2330020C2 (ru) | 2008-07-27 |
| PL1603877T3 (pl) | 2009-05-29 |
| ES2316968T3 (es) | 2009-04-16 |
| EP2028180A1 (en) | 2009-02-25 |
| DE602004017966D1 (de) | 2009-01-08 |
| JP2006519251A (ja) | 2006-08-24 |
| DK1603877T3 (da) | 2009-03-09 |
| RU2005130647A (ru) | 2006-04-10 |
| US20060030601A1 (en) | 2006-02-09 |
| US7205411B2 (en) | 2007-04-17 |
| SI1603877T1 (sl) | 2009-04-30 |
| EP1603877A1 (en) | 2005-12-14 |
| AU2004218180B2 (en) | 2009-11-12 |
| US20080004316A1 (en) | 2008-01-03 |
| UA81464C2 (en) | 2008-01-10 |
| WO2004078728A1 (en) | 2004-09-16 |
| ATE415390T1 (de) | 2008-12-15 |
| CA2517083A1 (en) | 2004-09-16 |
| EP1603877B1 (en) | 2008-11-26 |
| AU2004218180A1 (en) | 2004-09-16 |
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