ES2315430T3 - Inhibidores de nf-kb. - Google Patents
Inhibidores de nf-kb. Download PDFInfo
- Publication number
- ES2315430T3 ES2315430T3 ES02800491T ES02800491T ES2315430T3 ES 2315430 T3 ES2315430 T3 ES 2315430T3 ES 02800491 T ES02800491 T ES 02800491T ES 02800491 T ES02800491 T ES 02800491T ES 2315430 T3 ES2315430 T3 ES 2315430T3
- Authority
- ES
- Spain
- Prior art keywords
- disease
- thiophene
- phenyl
- quad
- acid amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32697601P | 2001-10-04 | 2001-10-04 | |
| US326976P | 2001-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2315430T3 true ES2315430T3 (es) | 2009-04-01 |
Family
ID=23274589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02800491T Expired - Lifetime ES2315430T3 (es) | 2001-10-04 | 2002-10-04 | Inhibidores de nf-kb. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7166639B2 (OSRAM) |
| EP (1) | EP1448545B1 (OSRAM) |
| JP (1) | JP2005506334A (OSRAM) |
| AT (1) | ATE414697T1 (OSRAM) |
| DE (1) | DE60229975D1 (OSRAM) |
| ES (1) | ES2315430T3 (OSRAM) |
| WO (1) | WO2003029242A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0003154D0 (en) * | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| WO2002100851A2 (en) * | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| TW200403991A (en) * | 2002-04-11 | 2004-03-16 | Smithkline Beecham Corp | NF-κb inhibitors |
| US7375131B2 (en) * | 2002-06-06 | 2008-05-20 | Smithklinebeecham Corp. | NF-κB inhibitors |
| SE0202280D0 (sv) * | 2002-07-19 | 2002-07-19 | Astrazeneca Ab | Novel compounds |
| SE0202279D0 (sv) * | 2002-07-19 | 2002-07-19 | Astrazeneca Ab | Novel comppounds |
| JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
| AU2003300832A1 (en) * | 2002-12-06 | 2004-06-30 | Smithkline Beecham Corporation | NF-KappaB INHIBITORS |
| CN100413861C (zh) * | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| WO2005016909A1 (en) | 2003-08-15 | 2005-02-24 | Astrazeneca Ab | Substituted thiophenes and uses thereof |
| JP4557984B2 (ja) * | 2003-12-05 | 2010-10-06 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Ｉｋｋインヒビターとしての置換３−アミノ−チエノ−［２，３−ｂ］ピリジン−２−カルボン酸アミド化合物 |
| CN100584840C (zh) * | 2004-01-05 | 2010-01-27 | 阿斯利康(瑞典)有限公司 | 取代杂环化合物及其应用 |
| GB0402809D0 (en) * | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
| CN1968954A (zh) * | 2004-04-12 | 2007-05-23 | 三共株式会社 | 噻吩并吡啶衍生物 |
| TWI375559B (en) | 2005-03-29 | 2012-11-01 | Icos Corp | Compounds useful for inhibting chk1 |
| JP5030947B2 (ja) * | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
| US7812018B2 (en) | 2006-02-16 | 2010-10-12 | Millennium Pharmaceuticals, Inc. | Alpha carbolines and uses thereof |
| CN101568538B (zh) | 2006-11-15 | 2012-09-05 | Viro化学制药公司 | 用于治疗或预防黄病毒属感染的噻吩类似物 |
| AU2009239429B2 (en) | 2008-04-21 | 2013-08-29 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| JP2010006717A (ja) * | 2008-06-24 | 2010-01-14 | Kyorin Pharmaceut Co Ltd | ジヒドロチエノ［２，３−ｅ］インダゾール化合物 |
| KR101323448B1 (ko) | 2008-10-02 | 2013-11-27 | 아사히 가세이 파마 가부시키가이샤 | ８위 치환 이소퀴놀린 유도체 및 이의 용도 |
| US20100137246A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100135984A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100135983A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100137843A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Delivery devices for modulating inflammation |
| US20100136096A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136094A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136095A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| WO2011077502A1 (ja) * | 2009-12-21 | 2011-06-30 | 杏林製薬株式会社 | ジヒドロチエノ［２，３－ｅ］インダゾール化合物 |
| EP2520292A1 (en) | 2011-05-06 | 2012-11-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated disorders |
| EP2898102A4 (en) | 2012-09-20 | 2016-05-18 | Univ Emory | CLASSIFIERS OF NF-KB-PFADAKTIVIERUNG AND DEVICES AND METHODS OF USE THEREOF |
| CA3029281A1 (en) | 2016-06-29 | 2018-01-04 | Otonomy, Inc. | Triglyceride otic formulations and uses thereof |
| EP3652542A1 (en) | 2017-07-14 | 2020-05-20 | Protea Biopharma N.V. | Methods and means for diagnosing and/or treating a fatiguing illness |
| EP3676260B1 (en) * | 2017-08-31 | 2024-10-30 | Ahammune Biosciences Private Limited | Thiophene compounds, process for synthesis and use thereof for the treatment of autoimmune disorders |
| CN115161289B (zh) * | 2022-03-14 | 2023-12-05 | 东南大学 | 一种用于炎症性疾病治疗的重组腺相关病毒及其构建方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1468012A (en) * | 1973-08-09 | 1977-03-23 | Beecham Group Ltd | 2-amino-3-carboxy-thiophene derivatives |
| DE4039734A1 (de) * | 1990-12-13 | 1992-06-17 | Basf Ag | Substituierte 2-aminothiophene enthaltende herbizide mittel |
| US6274590B1 (en) * | 1993-01-15 | 2001-08-14 | G. D. Searle & Co. | Method of treating skin related conditions |
| DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| WO2000002851A1 (en) * | 1998-07-08 | 2000-01-20 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
| GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| US6414013B1 (en) * | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| EP1324759A4 (en) * | 2000-10-12 | 2004-05-12 | Smithkline Beecham Corp | NF - G (K) B INHIBITORS |
| US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
| WO2002100851A2 (en) * | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
| US7084178B2 (en) * | 2003-11-26 | 2006-08-01 | Bristol-Myers Squibb Company | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives |
-
2002
- 2002-10-04 ES ES02800491T patent/ES2315430T3/es not_active Expired - Lifetime
- 2002-10-04 WO PCT/US2002/031902 patent/WO2003029242A1/en not_active Ceased
- 2002-10-04 EP EP02800491A patent/EP1448545B1/en not_active Expired - Lifetime
- 2002-10-04 JP JP2003532491A patent/JP2005506334A/ja active Pending
- 2002-10-04 DE DE60229975T patent/DE60229975D1/de not_active Expired - Lifetime
- 2002-10-04 US US10/491,710 patent/US7166639B2/en not_active Expired - Fee Related
- 2002-10-04 AT AT02800491T patent/ATE414697T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE414697T1 (de) | 2008-12-15 |
| EP1448545A1 (en) | 2004-08-25 |
| JP2005506334A (ja) | 2005-03-03 |
| WO2003029242A1 (en) | 2003-04-10 |
| DE60229975D1 (de) | 2009-01-02 |
| EP1448545A4 (en) | 2005-01-12 |
| US20040192943A1 (en) | 2004-09-30 |
| EP1448545B1 (en) | 2008-11-19 |
| US7166639B2 (en) | 2007-01-23 |
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