ES2310167T3 - Inmovilizacion de acidos nucleicos sin modificar a sustratos con grupos fluoruro de acilo pendientes. - Google Patents

Inmovilizacion de acidos nucleicos sin modificar a sustratos con grupos fluoruro de acilo pendientes. Download PDF

Info

Publication number
ES2310167T3
ES2310167T3 ES00928944T ES00928944T ES2310167T3 ES 2310167 T3 ES2310167 T3 ES 2310167T3 ES 00928944 T ES00928944 T ES 00928944T ES 00928944 T ES00928944 T ES 00928944T ES 2310167 T3 ES2310167 T3 ES 2310167T3
Authority
ES
Spain
Prior art keywords
solid support
nucleic acid
unmodified
agent
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00928944T
Other languages
English (en)
Spanish (es)
Inventor
Robert S. Matson
Raymond C. Milton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of ES2310167T3 publication Critical patent/ES2310167T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811Peptides or proteins is immobilized on, or in, an inorganic carrier
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815Carrier is a synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
ES00928944T 1999-05-12 2000-05-10 Inmovilizacion de acidos nucleicos sin modificar a sustratos con grupos fluoruro de acilo pendientes. Expired - Lifetime ES2310167T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US312095 1999-05-12
US09/312,095 US6268141B1 (en) 1999-05-12 1999-05-12 Immobilization of unmodified biopolymers to acyl fluoride activated substrates

Publications (1)

Publication Number Publication Date
ES2310167T3 true ES2310167T3 (es) 2009-01-01

Family

ID=23209859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00928944T Expired - Lifetime ES2310167T3 (es) 1999-05-12 2000-05-10 Inmovilizacion de acidos nucleicos sin modificar a sustratos con grupos fluoruro de acilo pendientes.

Country Status (7)

Country Link
US (2) US6268141B1 (enExample)
EP (1) EP1208226B1 (enExample)
JP (1) JP4608107B2 (enExample)
AT (1) ATE401419T1 (enExample)
DE (1) DE60039519D1 (enExample)
ES (1) ES2310167T3 (enExample)
WO (1) WO2000070088A2 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7027932B2 (en) * 2001-03-21 2006-04-11 Olympus Optical Co., Ltd. Biochemical examination method
EP1379644A2 (en) * 2001-04-05 2004-01-14 Nextgen Sciences Ltd Protein analysis by means of immobilized arrays of antigens or antibodies
US20030092062A1 (en) * 2001-10-24 2003-05-15 Reddy M. Parameswara Immobilizing biological molecules
US6989175B2 (en) * 2002-03-08 2006-01-24 Beckman Coulter, Inc. Acyl fluoride activation of carboxysilyl-coated glass substrates
US20050158848A1 (en) * 2002-04-12 2005-07-21 Ulrich Sieben Method for immobolizing molecules on surfaces
US6984485B2 (en) * 2002-04-23 2006-01-10 Beckman Coulter, Inc. Polymer-coated substrates for immobilization of biomolecules and cells
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US6841379B2 (en) * 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
US20040049351A1 (en) * 2002-08-28 2004-03-11 Matson Robert S. Immunosorbent assay in microarray format
US20040229226A1 (en) * 2003-05-16 2004-11-18 Reddy M. Parameswara Reducing microarray variation with internal reference spots
EP1682261B1 (en) * 2003-11-12 2012-08-15 BIO-RAD Haifa Ltd. Method for carrying out multiple binding reactions in an array format
US20070207483A1 (en) * 2006-03-02 2007-09-06 Bio-Rad Laboratories, Inc. BUFFERS FOR DETECTION OF mRNA SEPARATED IN A MICROFLUIDIC DEVICE
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US9790538B2 (en) * 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
US8404242B2 (en) 2009-03-16 2013-03-26 Atyr Pharma, Inc. Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ, インコーポレイテッド システイニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8961960B2 (en) 2010-04-27 2015-02-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
JP6008837B2 (ja) 2010-04-28 2016-10-19 エータイアー ファーマ, インコーポレイテッド アラニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
US8986680B2 (en) 2010-04-29 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
JP6008841B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ, インコーポレイテッド メチオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2566499B1 (en) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
EP2568996B1 (en) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
JP5964304B2 (ja) 2010-08-25 2016-08-03 エータイアー ファーマ, インコーポレイテッド チロシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6170077B2 (ja) 2012-02-16 2017-07-26 エータイアー ファーマ, インコーポレイテッド 自己免疫および炎症疾患を処置するためのヒスチジルtRNA合成酵素
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US9297032B2 (en) 2012-10-10 2016-03-29 Apdn (B.V.I.) Inc. Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
EP2925886B1 (en) 2012-11-27 2019-04-24 Pontificia Universidad Católica de Chile Compositions and methods for diagnosing thyroid tumors
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
WO2015054188A1 (en) 2013-10-07 2015-04-16 Apdn (B.V.I), Inc. Multimode image and spectral reader
CN106103121B (zh) 2014-03-18 2019-12-06 亚普蒂恩(B.V.I.)公司 用于安全应用的加密光学标记物
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
WO2017180302A1 (en) 2016-04-11 2017-10-19 Apdn (B.V.I.) Inc. Method of marking cellulosic products
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US10920274B2 (en) 2017-02-21 2021-02-16 Apdn (B.V.I.) Inc. Nucleic acid coated submicron particles for authentication
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
GB2580385B (en) * 2019-01-08 2022-10-12 Quantumdx Group Ltd Oligonucleotide deposition onto polypropylene substrates
GB2580384B (en) * 2019-01-08 2021-01-27 Quantumdx Group Ltd Oligonucleotide deposition onto polypropylene substrates
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144374A (en) * 1974-12-12 1979-03-13 Massachusetts Institute Of Technology Perfluorinated functionalized materials
US5011861A (en) * 1988-06-28 1991-04-30 Millipore Corporation Membranes for solid phase protein sequencing
EP0455905B1 (en) * 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5554501A (en) * 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5602207A (en) * 1993-01-11 1997-02-11 The Perkin-Elmer Corporation Support and method for immobilizing polypeptides
US5470307A (en) * 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
JP3093116B2 (ja) * 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP0904542B1 (en) * 1996-03-01 2005-06-29 Beckman Coulter, Inc. System for simultaneously conducting multiple ligand binding assays
US6110669A (en) 1996-06-05 2000-08-29 Milton; Raymond C. Polymeric reagents for immobilizing biopolymers
US6037124A (en) * 1996-09-27 2000-03-14 Beckman Coulter, Inc. Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof
EP0988398A4 (en) * 1997-05-21 2005-05-18 Clontech Lab Inc Nucleic Acid Arrays
US5985567A (en) * 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
US6750344B1 (en) * 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same

Also Published As

Publication number Publication date
EP1208226A2 (en) 2002-05-29
US6268141B1 (en) 2001-07-31
EP1208226B1 (en) 2008-07-16
WO2000070088A3 (en) 2002-03-28
US20010039018A1 (en) 2001-11-08
JP2002544508A (ja) 2002-12-24
WO2000070088A2 (en) 2000-11-23
ATE401419T1 (de) 2008-08-15
DE60039519D1 (de) 2008-08-28
JP4608107B2 (ja) 2011-01-05

Similar Documents

Publication Publication Date Title
ES2310167T3 (es) Inmovilizacion de acidos nucleicos sin modificar a sustratos con grupos fluoruro de acilo pendientes.
ES2211603T3 (es) Dispositivo de ensayos analiticos con substrato dotado de canales pasantes y metodos mejorados y aparato para su utilizacion.
ES2234513T3 (es) Metodo de fabricacion de un dispositivo para la realizacion de un ensayo, uso de una membrana en la fabricacion de dicho dispositivo, kit que comprende dicho dispositivo y metodo para la deteccion de un analito usando dicho dispositivo.
ES2206848T3 (es) Metodo de chorros de burbujas para depositar sondas sobre soportes solidos y metodo para la fabricacion de dispositivos de sondas.
JP6754701B2 (ja) マルチインデックス検出マイクロ流体チップおよび使用方法
US6861214B1 (en) Immobilization of biopolymers to aminated substrates by direct adsorption
JP2002544508A5 (enExample)
US20020187485A1 (en) Open substrate platforms suitable for analysis of biomolecules
JP3872227B2 (ja) 新規の生物学的チップ及び分析方法
ES2462549T3 (es) Composición de sol para biochip de sol-gel para inmovilizar una sonda sobre un sustrato sin tratamiento de la superficie y método para su rastreo
JP2004526420A6 (ja) 直接的な吸着によるアミノ化基質への生体高分子の不動化
CA2595268A1 (en) Dna purification and analysis on nanoengineered surfaces
AU2003217306A1 (en) Diagnostic microarray and method of use thereof
JP2008180711A (ja) 臨床的にインテリジェントな診断装置および方法
US20030198967A1 (en) Multi-functional microarrays and methods
CA2245013C (en) Analytical measurement method and its use
WO2004083863A1 (en) An integrating analysis chip with minimized reactors and its application
JP2006519384A5 (enExample)
ES2296297T3 (es) Orientacion molecular de macromoleculas mediante la accion de un menisco sobre superficies altamente especificas.
AU2018397330B2 (en) A sensor body for binding and/or enriching and/or detecting an analyte in a sample
WO2004079367A1 (ja) バイオアレイ
WO2000055627A1 (en) Reusable low fluorescent plastic biochip
ES2298738T3 (es) Metodo de inmovilizacion y kit para ello.
JP6076500B2 (ja) 標的物質の検出方法
WO2002039113A2 (en) Schiff base reductant co-dispense process