ES2304638T3 - Purificacion de inmunoglobulinas. - Google Patents

Purificacion de inmunoglobulinas. Download PDF

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Publication number
ES2304638T3
ES2304638T3 ES04809180T ES04809180T ES2304638T3 ES 2304638 T3 ES2304638 T3 ES 2304638T3 ES 04809180 T ES04809180 T ES 04809180T ES 04809180 T ES04809180 T ES 04809180T ES 2304638 T3 ES2304638 T3 ES 2304638T3
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ES
Spain
Prior art keywords
matrix
ligands
antibodies
separation
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04809180T
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English (en)
Spanish (es)
Inventor
Gunnar Glad
Bo-Lennart Johansson
Jean-Luc Maloisel
Nils Norrman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
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GE Healthcare Bio Sciences Corp
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
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    • Y10T428/249963—And a force disintegratable component [e.g., stencil sheet, etc.]

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES04809180T 2003-12-23 2004-12-21 Purificacion de inmunoglobulinas. Expired - Lifetime ES2304638T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0303532 2003-12-23
SE0303532A SE0303532D0 (sv) 2003-12-23 2003-12-23 Purification of immunoglobulins
PCT/SE2004/002007 WO2005061543A1 (en) 2003-12-23 2004-12-21 Purification of immunoglobulins

Publications (1)

Publication Number Publication Date
ES2304638T3 true ES2304638T3 (es) 2008-10-16

Family

ID=30768847

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04809180T Expired - Lifetime ES2304638T3 (es) 2003-12-23 2004-12-21 Purificacion de inmunoglobulinas.

Country Status (11)

Country Link
US (2) US20070151928A1 (enExample)
EP (1) EP1697416B1 (enExample)
JP (1) JP4739233B2 (enExample)
CN (1) CN100516086C (enExample)
AT (1) ATE391729T1 (enExample)
AU (1) AU2004303746B2 (enExample)
CA (1) CA2549923A1 (enExample)
DE (1) DE602004013040T2 (enExample)
ES (1) ES2304638T3 (enExample)
SE (1) SE0303532D0 (enExample)
WO (1) WO2005061543A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401665D0 (sv) 2004-06-24 2004-06-24 Amersham Biosciences Ab Purification of immunoglobulins
WO2006123576A1 (ja) * 2005-05-16 2006-11-23 National Institute Of Advanced Industrial Science And Technology 液体クロマトグラフィー用担体、該担体を充填したクロマトグラフィー用カラム、及び該カラムを用いた有機物の分離方法
SE529259C2 (sv) * 2005-08-31 2007-06-12 Ge Healthcare Bio Sciences Ab Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi
WO2007064281A1 (en) * 2005-12-02 2007-06-07 Ge Healthcare Bio-Sciences Ab Hydrophobic interaction chromatography
US9044740B2 (en) 2007-03-30 2015-06-02 Ge Healthcare Bio-Sciences Ab Purification of immunoglobulins
JP2014507649A (ja) * 2011-01-18 2014-03-27 バクスター・インターナショナル・インコーポレイテッド ヒト血液中の抗βアミロイド抗体の測定
CN102276840B (zh) * 2011-05-06 2012-08-01 中国药科大学 一种樟脑磺酰胺掺杂乙烷桥键球形介孔硅胶
EP2570183A1 (en) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
WO2014078729A1 (en) * 2012-11-15 2014-05-22 Genentech, Inc. IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY
CN105579463B (zh) * 2014-03-14 2020-01-31 生物辐射实验室股份有限公司 混合模式配体
CN114917884A (zh) * 2014-03-14 2022-08-19 思拓凡生物工艺研发有限公司 用于生物颗粒纯化的分离基质
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
CN113164915A (zh) * 2018-11-28 2021-07-23 库贝生物科技有限公司 固相螯合剂材料，其制备方法及其用于纯化蛋白质的用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212905A (en) * 1976-06-30 1980-07-15 Board of Reagents, for and on behalf of the University of Florida Method of coating supports using addition copolymers of aminimides
JPS6145773A (ja) * 1984-08-07 1986-03-05 テルモ株式会社 体液浄化材
DE3664729D1 (en) * 1985-04-09 1989-09-07 Terumo Corp Immunoglobulin adsorbent and adsorption apparatus
US4752398A (en) * 1985-08-05 1988-06-21 Holbein Bruce E Method for removing mercury and other related metals from a liquid medium
JPS6253669A (ja) * 1985-08-31 1987-03-09 テルモ株式会社 免疫グロブリン物質の吸着材および吸着装置
JPS639450A (ja) * 1986-06-28 1988-01-16 テルモ株式会社 体液成分分離材およびこれを備えた体液成分分離装置
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
US5043062A (en) * 1989-02-21 1991-08-27 Eastman Kodak Company High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material
JP2558007B2 (ja) * 1990-10-31 1996-11-27 株式会社資生堂 液体クロマトグラフィー用充填剤およびその製造方法
US5410648A (en) * 1991-08-30 1995-04-25 International Business Machines Corporation Debugging system wherein multiple code views are simultaneously managed
US6117996A (en) * 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
SE9600590D0 (sv) * 1996-02-19 1996-02-19 Pharmacia Biotech Ab Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris
JP4425994B2 (ja) * 1996-08-30 2010-03-03 ウプフロント クロマトグラフィー アクティーゼルスカブ 免疫グロブリンの単離
US5953526A (en) * 1997-11-10 1999-09-14 Internatinal Business Machines Corp. Object oriented programming system with displayable natural language documentation through dual translation of program source code
US7060187B2 (en) * 2001-11-26 2006-06-13 Ge Healthcare Bio-Sciences Ab Post-modification of a porous support
WO2007064281A1 (en) * 2005-12-02 2007-06-07 Ge Healthcare Bio-Sciences Ab Hydrophobic interaction chromatography

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CA2549923A1 (en) 2005-07-07
DE602004013040D1 (de) 2008-05-21
US20100151581A1 (en) 2010-06-17
AU2004303746A1 (en) 2005-07-07
US20070151928A1 (en) 2007-07-05
JP2007535658A (ja) 2007-12-06
AU2004303746B2 (en) 2011-03-24
CN100516086C (zh) 2009-07-22
US8685248B2 (en) 2014-04-01
DE602004013040T2 (de) 2009-07-02
EP1697416A1 (en) 2006-09-06
EP1697416B1 (en) 2008-04-09
SE0303532D0 (sv) 2003-12-23
CN1898265A (zh) 2007-01-17
ATE391729T1 (de) 2008-04-15
WO2005061543A1 (en) 2005-07-07
JP4739233B2 (ja) 2011-08-03

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