ES2296895T3 - Montaje mezclador extremo. - Google Patents
Montaje mezclador extremo. Download PDFInfo
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- ES2296895T3 ES2296895T3 ES02704461T ES02704461T ES2296895T3 ES 2296895 T3 ES2296895 T3 ES 2296895T3 ES 02704461 T ES02704461 T ES 02704461T ES 02704461 T ES02704461 T ES 02704461T ES 2296895 T3 ES2296895 T3 ES 2296895T3
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
- B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
- B05C17/00503—Details of the outlet element
- B05C17/00516—Shape or geometry of the outlet orifice or the outlet element
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
- B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
- B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Abstract
Un sistema de suministro de fluido (100) para dispensar un adhesivo biológico multicomponente, sistema que comprende: una carcasa alargada (120) configurada para recibir una pluralidad de reservorios en un extremo proximal de la misma; en el extremo distal de la carcasa una boquilla de descarga que aloja un montaje de conductos que tiene una pluralidad de conductos (112a, b) con un extremo proximal de los mismos que ha de estar, en uso, en comunicación de fluido respectiva con unos conductos separados de dichos reservorios, un extremo distal de cada uno de dichos conductos que define un respectivo orificio de salida (110a, b) en una cara distal (108) que está en ángulo con la dirección longitudinal de la carcasa; y caracterizado por: un montaje deflector proporcionado en dicha carcasa que tiene una placa deflectora (144) en alineación yuxtapuesta con dicho al menos un orifico de salida, orientada dicha placa deflectora sustancialmente paralela a dicha cara distal, para deflectar dichos componentes después de la salida de dicho al menos un orificio de salida, y en el que un primero de dicho al menos un orificio de salida y un segundo de dicho al menos un orificio de salida son independientes, de tal manera que dichos componentes primero y segundo se deflectan y entremezclan externamente a dicha boquilla de descarga contra dicha placa deflectora para aplicación mediante la placa deflectora al tejido corporal.
Description
Montaje mezclador externo.
La descripción se refiere a un sistema de
suministro de fluido para selladores, hemostáticos y adhesivos
biológicos así como sintéticos y, más particularmente a un montaje
mezclador externo para mezclar y suministrar selladores,
hemostáticos y adhesivos biológicos y/o sintéticos biocompatibles a
tejidos u órganos para sellar heridas, detener hemorragia y
similares. Para ejemplos de sistemas para mezclar dos componentes de
un fluido que se ha de suministrar, véanse los documentos
WO-A-00/56221,
US-A-4979942 y
DE-U-7925536. Los rasgos de la parte
de pre-caracterización de la reivindicación 1 más
adelante se describen en WO 00/56221.
Se usan selladores, hemostáticos y adhesivos
derivados biológicamente así como sintéticos para tratar heridas en
casos en los que no son totalmente eficaces los apósitos externos ni
las suturas. Un tratamiento común obtiene ventajas de la
polimerización rápida que sucede cuando una solución de factores de
coagulación proteómicos, tal como fibrinógeno, se pone contacto con
una solución de un catalizador proteómico, tal como trombina, para
formar un complejo que actúa como agente hemostático y como adhesivo
de tejido. Esta polimerización rápida comienza típicamente dentro
de los dos segundos después de que las soluciones se ponen
inicialmente en contacto una con otra, y alcanza típicamente una
solidificación blanda dentro de diez segundos de contacto. Un nombre
común para un complejo de este tipo es cola de fibrina o sellador
de fibrina.
Los componentes de proteínas de fibrinógeno y
trombina que, junto con una diversidad de adyuvantes conocidos,
forman un sellador de fibrina se derivan típicamente del plasma
humano y se someten a procedimientos de eliminación de virus. Los
componentes son típicamente deshidratados individualmente y se
almacenan en viales separados como polvos estériles.
Debido a la rápida polimerización tras la íntima
interacción de fibrinógeno y trombina, es importante mantener
separadas estas dos proteínas sanguíneas hasta que se apliquen en el
sitio de aplicación. Estas soluciones de proteínas se suministran
generalmente mediante sistemas de suministro de fluidos, tales como
un aparato de jeringa dual, en el que cada solución está confinada
dentro de una jeringa separada antes del mezclado.
Un aparato de jeringa dual para aplicar adhesivo
de tejido a base de fibrinógeno se describe en el documento de
patente de EE.UU. Nº 4.359.049 de Redl y col. Redl y col. describen
un mecanismo en el que dos jeringas normalizadas de una vía se
mantienen en un soporte teniendo un medio de accionamiento común. El
extremo dispensador de cada jeringa se inserta en un colector de
recogida en el que se mezclan los dos componentes. A continuación
se dispensan los componentes a través de una aguja común capaz de
cubrir un área limitada del sitio de aplicación. A menudo es
deseable o necesario cubrir un área extensa de una herida, ya sea
para detener una hemorragia, para fijar un tejido o para prevenir
una infección. También es deseable prevenir que los dos componentes
se mezclen dentro del dispositivo dispensador.
Además, todos los dispositivos conocidos para
dispensar soluciones de fibrinógeno y trombina requieren la adición
de estas proteínas en forma de polvo al cuerpo de la jeringa. Esto
hace a las proteínas susceptibles de contaminación por impurezas
que pueden entrar en el cuerpo de la jeringa. Aún más, el uso del
cuerpo de la jeringa para mezclar las proteínas con agua para crear
las soluciones de proteínas puede provocar que las soluciones
tengan fugas tanto desde el extremo dispensador de cada jeringa como
desde el extremo proximal del cuerpo de la jeringa. Adicionalmente,
un aparato de jeringa dual para la aplicación de soluciones de
fibrinógeno y trombina a un sitio de aplicación generalmente
contiene varias piezas, tales como un émbolo de jeringa, un
conector de colector en "Y", una aguja dispensadora, un soporte
de jeringa, agujas de jeringa, y conductos para transportar las
soluciones a la aguja dispensadora. Por lo tanto, los sistemas o
aplicadores de suministro de selladores de fibrina conocidos, tales
como los que se describen la patente de EE.UU. de Redl y col.
anteriormente descrita, y en las patentes de EE.UU. N^{os}
4.874.368 de Millar y col. y 4.979.942 de Wolf y col. son difíciles
de reutilizar. El rellenado de los componentes de proteínas requiere
típicamente retirar un gancho que sujeta el émbolo de la jeringa,
retirar el émbolo de la jeringa, separar las jeringas del conector
en "Y", retirar las jeringas del soporte, insertar nuevas
jeringas, fijar las jeringas al conector en "Y", y añadir
fibrinógeno a una jeringa y trombina a la otra jeringa, añadir agua
estéril a cada jeringa, volver a colocar el émbolo de la jeringa,
volver a colocar el gancho del émbolo, y mezclar las soluciones. En
una aplicación en la que el tiempo es esencial, un procedimiento de
rellenado tan largo no es práctico y es engorroso.
Adicionalmente, los sistemas conocidos de
suministro de fluido para dispensar un adhesivo biológico requieren
el empleo manual de una fuerza sobre los componentes de proteínas de
modo que puedan ser dispensados desde el sistema de suministro de
fluido. Típicamente, se emplea una fuerza manual sobre los
componentes por medio del émbolo en la jeringa estándar de una vía.
Este tipo de disposición se muestra en las patentes de EE.UU.
N^{os} 4.359.049 anteriormente descrita, y 4.631.055 de Redl y
col. Emplear manualmente una fuerza sobre un émbolo situado en el
extremo proximal del sistema de suministro de fluido puede hacer
difícil la aplicación del adhesivo. Por ejemplo, el usuario es
incapaz de ver claramente el sitio de aplicación cuando sostiene el
sistema de suministro de fluido perpendicularmente al sitio de
aplicación. Además, una disposición de este tipo provoca que entre
aire a las jeringas, provocando dificultad para emplear una fuerza
por la vía del émbolo de la jeringa.
Así pues, existe necesidad en la técnica de un
sistema de suministro de fluido para aplicar un adhesivo de tejido
en el que el adhesivo cubra un área extensa de la herida, ya sea
para detener una hemorragia, para fijar un tejido o para prevenir
una infección. También existe necesidad de un sistema de suministro
de fluido en el que los componentes adhesivos no sean susceptibles
de contaminación y los componentes adhesivos no se entremezclen
dentro del sistema de suministro de fluido. Además, existe necesidad
de un sistema de suministro de fluido en el que las soluciones
componentes se rellenen fácilmente. También existe necesidad de un
sistema de suministro de fluido que sea autolimpiante y
reutilizable con diferentes soluciones componentes. Además, existe
necesidad de un sistema de suministro de fluido que sea económico de
fabricar para que permita que el sistema de suministro de fluido
sea desechado después de uso. Adicionalmente, existe necesidad de un
sistema de suministro de fluido que evite desperdiciar solución
adhesiva y permita que se vea claramente por el usuario el sitio de
aplicación cuando se aplican las soluciones componentes
perpendiculares al sitio de aplicación.
La presente invención se define en la
reivindicación 1 más adelante. Las reivindicaciones dependientes se
dirigen a rasgos óptimos y preferidos.
Se proporciona un sistema de suministro de
fluido al que se hace referencia en este documento como montaje
mezclador externo. El montaje mezclador externo mezcla y suministra
externamente un primer y un segundo componente de un adhesivo
biológico a tejidos u órganos para sellar heridas, detener
hemorragia y similares. Los componentes primero y segundo se
mezclan inmediatamente después de salir de orificios de salida
separados que se disponen en comunicación de fluido con reservorios
de componentes.
En una realización preferida, la carcasa tiene
una cabeza de carcasa para incluir en la misma el primer reservorio
que contiene el primer componente, y el segundo reservorio que
contiene el segundo componente. Se prevé que la boquilla de
descarga y el montaje deflector puedan estar conformados en diversas
configuraciones para proporcionar mezcla y dispensación adecuadas
de los componentes primero y segundo.
La boquilla de descarga incluye una cara distal
que tiene una configuración angular. La placa deflectora se orienta
en relación generalmente paralela yuxtapuesta distal a la cara
distal de la boquilla de descarga. Sin embargo, se prevé que la
placa deflectora se disponga abierta o cerrada en cierta medida en
relación con la cara distal de la boquilla de descarga dependiendo
de las necesidades quirúrgicas particulares. El tamaño y
configuración de la placa deflectora pueden variar. También se
contempla que la cara distal de la boquilla de descarga pueda ser
también sustancialmente perpendicular al eje longitudinal de la
boquilla de descarga. Los componentes primero y segundo son
preferiblemente fibrinógeno y trombina que se entremezclan para
formar un sellador de fibrina.
En este documento se describen diversas
realizaciones con referencia a los dibujos, en los que:
Fig. 1 es una imagen, vista en perspectiva de un
montaje mezclador externo según una realización de la presente
descripción;
Fig. 2 es una vista posterior de la imagen de la
realización ilustrada en Fig. 1, que muestra porciones del extremo
proximal de la boquilla de descarga;
Fig. 3 es una vista en sección transversal de la
realización ilustrada en Fig. 2, tomada a lo largo de la línea
3-3;
Fig. 4 es una vista en sección transversal de la
realización ilustrada en Fig. 2, tomada a lo largo de la línea
4-4;
Fig. 5 es una vista en perspectiva de un montaje
mezclador externo según otra realización de la presente
descripción;
Fig. 6 es una vista frontal de la realización
ilustrada en Fig. 5, que muestra porciones del extremo distal de la
punta de la boquilla y la placa deflectora; y
Fig. 7 es una vista en sección transversal de la
realización ilustrada en Fig. 6, tomada a lo largo de la línea
7-7.
Con referencia a las Figs. 4 a 7, se ilustra un
montaje mezclador externo según una realización de la presente
descripción. El montaje que se designa generalmente por el número
100 incluye una carcasa (que no se muestra) que tiene una cabeza de
carcasa y una boquilla de descarga 120 que definen un eje
longitudinal. La cabeza de carcasa puede contribuir a la facilidad
de manejo y control del montaje mezclador 100.
Se proporciona una punta de boquilla 106 en un
extremo distal o cara 108 de la boquilla de descarga 120. La punta
de boquilla 106 incluye dos orificios dispensadores 110a, 110b en
los que cada orificio dispensador está en comunicación de fluido
con un respectivo conducto 112a, 112b de un montaje de conductos 114
dentro de la boquilla de descarga 120 para dispensar componentes
biológicos contenidos dentro de la cabeza de carcasa 104.
Preferiblemente, los componentes biológicos son una solución de
fibrinógeno y una solución de trombina que se intermezclan para
formar un sellador de fibrina. Sin embargo, se ha de entender que se
pueden sustituir con otros fluidos biológicos, dependiendo de la
elección de la mezcla que se ha de dispensar.
La carcasa se forma preferiblemente a partir de
semisecciones de carcasa moldeadas que se forman con particiones
internas configuradas para alinear apropiadamente unos con respecto
a otros los componentes internos del montaje 100 y para prevenir el
movimiento de un primer y un segundo reservorio que almacena cada
uno un componente biológico cuando los reservorios se ajustan
dentro de conductos de reservorios 124 y 126, como se muestra
mediante Figs. 3 y 4. Los componentes internos principales del
montaje 100 incluyen el montaje de conductos 114 y un montaje de
reservorios. Los dos montajes se interrelacionan entre sí para
dispensar los componentes biológicos almacenados dentro de los
reservorios primero y segundo por la vía de los dos orificios
dispensadores 110a, 110b.
El montaje 100 incluye adicionalmente un montaje
deflector 140 conectado a la carcasa 102 y a la boquilla de
descarga 120 por la vía de los soportes 148 y 149. Se contempla que
los soportes 148 y 149 se pueden sustituir por uno o más diferentes
tipos de estructura de conexión como se conocen en la técnica. El
montaje deflector 140 incluye una carcasa deflectora cilíndrica 142
que aloja la boquilla de descarga 120 cuando el montaje deflector
140 se conecta a la carcasa 102 y a la boquilla de descarga 120.
Una placa deflectora 144 se extiende desde un
extremo distal de la carcasa deflectora 142. La placa deflectora
144 está desplazada una distancia relativamente corta de la cara
distal 108 de la boquilla de descarga 120 para proporcionar espacio
para la mezcla inicial de los componentes biológicos dispensados
desde los dos orificios dispensadores 110a, 110b.
La placa deflectora 144 se configura para
facilitar tanto el mezclado como el direccionamiento de los
componentes. La placa deflectora 144 se orienta preferiblemente en
relación paralela general con la cara distal 108 de la boquilla de
descarga 120. Se contempla que la placa deflectora 144 se pueda
disponer en una relación abierta o cerrada en cierta medida con
relación a la cara distal 108 de la boquilla de descarga 120
dependiendo de la aplicación específica. También se contempla que
la placa deflectora 144 se pueda conectar a la carcasa deflectora
142 de modo que pueda pivotar mediante un mecanismo de trinquete
para pivotar y bloquear la placa deflectora 144 en una o varias
posiciones con respecto a la cara distal 108 de la boquilla de
descarga 120 según las necesidades quirúrgicas particulares.
El tamaño y configuración de la placa deflectora
144, y el hueco que deja con la cara distal 108 de la boquilla de
descarga 120, se pueden variar. Las posiciones y orientaciones de
los orificios de descarga 110a, 110b, con relación a la placa
deflectora 144, también se pueden variar en función de las
necesidades quirúrgicas cambiando la alineación de los conductos
112a, 112b con respecto al eje longitudinal de la boquilla de
descarga 120. Esto es, uno o ambos conductos 112a, 112b pueden
tener una o más curvas, los conductos 112a, 112b pueden estar en
orientación divergente, convergente o paralela de uno con respecto
al otro, los conductos 112a, 112b se pueden juntar en la proximidad
de la cara distal 108 de la boquilla de descarga 120 para formar un
conducto, etc.
Como se sabe en la técnica, los reservorios
primero y segundo incluyen un cuerpo principal o perforación pasante
central para almacenar los componentes biológicos. Se usa una tapa
para sellar al vacío la perforación pasante central para prevenir
la contaminación de los componentes biológicos. La tapa incluye
preferiblemente una superficie de silicona capaz de ser penetrada
por una aguja de jeringa para añadir un líquido, preferiblemente
agua estéril, dentro de los reservorios que se entremezcle con los
componentes biológicos para formar soluciones de proteínas. Las
soluciones de proteínas se dispensan en el sitio de aplicación como
se ha descrito anteriormente. El montaje del conducto 114 incluye
los dos conductos 112a, 112b. Preferiblemente, cada conducto incluye
una punta proximal biselada para penetrar en la tapa respectiva de
los reservorios primero y segundo.
Preferiblemente, los reservorios primero y
segundo son idénticos para contener una cantidad volumétrica igual
de su respectiva solución de proteína en comparación con el otro
reservorio. Se contempla proporcionar un color diferente para cada
reservorio para reconocer fácilmente el reservorio que contiene
fibrinógeno y el reservorio que contiene trombina. Se contempla
adicionalmente proporcionar una forma diferente para cada reservorio
y cambiar la forma de uno o de ambos conductos de reservorios 124,
126 consecuentemente con la misma finalidad, es decir, reconocer
fácilmente el reservorio que contiene fibrinógeno y el reservorio
que contiene trombina. Sin embargo, la cantidad volumétrica
almacenada dentro del primer reservorio debería ser igual a la
cantidad volumétrica almacenada dentro del segundo reservorio para
mantener una relación previamente determinada de solución de
fibrinógeno a trombina, que es típicamente una relación 1:1.
Los reservorios primero y segundo se construyen
preferiblemente de un material flexible y contienen los componentes
biológicos primero y segundo, respectivamente. Se contempla que las
semisecciones de la carcasa sean completamente o parcialmente
transparentes, así como los reservorios primero y segundo para
permitir que el usuario vea la cantidad de solución y determine si
la solución se ha entremezclado suficientemente antes de que sea
dispensada en el sitio de aplicación. Se contempla adicionalmente
proporcionar marcas de calibración en el reservorio primero y en el
segundo.
Con referencia a Figs. 1 a 3, se muestra un
montaje mezclador externo según una realización alternativa de la
presente descripción.
El montaje mezclador externo 10 incluye una
boquilla de descarga 20 y un montaje deflector 40 conectado a un
extremo distal de la boquilla de descarga 20. La boquilla de
descarga 20 incluye un cuerpo de boquilla 22 que define dos
orificios de salida longitudinales 24 y 26 en el mismo con
comunicación de fluido con sus respectivos reservorios de
componentes (que no se muestran). El cuerpo de boquilla 22 incluye
una punta de boquilla 28 en una porción del extremo distal de la
misma, que se configura preferiblemente como un cilindro que tiene
una cara distal en ángulo.
El montaje deflector 40 incluye una porción de
conexión 42 en un extremo proximal del mismo para conectarse con el
extremo distal del cuerpo de boquilla 22. El montaje deflector 40
incluye adicionalmente una placa deflectora 44 en un extremo distal
del mismo, que está desplazada una corta distancia de la cara distal
de la punta de la boquilla 28 para proporcionar un espacio para la
mezcla inicial de los componentes biológicos. La placa deflectora
44 se configura para facilitar tanto el mezclado como el
direccionamiento de los componentes. La placa deflectora se orienta
preferiblemente en relación general paralela con la cara distal de
la boquilla de descarga 28.
Se contempla que la placa deflectora 44 se pueda
disponer en una relación abierta o cerrada en cierta medida con
relación a la cara distal de la punta de la boquilla 28 dependiendo
de la aplicación específica. También se contempla que la placa
deflectora 44 se pueda conectar a la porción de conexión 42 de modo
que pueda pivotar mediante un mecanismo de trinquete para pivotar y
bloquear la placa deflectora 44 en una o varias posiciones con
respecto a la cara distal de la punta de la boquilla 28 según las
necesidades quirúrgicas particulares.
El tamaño y configuración de la placa deflectora
44 y el hueco que deja con la cara distal de la punta de la
boquilla 28, se pueden variar. Las posiciones y orientaciones de los
orificios de salida 24 y 26, con relación a la placa deflectora 44,
también se pueden variar en función de las necesidades quirúrgicas
cambiando la alineación de los orificios de salida 24 y 26 con
respecto al eje longitudinal de la boquilla de descarga 20. Esto
es, uno o ambos orificios de salida 24 y 26 pueden tener una o más
curvas, los orificios de salida 24 y 26 pueden estar en orientación
divergente, convergente o paralela de uno con respecto al otro, los
orificios de salida 24 y 26 se pueden juntar en la proximidad de la
cara distal de la punta de la boquilla 28 para formar un orifico de
salida, etc.
Los montajes mezcladores externos según la
presente descripción son capaces de aplicar un adhesivo de tejido
en el que el adhesivo cubre un área extensa de una herida, ya sea
para detener una hemorragia, para fijar un tejido o para prevenir
una infección. Los montajes mezcladores externos según la presente
descripción previenen que los componentes adhesivos sean
susceptibles de contaminación y que se entremezclen los componentes
adhesivos externamente.
Además, el montaje mezclador externo de la
primera realización permite que las soluciones componentes se
rellenen fácilmente retirando los reservorios gastados de los
conductos de reservorios y reemplazándolos con reservorios nuevos.
Adicionalmente los montajes mezcladores externos según la presente
descripción evitan desperdiciar solución adhesiva y permiten que se
vea claramente por el usuario el sitio de aplicación cuando se
aplican las soluciones componentes perpendiculares al sitio de
aplicación.
Se contempla que todas las realizaciones que se
describen en este documento sean desechables o tengan uno o más
componentes desechables. También se contempla que todas las
realizaciones que se describen en este documento puedan ser
esterilizadas para reutilizarlas.
Por lo tanto, se entiende que se pueden hacer
diversas modificaciones a las realizaciones que se describen en
este documento. Por ejemplo, aun cuando se han descrito con detalle
realizaciones específicas del montaje mezclador externo, también se
pueden usar estructuras que llevan a cabo sustancialmente la misma
función sustancialmente de la misma manera para conseguir
sustancialmente el mismo resultado. Asimismo, además de aplicar un
sellador de fibrina, el montaje mezclador externo se puede usar
para llevar a cabo procedimientos quirúrgicos humanos o
veterinarios que incluyen aplicar antisépticos, medicación y otros
procedimientos similares.
Claims (5)
1. Un sistema de suministro de fluido (100) para
dispensar un adhesivo biológico multicomponente, sistema que
comprende:
una carcasa alargada (120) configurada para
recibir una pluralidad de reservorios en un extremo proximal de la
misma;
en el extremo distal de la carcasa una boquilla
de descarga que aloja un montaje de conductos que tiene una
pluralidad de conductos (112a, b) con un extremo proximal de los
mismos que ha de estar, en uso, en comunicación de fluido
respectiva con unos conductos separados de dichos reservorios, un
extremo distal de cada uno de dichos conductos que define un
respectivo orificio de salida (110a, b) en una cara distal (108) que
está en ángulo con la dirección longitudinal de la carcasa; y
caracterizado por:
un montaje deflector proporcionado en dicha
carcasa que tiene una placa deflectora (144) en alineación
yuxtapuesta con dicho al menos un orifico de salida, orientada
dicha placa deflectora sustancialmente paralela a dicha cara
distal, para deflectar dichos componentes después de la salida de
dicho al menos un orificio de salida, y
en el que un primero de dicho al menos un
orificio de salida y un segundo de dicho al menos un orificio de
salida son independientes, de tal manera que dichos componentes
primero y segundo se deflectan y entremezclan externamente a dicha
boquilla de descarga contra dicha placa deflectora para aplicación
mediante la placa deflectora al tejido corporal.
2. El sistema de la reivindicación 1, que
incluye dichos reservorios, y en el que cada uno de dicha pluralidad
de reservorios incluye un orificio sellable configurado para ser
penetrado por un extremo proximal de uno de los conductos
respectivos de dicha pluralidad.
3. El sistema de la reivindicación 1, en el que
dicha carcasa incluye una cabeza de carcasa para almacenar dicha
pluralidad de reservorios en la misma.
4. El sistema de la reivindicación 1, 2 ó 3, que
incluye dicho primer componente, que es una solución de trombina, y
dicho segundo componente, que es una solución de fibrinógeno, con lo
que dicho adhesivo biológico es un sellador de fibrina.
5. El sistema de la reivindicación 1, 2 ó 3, que
incluye dicho adhesivo biológico y en el que dicho adhesivo
comprende una relación determinada previamente de dicho primer
componente a dicho segundo componente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27179301P | 2001-02-27 | 2001-02-27 | |
| US271793P | 2001-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2296895T3 true ES2296895T3 (es) | 2008-05-01 |
Family
ID=23037104
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02704461T Expired - Lifetime ES2296895T3 (es) | 2001-02-27 | 2002-02-27 | Montaje mezclador extremo. |
| ES08002355T Expired - Lifetime ES2328087T3 (es) | 2001-02-27 | 2002-02-27 | Montaje mezclador externo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08002355T Expired - Lifetime ES2328087T3 (es) | 2001-02-27 | 2002-02-27 | Montaje mezclador externo. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7018357B2 (es) |
| EP (2) | EP1372488B1 (es) |
| AU (1) | AU2002238143B2 (es) |
| CA (2) | CA2766682A1 (es) |
| DE (2) | DE60232926D1 (es) |
| ES (2) | ES2296895T3 (es) |
| WO (1) | WO2002067785A2 (es) |
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- 2002-02-27 CA CA2766682A patent/CA2766682A1/en not_active Abandoned
- 2002-02-27 DE DE60232926T patent/DE60232926D1/de not_active Expired - Lifetime
- 2002-02-27 ES ES02704461T patent/ES2296895T3/es not_active Expired - Lifetime
- 2002-02-27 WO PCT/US2002/006142 patent/WO2002067785A2/en active IP Right Grant
- 2002-02-27 US US10/085,150 patent/US7018357B2/en not_active Expired - Fee Related
- 2002-02-27 DE DE60224990T patent/DE60224990T2/de not_active Expired - Lifetime
- 2002-02-27 AU AU2002238143A patent/AU2002238143B2/en not_active Ceased
- 2002-02-27 EP EP02704461A patent/EP1372488B1/en not_active Expired - Lifetime
- 2002-02-27 CA CA2438858A patent/CA2438858C/en not_active Expired - Fee Related
- 2002-02-27 ES ES08002355T patent/ES2328087T3/es not_active Expired - Lifetime
- 2002-02-27 EP EP09164775A patent/EP2105096A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE60232926D1 (de) | 2009-08-20 |
| WO2002067785A2 (en) | 2002-09-06 |
| US7018357B2 (en) | 2006-03-28 |
| EP1372488A2 (en) | 2004-01-02 |
| DE60224990T2 (de) | 2009-02-05 |
| CA2438858C (en) | 2012-05-01 |
| CA2766682A1 (en) | 2002-09-06 |
| AU2002238143B2 (en) | 2006-06-01 |
| CA2438858A1 (en) | 2002-09-06 |
| DE60224990D1 (de) | 2008-03-27 |
| ES2328087T3 (es) | 2009-11-06 |
| WO2002067785A3 (en) | 2003-01-09 |
| EP1372488B1 (en) | 2008-02-13 |
| US20020179641A1 (en) | 2002-12-05 |
| EP2105096A1 (en) | 2009-09-30 |
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