ES2290741T3 - Metodo de tratamiento de trastornos del tracto urinario inferior. - Google Patents
Metodo de tratamiento de trastornos del tracto urinario inferior. Download PDFInfo
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- ES2290741T3 ES2290741T3 ES04758741T ES04758741T ES2290741T3 ES 2290741 T3 ES2290741 T3 ES 2290741T3 ES 04758741 T ES04758741 T ES 04758741T ES 04758741 T ES04758741 T ES 04758741T ES 2290741 T3 ES2290741 T3 ES 2290741T3
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Landscapes
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46102203P | 2003-04-04 | 2003-04-04 | |
| US461022P | 2003-04-04 | ||
| US49650203P | 2003-08-20 | 2003-08-20 | |
| US496502P | 2003-08-20 | ||
| US53634104P | 2004-01-13 | 2004-01-13 | |
| US536341P | 2004-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2290741T3 true ES2290741T3 (es) | 2008-02-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES04758741T Expired - Lifetime ES2290741T3 (es) | 2003-04-04 | 2004-04-02 | Metodo de tratamiento de trastornos del tracto urinario inferior. |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6846823B2 (https=) |
| EP (1) | EP1539181B1 (https=) |
| JP (1) | JP2006522144A (https=) |
| AT (1) | ATE365554T1 (https=) |
| AU (1) | AU2004227945B2 (https=) |
| CA (1) | CA2519379A1 (https=) |
| DE (1) | DE602004007225T2 (https=) |
| ES (1) | ES2290741T3 (https=) |
| WO (1) | WO2004089288A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7085845B2 (en) * | 2001-05-09 | 2006-08-01 | Gene Fein | Method, apparatus and computer program product for identifying a playing media file and tracking associated user preferences |
| CN100355419C (zh) * | 2002-06-07 | 2007-12-19 | 安斯泰来制药有限公司 | 治疗膀胱过度活动的药物 |
| US20040180958A1 (en) * | 2002-12-13 | 2004-09-16 | Taylor Charles Price | Method of treatment |
| ES2288641T3 (es) * | 2002-12-20 | 2008-01-16 | Dynogen Pharmaceuticals Inc. | Metodo para tratar trastornos indoloros de la vejiga usando moduladores de canales del calcio de la subunidad alfa2-delta. |
| DE602004003172T2 (de) * | 2003-03-21 | 2007-09-27 | Dynogen Pharmaceuticals Inc., Waltham | Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals |
| EP1539181B1 (en) * | 2003-04-04 | 2007-06-27 | Dynogen Pharmaceuticals Inc. | Method of treating lower urinary tract disorders |
| WO2005011683A1 (ja) * | 2003-08-04 | 2005-02-10 | Kyorin Pharmaceutical Co., Ltd. | 経皮吸収型製剤 |
| CA2560279A1 (en) * | 2004-03-19 | 2005-09-29 | Solvay Pharmaceuticals Gmbh | Use of a 5-ht3 receptor antagonist for the manufacture of a medicament for the treatment of non-digestive tract derived abdominal disorders associated with pain |
| US7820690B2 (en) | 2004-03-19 | 2010-10-26 | Solvay Pharmaceuticals Gmbh | Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist |
| WO2006042679A1 (de) * | 2004-10-18 | 2006-04-27 | Boehringer Ingelheim International Gmbh | Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts |
| WO2006066110A2 (en) * | 2004-12-14 | 2006-06-22 | The Johns Hopkins University | Cav2 RELATED COMPOSITIONS AND METHODS |
| KR20070087678A (ko) | 2004-12-20 | 2007-08-28 | 컬리지움 파마슈티칼, 인코포레이티드 | 수면 장애용 약제 조성물 |
| DK2839830T3 (da) * | 2005-01-14 | 2019-08-19 | Urigen Inc | Kits og sammensætninger til behandling af lidelser i de nedre urinveje |
| EP1855680A2 (en) * | 2005-02-25 | 2007-11-21 | Solvay Pharmaceuticals, Inc. | Method of treatment of diarrhea-predominant ibs in a female subject receiving contraceptive therapy |
| US20060293309A1 (en) * | 2005-03-28 | 2006-12-28 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| US20070093520A1 (en) * | 2005-04-15 | 2007-04-26 | Caras Steven D | Method of treatment of diarrhea-predominant irritable bowel syndrome in a subject |
| US20070010543A1 (en) * | 2005-07-01 | 2007-01-11 | Dynogen Pharmaceuticals, Inc. | Compositions and methods for treating gastrointestinal hypomotility and associated disorders |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| FR2895259B1 (fr) * | 2005-12-22 | 2008-02-22 | Urosphere Sas | Methodes de traitement des incontinences urinaires |
| US20070172507A1 (en) * | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
| US20070172508A1 (en) * | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP1991212A1 (en) * | 2006-03-08 | 2008-11-19 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2068872A1 (en) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| AU2007299920A1 (en) * | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| EP1997807A1 (en) * | 2007-05-28 | 2008-12-03 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
| US20090112197A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc | Devices configured to facilitate release of nitric oxide |
| CA2673545A1 (en) * | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| US20080171750A1 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation Of Neurogenesis With Use of Modafinil |
| US20090274722A1 (en) * | 2007-01-29 | 2009-11-05 | Ligums John E | Therapeutic Composition for the Treatment of BPH and ED |
| MX2009010000A (es) * | 2007-03-19 | 2010-03-17 | Insuline Medical Ltd | Dispositivo para el suministro de farmaco. |
| EP2136863A2 (en) * | 2007-03-19 | 2009-12-30 | Insuline Medical Ltd. | Device for drug delivery and associated connections thereto |
| US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
| US9220837B2 (en) * | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
| US8415390B2 (en) | 2008-05-30 | 2013-04-09 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| AU2008259864C1 (en) * | 2007-05-30 | 2014-03-06 | Microdose Therapeutx, Inc. | Methods and compositions for administration of Oxybutynin |
| WO2008157205A2 (en) * | 2007-06-15 | 2008-12-24 | Duke University | Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp |
| US8877508B2 (en) | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US20110182970A1 (en) * | 2007-10-30 | 2011-07-28 | Hyde Roderick A | Nitric oxide sensors and systems |
| US10080823B2 (en) * | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
| DK2216021T3 (da) | 2007-11-02 | 2012-11-05 | Astellas Pharma Inc | Farmaceutisk sammensætning til behandling af overaktiv blære |
| US8409133B2 (en) | 2007-12-18 | 2013-04-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| WO2009128058A1 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| CA2743027C (en) | 2008-11-07 | 2016-04-12 | Insuline Medical Ltd. | Device and method for drug delivery |
| WO2010077669A2 (en) * | 2008-12-08 | 2010-07-08 | Teva Pharmaceutical Industries Ltd. | Palonosetron formulation |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US9180263B2 (en) * | 2009-07-01 | 2015-11-10 | Microdose Therapeutx, Inc. | Laboratory animal pulmonary dosing device |
| US20110000481A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Nebulizer for infants and respiratory compromised patients |
| ES2702753T3 (es) * | 2010-01-05 | 2019-03-05 | Microdose Therapeutx Inc | Dispositivo de inhalación |
| WO2018071435A1 (en) | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| WO2020030777A1 (en) * | 2018-08-10 | 2020-02-13 | Grünenthal GmbH | Composition for treating urinary frequency and/or urinary urgency |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046489A (en) | 1958-11-28 | 1962-07-24 | Elcor Inc | Wide band direct coupled amplifier |
| US3161155A (en) | 1961-02-04 | 1964-12-15 | Orlandi Giorgio | Food-dough cords spacing device |
| JPS60146891A (ja) * | 1984-01-05 | 1985-08-02 | Mitsubishi Chem Ind Ltd | 〔2,3−d〕チエノピリミジン誘導体およびその塩 |
| DE3422155A1 (de) | 1984-06-14 | 1985-12-19 | Alfred Teves Gmbh, 6000 Frankfurt | Hydraulische servofahrzeugbremse |
| IE880255L (en) | 1987-01-30 | 1988-07-30 | American Home Prod | Des-epidermal growth factor activators. |
| DE3885357T2 (de) | 1987-06-29 | 1994-03-24 | Duphar Int Res | Anellierte Indolderivate. |
| US5225407A (en) | 1990-02-22 | 1993-07-06 | Glaxo Group Limited | 5-HT3 receptor antagonists for the treatment of autism |
| CA2044854A1 (en) * | 1990-07-19 | 1992-01-20 | Hong-I Chen | Method for preventing or treating urinary incontinence |
| PH30083A (en) * | 1991-02-25 | 1996-12-27 | Lilly Co Eli | Treatment of lower urinary tract disorders |
| WO1993000074A1 (en) | 1991-06-26 | 1993-01-07 | Sepracor, Inc. | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
| US5281624A (en) * | 1991-09-27 | 1994-01-25 | Eli Lilly And Company | N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof |
| JP2699794B2 (ja) | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔3,2−b〕ピリジン誘導体 |
| JPH0616557A (ja) * | 1992-12-21 | 1994-01-25 | Mitsubishi Kasei Corp | 脳機能障害改善剤 |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| DK0855397T3 (da) | 1995-07-28 | 2001-06-25 | Dainippon Pharmaceutical Co | (R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse |
| AU702594B2 (en) | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
| CA2286076C (en) | 1997-04-18 | 2006-12-12 | Janssen Pharmaceutica N.V. | Use of 5ht3 antagonists for promoting intestinal lavage |
| JPH10298078A (ja) | 1997-05-06 | 1998-11-10 | Mitsubishi Chem Corp | 抗不安薬 |
| DE19813661A1 (de) | 1997-08-01 | 1999-02-04 | Solvay Pharm Gmbh | Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron |
| DE19734444A1 (de) | 1997-08-08 | 1999-02-11 | Basf Ag | 3-Substituierte 3,4,5,7-Tetrahydro-pyrrolo(3',4':4,5) thieno (2,3-d) pyrimidin-Derivate, ihre Herstellung und Verwendung |
| FR2781671A1 (fr) | 1998-07-28 | 2000-02-04 | Synthelabo | Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique |
| WO2000024716A1 (en) | 1998-10-23 | 2000-05-04 | Ajinomoto Co., Inc. | Dihydropyridine derivatives and drug compositions containing the same |
| US6272553B2 (en) * | 1998-11-20 | 2001-08-07 | Sprint Communications Company, L.P. | Multi-services communications device |
| ES2327600T3 (es) | 1999-02-18 | 2009-11-02 | Novasearch Ag | Uso de antagonistas del receptor de la 5-ht3 para el tratamiento de enfermedades musculoesqueleticas. |
| US6342496B1 (en) * | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
| DE19911371A1 (de) | 1999-03-15 | 2000-09-21 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen |
| US6589570B1 (en) * | 1999-04-12 | 2003-07-08 | University Of Madras | Pharmaceutical formulation useful for the treatment of hepatitis B, hepatitis C and other viral infections of the liver and a process for its preparation |
| DE19929197A1 (de) | 1999-06-25 | 2000-12-28 | Novosis Pharma Ag | Transdermalsysteme zur Abgabe von 5-HT3-Rezeptor-Antagonisten und ihre Verwendung zur antiemitischen Behandlung |
| US6465458B1 (en) | 1999-07-01 | 2002-10-15 | Pharmacia & Upjohn Company | Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor |
| GB2355191A (en) | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
| US6846496B1 (en) * | 1999-10-15 | 2005-01-25 | Orion Corporation | Treatment of osteoporosis |
| WO2001051496A1 (en) * | 2000-01-14 | 2001-07-19 | Rhodia, Inc. | Crosslinking agents for textile finishing baths |
| PT1257277E (pt) | 2000-02-24 | 2005-09-30 | Pharmacia & Upjohn Co Llc | Novas combinacoes de farmacos |
| JP2002026134A (ja) * | 2000-07-12 | 2002-01-25 | Seiko Epson Corp | 半導体集積回路の製造方法及びこの方法により製造した半導体集積回路 |
| GB0112494D0 (en) | 2001-05-22 | 2001-07-11 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| WO2003061657A1 (en) | 2002-01-18 | 2003-07-31 | Aryx Therapeutics | 5-ht3 receptor antagonists and methods of use |
| GB0202265D0 (en) | 2002-01-31 | 2002-03-20 | Arachnova Therapeutics Ltd | New therapeutic use |
| JP2005526079A (ja) | 2002-03-15 | 2005-09-02 | サイプレス バイオサイエンス, インコーポレイテッド | 内蔵痛症候群を処置するためのneおよび5−ht再取り込み阻害剤 |
| CA2491836C (en) | 2002-07-10 | 2011-01-25 | Arachnova Therapeutics Ltd. | 4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-d) pyrimidine in the treatment of functional bowel disorder |
| AU2003259373B2 (en) | 2002-08-29 | 2006-03-09 | Dynogen Pharmaceuticals, Inc. | New therapeutic uses of (4-(2-Fluorophenyl)-6-methyl-2-(1-piperazinyl) thieno[2,3-D]pyrimidine |
| MXPA05007381A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para el tratamiento de transtornos funcionales del intestino. |
| NZ541009A (en) * | 2003-01-13 | 2007-09-28 | Dynogen Pharmaceuticals Inc | Method of treating nausea, vomiting, retching or any combination thereof |
| EP1539181B1 (en) * | 2003-04-04 | 2007-06-27 | Dynogen Pharmaceuticals Inc. | Method of treating lower urinary tract disorders |
| US7356884B2 (en) * | 2003-12-18 | 2008-04-15 | 3M Innovative Properties Company | Fastener for a display page |
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- 2004-04-02 AT AT04758741T patent/ATE365554T1/de not_active IP Right Cessation
- 2004-04-02 JP JP2006509595A patent/JP2006522144A/ja active Pending
- 2004-04-02 DE DE602004007225T patent/DE602004007225T2/de not_active Expired - Fee Related
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Also Published As
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| AU2004227945B2 (en) | 2006-10-26 |
| CA2519379A1 (en) | 2004-10-21 |
| DE602004007225D1 (de) | 2007-08-09 |
| US20050282799A1 (en) | 2005-12-22 |
| WO2004089288A3 (en) | 2005-04-21 |
| AU2004227945A1 (en) | 2004-10-21 |
| EP1539181B1 (en) | 2007-06-27 |
| DE602004007225T2 (de) | 2008-03-06 |
| US20050026909A1 (en) | 2005-02-03 |
| US20040209869A1 (en) | 2004-10-21 |
| EP1539181A2 (en) | 2005-06-15 |
| ATE365554T1 (de) | 2007-07-15 |
| US20050272719A1 (en) | 2005-12-08 |
| EP1539181A4 (en) | 2005-12-28 |
| WO2004089288A2 (en) | 2004-10-21 |
| US20050020577A1 (en) | 2005-01-27 |
| US7115606B2 (en) | 2006-10-03 |
| US6846823B2 (en) | 2005-01-25 |
| JP2006522144A (ja) | 2006-09-28 |
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