ES2281915T3 - Proteina tirosina fosfatasas de captura de sustrato. - Google Patents

Proteina tirosina fosfatasas de captura de sustrato. Download PDF

Info

Publication number
ES2281915T3
ES2281915T3 ES97937017T ES97937017T ES2281915T3 ES 2281915 T3 ES2281915 T3 ES 2281915T3 ES 97937017 T ES97937017 T ES 97937017T ES 97937017 T ES97937017 T ES 97937017T ES 2281915 T3 ES2281915 T3 ES 2281915T3
Authority
ES
Spain
Prior art keywords
protein
tyrosine
ptp
baselineskip
phosphorylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97937017T
Other languages
English (en)
Spanish (es)
Inventor
Nicholas Tonks
Andrew J. Flint
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cold Spring Harbor Laboratory
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Application granted granted Critical
Publication of ES2281915T3 publication Critical patent/ES2281915T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Alcoholic Beverages (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES97937017T 1996-07-25 1997-07-24 Proteina tirosina fosfatasas de captura de sustrato. Expired - Lifetime ES2281915T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US685992 1996-07-25
US08/685,992 US5912138A (en) 1996-07-25 1996-07-25 Substrate trapping protein tyrosine phosphatases

Publications (1)

Publication Number Publication Date
ES2281915T3 true ES2281915T3 (es) 2007-10-01

Family

ID=24754471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97937017T Expired - Lifetime ES2281915T3 (es) 1996-07-25 1997-07-24 Proteina tirosina fosfatasas de captura de sustrato.

Country Status (9)

Country Link
US (2) US5912138A (cg-RX-API-DMAC10.html)
EP (1) EP0918867B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000515760A (cg-RX-API-DMAC10.html)
AT (1) ATE352625T1 (cg-RX-API-DMAC10.html)
AU (1) AU728405B2 (cg-RX-API-DMAC10.html)
CA (1) CA2262440A1 (cg-RX-API-DMAC10.html)
DE (1) DE69737290T2 (cg-RX-API-DMAC10.html)
ES (1) ES2281915T3 (cg-RX-API-DMAC10.html)
WO (1) WO1998004712A2 (cg-RX-API-DMAC10.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
WO1999061467A2 (en) * 1998-05-21 1999-12-02 Mcgill University Inhibition of the binding of protein tyrosine phosphatase pest to domains of signalling proteins
US6156551A (en) * 1998-06-05 2000-12-05 Beth Israel Deaconess Medical Center Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US7176289B1 (en) 1998-09-11 2007-02-13 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US6355786B1 (en) 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
EP1161558A1 (en) 1999-03-08 2001-12-12 Merck Frosst Canada & Co. Intact cell assay for protein tyrosine phosphatases
US6852520B1 (en) 1999-03-24 2005-02-08 Ceptyr, Inc. DSP-2 dual-specificity phosphatase
US6841369B1 (en) 1999-04-07 2005-01-11 Ceptyr, Inc. DSP-4 dual specificity phosphatase
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
US6551810B1 (en) 1999-04-23 2003-04-22 Ceptyr, Inc. DSP-10 dual-specificity phosphatase
US6645753B1 (en) 1999-04-27 2003-11-11 Ceptyr, Inc. DSP-5 dual-specificity phosphatase
CA2375145A1 (en) * 1999-06-03 2000-12-14 Cold Spring Harbor Laboratory Substrate trapping protein tyrosine phosphatases
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
EP1200602A1 (en) 1999-07-20 2002-05-02 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phophatase
AU2001233252A1 (en) 2000-02-02 2001-08-14 Ceptyr, Inc. Dsp-12 and dsp-13 dual-specificity phosphatases
EP1257824A2 (en) * 2000-02-14 2002-11-20 Ceptyr, Inc. Improved assay for protein tyrosine phosphatases
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
US8071348B2 (en) * 2002-01-14 2011-12-06 Albert Einstein College Of Medicine Of Yeshiva University Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
US20030215899A1 (en) * 2002-02-13 2003-11-20 Ceptyr, Inc. Reversible oxidation of protein tyrosine phosphatases
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
CA2525976A1 (en) * 2002-05-23 2003-12-04 Ceptyr, Inc. Modulation of ptp1b signal transduction by rna interference
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
WO2004048549A2 (en) * 2002-11-26 2004-06-10 Cold Spring Harbor Laboratory Dep-1 receptor protein tyrosine phosphatase interacting proteins and related methods
US20070238129A1 (en) * 2006-03-29 2007-10-11 Moyer Susanne C Catalytically inactive enzymes for affinity binding
WO2011060076A1 (en) * 2009-11-10 2011-05-19 Amgen Inc. Anti-c-mpl antibodies
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054602C (en) * 1991-10-31 2003-04-22 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system
US5589375A (en) * 1992-10-06 1996-12-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. PTP 1D: a novel protein tyrosine phosphatase
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
EP0789771A2 (en) * 1993-09-01 1997-08-20 Ludwig Institute For Cancer Research Primary structure and functional expression of nucleotide sequences for novel protein tyrosine phosphatases
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins

Also Published As

Publication number Publication date
EP0918867B1 (en) 2007-01-24
DE69737290T2 (de) 2007-11-08
CA2262440A1 (en) 1998-02-05
JP2000515760A (ja) 2000-11-28
ATE352625T1 (de) 2007-02-15
AU5939598A (en) 1999-02-16
EP0918867A2 (en) 1999-06-02
AU728405B2 (en) 2001-01-11
DE69737290D1 (en) 2007-03-15
US5951979A (en) 1999-09-14
US5912138A (en) 1999-06-15
WO1998004712A3 (en) 1998-03-12
WO1998004712A2 (en) 1998-02-05

Similar Documents

Publication Publication Date Title
ES2281915T3 (es) Proteina tirosina fosfatasas de captura de sustrato.
Garton et al. Identification of p130 cas as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST
Garton et al. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
Otero NM23/nucleoside diphosphate kinase and signal transduction
US6903189B2 (en) Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
US6326469B1 (en) Megakaryocytic protein tyrosine kinases
US7989606B2 (en) Phosphatase inhibitor protein-1 as a regulator of cardiac function
JP5822897B2 (ja) 血管新生及び脈管形成のモジュレーターとしてのrスポンジン
AU8601498A (en) Inhibitors of cell-cycle progression and uses related thereto
ES2263161T3 (es) Variantes de la proteina p53 y utilizaciones terapeuticas.
US6252048B1 (en) DNA sequences encoding fusions of DNA repair proteins and uses thereof
Thulin et al. The immunolocalization and divergent roles of phosducin and phosducin-like protein in the retina
ES2361660T3 (es) Ubicutina-ligasa e3 humana para la modulación de nk-kappa b.
ES2249774T3 (es) Proteinas serina/tronina quinasas nucleares.
AU756175B2 (en) Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof
Sato et al. Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4, 5-bisphosphate-dependent phosphorylation sites by c-Src
Esposito-Verza et al. Molecular requirements for PLK1 activation by T-loop phosphorylation
JP2003501098A (ja) 基質捕捉性プロテインチロシンホスファターゼ
WO1999042593A1 (en) Compositions and methods for sensitizing and inhibiting growth of human tumor cells
ES2326442T3 (es) Proteina fha1 con dominio asociado en forma de cabeza de tenedor, que interactua con resina treonina quinasas mekk1 (mif1).
US20020192790A1 (en) Novel megakaryocytic protein tyrosine kinases
CA2362936A1 (en) A caspase activated protein kinase
Whatcott The role of ADP-ribosylation in mitochondria-mediated cell death