ES2277831T3 - Utilizacion de pirenoxina para la proteccion de tejidos corneales en fotoqueratectomia. - Google Patents
Utilizacion de pirenoxina para la proteccion de tejidos corneales en fotoqueratectomia. Download PDFInfo
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- ES2277831T3 ES2277831T3 ES00911259T ES00911259T ES2277831T3 ES 2277831 T3 ES2277831 T3 ES 2277831T3 ES 00911259 T ES00911259 T ES 00911259T ES 00911259 T ES00911259 T ES 00911259T ES 2277831 T3 ES2277831 T3 ES 2277831T3
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- Prior art keywords
- corneal
- pyrenoxine
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- cornea
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- 229910052756 noble gas Inorganic materials 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000003617 peroxidasic effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000011422 pharmacological therapy Methods 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000006950 reactive oxygen species formation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 201000002002 recurrent corneal erosion Diseases 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229910019655 synthetic inorganic crystalline material Inorganic materials 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- KMZJRCPGGAQHGC-UHFFFAOYSA-N trisodium boric acid borate Chemical compound [Na+].[Na+].[Na+].OB(O)O.[O-]B([O-])[O-] KMZJRCPGGAQHGC-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 229910019901 yttrium aluminum garnet Inorganic materials 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM99A0166 | 1999-03-17 | ||
| IT1999RM000166A IT1305306B1 (it) | 1999-03-17 | 1999-03-17 | Uso della pirenoxina per la protezione dei tessuti corneali ininterventi di fotocheratectomia. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2277831T3 true ES2277831T3 (es) | 2007-08-01 |
Family
ID=11406570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00911259T Expired - Lifetime ES2277831T3 (es) | 1999-03-17 | 2000-03-13 | Utilizacion de pirenoxina para la proteccion de tejidos corneales en fotoqueratectomia. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6610686B1 (enExample) |
| EP (1) | EP1173255B1 (enExample) |
| JP (1) | JP5167499B2 (enExample) |
| AT (1) | ATE349244T1 (enExample) |
| AU (1) | AU3324100A (enExample) |
| DE (1) | DE60032594T2 (enExample) |
| ES (1) | ES2277831T3 (enExample) |
| IT (1) | IT1305306B1 (enExample) |
| PT (1) | PT1173255E (enExample) |
| WO (1) | WO2000054757A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7655002B2 (en) * | 1996-03-21 | 2010-02-02 | Second Sight Laser Technologies, Inc. | Lenticular refractive surgery of presbyopia, other refractive errors, and cataract retardation |
| US9889043B2 (en) | 2006-01-20 | 2018-02-13 | Lensar, Inc. | System and apparatus for delivering a laser beam to the lens of an eye |
| US10842675B2 (en) | 2006-01-20 | 2020-11-24 | Lensar, Inc. | System and method for treating the structure of the human lens with a laser |
| US9545338B2 (en) | 2006-01-20 | 2017-01-17 | Lensar, Llc. | System and method for improving the accommodative amplitude and increasing the refractive power of the human lens with a laser |
| US8500723B2 (en) | 2008-07-25 | 2013-08-06 | Lensar, Inc. | Liquid filled index matching device for ophthalmic laser procedures |
| US8480659B2 (en) | 2008-07-25 | 2013-07-09 | Lensar, Inc. | Method and system for removal and replacement of lens material from the lens of an eye |
| US8617146B2 (en) | 2009-07-24 | 2013-12-31 | Lensar, Inc. | Laser system and method for correction of induced astigmatism |
| US8382745B2 (en) | 2009-07-24 | 2013-02-26 | Lensar, Inc. | Laser system and method for astigmatic corrections in association with cataract treatment |
| US8758332B2 (en) | 2009-07-24 | 2014-06-24 | Lensar, Inc. | Laser system and method for performing and sealing corneal incisions in the eye |
| CA2769097A1 (en) | 2009-07-24 | 2011-01-27 | Lensar, Inc. | System and method for performing ladar assisted procedures on the lens of an eye |
| EP2456384B1 (en) | 2009-07-24 | 2023-09-20 | LENSAR, Inc. | System for providing laser shot patterns to the lens of an eye |
| US8556425B2 (en) | 2010-02-01 | 2013-10-15 | Lensar, Inc. | Purkinjie image-based alignment of suction ring in ophthalmic applications |
| CN103338692B (zh) | 2010-10-15 | 2016-12-28 | 雷萨有限责任公司 | 眼睛内部的结构的扫描控制照明的系统和方法 |
| USD695408S1 (en) | 2010-10-15 | 2013-12-10 | Lensar, Inc. | Laser system for treatment of the eye |
| USD694890S1 (en) | 2010-10-15 | 2013-12-03 | Lensar, Inc. | Laser system for treatment of the eye |
| US10463541B2 (en) | 2011-03-25 | 2019-11-05 | Lensar, Inc. | System and method for correcting astigmatism using multiple paired arcuate laser generated corneal incisions |
| CA2858627C (en) * | 2012-01-04 | 2020-12-01 | Quark Pharmaceuticals, Inc. | Double-stranded rna compounds to casp2 and uses thereof |
| CN103211754A (zh) * | 2012-01-19 | 2013-07-24 | 武汉诺安药业有限公司 | 无菌稳定的吡诺克辛钠滴眼液的生产方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510962A (ja) * | 1994-01-21 | 1997-11-04 | ジョナサン ジャビット | 目の治療のためのシス−ハイドロキシプロリン類 |
| WO1998053806A1 (en) * | 1997-05-26 | 1998-12-03 | New Vision Co., Ltd. | Medicinal compositions for topical administration containing vitamin d and vitamin k |
| IT1292103B1 (it) * | 1997-06-06 | 1999-01-25 | Pharmaconsult S A S | Composizioni farmaceutiche topiche contenenti pirfenossone e uso dello stesso nel trattamento di condizioni infiammatorie |
| EP1060748A4 (en) * | 1998-02-25 | 2002-09-04 | Wakamoto Pharma Co Ltd | MEDICINES FOR CORNEAEPITHEL DISORDER |
-
1999
- 1999-03-17 IT IT1999RM000166A patent/IT1305306B1/it active
-
2000
- 2000-03-13 US US09/936,597 patent/US6610686B1/en not_active Expired - Lifetime
- 2000-03-13 PT PT00911259T patent/PT1173255E/pt unknown
- 2000-03-13 WO PCT/IT2000/000081 patent/WO2000054757A2/en not_active Ceased
- 2000-03-13 DE DE60032594T patent/DE60032594T2/de not_active Expired - Lifetime
- 2000-03-13 AT AT00911259T patent/ATE349244T1/de active
- 2000-03-13 ES ES00911259T patent/ES2277831T3/es not_active Expired - Lifetime
- 2000-03-13 JP JP2000604833A patent/JP5167499B2/ja not_active Expired - Fee Related
- 2000-03-13 AU AU33241/00A patent/AU3324100A/en not_active Abandoned
- 2000-03-13 EP EP00911259A patent/EP1173255B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1173255A2 (en) | 2002-01-23 |
| JP2002539153A (ja) | 2002-11-19 |
| JP5167499B2 (ja) | 2013-03-21 |
| EP1173255B1 (en) | 2006-12-27 |
| AU3324100A (en) | 2000-10-04 |
| WO2000054757A2 (en) | 2000-09-21 |
| ATE349244T1 (de) | 2007-01-15 |
| ITRM990166A1 (it) | 2000-09-17 |
| WO2000054757A3 (en) | 2001-03-29 |
| IT1305306B1 (it) | 2001-05-04 |
| DE60032594D1 (de) | 2007-02-08 |
| US6610686B1 (en) | 2003-08-26 |
| DE60032594T2 (de) | 2007-10-11 |
| PT1173255E (pt) | 2007-03-30 |
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