DE60032594T2 - Verwendung von pirenoxin zum schutz des kornealgewebes während photokeratektomie - Google Patents
Verwendung von pirenoxin zum schutz des kornealgewebes während photokeratektomie Download PDFInfo
- Publication number
- DE60032594T2 DE60032594T2 DE60032594T DE60032594T DE60032594T2 DE 60032594 T2 DE60032594 T2 DE 60032594T2 DE 60032594 T DE60032594 T DE 60032594T DE 60032594 T DE60032594 T DE 60032594T DE 60032594 T2 DE60032594 T2 DE 60032594T2
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- Prior art keywords
- pirenoxine
- corneal
- use according
- ros
- photokeratectomy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 229940054534 ophthalmic solution Drugs 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 238000011422 pharmacological therapy Methods 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 201000002002 recurrent corneal erosion Diseases 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 229930183288 spiroxin Natural products 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- KMZJRCPGGAQHGC-UHFFFAOYSA-N trisodium boric acid borate Chemical compound [Na+].[Na+].[Na+].OB(O)O.[O-]B([O-])[O-] KMZJRCPGGAQHGC-UHFFFAOYSA-N 0.000 description 1
- LEAHFJQFYSDGGP-UHFFFAOYSA-K trisodium;dihydrogen phosphate;hydrogen phosphate Chemical compound [Na+].[Na+].[Na+].OP(O)([O-])=O.OP([O-])([O-])=O LEAHFJQFYSDGGP-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229910019901 yttrium aluminum garnet Inorganic materials 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000166A IT1305306B1 (it) | 1999-03-17 | 1999-03-17 | Uso della pirenoxina per la protezione dei tessuti corneali ininterventi di fotocheratectomia. |
| ITRM990166 | 1999-03-17 | ||
| PCT/IT2000/000081 WO2000054757A2 (en) | 1999-03-17 | 2000-03-13 | Use of pirenoxine for the protection of corneal tissues in photokeratectomy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60032594D1 DE60032594D1 (de) | 2007-02-08 |
| DE60032594T2 true DE60032594T2 (de) | 2007-10-11 |
Family
ID=11406570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60032594T Expired - Lifetime DE60032594T2 (de) | 1999-03-17 | 2000-03-13 | Verwendung von pirenoxin zum schutz des kornealgewebes während photokeratektomie |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6610686B1 (enExample) |
| EP (1) | EP1173255B1 (enExample) |
| JP (1) | JP5167499B2 (enExample) |
| AT (1) | ATE349244T1 (enExample) |
| AU (1) | AU3324100A (enExample) |
| DE (1) | DE60032594T2 (enExample) |
| ES (1) | ES2277831T3 (enExample) |
| IT (1) | IT1305306B1 (enExample) |
| PT (1) | PT1173255E (enExample) |
| WO (1) | WO2000054757A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7655002B2 (en) * | 1996-03-21 | 2010-02-02 | Second Sight Laser Technologies, Inc. | Lenticular refractive surgery of presbyopia, other refractive errors, and cataract retardation |
| US9889043B2 (en) | 2006-01-20 | 2018-02-13 | Lensar, Inc. | System and apparatus for delivering a laser beam to the lens of an eye |
| US10842675B2 (en) | 2006-01-20 | 2020-11-24 | Lensar, Inc. | System and method for treating the structure of the human lens with a laser |
| US9545338B2 (en) | 2006-01-20 | 2017-01-17 | Lensar, Llc. | System and method for improving the accommodative amplitude and increasing the refractive power of the human lens with a laser |
| US8500723B2 (en) | 2008-07-25 | 2013-08-06 | Lensar, Inc. | Liquid filled index matching device for ophthalmic laser procedures |
| US8480659B2 (en) | 2008-07-25 | 2013-07-09 | Lensar, Inc. | Method and system for removal and replacement of lens material from the lens of an eye |
| US8617146B2 (en) | 2009-07-24 | 2013-12-31 | Lensar, Inc. | Laser system and method for correction of induced astigmatism |
| US8382745B2 (en) | 2009-07-24 | 2013-02-26 | Lensar, Inc. | Laser system and method for astigmatic corrections in association with cataract treatment |
| US8758332B2 (en) | 2009-07-24 | 2014-06-24 | Lensar, Inc. | Laser system and method for performing and sealing corneal incisions in the eye |
| CA2769097A1 (en) | 2009-07-24 | 2011-01-27 | Lensar, Inc. | System and method for performing ladar assisted procedures on the lens of an eye |
| EP2456384B1 (en) | 2009-07-24 | 2023-09-20 | LENSAR, Inc. | System for providing laser shot patterns to the lens of an eye |
| US8556425B2 (en) | 2010-02-01 | 2013-10-15 | Lensar, Inc. | Purkinjie image-based alignment of suction ring in ophthalmic applications |
| CN103338692B (zh) | 2010-10-15 | 2016-12-28 | 雷萨有限责任公司 | 眼睛内部的结构的扫描控制照明的系统和方法 |
| USD695408S1 (en) | 2010-10-15 | 2013-12-10 | Lensar, Inc. | Laser system for treatment of the eye |
| USD694890S1 (en) | 2010-10-15 | 2013-12-03 | Lensar, Inc. | Laser system for treatment of the eye |
| US10463541B2 (en) | 2011-03-25 | 2019-11-05 | Lensar, Inc. | System and method for correcting astigmatism using multiple paired arcuate laser generated corneal incisions |
| CA2858627C (en) * | 2012-01-04 | 2020-12-01 | Quark Pharmaceuticals, Inc. | Double-stranded rna compounds to casp2 and uses thereof |
| CN103211754A (zh) * | 2012-01-19 | 2013-07-24 | 武汉诺安药业有限公司 | 无菌稳定的吡诺克辛钠滴眼液的生产方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510962A (ja) * | 1994-01-21 | 1997-11-04 | ジョナサン ジャビット | 目の治療のためのシス−ハイドロキシプロリン類 |
| WO1998053806A1 (en) * | 1997-05-26 | 1998-12-03 | New Vision Co., Ltd. | Medicinal compositions for topical administration containing vitamin d and vitamin k |
| IT1292103B1 (it) * | 1997-06-06 | 1999-01-25 | Pharmaconsult S A S | Composizioni farmaceutiche topiche contenenti pirfenossone e uso dello stesso nel trattamento di condizioni infiammatorie |
| EP1060748A4 (en) * | 1998-02-25 | 2002-09-04 | Wakamoto Pharma Co Ltd | MEDICINES FOR CORNEAEPITHEL DISORDER |
-
1999
- 1999-03-17 IT IT1999RM000166A patent/IT1305306B1/it active
-
2000
- 2000-03-13 US US09/936,597 patent/US6610686B1/en not_active Expired - Lifetime
- 2000-03-13 PT PT00911259T patent/PT1173255E/pt unknown
- 2000-03-13 WO PCT/IT2000/000081 patent/WO2000054757A2/en not_active Ceased
- 2000-03-13 DE DE60032594T patent/DE60032594T2/de not_active Expired - Lifetime
- 2000-03-13 AT AT00911259T patent/ATE349244T1/de active
- 2000-03-13 ES ES00911259T patent/ES2277831T3/es not_active Expired - Lifetime
- 2000-03-13 JP JP2000604833A patent/JP5167499B2/ja not_active Expired - Fee Related
- 2000-03-13 AU AU33241/00A patent/AU3324100A/en not_active Abandoned
- 2000-03-13 EP EP00911259A patent/EP1173255B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1173255A2 (en) | 2002-01-23 |
| JP2002539153A (ja) | 2002-11-19 |
| JP5167499B2 (ja) | 2013-03-21 |
| EP1173255B1 (en) | 2006-12-27 |
| AU3324100A (en) | 2000-10-04 |
| WO2000054757A2 (en) | 2000-09-21 |
| ES2277831T3 (es) | 2007-08-01 |
| ATE349244T1 (de) | 2007-01-15 |
| ITRM990166A1 (it) | 2000-09-17 |
| WO2000054757A3 (en) | 2001-03-29 |
| IT1305306B1 (it) | 2001-05-04 |
| DE60032594D1 (de) | 2007-02-08 |
| US6610686B1 (en) | 2003-08-26 |
| PT1173255E (pt) | 2007-03-30 |
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