ES2266563T3 - Aislado de proteina de lino y su produccion. - Google Patents
Aislado de proteina de lino y su produccion. Download PDFInfo
- Publication number
- ES2266563T3 ES2266563T3 ES02767015T ES02767015T ES2266563T3 ES 2266563 T3 ES2266563 T3 ES 2266563T3 ES 02767015 T ES02767015 T ES 02767015T ES 02767015 T ES02767015 T ES 02767015T ES 2266563 T3 ES2266563 T3 ES 2266563T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- flax
- solution
- concentrated
- supernatant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 204
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 204
- 238000004519 manufacturing process Methods 0.000 title description 6
- 241000208202 Linaceae Species 0.000 claims abstract description 80
- 235000004431 Linum usitatissimum Nutrition 0.000 claims abstract description 76
- 239000012460 protein solution Substances 0.000 claims abstract description 53
- 239000006228 supernatant Substances 0.000 claims abstract description 35
- 239000000693 micelle Substances 0.000 claims abstract description 26
- 239000004465 oilseed meal Substances 0.000 claims abstract description 15
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 13
- 235000018102 proteins Nutrition 0.000 claims description 196
- 238000000034 method Methods 0.000 claims description 63
- 235000021388 linseed oil Nutrition 0.000 claims description 53
- 239000000944 linseed oil Substances 0.000 claims description 53
- 239000000243 solution Substances 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 26
- 239000012528 membrane Substances 0.000 claims description 25
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 claims description 23
- 235000012054 meals Nutrition 0.000 claims description 23
- 235000004426 flaxseed Nutrition 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 238000010790 dilution Methods 0.000 claims description 19
- 239000012895 dilution Substances 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- 239000003921 oil Substances 0.000 claims description 16
- 235000019198 oils Nutrition 0.000 claims description 16
- 239000012266 salt solution Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 11
- 238000004062 sedimentation Methods 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 230000007423 decrease Effects 0.000 claims description 8
- 108010068370 Glutens Proteins 0.000 claims description 7
- 235000021312 gluten Nutrition 0.000 claims description 7
- 229960004488 linolenic acid Drugs 0.000 claims description 5
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 4
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 4
- 230000007925 protein solubilization Effects 0.000 claims description 4
- 238000001799 protein solubilization Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000013049 sediment Substances 0.000 claims description 3
- 238000007865 diluting Methods 0.000 abstract description 2
- 235000013312 flour Nutrition 0.000 description 21
- 239000000463 material Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000005063 solubilization Methods 0.000 description 9
- 230000007928 solubilization Effects 0.000 description 9
- 238000000108 ultra-filtration Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000000751 protein extraction Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 235000014103 egg white Nutrition 0.000 description 2
- 210000000969 egg white Anatomy 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 238000003828 vacuum filtration Methods 0.000 description 2
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241000219745 Lupinus Species 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000433 anti-nutritional effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 238000002036 drum drying Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000013627 low molecular weight specie Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- -1 potassium chloride Chemical class 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 238000000646 scanning calorimetry Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
- A23J1/142—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds by extracting with organic solvents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32777501P | 2001-10-10 | 2001-10-10 | |
US327775P | 2001-10-10 | ||
US33349201P | 2001-11-28 | 2001-11-28 | |
US333492P | 2001-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2266563T3 true ES2266563T3 (es) | 2007-03-01 |
Family
ID=26986057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02767015T Expired - Lifetime ES2266563T3 (es) | 2001-10-10 | 2002-10-10 | Aislado de proteina de lino y su produccion. |
Country Status (18)
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2451190C (en) * | 2002-11-26 | 2008-05-06 | Nutrex Wellness Inc. | Process for extracting flax protein concentrate from flax meal |
AU2004248870B2 (en) * | 2003-06-20 | 2010-08-19 | Burcon Nutrascience (Mb) Corp. | Oil seed meal preparation |
ZA200601513B (en) * | 2003-08-01 | 2007-05-30 | Burcon Nutrascience Mb Corp | Process for preparation of flax protein isolate |
US7842330B2 (en) * | 2003-08-01 | 2010-11-30 | Burcon Nutrascience (Mb) Corp. | Process for preparation of flax protein isolate |
DE102008039103A1 (de) * | 2007-10-31 | 2009-05-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Gewinnung einer proteinhaltigen Lebensmittelzutat aus Leinschrot |
US8821955B2 (en) | 2008-05-16 | 2014-09-02 | Siebte Pmi Verwaltungs Gmbh | Protein concentrates and isolates, and processes for the production thereof |
CA2724391C (en) * | 2008-05-16 | 2017-10-31 | Bioexx Specialty Proteins Ltd. | Oilseed protein concentrates and isolates, and processes for the production thereof |
US8623445B2 (en) | 2008-05-16 | 2014-01-07 | Bio-Extraction Inc. | Protein concentrates and isolates, and processes for the production thereof |
US20100036099A1 (en) | 2008-07-11 | 2010-02-11 | Martin Schweizer | Soluble canola protein isolate production ("nutratein") |
US8697144B2 (en) * | 2008-07-11 | 2014-04-15 | Burcon Nutrascience (Mb) Corp. | Soluble canola protein isolate production (“nutratein”) |
US8486675B2 (en) | 2009-11-11 | 2013-07-16 | Bioexx Specialty Proteins Ltd. | Protein concentrates and isolates, and processes for the production thereof from macroalgae and/or microalgae |
HUE034328T2 (en) | 2009-11-11 | 2018-02-28 | Siebte Pmi Verwaltungs Gmbh | Protein concentrates and isolates, and methods for producing them from flour of fried oil seeds |
AP3600A (en) * | 2010-03-17 | 2016-02-22 | Parabel Ltd | Method and system for processing of aquatic species |
AU2012275591C1 (en) * | 2011-06-27 | 2017-11-02 | Archer Daniels Midland Company | Wheat protein isolates and processes for producing |
UA113181C2 (xx) * | 2011-07-28 | 2016-12-26 | Виділення білка з олієвмісного насіння | |
US9371489B2 (en) | 2013-03-15 | 2016-06-21 | GreenStract, LLC | Plant-based compositions and uses thereof |
HK1220679A1 (zh) | 2013-03-15 | 2017-05-12 | GreenStract, LLC | 基於植物的组合物及其应用 |
CN105924495B (zh) * | 2016-05-12 | 2020-01-10 | 中国科学院西北高原生物研究所 | 一种高纯度亚麻籽蛋白的高效制备方法 |
CN110679915B (zh) * | 2019-09-19 | 2022-11-18 | 郑州轻工业大学 | 一种亚麻籽蛋白/亚麻籽胶/多酚复合凝聚包埋体系的制备方法 |
CN111528335B (zh) * | 2020-05-29 | 2022-01-25 | 江南大学 | 一种水媒法制备高蛋白质含量亚麻籽蛋白的方法 |
CN114262357B (zh) * | 2021-12-29 | 2023-08-11 | 浙江旅游职业学院 | 一种基于ph偏移技术的亚麻蛋白改性设备及方法 |
EP4539688A2 (en) * | 2022-06-16 | 2025-04-23 | Climax Foods Inc. | Structured protein isolates and related methods |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2502485A (en) * | 1947-09-22 | 1950-04-04 | Sherwin Williams Co | Distillation of water-immiscible solvents from proteinaceous residues |
US2573072A (en) * | 1947-11-07 | 1951-10-30 | Int Minerals & Chem Corp | Production of vegetable protein |
US2607767A (en) * | 1949-05-14 | 1952-08-19 | Int Minerals & Chem Corp | Process for extracting vegetable protein |
US3099649A (en) * | 1960-06-28 | 1963-07-30 | Ajinomoto Kk | Process for refining of vegetable protein |
FR2310706A1 (fr) * | 1975-05-12 | 1976-12-10 | Agronomique Inst Nat Rech | Procede de traitement de tourteaux et graines d'origine |
US4285862A (en) * | 1976-09-30 | 1981-08-25 | General Foods, Limited | Protein isolate product |
US4091121A (en) * | 1977-03-14 | 1978-05-23 | Ralston Purina Company | Method for making imitation margarine |
CA1099576A (en) * | 1978-03-23 | 1981-04-21 | Chester D. Myers | Improved process for isolation of proteins |
EP0006654B1 (en) * | 1978-06-26 | 1982-03-31 | Unilever N.V. | A process for producing a detoxified rapeseed protein concentrate |
FI100089B (fi) * | 1995-01-20 | 1997-09-30 | Markku Anttila | Pellavavalmiste, sen käyttö ja valmistus |
US5844086A (en) * | 1996-01-31 | 1998-12-01 | Stilts Corporation | Oil seed protein extraction |
US6148414A (en) * | 1998-09-24 | 2000-11-14 | Seek Systems, Inc. | Methods and systems for implementing shared disk array management functions |
ES2384452T3 (es) * | 1999-02-24 | 2012-07-05 | The Iams Company | Composición alimentaria y métodos |
HRP20010683A2 (en) * | 1999-03-17 | 2002-12-31 | Fraunhofer Ges Forschung | Method for treating and processing lupine seeds containing alkaloid, oil and protein |
US7842330B2 (en) * | 2003-08-01 | 2010-11-30 | Burcon Nutrascience (Mb) Corp. | Process for preparation of flax protein isolate |
-
2002
- 2002-10-09 US US10/266,677 patent/US20030109679A1/en not_active Abandoned
- 2002-10-10 CN CNB028244362A patent/CN100374036C/zh not_active Expired - Fee Related
- 2002-10-10 KR KR1020047005342A patent/KR100936074B1/ko not_active Expired - Fee Related
- 2002-10-10 AU AU2002331497A patent/AU2002331497B2/en not_active Ceased
- 2002-10-10 EP EP02767015A patent/EP1434493B2/en not_active Expired - Lifetime
- 2002-10-10 JP JP2003533698A patent/JP4263097B2/ja not_active Expired - Lifetime
- 2002-10-10 ES ES02767015T patent/ES2266563T3/es not_active Expired - Lifetime
- 2002-10-10 DE DE60212159T patent/DE60212159T3/de not_active Expired - Lifetime
- 2002-10-10 MX MXPA04003418A patent/MXPA04003418A/es active IP Right Grant
- 2002-10-10 NZ NZ532465A patent/NZ532465A/en not_active IP Right Cessation
- 2002-10-10 DK DK02767015T patent/DK1434493T3/da active
- 2002-10-10 US US10/493,110 patent/US7820226B2/en active Active
- 2002-10-10 BR BR0213209-5A patent/BR0213209A/pt not_active Application Discontinuation
- 2002-10-10 RU RU2004114218/13A patent/RU2336717C2/ru active
- 2002-10-10 WO PCT/CA2002/001526 patent/WO2003030652A1/en active IP Right Grant
- 2002-10-10 PT PT02767015T patent/PT1434493E/pt unknown
- 2002-10-10 CA CA2463106A patent/CA2463106C/en not_active Expired - Fee Related
- 2002-10-10 AT AT02767015T patent/ATE328490T1/de not_active IP Right Cessation
-
2004
- 2004-04-22 ZA ZA2004/03077A patent/ZA200403077B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR100936074B1 (ko) | 2010-01-12 |
HK1075806A1 (zh) | 2005-12-30 |
DE60212159D1 (de) | 2006-07-20 |
CA2463106C (en) | 2012-05-01 |
JP2005504833A (ja) | 2005-02-17 |
NZ532465A (en) | 2005-09-30 |
DK1434493T3 (da) | 2006-10-16 |
CN100374036C (zh) | 2008-03-12 |
RU2336717C2 (ru) | 2008-10-27 |
BR0213209A (pt) | 2005-03-29 |
ZA200403077B (en) | 2005-06-29 |
US7820226B2 (en) | 2010-10-26 |
US20030109679A1 (en) | 2003-06-12 |
EP1434493B2 (en) | 2011-01-26 |
RU2004114218A (ru) | 2005-05-10 |
WO2003030652A1 (en) | 2003-04-17 |
JP4263097B2 (ja) | 2009-05-13 |
EP1434493B1 (en) | 2006-06-07 |
ATE328490T1 (de) | 2006-06-15 |
US20050107593A1 (en) | 2005-05-19 |
MXPA04003418A (es) | 2004-07-08 |
DE60212159T3 (de) | 2011-08-18 |
DE60212159T2 (de) | 2007-04-26 |
PT1434493E (pt) | 2006-10-31 |
CA2463106A1 (en) | 2003-04-17 |
KR20050035152A (ko) | 2005-04-15 |
CN1599563A (zh) | 2005-03-23 |
AU2002331497B2 (en) | 2007-11-29 |
EP1434493A1 (en) | 2004-07-07 |
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