ES2260788T3 - Anticuerpos monoclonales especificos para el dominio estracelular de antigeno de membrana especifico de la prostata. - Google Patents
Anticuerpos monoclonales especificos para el dominio estracelular de antigeno de membrana especifico de la prostata.Info
- Publication number
- ES2260788T3 ES2260788T3 ES97917121T ES97917121T ES2260788T3 ES 2260788 T3 ES2260788 T3 ES 2260788T3 ES 97917121 T ES97917121 T ES 97917121T ES 97917121 T ES97917121 T ES 97917121T ES 2260788 T3 ES2260788 T3 ES 2260788T3
- Authority
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- Prior art keywords
- psma
- antibody
- hybridoma
- monoclonal antibody
- atcc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
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- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US62139996A | 1996-03-25 | 1996-03-25 | |
| US621399 | 1996-03-25 |
Publications (1)
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|---|---|
| ES2260788T3 true ES2260788T3 (es) | 2006-11-01 |
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|---|---|---|---|
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|---|---|
| EP (1) | EP0914155B1 (enExample) |
| JP (1) | JP4295826B2 (enExample) |
| AT (1) | ATE318147T1 (enExample) |
| AU (1) | AU725583B2 (enExample) |
| CA (1) | CA2250141C (enExample) |
| DE (1) | DE69735294T2 (enExample) |
| DK (1) | DK0914155T3 (enExample) |
| ES (1) | ES2260788T3 (enExample) |
| IL (1) | IL126314A (enExample) |
| WO (1) | WO1997035616A1 (enExample) |
Families Citing this family (55)
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| US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
| US7070782B1 (en) | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US6569432B1 (en) | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| EP0812356B1 (en) | 1995-02-24 | 2006-02-08 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| US6150508A (en) * | 1996-03-25 | 2000-11-21 | Northwest Biotherapeutics, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US6962981B1 (en) | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US7381407B1 (en) | 1996-03-25 | 2008-06-03 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| US6207805B1 (en) | 1997-07-18 | 2001-03-27 | University Of Iowa Research Foundation | Prostate cell surface antigen-specific antibodies |
| GB2328871A (en) * | 1997-09-05 | 1999-03-10 | Merck & Co Inc | Compositions for inhibiting platelet aggregation |
| WO1999043710A1 (en) * | 1998-02-26 | 1999-09-02 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| IL139699A0 (en) * | 1998-06-01 | 2002-02-10 | Urogenesys Inc | Novel serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| SE9900495D0 (sv) * | 1999-02-12 | 1999-02-12 | Pharmatrix Ab | Vaccine composition |
| WO2000050457A1 (en) * | 1999-02-22 | 2000-08-31 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| MXPA02000961A (es) * | 1999-07-29 | 2003-08-20 | Medarex Inc | Anticuerpos monoclonales humanos para antigeno de membrana especifico de la prostata. |
| EP1710256A1 (en) * | 1999-07-29 | 2006-10-11 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen |
| FR2797743B1 (fr) * | 1999-08-23 | 2003-08-08 | Urogene | Lignee cellulaire prostatique et son utilisation pour l'obtention d'une tumeur prostatique etablie chez l'animal |
| EP1221053A4 (en) * | 1999-09-13 | 2004-12-22 | Neil H Bander | METHOD FOR INSULATING PROSTATIC EPITHELIC CELLS FROM SPERM |
| JP4838436B2 (ja) * | 2001-04-04 | 2011-12-14 | 積水メディカル株式会社 | 抗ヒト肝性トリグリセリドリパーゼ抗体 |
| IL158969A0 (en) | 2001-06-01 | 2004-05-12 | Cornell Res Foundation Inc | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| AU2002305767B2 (en) | 2001-09-20 | 2008-04-10 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for PSMA |
| EP1448588A4 (en) | 2001-10-23 | 2006-10-25 | Psma Dev Company L L C | ANTIBODIES AND MULTIMERS OF PSMA PROTEINS |
| US20040161776A1 (en) * | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| EP1581794B1 (en) | 2003-01-10 | 2008-09-17 | Millennium Pharmaceuticals, Inc. | Method of determining risk for prostate cancer recurrence |
| WO2006089231A2 (en) | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |
| EP1863848A4 (en) * | 2005-03-31 | 2009-09-23 | Agensys Inc | CORRESPONDING ANTIBODIES AND MOLECULES THAT ATTACH PROTEINS 161P2F10B |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| EP1934261B1 (en) | 2005-09-26 | 2014-10-29 | Medarex, L.L.C. | Human monoclonal antibodies to cd70 |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| WO2009106101A1 (en) * | 2008-02-29 | 2009-09-03 | Interuniversitair Microelektronica Centrum | Cell-enzyme based biosensors |
| WO2010027513A2 (en) | 2008-09-08 | 2010-03-11 | Psma Development Company, Llc | Methods for killing psma-expressing, taxane-resistant cancer cells |
| US10517969B2 (en) | 2009-02-17 | 2019-12-31 | Cornell University | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| US8772459B2 (en) | 2009-12-02 | 2014-07-08 | Imaginab, Inc. | J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use |
| RU2610336C2 (ru) | 2011-04-21 | 2017-02-09 | Сиэтл Дженетикс, Инк. | Новые конъюгаты связывающее соединение - активное соединение (adc) и их применение |
| RU2632647C2 (ru) | 2011-04-22 | 2017-10-06 | Аптево Рисерч Энд Девелопмент Ллс | Белки, связывающие специфический мембранный антиген простаты, и соответствующие композиции и способы |
| PE20160996A1 (es) | 2013-12-23 | 2016-11-09 | Bayer Pharma AG | Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp |
| CN108025084B (zh) | 2015-06-22 | 2024-08-09 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
| JOP20160154B1 (ar) | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
| CN108367004B (zh) | 2015-09-21 | 2022-09-13 | 阿帕特夫研究和发展有限公司 | Cd3结合多肽 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| CA3018630A1 (en) | 2016-03-24 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| RU2761390C2 (ru) | 2016-12-21 | 2021-12-07 | Байер Фарма Акциенгезельшафт | Конъюгаты связующего и активного вещества (adc), имеющие ферментативно расщепляемые группы |
| CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
| JP7174704B2 (ja) | 2016-12-21 | 2022-11-17 | バイエル・アクチエンゲゼルシヤフト | 酵素開裂基を有する細胞毒性活性剤のプロドラッグ |
| EP3762410A4 (en) | 2018-03-06 | 2022-04-06 | The Trustees of the University of Pennsylvania | CHEMICAL PROSTATE MEMBRANE SPECIFIC ANTIGEN SPECIFIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF |
| CN112469440B (zh) | 2018-06-18 | 2024-09-06 | 优瑞科生物技术公司 | 靶向前列腺特异性膜抗原(psma)的构建体和其用途 |
| IL279823B1 (en) | 2018-07-31 | 2025-10-01 | Heidelberg Pharma Res Gmbh | Cultured antibodies against PSMA |
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|---|---|---|---|---|
| DE69334071T2 (de) * | 1992-11-05 | 2007-10-25 | Sloan-Kettering Institute For Cancer Research | Prostata-spezifisches membranantigen |
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| EP0812356B1 (en) * | 1995-02-24 | 2006-02-08 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
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1997
- 1997-03-25 AT AT97917121T patent/ATE318147T1/de not_active IP Right Cessation
- 1997-03-25 IL IL12631497A patent/IL126314A/xx not_active IP Right Cessation
- 1997-03-25 JP JP53466797A patent/JP4295826B2/ja not_active Expired - Lifetime
- 1997-03-25 DK DK97917121T patent/DK0914155T3/da active
- 1997-03-25 CA CA002250141A patent/CA2250141C/en not_active Expired - Lifetime
- 1997-03-25 ES ES97917121T patent/ES2260788T3/es not_active Expired - Lifetime
- 1997-03-25 AU AU25552/97A patent/AU725583B2/en not_active Expired
- 1997-03-25 EP EP97917121A patent/EP0914155B1/en not_active Revoked
- 1997-03-25 DE DE69735294T patent/DE69735294T2/de not_active Revoked
- 1997-03-25 WO PCT/US1997/005214 patent/WO1997035616A1/en not_active Ceased
Also Published As
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| DK0914155T3 (da) | 2006-06-26 |
| ATE318147T1 (de) | 2006-03-15 |
| JP4295826B2 (ja) | 2009-07-15 |
| CA2250141C (en) | 2008-07-29 |
| WO1997035616A1 (en) | 1997-10-02 |
| DE69735294D1 (de) | 2006-04-27 |
| DE69735294T2 (de) | 2006-09-21 |
| AU2555297A (en) | 1997-10-17 |
| IL126314A0 (en) | 1999-05-09 |
| AU725583B2 (en) | 2000-10-12 |
| JP2001503601A (ja) | 2001-03-21 |
| IL126314A (en) | 2003-07-31 |
| EP0914155A4 (en) | 2001-05-16 |
| EP0914155B1 (en) | 2006-02-22 |
| EP0914155A1 (en) | 1999-05-12 |
| CA2250141A1 (en) | 1997-10-02 |
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