ES2260788T3 - Anticuerpos monoclonales especificos para el dominio estracelular de antigeno de membrana especifico de la prostata. - Google Patents
Anticuerpos monoclonales especificos para el dominio estracelular de antigeno de membrana especifico de la prostata.Info
- Publication number
- ES2260788T3 ES2260788T3 ES97917121T ES97917121T ES2260788T3 ES 2260788 T3 ES2260788 T3 ES 2260788T3 ES 97917121 T ES97917121 T ES 97917121T ES 97917121 T ES97917121 T ES 97917121T ES 2260788 T3 ES2260788 T3 ES 2260788T3
- Authority
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- Prior art keywords
- psma
- antibody
- hybridoma
- monoclonal antibody
- atcc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
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- Immunology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Biochemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US621399 | 1984-06-18 | ||
| US62139996A | 1996-03-25 | 1996-03-25 |
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| ES2260788T3 true ES2260788T3 (es) | 2006-11-01 |
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| JP (1) | JP4295826B2 (enExample) |
| AT (1) | ATE318147T1 (enExample) |
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| ES (1) | ES2260788T3 (enExample) |
| IL (1) | IL126314A (enExample) |
| WO (1) | WO1997035616A1 (enExample) |
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| US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
| US7070782B1 (en) | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US6569432B1 (en) | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| JP2001526522A (ja) | 1995-02-24 | 2001-12-18 | スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺特異的膜抗原およびその使用 |
| US6962981B1 (en) | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US6150508A (en) * | 1996-03-25 | 2000-11-21 | Northwest Biotherapeutics, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US7381407B1 (en) | 1996-03-25 | 2008-06-03 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| US6207805B1 (en) | 1997-07-18 | 2001-03-27 | University Of Iowa Research Foundation | Prostate cell surface antigen-specific antibodies |
| GB2328871A (en) * | 1997-09-05 | 1999-03-10 | Merck & Co Inc | Compositions for inhibiting platelet aggregation |
| AU3305699A (en) * | 1998-02-26 | 1999-09-15 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| DK1086223T3 (da) * | 1998-06-01 | 2009-11-30 | Agensys Inc | Nye serpentintransmembranantigener udtrykt i humane cancerformer og anvendelser deraf |
| US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| SE9900495D0 (sv) * | 1999-02-12 | 1999-02-12 | Pharmatrix Ab | Vaccine composition |
| WO2000050457A1 (en) * | 1999-02-22 | 2000-08-31 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| EP1710256A1 (en) * | 1999-07-29 | 2006-10-11 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen |
| ES2277846T3 (es) * | 1999-07-29 | 2007-08-01 | Medarex, Inc. | Anticuerpos monoclonales humanos para antigeno prostatico especifico. |
| FR2797743B1 (fr) * | 1999-08-23 | 2003-08-08 | Urogene | Lignee cellulaire prostatique et son utilisation pour l'obtention d'une tumeur prostatique etablie chez l'animal |
| US6653129B1 (en) * | 1999-09-13 | 2003-11-25 | The Regents Of The University Of Colorado | Method for isolation of cells from a solution |
| JP4838436B2 (ja) * | 2001-04-04 | 2011-12-14 | 積水メディカル株式会社 | 抗ヒト肝性トリグリセリドリパーゼ抗体 |
| IL158969A0 (en) | 2001-06-01 | 2004-05-12 | Cornell Res Foundation Inc | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| JP2005527474A (ja) | 2001-09-20 | 2005-09-15 | コーネル リサーチ ファンデーション インコーポレーテッド | 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物 |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| US20040161776A1 (en) * | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
| EP2360169B1 (en) | 2001-10-23 | 2015-10-14 | Psma Development Company, L.L.C. | PSMA antibodies |
| EP1581794B1 (en) | 2003-01-10 | 2008-09-17 | Millennium Pharmaceuticals, Inc. | Method of determining risk for prostate cancer recurrence |
| JP5249587B2 (ja) | 2005-02-18 | 2013-07-31 | メダレックス， インク． | フコシル残基を欠く前立腺特異的膜抗原（ｐｓｍａ）に対するモノクローナル抗体 |
| JP4324636B2 (ja) * | 2005-03-31 | 2009-09-02 | アジェンシス，インコーポレイテッド | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体および関連分子 |
| EP1726650A1 (en) | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| AU2006294663B2 (en) | 2005-09-26 | 2012-03-22 | Medarex, Inc. | Human monoclonal antibodies to CD70 |
| ES2363891T3 (es) | 2006-03-20 | 2011-08-18 | The Regents Of The University Of California | Anticuerpos contra el antígeno de células troncales de la próstata (psca) modificados genéticamente para el direccionamiento al cáncer. |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| US8569006B2 (en) | 2008-02-29 | 2013-10-29 | Imec | Cell-enzyme based biosensors |
| PT2326350E (pt) | 2008-09-08 | 2013-12-10 | Psma Dev Company L L C | Compostos para matar células cancerosas resistentes a taxano, que expressam psma |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| WO2011069019A2 (en) | 2009-12-02 | 2011-06-09 | David Ho | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| CA2833477A1 (en) | 2011-04-21 | 2012-10-26 | Seattle Genetics, Inc. | Novel binder-drug conjugates (adcs) and their use |
| US20140161800A1 (en) | 2011-04-22 | 2014-06-12 | John W. Blankenship | Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods |
| CA2934617A1 (en) | 2013-12-23 | 2015-07-02 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with kinesin spindle protein (ksp) |
| JP6971858B2 (ja) | 2015-06-22 | 2021-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂性基を有する抗体薬物複合体（ａｄｃ）および抗体プロドラッグ複合体（ａｐｄｃ） |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
| UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| JP7251981B2 (ja) | 2016-03-24 | 2023-04-04 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂基を有する細胞毒性活性剤のプロドラッグ |
| CN109310781B (zh) | 2016-06-15 | 2024-06-18 | 拜耳制药股份公司 | 具有ksp抑制剂和抗-cd123-抗体的特异性抗体-药物-缀合物(adc) |
| US11660351B2 (en) | 2016-12-21 | 2023-05-30 | Bayer Aktiengesellschaft | Antibody drug conjugates (ADCs) having enzymatically cleavable groups |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| US12059472B2 (en) | 2016-12-21 | 2024-08-13 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| WO2019173324A1 (en) | 2018-03-06 | 2019-09-12 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
| WO2019245991A1 (en) | 2018-06-18 | 2019-12-26 | Eureka Therapeutics, Inc. | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
| CN112533956B (zh) | 2018-07-31 | 2025-05-06 | 海德堡医药研究有限责任公司 | 针对psma的人源化抗体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0668777T3 (da) * | 1992-11-05 | 2007-02-19 | Sloan Kettering Inst Cancer | Prostataspecifikt membran-antigen |
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| JP2001526522A (ja) * | 1995-02-24 | 2001-12-18 | スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺特異的膜抗原およびその使用 |
-
1997
- 1997-03-25 IL IL12631497A patent/IL126314A/xx not_active IP Right Cessation
- 1997-03-25 AT AT97917121T patent/ATE318147T1/de not_active IP Right Cessation
- 1997-03-25 JP JP53466797A patent/JP4295826B2/ja not_active Expired - Lifetime
- 1997-03-25 DK DK97917121T patent/DK0914155T3/da active
- 1997-03-25 AU AU25552/97A patent/AU725583B2/en not_active Expired
- 1997-03-25 DE DE69735294T patent/DE69735294T2/de not_active Revoked
- 1997-03-25 ES ES97917121T patent/ES2260788T3/es not_active Expired - Lifetime
- 1997-03-25 WO PCT/US1997/005214 patent/WO1997035616A1/en not_active Ceased
- 1997-03-25 EP EP97917121A patent/EP0914155B1/en not_active Revoked
- 1997-03-25 CA CA002250141A patent/CA2250141C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE318147T1 (de) | 2006-03-15 |
| DE69735294T2 (de) | 2006-09-21 |
| IL126314A0 (en) | 1999-05-09 |
| EP0914155B1 (en) | 2006-02-22 |
| DK0914155T3 (da) | 2006-06-26 |
| DE69735294D1 (de) | 2006-04-27 |
| CA2250141A1 (en) | 1997-10-02 |
| WO1997035616A1 (en) | 1997-10-02 |
| JP2001503601A (ja) | 2001-03-21 |
| AU725583B2 (en) | 2000-10-12 |
| CA2250141C (en) | 2008-07-29 |
| AU2555297A (en) | 1997-10-17 |
| EP0914155A4 (en) | 2001-05-16 |
| EP0914155A1 (en) | 1999-05-12 |
| JP4295826B2 (ja) | 2009-07-15 |
| IL126314A (en) | 2003-07-31 |
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