ES2255862A1 - Set of additives for skin peelings based on alpha hydroxy acids incorporate e.g. kojic acid in powders, dimethylamino ethanol, and palmitol pentapeptide in liquids - Google Patents

Abstract

Additives for skin peeling based on alpha-hydroxy acids comprise: (a) an additive with skin lightening function (b) an additive with skin lightening-k function (c) an additive with antioxidant properties (d) an additive with skin peeling light function (e) an additive with anti-acne function (f) an additive with activating function of collagen I (g) an additive with active role of collagen II (h) an additive with activating function of collagen III and (i) an additive with lifting function. Additives for skin peeling based on alpha-hydroxy acids comprise: (a) an additive with skin lightening function comprising kojic acid, Phyllanthus emblicaextract, Curcuma longaextract, green tea extract, and Piper longumextract (b) an additive with skin lightening-k function comprising kojic acid and P. longumextract (c) an additive with antioxidant properties comprising ascorbic acid, thioctic acid, red grape extract, soy isoflavones, and P. longumextract (d) an additive with skin peeling light function comprising ascorbic acid and P. longumextract (e) an additive with anti-acne function comprising niacinamide, salicylic acid, aloe vera extract, chamomile extract, and P. longum (f) an additive with activating function of collagen I comprising propylene glycol, water, ascorbic acid 2-glucoside, Centella asiaticaextract, alcohol, triethanolamine, xanthan gum, phenoxyethanol, methylparaben, propylparaben, butylparaben, and ethylparaben (g) an additive with active role of collagen II comprising glycerin, water, butylene glycol, gnaw, polysorbate, and palmitoyl-pentapeptide (h) an additive with activating function of collagen III comprising retinol, polysorbate, butylated hydroxytoluene, and butylated hydroxyanisole and (i) an additive with lifting function comprising water, lactic acid, dimethylamino ethanol, propylene glycol, polysorbate, sclerotium gum, hydrolyzed wheat protein, phenoxyethanol, perfume, methylparaben, butylparaben, ethylparaben, and propylparaben.

Description

Additives for skin peels .

Object of the invention

The object of the present invention patent is to describe a series of additives for dermatological treatments known as scrubs . These additives can be applied both during treatment (powder additives), and after treatment (liquid additives). These additives substantially improve the virtues of the peels , depending on the effects that are needed.

Background of the invention

So far additives have been used to all kinds of products, with the idea of enhancing their effects or Add new features to the original product. So by For example, food additives delay degradation (preservatives), dyes reinforce color, flavorings Accentuate the taste, etc.

In general, and according to the Royal Spanish Academy, a additive, in its fourth meaning is:

" Substance that is added to others to give them qualities that they lack or to improve those they possess. "

On the other hand, a facial peel is a chemical in the form of a liquid or gel, formulated based on alpha-hydroxy acids (AHA's) whose effect on the skin depends on the concentration and pH.

Applying the definition of additive to the field of skin peels we would face a substance of proven efficacy that is added to certain skin peels, in determined proportions, to accentuate and / or improve both the beneficial effects of peeling , as well as the substances themselves added.

Once the background of the present invention patent is established, it only remains to be added that the inventor, an expert in this field of medical science, is unaware of the existence of any specific additive for skin peels of the same or similar characteristics to those described below. .

Description of the invention

In order to complete the vacuum existing in this field of the art, the additives for skin peels , object of the present invention patent, are presented. Additives for skin peels are substances of proven efficacy and are added to certain skin peels to accentuate their effects. In addition, these are provided in sufficient quantity to achieve a relatively high concentration in the peel , without significantly modifying its characteristics.

The peels manage to eliminate the corneal layer of the skin and allow the penetration of high concentrations of the peeling active in the skin, improving the results. Also, the peel accentuates transepidermal penetration and allows the penetration of unstable ingredients, such as vitamin C, at high concentrations.

In the present invention patent are presented a series of additives, each of which has some own characteristics. These additives are divided into two families, powder additives and liquid additives.

Powder additives have been designed to be mixed in the recommended proportions with peeling at the time of application. The mixing of both products will be produced as follows:

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Be they will take between 1.5 and 2.5 gr. of additive and will be placed in a container.

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Approximately 8.5 gr will be taken. of peeling and will be placed in the same container.

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Be homogenize the mixture with the help of a spatula and apply on the skin.

These powder additives, in turn, are divided into five classes based on their main utility: depigmenting, depigmenting-k, antioxidant, bright and anti-acne

The luminous additive is acid based ascorbic and tetrahydropiperine. It is especially suitable for combat photoaging, skin pigmentation or melasmas, stretch marks and scars, as well as accentuate the photoprotection Ascorbic acid is a well known element in dermatological applications, while tetrahydropiperine is prepare from piperine (active ingredients of pepper) and improves the penetration of active ingredients by accelerating their absorption.

The antioxidant additive is acid based ascorbic, thioctic acid, grape extract, soy isoflavones and tetrahydropiperine. Thioctic acid is an antioxidant that inhibits tyrosonase and matrix degrading proteases, while soy isoflavones contain phytoestrogens such as Genistein, and Gaidzena. Genistein stimulates the synthesis of collagen and has an antioxidant action blocking radicals peroxyl, reducing lipid peroxidation. It also reduces the redness, has anti-inflammatory action and reduces the immunosuppressive effect of the RUV (radiation ultraviolet).

On the other hand, the red grape is rich in polyphenols and has a powerful antioxidant action, also decreases the ability of the RUV to induce skin cancers and redness

The antioxidant additive is especially indicated for the reduction of sun damage, photo aging, flushed skin, melasmas and associated hormonal acne With menopause

The depigmenting additive-k is based solely on kojic acid, in addition to tetrahydropiperine, with the aforementioned effects. The Kojic acid effects are well known in the field of dermatology as a powerful depigmentor.

The depigmenting additive is based mainly on kojic acid, but adding Phyllantus emblica , tetrahydrocurcuminoids, green tea powder and tetrahydropyperine.

Phyllantus emblica is the fruit powder of the same name ( Emblica officinalis ) and is rich in vitamin C and polyphenols, it also has antioxidant activity and reduces hyperpigmentation or freckles. On the other hand, tetrahydrocurcuminoids are polyphenolic compounds derived from curcuminoids (which are extracted from the roots of Curcuma longa ), have an antioxidant action greater than vitamin E in addition to an anti-inflammatory and depigmenting action. Green tea is widely consumed in Asia and offers an appreciable moment of "tranquility" to the cells for their anti-radical properties. It also contains polyphenols that prevent oxidative damage due to external aggressions such as UV radiation from the sun, helping the skin to preserve its youth.

Finally, the anti-acne additive It is basically composed of niacimide, salicylic acid, chamomile, aloe vera and tetrahydropiperine.

Niacimide is essentially vitamin B3, well known as very useful in the topical treatment of acne, in addition It has a powerful anti-inflammatory action that together with the Salicylic acid, has no risk of inducing resistance bacterial Salicylic acid is a β-hydroxy acid, larger molecule than AHAS (α-hydroxy acids). It is also a lipophilic that penetrates slower and deeper into the skin allowing a greater exfoliation inside the pore, it is also a keratolytic agent (which promotes the exfoliation of corneocytes) accelerating cell turnover. It also reduces acne lesions, oily skin, textural alterations and post-inflammatory hyperpigmentation.

The liquid additives are for use after the application of facial peeling , applying a light massage after the treatment.

Liquid additives are divided into two classes: collagen stimulating additives (I, II and III) and lifting additive.

Collagen stimulating additives are based on palmitoyl-pentapeptide, in the ascorbil-2-glycoside, the scintillation Asian, and retinol.

Palmitoyl-pentapeptide is a micro-collagen that mimics the regeneration process natural tissue (repair matrix and joint D-E) sending signals to the dermis cells to synthesize proteins (collagen I, III and IV), fibronectin and GAGs (hyaluronic acid) that make up connective tissue necessary to structure the skin. Against photoaging is as effective as retinol. On the other hand, the Asian sparkle stimulates fibroblast and the synthesis of collagen I, thereby have a component of firming characteristics, regenerating, repairing and softening, also inhibits the process inflammatory that could cause hypertrophy in scars. Finally, retinol is a fat-soluble vitamin, with action antioxidant, regenerating, normalizing keratinization, which regulates the process of cell renewal. It also increases the thickness of dermis and epidermis.

The lifting additive is based on DMAE (dimethylamino ethanol), lactic acid and wheat proteins.

DMAE is a component that releases acetylcholine, which is a neurotransmitter required for muscle contraction, that is, what we get with this compound is a better tone muscle in the skin muscles. Lactic acid is used to dissolve the DMAE in liquid form.

This solution has a high pH, then you have to neutralize it Wheat proteins are high tensing agents molecular weight, obtained from special protein fractions of wheat, purified and selected for their properties viscoelastic

By way of conclusion, we can indicate that the additives for peels , object of the present invention patent, have the following advantages:

one.-

Is an à la carte procedure, that is, is designed for each patient and problem

2.-

It allows the use of various assets to high concentrations

3.-

He asset is immediately incorporated into the delivery device, allowing the use of unstable assets such as vitamin C.

4.-

The results of the peeling and the additive are accentuated, rapid clinical improvements.

5.-

It is a very favorable change in the way in which the peels are currently made.

Preferred Embodiment of the Invention

The additives for skin peels , object of the present invention patent, are a series of additives with different characteristics and compositions. They are divided into two large groups, powder additives and liquid additives.

Powder additives are divided, in turn, into Five types according to their functionality: depigmenting, depigmenting-k, antioxidant, bright and anti-acne

The composition of the depigmenting additive, in International chemical nomenclature, is stated below. The maximum and minimum weights correspond to the percentages of maximum and minimum admissible ingredient to maintain results dermatologically acceptable, adjusting the rest of ingredients:

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Depigmenting Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid Kojico 80.45 47 99.95 Phyllantus emblica extract 10.50 0.01 twenty Curcuma longa extract 5.50 0.02 10 Green tea extract ( Camelia sinensis ) 3.00 0.01 fifteen Piper longum extract (tetrahydropiperine) 0.55 0.01 8

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The composition of the additive depigmenting-k, in chemical nomenclature International is listed below. The maximum and minimum weights  correspond to the percentages of the maximum and minimum ingredient admissible to maintain results dermatologically acceptable, adjusting the rest of the ingredients:

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Depigmenting Additive-K Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid Kojico 99.45 92 99.99 Piper longum extract (tetrahydropiperine) 0.55 0.01 8

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The composition of the antioxidant additive, in International chemical nomenclature is set forth below. The maximum and minimum weights correspond to the percentages of maximum and minimum admissible ingredient to maintain results dermatologically acceptable, adjusting the rest of ingredients:

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Antioxidant additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid ascorbic 76.20 42 99.87 Acid thioctic 12.75 0.1 25 Red grape extract ( Vitis vinifera ) 8.50 0.01 fifteen Isoflavones from soy 2.00 0.01 10 Piper longum extract (tetrahydropiperine) 0.55 0.01 8

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The composition of the luminous additive, in International chemical nomenclature is set forth below. The maximum and minimum weights correspond to the percentages of maximum and minimum admissible ingredient to maintain results dermatologically acceptable, adjusting the rest of ingredients:

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Luminous additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid ascorbic 99.45 92 99.99 Piper longum extract (tetrahydropiperine) 0.55 0.01 8

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The composition of the additive anti-acne, in international chemical nomenclature it set forth below. The maximum and minimum weights correspond to the percentages of the maximum and minimum admissible ingredient for maintain dermatologically acceptable results by adjusting the rest of the ingredients:

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Anti-acne additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Niacinamide 58 0.1 60 Acid salicylic 29.82 2 99.87 Aloe Vera Extract 5.8 0.01 fifteen Chamomile Extract ( Chamomilla recutita ) 5.8 0.01 fifteen Piper longum extract (tetrahydropiperine) 0.58 0.01 8

The liquid additives are for use after the application of facial peeling , applying a light massage after the treatment. Liquid additives are divided into two types, collagen stimulating additives (I, II and III) and lifting additive.

The composition of the stimulant additive of collagen I, in international chemical nomenclature is stated continuation. The maximum and minimum weights correspond to the maximum and minimum allowable ingredient percentages to maintain Dermatologically acceptable results, adjusting the rest of  ingredients:

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Collagen Stimulator Additive I Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Glycol Propylene 38,000 Anyone Anyone Water 34,700 Anyone Anyone Ascorbic acid 2-glycoside 15,400 0.1 twenty Centella Extract Asian 2,000 Anyone Anyone Alcohol 7,000 Anyone Anyone Triethanolamine 2,000 Anyone Anyone Gum of Xantan 0.400 Anyone Anyone Phenoxyethanol 0.375 Anyone Anyone Methylparaben 0.050 Anyone Anyone Propylparaben 0.025 Anyone Anyone Butylparaben 0.025 Anyone Anyone Ethylparaben 0.025 Anyone Anyone

The composition of the stimulant additive of collagen II, in international chemical nomenclature is stated continuation. The maximum and minimum weights correspond to the maximum and minimum allowable ingredient percentages to maintain Dermatologically acceptable results, adjusting the rest of  ingredients:

Collagen II Stimulating Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Glycerin 53,490 Anyone Anyone Water 25,000 Anyone Anyone Glycol Butylene 20,000 Anyone Anyone Gnaw 1,000 Anyone Anyone Polysorbate twenty 0.500 Anyone Anyone Palmitoil-Pentapeptide 0.010 Anyone Anyone

The composition of the stimulant additive of collagen III, in international chemical nomenclature is stated continuation. The maximum and minimum weights correspond to the maximum and minimum allowable ingredient percentages to maintain Dermatologically acceptable results, adjusting the rest of  ingredients:

Collagen III Stimulator Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Retinol 4,000 0.01 8 Polysorbate twenty 95,640 Anyone Anyone B HT (butylhydroxytoluene) 0.280 Anyone Anyone B.H.A. (butylhydroxyanisole) 0.080 Anyone Anyone

The composition of the lifting additive, in international chemical nomenclature is set forth below. The maximum and minimum weights correspond to the percentages of the maximum and minimum admissible ingredient to maintain dermatologically acceptable results, adjusting the rest of the ingredients:

lifting additive ingredients % w / w Preferred % w / w Minimum % w / w Maximum Water 70.8775 Anyone Anyone Acid lactic 15,0000 0.5 40 Dimethylamino ethanol (DMEA) 10,0000 0.5 twenty Glycol Propylene 1,0000 Anyone Anyone Polysorbate twenty 1,0000 Anyone Anyone Sclerotium rubber 1,0000 Anyone Anyone Wheat protein hydrolyzed 0.5000 0.01 2 Phenoxyethanol 0.3930 Anyone Anyone Fragrance 0,1000 Anyone Anyone Methylparaben 0.0515 Anyone Anyone Butylparaben 0.0265 Anyone Anyone Ethylparaben 0.0260 Anyone Anyone Propylparaben 0.0255 Anyone Anyone

Once the nature of the present invention, as well as a way of bringing it to the practice, it only remains to be added that said invention can suffer certain variations in its percentage distribution between ingredients, as long as these alterations do not vary substantially the characteristics that are claimed to continuation.

Claims (3)

1. Additives for skin peels , which are used to accentuate the functionality of peels based on alpha hydroxy acids, and which include: (A) An additive for skin peeling with function depigmenting, consisting of: Depigmenting Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid Kojico 80.45 47 99.95 Phyllantus emblica extract 10.50 0.01 twenty Curcuma longa extract 5.50 0.02 10 Green tea extract ( Camelia sinensis ) 3.00 0.01 fifteen Piper longum extract (tetrahydropiperine) 0.55 0.01 8 (B) An additive for skin peeling with function depigmenting-k, consisting of: Depigmenting Additive-K Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid Kojico 99.45 92 99.99 Piper longum extract (tetrahydropiperine) 0.55 0.01 8 (C) An additive for skin peeling with function antioxidant, composed of: Antioxidant additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid ascorbic 76.20 42 99.87 Acid thioctic 12.75 0.1 25 Red grape extract ( Vitis vinifera ) 8.50 0.01 fifteen Isoflavones from soy 2.00 0.01 10 Piper longum extract (tetrahydropiperine) 0.55 0.01 8 (D) An additive for skin peeling with function bright, consisting of: Luminous additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Acid ascorbic 99.45 92 99.99 Piper longum extract (tetrahydropiperine) 0.55 0.01 8 (E) An additive for skin peeling with function anti-acne, consisting of: Anti-acne additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Niacinamide 58 0.1 60 Acid salicylic 29.82 2 99.87 Aloe Vera Extract 5.8 0.01 fifteen Chamomile Extract ( Chamomilla recutita ) 5.8 0.01 fifteen Piper longum extract (tetrahydropiperine) 0.58 0.01 8 (F) An additive for skin peeling with function activator of collagen I, composed of: Collagen Stimulator Additive I Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Glycol Propylene 38,000 Anyone Anyone Water 34,700 Anyone Anyone Ascorbic acid 2-glycoside 15,400 0.1 twenty Centella Extract Asian 2,000 Anyone Anyone Alcohol 7,000 Anyone Anyone Triethanolamine 2,000 Anyone Anyone Gum of Xantan 0.400 Anyone Anyone Phenoxyethanol 0.375 Anyone Anyone Methylparaben 0.050 Anyone Anyone Propylparaben 0.025 Anyone Anyone Butylparaben 0.025 Anyone Anyone Ethylparaben 0.025 Anyone Anyone (G) An additive for skin peeling with function activator of collagen II, composed of: Collagen II Stimulating Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Glycerin 53,490 Anyone Anyone Water 25,000 Anyone Anyone Glycol Butylene 20,000 Anyone Anyone (Continuation) Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Gnaw 1,000 Anyone Anyone Polysorbate twenty 0.500 Anyone Anyone Palmitoil-Pentapeptide 0.010 Anyone Anyone

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(H) An additive for skin peeling with function activator of collagen III, composed of: Collagen III Stimulator Additive Ingredients % w / w Preferred % w / w Minimum % w / w Maximum Retinol 4,000 0.01 8 Polysorbate twenty 95,640 Anyone Anyone B HT (butylhydroxytoluene) 0.280 Anyone Anyone B.H.A. (butylhydroxyanisole) 0.080 Anyone Anyone

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(I) An additive for skin peeling, with lifting function, consisting of: lifting additive ingredients % w / w Preferred % w / w Minimum % w / w Maximum Water 70.8775 Anyone Anyone Acid lactic 15,0000 0.5 40 Dimethylamino ethanol (DMEA) 10,0000 0.5 twenty Glycol Propylene 1,0000 Anyone Anyone Polysorbate twenty 1,0000 Anyone Anyone Sclerotium rubber 1,0000 Anyone Anyone Wheat protein hydrolyzed 0.5000 0.01 2 Phenoxyethanol 0.3930 Anyone Anyone Fragrance 0,1000 Anyone Anyone Methylparaben 0.0515 Anyone Anyone Butylparaben 0.0265 Anyone Anyone Ethylparaben 0.0260 Anyone Anyone Propylparaben 0.0255 Anyone Anyone

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2. Additives for skin peels, according to claim one, characterized in that the additives with depigmenting, depigmenting-k, antioxidant, luminous and anti-acne functionality are powdered and mixed as follows:

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They will take between 1.5 and 2.5 grams of additive and placed in a container.

?

It will take approximately 8.5 grams of peeling and placed in the same container as the additive.

?

The mixture will be homogenized with help of a spatula and is applied on the skin.

3. Additives for skin peels, according to claim one, characterized in that the additives with collagen activating functionality I, II and III and lifting are liquid and are used subsequently to the application of facial peeling, applying a light massage after treatment.