ES2248136T3 - Compuesto de rutenio (ii) semi-sandwich que comprenden ligandos que contienen nitrogeno para el tratamiento del cancer. - Google Patents

Compuesto de rutenio (ii) semi-sandwich que comprenden ligandos que contienen nitrogeno para el tratamiento del cancer.

Info

Publication number
ES2248136T3
ES2248136T3 ES00971599T ES00971599T ES2248136T3 ES 2248136 T3 ES2248136 T3 ES 2248136T3 ES 00971599 T ES00971599 T ES 00971599T ES 00971599 T ES00971599 T ES 00971599T ES 2248136 T3 ES2248136 T3 ES 2248136T3
Authority
ES
Spain
Prior art keywords
sup
compound according
pyridine
compound
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00971599T
Other languages
English (en)
Spanish (es)
Inventor
Robert Edward Morris
Peter John Sadler
Haimei Chen
Duncan Jodrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COURT UNIVERSITY OF E, University of
University of Edinburgh
Original Assignee
COURT UNIVERSITY OF E, University of
University of Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9925274.4A external-priority patent/GB9925274D0/en
Priority claimed from GB0016054A external-priority patent/GB0016054D0/en
Application filed by COURT UNIVERSITY OF E, University of, University of Edinburgh filed Critical COURT UNIVERSITY OF E, University of
Application granted granted Critical
Publication of ES2248136T3 publication Critical patent/ES2248136T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES00971599T 1999-10-27 2000-10-26 Compuesto de rutenio (ii) semi-sandwich que comprenden ligandos que contienen nitrogeno para el tratamiento del cancer. Expired - Lifetime ES2248136T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9925274 1999-10-27
GBGB9925274.4A GB9925274D0 (en) 1999-10-27 1999-10-27 Ruthenium (II) compounds
GB0016054A GB0016054D0 (en) 2000-06-30 2000-06-30 Ruthenium (II) compounds
GB0016054 2000-06-30

Publications (1)

Publication Number Publication Date
ES2248136T3 true ES2248136T3 (es) 2006-03-16

Family

ID=26244569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00971599T Expired - Lifetime ES2248136T3 (es) 1999-10-27 2000-10-26 Compuesto de rutenio (ii) semi-sandwich que comprenden ligandos que contienen nitrogeno para el tratamiento del cancer.

Country Status (8)

Country Link
US (3) US6750251B2 (https=)
EP (1) EP1224192B1 (https=)
JP (1) JP2003512471A (https=)
AT (1) ATE303393T1 (https=)
DE (1) DE60022372T2 (https=)
DK (1) DK1224192T3 (https=)
ES (1) ES2248136T3 (https=)
WO (1) WO2001030790A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001030790A1 (en) * 1999-10-27 2001-05-03 The University Court, The University Of Edinburgh Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer
GB0215526D0 (en) * 2002-07-05 2002-08-14 Univ Edinburgh Anticancer compounds
DK1618116T3 (da) 2003-04-30 2008-09-08 Univ Edinburgh Ruthenium(II)-komplekser til behandling af tumorer
GB0418643D0 (en) * 2004-08-20 2004-09-22 Univ Edinburgh Ruthenium (II) compounds
GB0604602D0 (en) * 2006-03-07 2006-04-19 Univ Edinburgh Ruthenium (II) compounds
US9018199B2 (en) 2006-05-09 2015-04-28 Ecole Polytechnique Federale De Lausanne (Epfl) Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis
GB0610062D0 (en) * 2006-05-19 2006-06-28 Univ Edinburgh Ruthenium (ll) compounds
CA2775356C (en) 2009-10-08 2016-04-26 Angus Chemical Company Low-voc polyamines
US8383673B2 (en) * 2010-03-19 2013-02-26 City University Of Hong Kong Nitridoosmium(VI) complexes for treatment of cancer
WO2013038395A1 (en) 2011-09-16 2013-03-21 Universidade De Lisboa Transition metal complexes for pharmaceutical applications
WO2013136296A2 (en) 2012-03-14 2013-09-19 Universidade De Lisboa Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands
US9290528B1 (en) 2013-03-15 2016-03-22 University Of Kentucky Research Foundation Light-activated compounds
US9751081B2 (en) 2014-12-01 2017-09-05 Clemson University Self-regenerating antioxidant catalysts and methods of using the same
US10053480B1 (en) 2017-10-11 2018-08-21 King Saud University Anti-quorum and DNA cleaving agent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980472A (en) 1983-06-23 1990-12-25 American Cyanamid Company Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones
EP0188585A1 (de) 1984-07-24 1986-07-30 Byk Gulden Lomberg Chemische Fabrik GmbH Tumorhemmend wirkende rutheniumverbindungen
EP0191096B1 (de) 1984-07-24 1989-09-13 ASTA Pharma AG Tumorhemmend wirkende rutheniumverbindungen
US4980473A (en) * 1985-01-18 1990-12-25 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US5225556A (en) 1985-01-18 1993-07-06 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers
US4699978A (en) 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US5386044A (en) 1993-11-30 1995-01-31 E. I. Du Pont De Nemours And Company Polyhaloaromatic ruthenium complexes and reactions thereof
WO1996013510A1 (en) 1994-10-28 1996-05-09 Procept, Inc. Ruthenium complexes and their use as immunosuppressive agents
US5708022A (en) 1994-10-28 1998-01-13 Procept, Inc. Method for inhibiting immune response
JPH11209314A (ja) * 1997-09-30 1999-08-03 Takasago Internatl Corp シクロオクタジエン類の製造方法
WO2001030790A1 (en) * 1999-10-27 2001-05-03 The University Court, The University Of Edinburgh Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer
GB0016052D0 (en) * 2000-06-30 2000-08-23 Univ Edinburgh Ruthenium (II) compounds
GB0028025D0 (en) 2000-11-17 2001-01-03 Univ York Compounds
GB0215526D0 (en) * 2002-07-05 2002-08-14 Univ Edinburgh Anticancer compounds

Also Published As

Publication number Publication date
EP1224192B1 (en) 2005-08-31
US6750251B2 (en) 2004-06-15
US20030023088A1 (en) 2003-01-30
US6979681B2 (en) 2005-12-27
WO2001030790A1 (en) 2001-05-03
ATE303393T1 (de) 2005-09-15
US20040220166A1 (en) 2004-11-04
US20050239765A1 (en) 2005-10-27
DE60022372T2 (de) 2006-06-08
DK1224192T3 (da) 2006-01-02
DE60022372D1 (de) 2005-10-06
JP2003512471A (ja) 2003-04-02
EP1224192A1 (en) 2002-07-24

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