ATE303393T1 - Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapie - Google Patents
Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapieInfo
- Publication number
- ATE303393T1 ATE303393T1 AT00971599T AT00971599T ATE303393T1 AT E303393 T1 ATE303393 T1 AT E303393T1 AT 00971599 T AT00971599 T AT 00971599T AT 00971599 T AT00971599 T AT 00971599T AT E303393 T1 ATE303393 T1 AT E303393T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- compounds
- cancer therapy
- nitrogen containing
- Prior art date
Links
- YAYGSLOSTXKUBW-UHFFFAOYSA-N ruthenium(2+) Chemical class [Ru+2] YAYGSLOSTXKUBW-UHFFFAOYSA-N 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 239000003446 ligand Substances 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- -1 cylcoalkyl Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9925274.4A GB9925274D0 (en) | 1999-10-27 | 1999-10-27 | Ruthenium (II) compounds |
| GB0016054A GB0016054D0 (en) | 2000-06-30 | 2000-06-30 | Ruthenium (II) compounds |
| PCT/GB2000/004144 WO2001030790A1 (en) | 1999-10-27 | 2000-10-26 | Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303393T1 true ATE303393T1 (de) | 2005-09-15 |
Family
ID=26244569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00971599T ATE303393T1 (de) | 1999-10-27 | 2000-10-26 | Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapie |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6750251B2 (https=) |
| EP (1) | EP1224192B1 (https=) |
| JP (1) | JP2003512471A (https=) |
| AT (1) | ATE303393T1 (https=) |
| DE (1) | DE60022372T2 (https=) |
| DK (1) | DK1224192T3 (https=) |
| ES (1) | ES2248136T3 (https=) |
| WO (1) | WO2001030790A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512471A (ja) * | 1999-10-27 | 2003-04-02 | ユニバーシティ コート， エディンバラ大学 | 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
| US7241913B2 (en) | 2003-04-30 | 2007-07-10 | The University Court Of The University Of Edinburgh | Ruthenium compounds |
| GB0418643D0 (en) * | 2004-08-20 | 2004-09-22 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0604602D0 (en) * | 2006-03-07 | 2006-04-19 | Univ Edinburgh | Ruthenium (II) compounds |
| US9018199B2 (en) | 2006-05-09 | 2015-04-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis |
| GB0610062D0 (en) * | 2006-05-19 | 2006-06-28 | Univ Edinburgh | Ruthenium (ll) compounds |
| WO2011044472A1 (en) * | 2009-10-08 | 2011-04-14 | Angus Chemical Company | Low-voc polyamines |
| US8383673B2 (en) * | 2010-03-19 | 2013-02-26 | City University Of Hong Kong | Nitridoosmium(VI) complexes for treatment of cancer |
| WO2013038395A1 (en) | 2011-09-16 | 2013-03-21 | Universidade De Lisboa | Transition metal complexes for pharmaceutical applications |
| WO2013136296A2 (en) | 2012-03-14 | 2013-09-19 | Universidade De Lisboa | Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands |
| US9290528B1 (en) | 2013-03-15 | 2016-03-22 | University Of Kentucky Research Foundation | Light-activated compounds |
| US9751081B2 (en) | 2014-12-01 | 2017-09-05 | Clemson University | Self-regenerating antioxidant catalysts and methods of using the same |
| US10053480B1 (en) | 2017-10-11 | 2018-08-21 | King Saud University | Anti-quorum and DNA cleaving agent |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980472A (en) | 1983-06-23 | 1990-12-25 | American Cyanamid Company | Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| WO1986000804A1 (fr) | 1984-07-24 | 1986-02-13 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft M | Compositions de ruthenium a effet inhibiteur de tumeurs |
| EP0191096B1 (de) | 1984-07-24 | 1989-09-13 | ASTA Pharma AG | Tumorhemmend wirkende rutheniumverbindungen |
| US5225556A (en) | 1985-01-18 | 1993-07-06 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers |
| US4980473A (en) * | 1985-01-18 | 1990-12-25 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents |
| US4699978A (en) | 1985-01-18 | 1987-10-13 | The Trustees Of Columbia University In The City Of New York | Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents |
| US5386044A (en) | 1993-11-30 | 1995-01-31 | E. I. Du Pont De Nemours And Company | Polyhaloaromatic ruthenium complexes and reactions thereof |
| AU4017695A (en) | 1994-10-28 | 1996-05-23 | Procept, Inc. | Ruthenium complexes and their use as immunosuppressive agents |
| US5708022A (en) | 1994-10-28 | 1998-01-13 | Procept, Inc. | Method for inhibiting immune response |
| JPH11209314A (ja) * | 1997-09-30 | 1999-08-03 | Takasago Internatl Corp | シクロオクタジエン類の製造方法 |
| JP2003512471A (ja) * | 1999-10-27 | 2003-04-02 | ユニバーシティ コート， エディンバラ大学 | 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 |
| GB0016052D0 (en) * | 2000-06-30 | 2000-08-23 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0028025D0 (en) | 2000-11-17 | 2001-01-03 | Univ York | Compounds |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
-
2000
- 2000-10-26 JP JP2001533142A patent/JP2003512471A/ja active Pending
- 2000-10-26 EP EP00971599A patent/EP1224192B1/en not_active Expired - Lifetime
- 2000-10-26 DE DE60022372T patent/DE60022372T2/de not_active Expired - Fee Related
- 2000-10-26 DK DK00971599T patent/DK1224192T3/da active
- 2000-10-26 WO PCT/GB2000/004144 patent/WO2001030790A1/en not_active Ceased
- 2000-10-26 AT AT00971599T patent/ATE303393T1/de not_active IP Right Cessation
- 2000-10-26 ES ES00971599T patent/ES2248136T3/es not_active Expired - Lifetime
-
2002
- 2002-04-26 US US10/134,404 patent/US6750251B2/en not_active Expired - Fee Related
-
2004
- 2004-05-18 US US10/848,416 patent/US6979681B2/en not_active Expired - Fee Related
-
2005
- 2005-06-23 US US11/165,372 patent/US20050239765A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6750251B2 (en) | 2004-06-15 |
| EP1224192B1 (en) | 2005-08-31 |
| US6979681B2 (en) | 2005-12-27 |
| DK1224192T3 (da) | 2006-01-02 |
| EP1224192A1 (en) | 2002-07-24 |
| ES2248136T3 (es) | 2006-03-16 |
| DE60022372D1 (de) | 2005-10-06 |
| US20040220166A1 (en) | 2004-11-04 |
| US20030023088A1 (en) | 2003-01-30 |
| US20050239765A1 (en) | 2005-10-27 |
| WO2001030790A1 (en) | 2001-05-03 |
| DE60022372T2 (de) | 2006-06-08 |
| JP2003512471A (ja) | 2003-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1224192 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |