ES2235626B1 - Formas de administracion masticables, no comprimidas dosificadas individualmente. - Google Patents
Formas de administracion masticables, no comprimidas dosificadas individualmente.Info
- Publication number
- ES2235626B1 ES2235626B1 ES200302612A ES200302612A ES2235626B1 ES 2235626 B1 ES2235626 B1 ES 2235626B1 ES 200302612 A ES200302612 A ES 200302612A ES 200302612 A ES200302612 A ES 200302612A ES 2235626 B1 ES2235626 B1 ES 2235626B1
- Authority
- ES
- Spain
- Prior art keywords
- composition
- water
- stabilizing agent
- esters
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 claims abstract description 113
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000003381 stabilizer Substances 0.000 claims abstract description 23
- 108010010803 Gelatin Proteins 0.000 claims abstract description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 15
- 239000000194 fatty acid Substances 0.000 claims abstract description 15
- 229930195729 fatty acid Natural products 0.000 claims abstract description 15
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 15
- 239000008273 gelatin Substances 0.000 claims abstract description 15
- 229920000159 gelatin Polymers 0.000 claims abstract description 15
- 235000019322 gelatine Nutrition 0.000 claims abstract description 15
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 15
- 235000011187 glycerol Nutrition 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000002148 esters Chemical class 0.000 claims abstract description 11
- 239000011159 matrix material Substances 0.000 claims abstract description 11
- 239000013543 active substance Substances 0.000 claims abstract description 10
- 229920003023 plastic Polymers 0.000 claims abstract description 10
- 239000004033 plastic Substances 0.000 claims abstract description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 238000002844 melting Methods 0.000 claims abstract description 9
- 230000008018 melting Effects 0.000 claims abstract description 9
- 238000006136 alcoholysis reaction Methods 0.000 claims abstract description 8
- 238000005886 esterification reaction Methods 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 13
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- 230000001458 anti-acid effect Effects 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
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- 230000032050 esterification Effects 0.000 abstract description 5
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- MTEOMEWVDVPTNN-UHFFFAOYSA-E almagate Chemical compound O.O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Al+3].[O-]C([O-])=O MTEOMEWVDVPTNN-UHFFFAOYSA-E 0.000 description 5
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- 239000011575 calcium Substances 0.000 description 4
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
- 239000000787 lecithin Substances 0.000 description 4
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- 229940067606 lecithin Drugs 0.000 description 4
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 4
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 4
- JUQLTPCYUFPYKE-UHFFFAOYSA-N ritanserin Chemical compound CC=1N=C2SC=CN2C(=O)C=1CCN(CC1)CCC1=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 JUQLTPCYUFPYKE-UHFFFAOYSA-N 0.000 description 4
- 229950009626 ritanserin Drugs 0.000 description 4
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- CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 description 3
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 3
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 3
- TZJUVVIWVWFLCD-UHFFFAOYSA-N 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one Chemical compound O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 TZJUVVIWVWFLCD-UHFFFAOYSA-N 0.000 description 3
- JXZZEXZZKAWDSP-UHFFFAOYSA-N 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole Chemical compound C1CN(CCC=2C3=CC=CC=C3NC=2)CCC1NC(=O)C1=CC=CC=C1 JXZZEXZZKAWDSP-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 3
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- 229940024545 aluminum hydroxide Drugs 0.000 description 3
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- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 3
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 108010086827 triletide Proteins 0.000 description 1
- 229950001562 triletide Drugs 0.000 description 1
- 229960001670 trilostane Drugs 0.000 description 1
- KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 description 1
- 229960001177 trimetazidine Drugs 0.000 description 1
- 229960002431 trimipramine Drugs 0.000 description 1
- ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
- 229950008298 trimoprostil Drugs 0.000 description 1
- 229960001128 triprolidine Drugs 0.000 description 1
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
- UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
- 229960000875 trofosfamide Drugs 0.000 description 1
- 229950000976 trospectomycin Drugs 0.000 description 1
- KHAUBYTYGDOYRU-IRXASZMISA-N trospectomycin Chemical compound CN[C@H]([C@H]1O2)[C@@H](O)[C@@H](NC)[C@H](O)[C@H]1O[C@H]1[C@]2(O)C(=O)C[C@@H](CCCC)O1 KHAUBYTYGDOYRU-IRXASZMISA-N 0.000 description 1
- 229960000859 tulobuterol Drugs 0.000 description 1
- 229950009436 ularitide Drugs 0.000 description 1
- IUCCYQIEZNQWRS-DWWHXVEHSA-N ularitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 IUCCYQIEZNQWRS-DWWHXVEHSA-N 0.000 description 1
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- 229960004699 valsartan Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- RYJXBGGBZJGVQF-UHFFFAOYSA-N veralipride Chemical compound COC1=CC(S(N)(=O)=O)=CC(C(=O)NCC2N(CCC2)CC=C)=C1OC RYJXBGGBZJGVQF-UHFFFAOYSA-N 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XFXANHWIBFMEOY-JKSUJKDBSA-N viqualine Chemical compound C12=CC(OC)=CC=C2N=CC=C1CCC[C@@H]1CCNC[C@@H]1C=C XFXANHWIBFMEOY-JKSUJKDBSA-N 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229950004893 xemilofiban Drugs 0.000 description 1
- 229960000537 xipamide Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- GEVJDDLLVRRIOL-UHFFFAOYSA-L zinc;6-acetamidohexanoate Chemical compound [Zn+2].CC(=O)NCCCCCC([O-])=O.CC(=O)NCCCCCC([O-])=O GEVJDDLLVRRIOL-UHFFFAOYSA-L 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229950001300 zofenoprilat Drugs 0.000 description 1
- UQWLOWFDKAFKAP-WXHSDQCUSA-N zofenoprilat Chemical compound C1[C@@H](C(O)=O)N(C(=O)[C@@H](CS)C)C[C@H]1SC1=CC=CC=C1 UQWLOWFDKAFKAP-WXHSDQCUSA-N 0.000 description 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
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- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302612A ES2235626B1 (es) | 2003-11-10 | 2003-11-10 | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
| PCT/EP2004/002513 WO2005048975A1 (en) | 2003-11-10 | 2004-03-11 | Non-tabletted, chewable, individually dosed administration forms |
| UY28586A UY28586A1 (es) | 2003-11-10 | 2004-10-28 | Formas de administración masticables, no comprimidas dosificadas individualmente |
| PE2004001080A PE20050488A1 (es) | 2003-11-10 | 2004-11-05 | Formas de administracion masticables, no comprimidas, dosificadas individualmente |
| MYPI20044643A MY143793A (en) | 2003-11-10 | 2004-11-08 | Non-tabletted, chewable, individually dosed administration forms |
| ARP040104105A AR048050A1 (es) | 2003-11-10 | 2004-11-08 | Formas de administracion masticables, no comprimidas, dosificadas individualmente |
| US10/578,515 US20070134318A1 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
| PCT/EP2004/012658 WO2005048974A2 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
| AU2004290517A AU2004290517B2 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
| UAA200606335A UA90253C2 (ru) | 2003-11-10 | 2004-11-09 | Нетаблетированные жевательные дозировочные формы для индивидуального введения |
| JP2006538767A JP4879021B2 (ja) | 2003-11-10 | 2004-11-09 | 非錠剤形チュアブル単回用投与形態 |
| EP04797734A EP1682097B1 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
| ES04797734T ES2358332T3 (es) | 2003-11-10 | 2004-11-09 | Formas de administración dosificadas individualmente, masticables, no comprimidas. |
| BRPI0416215-3A BRPI0416215A (pt) | 2003-11-10 | 2004-11-09 | forma de ministração individualmente dosada, não comprimida, processo para produzir uma forma de ministração individualmente dosada, não comprimida e uso de pelo menos um agente de estabilização |
| CNA2004800330379A CN1878542A (zh) | 2003-11-10 | 2004-11-09 | 非片剂化的、可咀嚼的单独剂量给药剂型 |
| AT04797734T ATE492270T1 (de) | 2003-11-10 | 2004-11-09 | Nicht tablettenförmige kaubare einzeln dosierte verabreichungsformen |
| DE602004030706T DE602004030706D1 (de) | 2003-11-10 | 2004-11-09 | Nicht tablettenförmige kaubare einzeln dosierte verabreichungsformen |
| RU2006120087/15A RU2369379C2 (ru) | 2003-11-10 | 2004-11-09 | Нетаблетированные жевательные дозировочные формы для индивидуального введения |
| CA002548615A CA2548615A1 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
| NZ546375A NZ546375A (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms containing stabilising agents that facilitate their removal from packaging |
| KR1020067009596A KR20060116821A (ko) | 2003-11-10 | 2004-11-09 | 비정제화되고, 씹을 수 있는, 개별 투여되는 투여 형태 |
| TW093134361A TW200526266A (en) | 2003-11-10 | 2004-11-10 | Non-tabletted, chewable, individually dosed administration forms |
| ZA200602416A ZA200602416B (en) | 2003-11-10 | 2006-03-24 | Non-tabletted, chewable, individually dosed administration forms |
| IL175285A IL175285A (en) | 2003-11-10 | 2006-04-27 | Non-tabletted, chewable, individually dosed administration forms and process for their production |
| EC2006006553A ECSP066553A (es) | 2003-11-10 | 2006-05-08 | Formas de administración masticables, no comprimidas dosificadas individualmente. |
| CO06043842A CO5690531A2 (es) | 2003-11-10 | 2006-05-09 | Formas de administracion masticables, no comprimidas dosificadas individualmente |
| NO20062723A NO20062723L (no) | 2003-11-10 | 2006-06-12 | Ikke-tabletterte, tyggbare, induviduelt doserte administrasjonsformer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302612A ES2235626B1 (es) | 2003-11-10 | 2003-11-10 | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2235626A1 ES2235626A1 (es) | 2005-07-01 |
| ES2235626B1 true ES2235626B1 (es) | 2006-11-01 |
Family
ID=34610359
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200302612A Expired - Fee Related ES2235626B1 (es) | 2003-11-10 | 2003-11-10 | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
| ES04797734T Expired - Lifetime ES2358332T3 (es) | 2003-11-10 | 2004-11-09 | Formas de administración dosificadas individualmente, masticables, no comprimidas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04797734T Expired - Lifetime ES2358332T3 (es) | 2003-11-10 | 2004-11-09 | Formas de administración dosificadas individualmente, masticables, no comprimidas. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20070134318A1 (enExample) |
| EP (1) | EP1682097B1 (enExample) |
| JP (1) | JP4879021B2 (enExample) |
| KR (1) | KR20060116821A (enExample) |
| CN (1) | CN1878542A (enExample) |
| AR (1) | AR048050A1 (enExample) |
| AT (1) | ATE492270T1 (enExample) |
| AU (1) | AU2004290517B2 (enExample) |
| BR (1) | BRPI0416215A (enExample) |
| CA (1) | CA2548615A1 (enExample) |
| CO (1) | CO5690531A2 (enExample) |
| DE (1) | DE602004030706D1 (enExample) |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050089559A1 (en) | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| ES2420960T3 (es) | 2006-08-23 | 2013-08-28 | Valeant Pharmaceuticals International | Derivados de 4-(N-azacicloalquil)anilidas como moduladores de los canales de potasio |
| AU2007325629A1 (en) | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| WO2009002084A2 (en) * | 2007-06-27 | 2008-12-31 | Hanmi Pharm. Co., Ltd. | Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same |
| IL187159A0 (en) | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| EP2323735A1 (en) | 2008-07-29 | 2011-05-25 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
| EP2238976B1 (en) * | 2009-04-03 | 2012-06-27 | Hexal AG | Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof |
| CA2766107A1 (en) | 2009-06-25 | 2010-12-29 | Alcobra Ltd. | A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
| EA021368B1 (ru) * | 2011-06-21 | 2015-06-30 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Препарат кардиопротекторного действия |
| CN105911057B (zh) * | 2016-06-22 | 2018-10-19 | 扬州一洋制药有限公司 | 一种铝镁加混悬液的质量控制方法 |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| PH12022551110A1 (en) | 2019-11-08 | 2024-02-26 | Xenon Pharmaceuticals Inc | Methods of treating depressive disorders |
| JP2024508660A (ja) | 2021-02-09 | 2024-02-28 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 |
| CN113425694A (zh) * | 2021-07-02 | 2021-09-24 | 杭州蚕宝生物技术有限公司 | 一种石斛生物碱口腔崩解片剂及其制备方法 |
| US12053484B2 (en) | 2021-10-29 | 2024-08-06 | Medicated Chews, Llc | Simethicone chewable composition |
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| JPS5645411A (en) * | 1979-09-20 | 1981-04-25 | Taiho Yakuhin Kogyo Kk | Poultice |
| EP0409432A2 (en) * | 1989-07-20 | 1991-01-23 | Warner-Lambert Company | Confectionery delivery system |
| JPH08319232A (ja) * | 1995-03-22 | 1996-12-03 | Takeda Chem Ind Ltd | 粉粒状組成物 |
| JPH0912463A (ja) * | 1995-06-23 | 1997-01-14 | Fujisawa Pharmaceut Co Ltd | 口中咀嚼用製剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515035A1 (fr) * | 1981-10-26 | 1983-04-29 | Rhone Poulenc Sante | Nouvelle forme galenique solide pour administration par voie orale et son procede de fabrication |
| US5433951A (en) * | 1993-10-13 | 1995-07-18 | Bristol-Myers Squibb Company | Sustained release formulation containing captopril and method |
| US20030216303A1 (en) * | 1998-03-06 | 2003-11-20 | Michael Ambuhl | Emulsion preconcentrates containing cyclosporin or a macrolide |
| US6171615B1 (en) * | 1998-07-06 | 2001-01-09 | Gattefoss{acute over (e)} | Sustained release theophylline formulations, excipient systems and methods of production |
| US6060078A (en) * | 1998-09-28 | 2000-05-09 | Sae Han Pharm Co., Ltd. | Chewable tablet and process for preparation thereof |
| US6652880B1 (en) * | 1999-04-01 | 2003-11-25 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants |
| EP2298284A3 (en) * | 2001-02-14 | 2013-12-18 | GW Pharma Limited | Mucoadhesive pharmaceutical formulations |
| US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| RU2197094C1 (ru) * | 2001-12-26 | 2003-01-27 | Ставрулов Игорь Анатольевич | Жевательная резинка |
-
2003
- 2003-11-10 ES ES200302612A patent/ES2235626B1/es not_active Expired - Fee Related
-
2004
- 2004-03-11 WO PCT/EP2004/002513 patent/WO2005048975A1/en not_active Ceased
- 2004-10-28 UY UY28586A patent/UY28586A1/es not_active Application Discontinuation
- 2004-11-05 PE PE2004001080A patent/PE20050488A1/es not_active Application Discontinuation
- 2004-11-08 AR ARP040104105A patent/AR048050A1/es not_active Application Discontinuation
- 2004-11-08 MY MYPI20044643A patent/MY143793A/en unknown
- 2004-11-09 CA CA002548615A patent/CA2548615A1/en not_active Abandoned
- 2004-11-09 BR BRPI0416215-3A patent/BRPI0416215A/pt not_active IP Right Cessation
- 2004-11-09 NZ NZ546375A patent/NZ546375A/en unknown
- 2004-11-09 EP EP04797734A patent/EP1682097B1/en not_active Expired - Lifetime
- 2004-11-09 DE DE602004030706T patent/DE602004030706D1/de not_active Expired - Lifetime
- 2004-11-09 UA UAA200606335A patent/UA90253C2/ru unknown
- 2004-11-09 US US10/578,515 patent/US20070134318A1/en not_active Abandoned
- 2004-11-09 RU RU2006120087/15A patent/RU2369379C2/ru not_active IP Right Cessation
- 2004-11-09 JP JP2006538767A patent/JP4879021B2/ja not_active Expired - Fee Related
- 2004-11-09 ES ES04797734T patent/ES2358332T3/es not_active Expired - Lifetime
- 2004-11-09 KR KR1020067009596A patent/KR20060116821A/ko not_active Ceased
- 2004-11-09 WO PCT/EP2004/012658 patent/WO2005048974A2/en not_active Ceased
- 2004-11-09 CN CNA2004800330379A patent/CN1878542A/zh active Pending
- 2004-11-09 AU AU2004290517A patent/AU2004290517B2/en not_active Ceased
- 2004-11-09 AT AT04797734T patent/ATE492270T1/de not_active IP Right Cessation
- 2004-11-10 TW TW093134361A patent/TW200526266A/zh unknown
-
2006
- 2006-03-24 ZA ZA200602416A patent/ZA200602416B/xx unknown
- 2006-04-27 IL IL175285A patent/IL175285A/en not_active IP Right Cessation
- 2006-05-08 EC EC2006006553A patent/ECSP066553A/es unknown
- 2006-05-09 CO CO06043842A patent/CO5690531A2/es not_active Application Discontinuation
- 2006-06-12 NO NO20062723A patent/NO20062723L/no not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645411A (en) * | 1979-09-20 | 1981-04-25 | Taiho Yakuhin Kogyo Kk | Poultice |
| EP0409432A2 (en) * | 1989-07-20 | 1991-01-23 | Warner-Lambert Company | Confectionery delivery system |
| JPH08319232A (ja) * | 1995-03-22 | 1996-12-03 | Takeda Chem Ind Ltd | 粉粒状組成物 |
| JPH0912463A (ja) * | 1995-06-23 | 1997-01-14 | Fujisawa Pharmaceut Co Ltd | 口中咀嚼用製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| CO5690531A2 (es) | 2006-10-31 |
| ATE492270T1 (de) | 2011-01-15 |
| AU2004290517A1 (en) | 2005-06-02 |
| ECSP066553A (es) | 2006-12-20 |
| WO2005048974A2 (en) | 2005-06-02 |
| AU2004290517B2 (en) | 2010-05-27 |
| EP1682097A2 (en) | 2006-07-26 |
| WO2005048974A3 (en) | 2006-02-23 |
| ZA200602416B (en) | 2009-06-24 |
| AR048050A1 (es) | 2006-03-29 |
| IL175285A (en) | 2011-04-28 |
| NZ546375A (en) | 2009-11-27 |
| EP1682097B1 (en) | 2010-12-22 |
| ES2235626A1 (es) | 2005-07-01 |
| CN1878542A (zh) | 2006-12-13 |
| PE20050488A1 (es) | 2005-08-24 |
| ES2358332T3 (es) | 2011-05-09 |
| JP4879021B2 (ja) | 2012-02-15 |
| MY143793A (en) | 2011-07-15 |
| TW200526266A (en) | 2005-08-16 |
| BRPI0416215A (pt) | 2006-12-26 |
| US20070134318A1 (en) | 2007-06-14 |
| UY28586A1 (es) | 2005-05-31 |
| NO20062723L (no) | 2006-06-12 |
| IL175285A0 (en) | 2006-09-05 |
| UA90253C2 (ru) | 2010-04-26 |
| RU2006120087A (ru) | 2007-12-27 |
| RU2369379C2 (ru) | 2009-10-10 |
| KR20060116821A (ko) | 2006-11-15 |
| DE602004030706D1 (de) | 2011-02-03 |
| WO2005048975A1 (en) | 2005-06-02 |
| CA2548615A1 (en) | 2005-06-02 |
| JP2007510690A (ja) | 2007-04-26 |
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