JP4879021B2 - 非錠剤形チュアブル単回用投与形態 - Google Patents

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Publication number

JP4879021B2

JP4879021B2 JP2006538767A JP2006538767A JP4879021B2 JP 4879021 B2 JP4879021 B2 JP 4879021B2 JP 2006538767 A JP2006538767 A JP 2006538767A JP 2006538767 A JP2006538767 A JP 2006538767A JP 4879021 B2 JP4879021 B2 JP 4879021B2

Authority

JP

Japan

Prior art keywords

composition

water

weight

dosage form

single dosage

Prior art date

2003-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 239000002552 dosage form Substances 0.000 title claims description 21
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• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
• 239000003381 stabilizer Substances 0.000 claims description 22
• 108010010803 Gelatin Proteins 0.000 claims description 21
• 239000008273 gelatin Substances 0.000 claims description 21
• 229920000159 gelatin Polymers 0.000 claims description 21
• 235000019322 gelatine Nutrition 0.000 claims description 21
• 235000011852 gelatine desserts Nutrition 0.000 claims description 21
• 238000000034 method Methods 0.000 claims description 21
• 239000013543 active substance Substances 0.000 claims description 19
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
• 235000011187 glycerol Nutrition 0.000 claims description 17
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 15
• 239000000194 fatty acid Substances 0.000 claims description 15
• 229930195729 fatty acid Natural products 0.000 claims description 15
• 150000002148 esters Chemical class 0.000 claims description 13
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• 239000011159 matrix material Substances 0.000 claims description 12
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• 229910052782 aluminium Inorganic materials 0.000 description 12
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 12
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• PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 description 4
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• 238000002360 preparation method Methods 0.000 description 4
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• JUQLTPCYUFPYKE-UHFFFAOYSA-N ritanserin Chemical compound CC=1N=C2SC=CN2C(=O)C=1CCN(CC1)CCC1=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 JUQLTPCYUFPYKE-UHFFFAOYSA-N 0.000 description 4
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• 238000012360 testing method Methods 0.000 description 4
• CEMAWMOMDPGJMB-CYBMUJFWSA-N (2r)-1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-CYBMUJFWSA-N 0.000 description 3
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• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 3
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• PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 3
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• 229930012538 Paclitaxel Natural products 0.000 description 3
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• SMTZFNFIKUPEJC-UHFFFAOYSA-N Roxane Chemical compound CC(=O)OCC(=O)NCCCOC1=CC=CC(CN2CCCCC2)=C1 SMTZFNFIKUPEJC-UHFFFAOYSA-N 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
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• 229960003120 clonazepam Drugs 0.000 description 3
• DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 3
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• 229910000021 magnesium carbonate Inorganic materials 0.000 description 3
• 229960002237 metoprolol Drugs 0.000 description 3
• IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 3
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• 229960002009 naproxen Drugs 0.000 description 3
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• 229960001592 paclitaxel Drugs 0.000 description 3
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• 229960003712 propranolol Drugs 0.000 description 3
• 102000004169 proteins and genes Human genes 0.000 description 3
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• AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 3
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