ES2234447B1 - Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. - Google Patents

Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.

Info

Publication number
ES2234447B1
ES2234447B1 ES200500513A ES200500513A ES2234447B1 ES 2234447 B1 ES2234447 B1 ES 2234447B1 ES 200500513 A ES200500513 A ES 200500513A ES 200500513 A ES200500513 A ES 200500513A ES 2234447 B1 ES2234447 B1 ES 2234447B1
Authority
ES
Spain
Prior art keywords
formula
derivative
dibenzo
process according
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200500513A
Other languages
English (en)
Spanish (es)
Other versions
ES2234447A1 (es
Inventor
Alexander Chris Comelv
Francesc Xavier Verdaguer Espaulella
Llorenc Rafecas Jane
Antonio Domingo Coto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Quimico Farmaceutica SA
Original Assignee
Union Quimico Farmaceutica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica SA filed Critical Union Quimico Farmaceutica SA
Priority to ES200500513A priority Critical patent/ES2234447B1/es
Publication of ES2234447A1 publication Critical patent/ES2234447A1/es
Priority to PT05850361T priority patent/PT1856073E/pt
Priority to DE602005021256T priority patent/DE602005021256D1/de
Priority to US11/817,884 priority patent/US7902355B2/en
Priority to AT05850361T priority patent/ATE467624T1/de
Priority to EP05850361A priority patent/EP1856073B1/de
Priority to DK05850361.6T priority patent/DK1856073T3/da
Priority to PCT/EP2005/014055 priority patent/WO2006094549A1/en
Application granted granted Critical
Publication of ES2234447B1 publication Critical patent/ES2234447B1/es
Priority to NO20075071A priority patent/NO20075071L/no
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ES200500513A 2005-03-07 2005-03-07 Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. Expired - Fee Related ES2234447B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES200500513A ES2234447B1 (es) 2005-03-07 2005-03-07 Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
AT05850361T ATE467624T1 (de) 2005-03-07 2005-12-21 Verfahren zur herstellung eines 11-(4- substituierten 1-piperazinyl)dibenzoäb,füä1, 4üthiazepinderivats
DE602005021256T DE602005021256D1 (de) 2005-03-07 2005-12-21 Verfahren zur herstellung eines 11-(4-substituierten 1-piperazinyl)dibenzoäb,füä1,4üthiazepinderivats
US11/817,884 US7902355B2 (en) 2005-03-07 2005-12-21 Process for the preparation of an 11-(4-substituted-1-piperazinyl)dibenzo[b,f][1,4]thiazepine derivative
PT05850361T PT1856073E (pt) 2005-03-07 2005-12-21 Processo para a preparaã†o de um derivado de 11-(4- substitudo-1-piperazinil)dibenzo[b,f][1,4]-tiazepina
EP05850361A EP1856073B1 (de) 2005-03-07 2005-12-21 Verfahren zur herstellung eines 11-(4-substituierten 1-piperazinyl)dibenzo[b,f][1,4]thiazepinderivats
DK05850361.6T DK1856073T3 (da) 2005-03-07 2005-12-21 Fremgangsmåde til fremstilling af et 11-(4-substitueret-1-piperazinyl)dibenzo[b,f][1,4]thiazepinderivat
PCT/EP2005/014055 WO2006094549A1 (en) 2005-03-07 2005-12-21 A PROCESS FOR THE PREPARATION OF AN 11-(4-SUBSTITUTED-I-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE DERIVATIVE
NO20075071A NO20075071L (no) 2005-03-07 2007-10-08 Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200500513A ES2234447B1 (es) 2005-03-07 2005-03-07 Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.

Publications (2)

Publication Number Publication Date
ES2234447A1 ES2234447A1 (es) 2005-06-16
ES2234447B1 true ES2234447B1 (es) 2006-03-01

Family

ID=34707636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200500513A Expired - Fee Related ES2234447B1 (es) 2005-03-07 2005-03-07 Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.

Country Status (9)

Country Link
US (1) US7902355B2 (de)
EP (1) EP1856073B1 (de)
AT (1) ATE467624T1 (de)
DE (1) DE602005021256D1 (de)
DK (1) DK1856073T3 (de)
ES (1) ES2234447B1 (de)
NO (1) NO20075071L (de)
PT (1) PT1856073E (de)
WO (1) WO2006094549A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2603795A1 (en) 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
CZ300451B6 (cs) * 2006-07-03 2009-05-20 Farmak, A. S. Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
JP2011510960A (ja) * 2008-01-31 2011-04-07 フェルミオン オサケ ユキチュア ケチアピンの製造方法
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
CN101891707B (zh) * 2010-07-29 2012-10-17 浙江海正药业股份有限公司 喹硫平或其可药用盐的制备方法
CN103664822B (zh) * 2012-09-18 2015-07-15 四川大学华西医院 一种可用作麻醉剂的化合物
CN104803947A (zh) * 2015-03-12 2015-07-29 常州康丽制药有限公司 11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂*富马酸盐的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006381A1 (en) * 1997-08-01 1999-02-11 Zeneca Limited A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent
WO2001055125A1 (en) * 2000-01-25 2001-08-02 EGIS Gyógyszergyár Rt. A process for the preparation of quetiapine and intermediates therefor
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006381A1 (en) * 1997-08-01 1999-02-11 Zeneca Limited A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent
WO2001055125A1 (en) * 2000-01-25 2001-08-02 EGIS Gyógyszergyár Rt. A process for the preparation of quetiapine and intermediates therefor
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
EP1856073A1 (de) 2007-11-21
EP1856073B1 (de) 2010-05-12
DE602005021256D1 (de) 2010-06-24
US20080171869A1 (en) 2008-07-17
ES2234447A1 (es) 2005-06-16
DK1856073T3 (da) 2010-08-23
NO20075071L (no) 2007-11-28
US7902355B2 (en) 2011-03-08
PT1856073E (pt) 2010-07-06
ATE467624T1 (de) 2010-05-15
WO2006094549A1 (en) 2006-09-14

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