ES2222828B1 - Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2222828B1
ES2222828B1 ES200301806A ES200301806A ES2222828B1 ES 2222828 B1 ES2222828 B1 ES 2222828B1 ES 200301806 A ES200301806 A ES 200301806A ES 200301806 A ES200301806 A ES 200301806A ES 2222828 B1 ES2222828 B1 ES 2222828B1
Authority
ES
Spain
Prior art keywords
radical
branched
linear
optionally
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200301806A
Other languages
English (en)
Spanish (es)
Other versions
ES2222828A1 (es
Inventor
Ramon Merce Vidal
Xavier Codony Soler
Alberto Dordal Zueras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200301806A priority Critical patent/ES2222828B1/es
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to US10/566,400 priority patent/US7655690B2/en
Priority to MXPA06001229A priority patent/MXPA06001229A/es
Priority to AU2004262490A priority patent/AU2004262490A1/en
Priority to CA002533996A priority patent/CA2533996A1/en
Priority to RU2006105782/04A priority patent/RU2006105782A/ru
Priority to ES04763613T priority patent/ES2348621T3/es
Priority to JP2006521532A priority patent/JP2007500168A/ja
Priority to PCT/EP2004/008516 priority patent/WO2005013974A1/en
Priority to DE602004028125T priority patent/DE602004028125D1/de
Priority to AT04763613T priority patent/ATE473738T1/de
Priority to KR1020067001740A priority patent/KR20060056347A/ko
Priority to BRPI0413062-6A priority patent/BRPI0413062A/pt
Priority to TW093122676A priority patent/TW200509908A/zh
Priority to ZA200600427A priority patent/ZA200600427B/en
Priority to ARP040102701A priority patent/AR045159A1/es
Priority to EP04763613A priority patent/EP1648443B1/en
Priority to CNA2004800280717A priority patent/CN1863527A/zh
Priority to PE2004000739A priority patent/PE20050726A1/es
Publication of ES2222828A1 publication Critical patent/ES2222828A1/es
Priority to IL172956A priority patent/IL172956A0/en
Priority to NO20060342A priority patent/NO20060342L/no
Priority to EC2006006330A priority patent/ECSP066330A/es
Application granted granted Critical
Publication of ES2222828B1 publication Critical patent/ES2222828B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES200301806A 2003-07-30 2003-07-30 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. Expired - Fee Related ES2222828B1 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES200301806A ES2222828B1 (es) 2003-07-30 2003-07-30 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
TW093122676A TW200509908A (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use in medicaments
AU2004262490A AU2004262490A1 (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-HT6 ligands
CA002533996A CA2533996A1 (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-ht6 ligands
RU2006105782/04A RU2006105782A (ru) 2003-07-30 2004-07-29 Производные 1-сульфонилиндола, их получение и их применение в качестве лигандов 5-нт-6
ES04763613T ES2348621T3 (es) 2003-07-30 2004-07-29 Derivados de 1-sulfonilindol, su preparación y su uso como ligandos de 5-ht6.
JP2006521532A JP2007500168A (ja) 2003-07-30 2004-07-29 １−スルホニルインドール誘導体、それらの調製及び５−ｈｔ６リガンドとしてのそれらの使用
PCT/EP2004/008516 WO2005013974A1 (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-ht6 ligands
DE602004028125T DE602004028125D1 (de) 2003-07-30 2004-07-29 1-sulfonylindolderivate, verfahren zu ihrer herstellung und ihre verwendung als 5-ht6 liganden
MXPA06001229A MXPA06001229A (es) 2003-07-30 2004-07-29 Derivados de 1-sulfonilindol, su preparacion y su uso como ligandos de 5-ht6.
KR1020067001740A KR20060056347A (ko) 2003-07-30 2004-07-29 1-술포닐인돌 유도체, 그것의 제조법 및 5-에이치티6리간드로서의 그것의 용도
BRPI0413062-6A BRPI0413062A (pt) 2003-07-30 2004-07-29 compostos de sulfonamida, processos de obtenção de seus derivados, seus medicamentos e usos
US10/566,400 US7655690B2 (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-HT6 ligands
ZA200600427A ZA200600427B (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-HT6 ligands
AT04763613T ATE473738T1 (de) 2003-07-30 2004-07-29 1-sulfonylindolderivate, verfahren zu ihrer herstellung und ihre verwendung als 5-ht6 liganden
EP04763613A EP1648443B1 (en) 2003-07-30 2004-07-29 1-sulfonylindole derivatives, their preparation and their use as 5-ht6 ligands
CNA2004800280717A CN1863527A (zh) 2003-07-30 2004-07-29 1－磺酰基吲哚衍生物、其制备及其作为5－ht6配体的用途
ARP040102701A AR045159A1 (es) 2003-07-30 2004-07-29 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos
PE2004000739A PE20050726A1 (es) 2003-07-30 2004-08-02 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos
IL172956A IL172956A0 (en) 2003-07-30 2006-01-02 1-sulfonylindole derivatives, their preparation and their use as 5-ht6 ligands
NO20060342A NO20060342L (no) 2003-07-30 2006-01-23 1-sulfonylindol derivater, deres fremstilling og deres andvendelse som 5-HT6 ligander
EC2006006330A ECSP066330A (es) 2003-07-30 2006-01-30 Derivados de 1-sulfonilindol, su preparación y su uso como lingados de 5-ht-6

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200301806A ES2222828B1 (es) 2003-07-30 2003-07-30 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2222828A1 ES2222828A1 (es) 2005-02-01
ES2222828B1 true ES2222828B1 (es) 2006-04-16

Family

ID=34130540

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200301806A Expired - Fee Related ES2222828B1 (es) 2003-07-30 2003-07-30 Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
ES04763613T Expired - Lifetime ES2348621T3 (es) 2003-07-30 2004-07-29 Derivados de 1-sulfonilindol, su preparación y su uso como ligandos de 5-ht6.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04763613T Expired - Lifetime ES2348621T3 (es) 2003-07-30 2004-07-29 Derivados de 1-sulfonilindol, su preparación y su uso como ligandos de 5-ht6.

Country Status (21)

Country Link
US (1) US7655690B2 (enExample)
EP (1) EP1648443B1 (enExample)
JP (1) JP2007500168A (enExample)
KR (1) KR20060056347A (enExample)
CN (1) CN1863527A (enExample)
AR (1) AR045159A1 (enExample)
AT (1) ATE473738T1 (enExample)
AU (1) AU2004262490A1 (enExample)
BR (1) BRPI0413062A (enExample)
CA (1) CA2533996A1 (enExample)
DE (1) DE602004028125D1 (enExample)
EC (1) ECSP066330A (enExample)
ES (2) ES2222828B1 (enExample)
IL (1) IL172956A0 (enExample)
MX (1) MXPA06001229A (enExample)
NO (1) NO20060342L (enExample)
PE (1) PE20050726A1 (enExample)
RU (1) RU2006105782A (enExample)
TW (1) TW200509908A (enExample)
WO (1) WO2005013974A1 (enExample)
ZA (1) ZA200600427B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2246721B1 (es) * 2004-08-10 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Compuestos indolicos sustituidos, su preparacion y su uso como medicamentos.
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
CN101247853B (zh) 2005-04-13 2014-11-12 轴突公司 具有nos抑制活性的取代的吲哚化合物
AU2007217040A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
US7989447B2 (en) 2006-04-13 2011-08-02 Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
WO2007138611A1 (en) * 2006-05-30 2007-12-06 Suven Life Sciences Limited 3-(heterocyclyl)-n-(arylsulfonyl)indole derivatives as functional 5-ht6 ligands
EP2046741B1 (en) * 2006-07-03 2012-10-31 Proximagen Ltd. Indoles as 5-ht6 modulators
JP2010515674A (ja) * 2007-01-08 2010-05-13 スベン ライフ サイエンシズ リミティド ５−（ヘテロシクリル）アルキル−ｎ−（アリールスルホニル）インドール化合物および５−ｈｔ６リガンドとしてのそれらの使用
EP1947085A1 (en) * 2007-01-19 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted indole sulfonamide compounds, their preparation and use as medicaments
CA2683124C (en) 2007-05-03 2012-09-25 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
ATE499099T1 (de) * 2007-07-19 2011-03-15 Esteve Labor Dr Substituierte tetrahydro- chinolinsulfonamidverbindungen, ihre herstellung und ihre verwendung als medikamente
EP2018861A1 (en) * 2007-07-26 2009-01-28 Laboratorios del Dr. Esteve S.A. 5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain
ATE495737T1 (de) 2007-08-01 2011-02-15 Esteve Labor Dr Kombination von mindestens zwei 5-ht6-liganden
JP2011503120A (ja) 2007-11-16 2011-01-27 ニューラクソン，インコーポレーテッド 内臓痛を治療するためのインドール化合物および方法
US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
ES2424036T3 (es) 2008-09-17 2013-09-26 Suven Life Sciences Limited Compuestos de amina de arilsulfonamida y su uso como ligandos de 5-HT6
CN104276993B (zh) * 2013-07-12 2019-03-15 广东东阳光药业有限公司 吲哚衍生物及其在药物上的应用
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EP1648443A1 (en) 2006-04-26
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ES2222828A1 (es) 2005-02-01
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ECSP066330A (es) 2006-08-30

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