ES2199845T3 - Formulacion nasal acuosa. - Google Patents
Formulacion nasal acuosa.Info
- Publication number
- ES2199845T3 ES2199845T3 ES00951876T ES00951876T ES2199845T3 ES 2199845 T3 ES2199845 T3 ES 2199845T3 ES 00951876 T ES00951876 T ES 00951876T ES 00951876 T ES00951876 T ES 00951876T ES 2199845 T3 ES2199845 T3 ES 2199845T3
- Authority
- ES
- Spain
- Prior art keywords
- anhydrous
- solution
- suspension
- add
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 238000009472 formulation Methods 0.000 title claims abstract description 42
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims abstract description 32
- 229950000210 beclometasone dipropionate Drugs 0.000 claims abstract description 17
- 238000011282 treatment Methods 0.000 claims abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 17
- 229940067107 phenylethyl alcohol Drugs 0.000 claims description 13
- 239000000725 suspension Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- -1 polyethylene Polymers 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 10
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 10
- 229920000573 polyethylene Polymers 0.000 claims description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 239000008213 purified water Substances 0.000 claims description 9
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 9
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 9
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 7
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 7
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims description 7
- 229960001716 benzalkonium Drugs 0.000 claims description 7
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 7
- 229960002303 citric acid monohydrate Drugs 0.000 claims description 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 7
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 6
- 229940089206 anhydrous dextrose Drugs 0.000 claims description 6
- 229940092705 beclomethasone Drugs 0.000 claims description 6
- 229960004106 citric acid Drugs 0.000 claims description 6
- 229940097496 nasal spray Drugs 0.000 claims description 6
- 239000007922 nasal spray Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 239000008121 dextrose Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 210000003928 nasal cavity Anatomy 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 201000010105 allergic rhinitis Diseases 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims 4
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 abstract description 2
- 235000016936 Dendrocalamus strictus Nutrition 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 230000000694 effects Effects 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 239000003755 preservative agent Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 241000700198 Cavia Species 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- 206010028748 Nasal obstruction Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 208000036071 Rhinorrhea Diseases 0.000 description 3
- 206010039101 Rhinorrhoea Diseases 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 229910000397 disodium phosphate Inorganic materials 0.000 description 3
- 235000019800 disodium phosphate Nutrition 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 241000244186 Ascaris Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940038482 beclomethasone dipropionate monohydrate Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 206010041232 sneezing Diseases 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 230000008728 vascular permeability Effects 0.000 description 2
- CTRXDTYTAAKVSM-UHFFFAOYSA-N 3-{[ethyl({4-[(4-{ethyl[(3-sulfophenyl)methyl]amino}phenyl)(2-sulfophenyl)methylidene]cyclohexa-2,5-dien-1-ylidene})azaniumyl]methyl}benzene-1-sulfonate Chemical compound C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S(O)(=O)=O)C=CC=1N(CC)CC1=CC=CC(S(O)(=O)=O)=C1 CTRXDTYTAAKVSM-UHFFFAOYSA-N 0.000 description 1
- 241000589513 Burkholderia cepacia Species 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000001388 Opportunistic Infections Diseases 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229940098032 beconase Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940105402 brillant blue Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9918559.7A GB9918559D0 (en) | 1999-08-07 | 1999-08-07 | Novel pharmaceutical formulation |
| GB9918559 | 1999-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2199845T3 true ES2199845T3 (es) | 2004-03-01 |
Family
ID=10858698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00951876T Expired - Lifetime ES2199845T3 (es) | 1999-08-07 | 2000-08-03 | Formulacion nasal acuosa. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6780398B1 (https=) |
| EP (1) | EP1200066B1 (https=) |
| JP (1) | JP2003506396A (https=) |
| AT (1) | ATE240717T1 (https=) |
| AU (1) | AU6471500A (https=) |
| DE (1) | DE60002885T2 (https=) |
| ES (1) | ES2199845T3 (https=) |
| GB (1) | GB9918559D0 (https=) |
| WO (1) | WO2001010409A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US20050147584A1 (en) * | 2004-01-05 | 2005-07-07 | Allergan, Inc. | Compositions and methods comprising memantine and polyanionic polymers |
| US9808471B2 (en) | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US7811606B2 (en) | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
| US8912174B2 (en) | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| ITMI20032054A1 (it) * | 2003-10-22 | 2005-04-23 | Monteres S R L | Processo per la preparazione di sospensioni farmaceutiche da inalare. |
| CA2550811C (en) * | 2003-12-24 | 2012-05-01 | Jane Hirsh | Temperature-stable formulations, and methods of development thereof |
| EP1645266A1 (en) * | 2004-10-08 | 2006-04-12 | Hisamitsu Medical Co., Ltd. | Aqueous suspension for nasal drops |
| US20060207596A1 (en) * | 2005-03-18 | 2006-09-21 | Fairfield Clinical Trials, Llc | Device and method for delivery of combination nasal medication |
| CN100369608C (zh) * | 2006-03-15 | 2008-02-20 | 修涞贵 | 一种治疗过敏性鼻炎的混悬液型喷雾剂及制备方法 |
| JP5258315B2 (ja) * | 2007-05-25 | 2013-08-07 | ロート製薬株式会社 | フルニソリド含有粘膜適用組成物 |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| EP2453872B1 (en) * | 2009-07-17 | 2013-08-21 | Alcon Research, Ltd. | Olopatadine nasal spray regimen for children |
| EP2736491B1 (en) * | 2011-01-04 | 2017-04-05 | Bausch & Lomb Incorporated | Bepotastine compositions |
| EP2704687B1 (en) * | 2011-05-04 | 2015-07-08 | Chiesi Farmaceutici S.p.A. | A topical formulation comprising a corticosteroid as active ingredient |
| BR112014004418A8 (pt) * | 2011-08-25 | 2018-01-23 | Evoke Pharma Inc | método de tratamento de sintomas associados à gastroparesia feminina |
| WO2013049538A1 (en) * | 2011-09-30 | 2013-04-04 | Mcneil-Ppc, Inc. | Allergen nasal compositions |
| WO2013049539A1 (en) * | 2011-09-30 | 2013-04-04 | Mcneil-Ppc, Inc. | A method of blocking or trapping allergens |
| EP3554489A4 (en) | 2016-12-15 | 2020-06-17 | Evoke Pharma, Inc. | TREATMENT FROM MODERATE TO HEAVY GASTROPARESIS |
| AU2022323269A1 (en) * | 2021-08-04 | 2024-02-29 | Indivior Inc. | Compositions and methods for the treatment of opioid overdose |
| WO2025017382A1 (en) * | 2023-07-15 | 2025-01-23 | Aodh Lifesciences Private Limited | Azithromycin nasal spray formulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4782047A (en) * | 1986-05-22 | 1988-11-01 | Syntex Pharmaceuticals International Ltd. | Aqueous steroid formulations for nasal administration |
| EP0780127A1 (en) * | 1995-12-19 | 1997-06-25 | The Procter & Gamble Company | A nasal spray containing a steroid and a antihistamine |
| BR9709650A (pt) * | 1996-06-04 | 1999-08-10 | Procter & Gamble | Aerosol nasal contendo um esteróide intransal e um anti-histamínico |
| GB9806937D0 (en) * | 1998-03-31 | 1998-05-27 | Procter & Gamble | A spray device |
-
1999
- 1999-08-07 GB GBGB9918559.7A patent/GB9918559D0/en not_active Ceased
-
2000
- 2000-08-03 ES ES00951876T patent/ES2199845T3/es not_active Expired - Lifetime
- 2000-08-03 AT AT00951876T patent/ATE240717T1/de not_active IP Right Cessation
- 2000-08-03 US US10/049,167 patent/US6780398B1/en not_active Expired - Lifetime
- 2000-08-03 JP JP2001514930A patent/JP2003506396A/ja active Pending
- 2000-08-03 DE DE60002885T patent/DE60002885T2/de not_active Expired - Lifetime
- 2000-08-03 WO PCT/JP2000/005200 patent/WO2001010409A1/en not_active Ceased
- 2000-08-03 AU AU64715/00A patent/AU6471500A/en not_active Abandoned
- 2000-08-03 EP EP00951876A patent/EP1200066B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6471500A (en) | 2001-03-05 |
| DE60002885T2 (de) | 2004-03-11 |
| DE60002885D1 (de) | 2003-06-26 |
| GB9918559D0 (en) | 1999-10-06 |
| JP2003506396A (ja) | 2003-02-18 |
| WO2001010409A1 (en) | 2001-02-15 |
| ATE240717T1 (de) | 2003-06-15 |
| US6780398B1 (en) | 2004-08-24 |
| EP1200066A1 (en) | 2002-05-02 |
| EP1200066B1 (en) | 2003-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2199845T3 (es) | Formulacion nasal acuosa. | |
| ES2891729T3 (es) | Composición farmacéutica estable de dosis fija que comprende mometasona y olopatadina para la administración nasal | |
| ES2626134T3 (es) | Composiciones de bepotastina | |
| RU2380090C2 (ru) | Назальные фармацевтические композиции и способы их применения | |
| ES2284531T3 (es) | Tratamiento nasal topico usando desloratadina y furoato de mometasona. | |
| US9370483B2 (en) | Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine | |
| KR20190055057A (ko) | 알코올 사용 장애의 치료용 조성물, 장치 및 방법 | |
| US10517880B2 (en) | Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine | |
| ES2609910T3 (es) | Formulaciones farmacéuticas nasales y métodos para usar las mismas | |
| TW200524615A (en) | Aqueous suspensions of ciclesonide for nebulisation | |
| JPH02196716A (ja) | 薬学的溶液 | |
| BR112020016817A2 (pt) | Método para tratar sintomas associados à rinite alérgica, método para fornecer um início de ação mais rápido para alívio da rinite alérgica e método para tratar um sujeito humano pediátrico que sofre de rinite alérgica | |
| JPH0383931A (ja) | 低刺激性ｇｒｆ経鼻投与製剤 | |
| JPS63316737A (ja) | 経鼻投与用医薬組成物 | |
| HK40092206A (zh) | 鼻内肾上腺素制剂及治疗疾病的方法 | |
| HK1091727B (en) | Nasal pharmaceutical formulations and methods of using the same | |
| HK1164133B (en) | Nasal pharmaceutical formulations and methods of using the same |