ES2197491T3 - Sintesis en fase de solucion de oligonucleotidos. - Google Patents

Sintesis en fase de solucion de oligonucleotidos.

Info

Publication number
ES2197491T3
ES2197491T3 ES98938782T ES98938782T ES2197491T3 ES 2197491 T3 ES2197491 T3 ES 2197491T3 ES 98938782 T ES98938782 T ES 98938782T ES 98938782 T ES98938782 T ES 98938782T ES 2197491 T3 ES2197491 T3 ES 2197491T3
Authority
ES
Spain
Prior art keywords
group
phosphonate
oligonucleotide
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98938782T
Other languages
English (en)
Spanish (es)
Inventor
Colin Bernard Reese
Quanlai Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avecia Ltd
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of ES2197491T3 publication Critical patent/ES2197491T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C07D265/33—Two oxygen atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/18—Esters of thiophosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES98938782T 1997-08-13 1998-08-10 Sintesis en fase de solucion de oligonucleotidos. Expired - Lifetime ES2197491T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9717158.1A GB9717158D0 (en) 1997-08-13 1997-08-13 Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9717158 1997-08-13

Publications (1)

Publication Number Publication Date
ES2197491T3 true ES2197491T3 (es) 2004-01-01

Family

ID=10817430

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98938782T Expired - Lifetime ES2197491T3 (es) 1997-08-13 1998-08-10 Sintesis en fase de solucion de oligonucleotidos.

Country Status (21)

Country Link
US (3) US6506894B1 (ref)
EP (2) EP1003758B1 (ref)
JP (1) JP2001515086A (ref)
KR (1) KR20010022840A (ref)
CN (1) CN1231492C (ref)
AT (1) ATE236916T1 (ref)
BR (1) BR9811166A (ref)
CA (1) CA2300874A1 (ref)
DE (1) DE69813243T2 (ref)
DK (1) DK1003758T3 (ref)
EA (1) EA003091B1 (ref)
ES (1) ES2197491T3 (ref)
GB (1) GB9717158D0 (ref)
HU (1) HUP0002684A3 (ref)
IL (1) IL134517A (ref)
IN (1) IN190784B (ref)
NO (1) NO20000690L (ref)
NZ (1) NZ502684A (ref)
PL (1) PL338888A1 (ref)
TR (1) TR200000384T2 (ref)
WO (1) WO1999009041A2 (ref)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924285D0 (en) * 1999-10-14 1999-12-15 Avecia Ltd Process
GB0004889D0 (en) * 2000-03-01 2000-04-19 Avecia Ltd Synthesis of oligonucleotides
AU2002339175A1 (en) * 2001-11-21 2003-06-10 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
CA2477039A1 (en) * 2002-02-22 2003-09-04 Honeywell International Inc. Methods of producing phosphitylated compounds
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
WO2005077966A1 (en) * 2004-02-10 2005-08-25 Isis Pharmaceuticals, Inc. Substituted pixyl protecting groups for oligonucleotide synthesis
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
US8272150B2 (en) * 2008-12-12 2012-09-25 Speedplay, Inc. Shoe sole mounting standard for bicycle cleat
WO2010072831A1 (en) 2008-12-23 2010-07-01 Girindus America, Inc Sulfurizing reagents and their use for oligonucleotides synthesis
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
KR20130029108A (ko) 2010-06-30 2013-03-21 기린두스 아메리카 인코포레이티드 올리고뉴클레오타이드 합성을 위한 n-thio 화합물의 새로운 사용 방법
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
WO2013017469A1 (en) 2011-07-29 2013-02-07 Girindus America, Inc. Sulfurization reagents on solid supports
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
WO2014085471A1 (en) * 2012-11-28 2014-06-05 Prognosdx Health, Inc. Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
WO2018215049A1 (en) * 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444300A (en) * 1964-05-05 1969-05-13 Chevron Res N-polyhaloalkylthio compounds as fungicidal agents
FR1519704A (fr) * 1967-02-14 1968-04-05 Roussel Uclaf Nouveaux composés dithiocarbamiques hétérocycliques et procédé de préparation
US3546185A (en) 1968-03-20 1970-12-08 Monsanto Co Inhibiting premature vulcanization of diene rubbers
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
EP0678096B1 (en) * 1993-01-08 1997-03-19 HYBRIDON, Inc. Synthesis of dimmer blocks and their use in assembling oligonucleotides
GB9501465D0 (en) * 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
GB0004889D0 (en) * 2000-03-01 2000-04-19 Avecia Ltd Synthesis of oligonucleotides

Also Published As

Publication number Publication date
US20050240015A1 (en) 2005-10-27
DE69813243T2 (de) 2004-01-29
KR20010022840A (ko) 2001-03-26
HUP0002684A2 (hu) 2000-12-28
US7019127B2 (en) 2006-03-28
NO20000690D0 (no) 2000-02-11
TR200000384T2 (tr) 2000-11-21
PL338888A1 (en) 2000-11-20
EP1003758A2 (en) 2000-05-31
JP2001515086A (ja) 2001-09-18
EP1325927A2 (en) 2003-07-09
DK1003758T3 (da) 2003-07-21
IL134517A (en) 2004-02-19
BR9811166A (pt) 2000-07-25
US20030083490A1 (en) 2003-05-01
EP1003758B1 (en) 2003-04-09
CN1274361A (zh) 2000-11-22
EA003091B1 (ru) 2002-12-26
US6506894B1 (en) 2003-01-14
IN190784B (ref) 2003-08-23
GB9717158D0 (en) 1997-10-22
HUP0002684A3 (en) 2001-11-28
WO1999009041A3 (en) 1999-05-06
CA2300874A1 (en) 1999-02-25
AU8738698A (en) 1999-03-08
NO20000690L (no) 2000-04-11
NZ502684A (en) 2002-12-20
WO1999009041A2 (en) 1999-02-25
CN1231492C (zh) 2005-12-14
ATE236916T1 (de) 2003-04-15
DE69813243D1 (de) 2003-05-15
EP1325927A3 (en) 2008-07-02
IL134517A0 (en) 2001-04-30
EA200000211A1 (ru) 2000-08-28
AU749343B2 (en) 2002-06-27

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