ES2194793T3 - Microcapsulas para la liberacion prolongada de farmacos. - Google Patents

Microcapsulas para la liberacion prolongada de farmacos.

Info

Publication number
ES2194793T3
ES2194793T3 ES00985267T ES00985267T ES2194793T3 ES 2194793 T3 ES2194793 T3 ES 2194793T3 ES 00985267 T ES00985267 T ES 00985267T ES 00985267 T ES00985267 T ES 00985267T ES 2194793 T3 ES2194793 T3 ES 2194793T3
Authority
ES
Spain
Prior art keywords
pharmacos
microcapsules
prolonged release
plasticiser
interested
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00985267T
Other languages
English (en)
Inventor
Duena Antonio Parente
Garces Josep Garces
Munoz Angel Bonilla
Colome David Cumillera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lipotec SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotec SA filed Critical Lipotec SA
Application granted granted Critical
Publication of ES2194793T3 publication Critical patent/ES2194793T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Microscápsulas para la liberación lenta de fármacos, que están constituidas por un copolímero láctico-co-glicólico, al que se ha incorporado un platificante y que contienen en su interior un fármaco de intéres farmacéutico.
ES00985267T 1999-12-17 2000-12-15 Microcapsulas para la liberacion prolongada de farmacos. Expired - Lifetime ES2194793T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902768A ES2169980B1 (es) 1999-12-17 1999-12-17 Microcapsulas para la liberacion prolongada de farmacos.

Publications (1)

Publication Number Publication Date
ES2194793T3 true ES2194793T3 (es) 2003-12-01

Family

ID=8310957

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009902768A Expired - Fee Related ES2169980B1 (es) 1999-12-17 1999-12-17 Microcapsulas para la liberacion prolongada de farmacos.
ES00985267T Expired - Lifetime ES2194793T3 (es) 1999-12-17 2000-12-15 Microcapsulas para la liberacion prolongada de farmacos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES009902768A Expired - Fee Related ES2169980B1 (es) 1999-12-17 1999-12-17 Microcapsulas para la liberacion prolongada de farmacos.

Country Status (13)

Country Link
US (3) US20020187196A1 (es)
EP (1) EP1151746B1 (es)
JP (1) JP5021880B2 (es)
AT (1) ATE234608T1 (es)
AU (1) AU774680B2 (es)
BR (1) BRPI0008197B8 (es)
CA (1) CA2362769C (es)
DE (1) DE60001717T2 (es)
DK (1) DK1151746T3 (es)
ES (2) ES2169980B1 (es)
MX (1) MXPA01008348A (es)
PT (1) PT1151746E (es)
WO (1) WO2001043724A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
EP1871348A4 (en) * 2005-03-01 2012-08-01 Sun Pharma Advanced Res Co Ltd PHARMACEUTICAL COMPOSITIONS WITH DELAYED RELEASE
WO2007071395A1 (en) * 2005-12-22 2007-06-28 Novartis Ag Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
EP3702442A1 (en) * 2011-12-22 2020-09-02 Life Technologies Corporation Cell culture media and methods
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN110954491B (zh) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法
JP7371519B2 (ja) 2020-02-14 2023-10-31 村田機械株式会社 自動倉庫

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2151185A (en) 1936-01-16 1939-03-21 Carbide & Carbon Chem Corp Esters of glycol monoesters and acylated hydroxy acids
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0052610A1 (en) 1980-05-29 1982-06-02 NICKLAUS, Helen Carol Stringed musical instrument teaching device and process
GB2132887A (en) * 1982-11-15 1984-07-18 Procter & Gamble Enteric-coated anti-inflammatory compositions
CH661206A5 (fr) 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
CH665558A5 (en) 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CH679207A5 (es) 1989-07-28 1992-01-15 Debiopharm Sa
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
SE9100610D0 (sv) * 1991-03-04 1991-03-04 Procordia Ortech Ab Bioresorbable material for medical use
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
CA2135767A1 (en) 1993-03-15 1994-09-29 Robert J. Levy System for controlled release of antiarrhythmic agents
CN1191787C (zh) 1995-10-05 2005-03-09 株式会社东芝 X射线摄像装置
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2283830C (en) * 1997-03-18 2008-07-22 Sunstar Inc. Composition for forming solid particles
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Also Published As

Publication number Publication date
US20050123618A1 (en) 2005-06-09
US20080233198A1 (en) 2008-09-25
EP1151746B1 (en) 2003-03-19
BRPI0008197B1 (pt) 2017-05-09
EP1151746A1 (en) 2001-11-07
JP5021880B2 (ja) 2012-09-12
MXPA01008348A (es) 2004-03-19
DE60001717D1 (de) 2003-04-24
CA2362769C (en) 2008-09-09
ATE234608T1 (de) 2003-04-15
US9789064B2 (en) 2017-10-17
AU774680B2 (en) 2004-07-01
BRPI0008197B8 (pt) 2021-05-25
WO2001043724A1 (es) 2001-06-21
DK1151746T3 (da) 2003-07-21
US20020187196A1 (en) 2002-12-12
JP2003516960A (ja) 2003-05-20
BR0008197A (pt) 2002-01-22
CA2362769A1 (en) 2001-06-21
AU2173501A (en) 2001-06-25
ES2169980A1 (es) 2002-07-16
DE60001717T2 (de) 2004-03-18
PT1151746E (pt) 2003-07-31
ES2169980B1 (es) 2003-11-01

Similar Documents

Publication Publication Date Title
ATE235234T1 (de) Mesalazine enthaltende pharmazeutische zusammensetzungen mit gesteuerte freisetzung
NO995753D0 (no) Gastroretarderende mikrosfaerer med styrt frigivelse for bedret administrasjon av medikament
DZ2685A1 (fr) Formulation pharmaceutique orale à libération prolongée.
HUP0101237A1 (hu) Elnyújtott kioldódású gyógyszerkészítmények
DK1183014T3 (da) Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse
FR2683146B1 (fr) Compositions pharmaceutiques a liberation reglee de la substance medicamenteuse.
BR9607752B1 (pt) formulação farmacêutica de microcápsula de liberação controlada.
ITMI20001173A0 (it) Composizioni farmaceutiche a rilascio prolungato per la somministrazione parenterale di sostanze idrofile biologicamente attiva.
FI4823U1 (fi) Muunnetulla tavalla vapauttava lääkeformulaatio
ATE200981T1 (de) Arzneizubereitung enthaltend amoxycillin und kaliumclavunalat
ATE383165T1 (de) Pharmazeutische zusammensetzung mit verzögerter freisetzung, die wasserunlösliche komplexverbindungen enthalten
ATE396712T1 (de) Pharmazeutische zubereitung zur modifizierten freisetzung
BR9917012A (pt) Comprimido matricial, permitindo a liberação prolongada de gliclazida, após administração por via oral
HK1027563A1 (en) Novel 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same.
DE60020501D1 (de) Trimetazidinhaltige Matrixtablette zur verlängerten Wirkstofffreisetzung nach oraler Gabe
ATE252377T1 (de) Kontrolliert freisetzende pharmazeutische zusammensetzung mit tilidinmesylat als wirkstoff
ES2169980B1 (es) Microcapsulas para la liberacion prolongada de farmacos.
GT200100033A (es) Sistema de administracion oral controlada para la ingestion diaria de ciprofloxacina.
DE60319983D1 (de) Universelle Zusammensetzung zur kontrollierten Wirkstoffabgabe enthaltend Chitosan
MA26788A1 (fr) COMPOSITIONS PHARMACEUTIQUES DESTINÉES à L'ADMINISTRATION PAR VOIE ORALE DE PHLOROGLUCINOL ET LEUR PRÉPARATION
ITMI20011457A0 (it) Composizione farmaceutica a rilascio modificato contenente bupropionehc1 come sostanza attiva
ATE275140T1 (de) Zns wirksame cyclobuta-indole-carboxamide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische präparate
ITMI20000972A0 (it) Formulazioni farmaceutiche, a rilascio modificato, con elevata biodisponibilita', contenenti principi attivi ad attivita' antibiotica.
DE10081277D2 (de) Kapsel mit kontrollierter Wirkstofffreisetzung