ES2192705T3 - Procedimientos y composiciones para una mejora de la biodisponibilidad de agentes bioactivos para una administracion por via mucosa. - Google Patents

Procedimientos y composiciones para una mejora de la biodisponibilidad de agentes bioactivos para una administracion por via mucosa.

Info

Publication number
ES2192705T3
ES2192705T3 ES97950343T ES97950343T ES2192705T3 ES 2192705 T3 ES2192705 T3 ES 2192705T3 ES 97950343 T ES97950343 T ES 97950343T ES 97950343 T ES97950343 T ES 97950343T ES 2192705 T3 ES2192705 T3 ES 2192705T3
Authority
ES
Spain
Prior art keywords
compositions
biodavailability
procedures
improvement
bioactive agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97950343T
Other languages
English (en)
Inventor
Ian Sanderson
Jaap Kampinga
Bruce Joseph Roser
Camilo Colaco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of ES2192705T3 publication Critical patent/ES2192705T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A COMPOSICIONES CON UNA MAYOR BIODISPONIBILIDAD EN SU ADMINISTRACION A LAS MUCOSAS QUE COMPRENDEN, PREFERIBLEMENTE EN FORMA DE POLVO, UNA MEZCLA INTIMA DE UNA CANTIDAD EFECTIVA DE UN AGENTE BIOACTIVO Y UN CARBOHIDRATO HIDROFOBICAMENTE DERIVADO. LAS COMPOSICIONES TAMBIEN PUEDEN CONTENER UN AGENTE SUPERFICIAL ACTIVO, PREFERIBLEMENTE PARA SU LIBERACION EN LA MUCOSA GASTROINTESTINAL O SU LIBERACION OCULAR.
ES97950343T 1996-12-31 1997-12-31 Procedimientos y composiciones para una mejora de la biodisponibilidad de agentes bioactivos para una administracion por via mucosa. Expired - Lifetime ES2192705T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3397696P 1996-12-31 1996-12-31

Publications (1)

Publication Number Publication Date
ES2192705T3 true ES2192705T3 (es) 2003-10-16

Family

ID=21873566

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97950343T Expired - Lifetime ES2192705T3 (es) 1996-12-31 1997-12-31 Procedimientos y composiciones para una mejora de la biodisponibilidad de agentes bioactivos para una administracion por via mucosa.

Country Status (12)

Country Link
US (1) US6517860B1 (es)
EP (1) EP0949907B1 (es)
JP (1) JP2001507357A (es)
AT (1) ATE234607T1 (es)
AU (1) AU732347B2 (es)
CA (1) CA2275502A1 (es)
DE (1) DE69720045T2 (es)
DK (1) DK0949907T3 (es)
ES (1) ES2192705T3 (es)
PT (1) PT949907E (es)
WO (1) WO1998029097A1 (es)
ZA (1) ZA9711732B (es)

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Also Published As

Publication number Publication date
WO1998029097A1 (en) 1998-07-09
PT949907E (pt) 2003-07-31
US6517860B1 (en) 2003-02-11
EP0949907B1 (en) 2003-03-19
JP2001507357A (ja) 2001-06-05
DE69720045D1 (de) 2003-04-24
DK0949907T3 (da) 2003-07-14
EP0949907A1 (en) 1999-10-20
ZA9711732B (en) 1998-12-28
ATE234607T1 (de) 2003-04-15
CA2275502A1 (en) 1998-07-09
AU5333898A (en) 1998-07-31
AU732347B2 (en) 2001-04-26
DE69720045T2 (de) 2003-09-04

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