ES2188970T3 - 4-aminoetoxiindoles, como agonistas d2 de dopamina y como ligandos de los receptores 5ht1a. - Google Patents

4-aminoetoxiindoles, como agonistas d2 de dopamina y como ligandos de los receptores 5ht1a.

Info

Publication number
ES2188970T3
ES2188970T3 ES97938629T ES97938629T ES2188970T3 ES 2188970 T3 ES2188970 T3 ES 2188970T3 ES 97938629 T ES97938629 T ES 97938629T ES 97938629 T ES97938629 T ES 97938629T ES 2188970 T3 ES2188970 T3 ES 2188970T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
addiction
dopamine
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97938629T
Other languages
English (en)
Inventor
Richard Eric Mewshaw
Michael Byron Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of ES2188970T3 publication Critical patent/ES2188970T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R 1 ES HIDROGENO, ALQUILO, CICLOALQUILALQUILO, ARILALQUILO, (HALOARIL)ALQUILO, (ALCOXI - ARIL)ALQUILO, TIENILMETILO, FURANILMETILO, PIRIDINILMETILO, ALQUILFENILO, 4 - FLUORO BUTIROFENONA O 6 - FLUORO - 1,2 - BENZISOXAZOL - IL - PROPILO; X ES HIDROGENO, HALOGENO, CIANO, ALQUILO, ACETILO, TRIFLUOROACETILO, TRIFLUOROMETILO O FORMILO; Y ES HIDROGENO, HALOGENO, ALCOXI O ALQUILO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS Y LIBERACION DE DOPAMINA, Y SON UTILES EN EL TRATAMIENTO DE LA ESQUIZOFRENIA, ENFERMEDAD DE PARKINSON, SINDROME DE GILLES DE LA TOURETTE, ADICCION AL ALCOHOL, LA COCAINA O DROGAS ANALOGAS, Y TIENEN ASIMISMO AFINIDAD POR LOS RECEPTORES 5 - HT 1A , LO CUAL LOS HACE ADECUADOS PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON ALTERACIONES DE LOS SISTEMAS SEROTONINERGICOS, COMO LA ANSIEDAD, EL ESTRES, LA DEPRESION, LAS ALTERACIONES SEXUALES Y LAS ALTERACIONES DEL SUEÑO.
ES97938629T 1996-08-27 1997-08-26 4-aminoetoxiindoles, como agonistas d2 de dopamina y como ligandos de los receptores 5ht1a. Expired - Lifetime ES2188970T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70356296A 1996-08-27 1996-08-27

Publications (1)

Publication Number Publication Date
ES2188970T3 true ES2188970T3 (es) 2003-07-01

Family

ID=24825871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97938629T Expired - Lifetime ES2188970T3 (es) 1996-08-27 1997-08-26 4-aminoetoxiindoles, como agonistas d2 de dopamina y como ligandos de los receptores 5ht1a.

Country Status (12)

Country Link
EP (1) EP0923548B1 (es)
JP (1) JP2000516936A (es)
KR (1) KR20000035880A (es)
CN (1) CN1234023A (es)
AT (1) ATE234281T1 (es)
AU (1) AU4091697A (es)
CA (1) CA2264080A1 (es)
DE (1) DE69719765T2 (es)
DK (1) DK0923548T3 (es)
ES (1) ES2188970T3 (es)
PT (1) PT923548E (es)
WO (1) WO1998008817A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127380A (en) * 1997-02-18 2000-10-03 American Home Products Corporation 4-aminoalkoxy-1H-benzoimidazoles
JP2001509814A (ja) * 1997-02-18 2001-07-24 アメリカン・ホーム・プロダクツ・コーポレイション ４−アミノアルコキシ−１ｈ−ベンゾイミダゾール誘導体、それらの調製およびそれらのドパミン自己受容体（ｄ▲下２▼）作動薬としての使用
CA2327513A1 (en) * 1998-04-08 1999-10-14 James Albert Nelson N-aryloxyethyl-indoly-alkylamines for the treatment of depression
WO1999051576A1 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethylamine derivatives for the treatment of depression
US6110956A (en) * 1998-04-08 2000-08-29 American Home Products Corp. N-aryloxyethylamine derivatives for the treatment of depression
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
EP0982030A3 (en) * 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
FR2786767B1 (fr) * 1998-12-02 2001-02-23 Pf Medicament Nouveaux derives de 3-alkoxybenzylamines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
DE10006139A1 (de) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl-Derivate
DE10029371A1 (de) * 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
KR100467693B1 (ko) * 2002-05-07 2005-01-24 삼성에스디아이 주식회사 플라즈마 디스플레이 패널의 어드레스 전력을 효율적으로회생시키는 회로
PL377464A1 (pl) * 2002-12-03 2006-02-06 F. Hoffmann-La Roche Ag Aminoalkoksyindole jako ligandy receptora 5-HT6 do leczenia zaburzeń OUN
DK1626720T3 (da) 2003-04-04 2008-12-01 Lundbeck & Co As H 4-(2-Phenylsulfanyl-phenyl)-piperidinderivater som serotonin-genoptagelseshæmmer
TWI347183B (en) * 2003-12-23 2011-08-21 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzyl amine derivatives
MXPA06007172A (es) 2003-12-23 2006-08-23 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri.
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
CN101563320B (zh) * 2006-09-28 2012-05-30 H.隆德贝克有限公司 用于治疗情感障碍的[2-(6-氟-1h-吲哚-3-基硫烷基)苄基]甲胺
CN110041318B (zh) * 2018-01-17 2022-07-29 中国科学院上海药物研究所 一类多巴胺d5受体激动剂及其制备和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906000A (en) * 1972-02-23 1975-09-16 Pfizer Tricyclicazaindole derivatives
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives

Also Published As

Publication number Publication date
AU4091697A (en) 1998-03-19
DE69719765D1 (de) 2003-04-17
EP0923548B1 (en) 2003-03-12
CA2264080A1 (en) 1998-03-05
WO1998008817A1 (en) 1998-03-05
EP0923548A1 (en) 1999-06-23
CN1234023A (zh) 1999-11-03
DK0923548T3 (da) 2003-06-23
KR20000035880A (ko) 2000-06-26
JP2000516936A (ja) 2000-12-19
PT923548E (pt) 2003-06-30
ATE234281T1 (de) 2003-03-15
DE69719765T2 (de) 2003-10-16

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