BR0107405A - Derivados de indol que atuam como antagonistas do receptor mcp-1 - Google Patents

Derivados de indol que atuam como antagonistas do receptor mcp-1

Info

Publication number
BR0107405A
BR0107405A BR0107405-9A BR0107405A BR0107405A BR 0107405 A BR0107405 A BR 0107405A BR 0107405 A BR0107405 A BR 0107405A BR 0107405 A BR0107405 A BR 0107405A
Authority
BR
Brazil
Prior art keywords
sup
halo
hydrogen
methoxy
lower alkyl
Prior art date
Application number
BR0107405-9A
Other languages
English (en)
Inventor
Alan Wellington Faull
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0107405A publication Critical patent/BR0107405A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE INDOL QUE ATUAM COMO ANTAGONISTAS DO RECEPTOR MCP-1". A presente invenção se refere a um composto de fórmula (I): em que R^ 1^ é hidrogênio, halogênio, metila, etila ou metóxi; R^ 2^ é hidrogênio, halogênio, metila, etila ou metóxi; R^ 3^ é um grupo halo, alquila inferior, alquenila inferior, alquinila inferior, trifluorometila, nitro, ciano, trifluorometóxi, C(O)R^ 7^ ou S(O)~ n~R^ 7^ onde n é 0, 1 ou 2 e R^ 7^ é um grupo alquila; R^ 4^ é um grupo halo, trifluorometila, metiltio, metóxi, trifluorometóxi ou alquila inferior, alquenila inferior ou alquinila inferior; R^ 5^ é hidrogênio, halogênio, ciano, alquila inferior, alquenila inferior ou alquinila inferior ou COR^ 8^, onde R^ 8^ é alquila inferior; R^ 6^ é hidrogênio, halogênio, alquila inferior, alquinila inferior ou COR^ 9^, onde R^ 9^ é alquila inferior; desde que quando R^ 1^ for hidrogênio, halogênio ou metóxi, R^ 2^ será hidrogênio, halogênio, metila, etila ou metóxi, R^ 5^ e R^ 6^ serão ambos hidrogênio, e um de R^ 3^ e R^ 4^ for cloro, flúor ou trifluorometila, então o outro de R^ 3^ e R^ 4^ não será halogênio nem trifluorometila; ou um sal ou pró-droga farmaceuticamente aceitáveis dos mesmos. Esse compostos apresentam atividade útil no tratamento de doenças inflamatórias, especificamente ao antagonizar o efeito mediado pela MCP-1 em um animal de sangue quente, tal como o ser humano.
BR0107405-9A 2000-01-13 2001-01-09 Derivados de indol que atuam como antagonistas do receptor mcp-1 BR0107405A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000625.4A GB0000625D0 (en) 2000-01-13 2000-01-13 Chemical compounds
PCT/GB2001/000074 WO2001051467A1 (en) 2000-01-13 2001-01-09 Indole derivatives as mcp-1 receptor antagonists

Publications (1)

Publication Number Publication Date
BR0107405A true BR0107405A (pt) 2002-10-08

Family

ID=9883550

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107405-9A BR0107405A (pt) 2000-01-13 2001-01-09 Derivados de indol que atuam como antagonistas do receptor mcp-1

Country Status (17)

Country Link
US (1) US6984657B1 (pt)
EP (1) EP1268423B1 (pt)
JP (1) JP2003519684A (pt)
KR (1) KR20020064374A (pt)
CN (1) CN1395564A (pt)
AT (1) ATE318800T1 (pt)
AU (1) AU779502B2 (pt)
BR (1) BR0107405A (pt)
CA (1) CA2393597A1 (pt)
DE (1) DE60117517T2 (pt)
GB (1) GB0000625D0 (pt)
IL (1) IL150276A0 (pt)
MX (1) MXPA02006612A (pt)
NO (1) NO20023381L (pt)
NZ (1) NZ519311A (pt)
WO (1) WO2001051467A1 (pt)
ZA (1) ZA200204351B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2017163263A1 (en) 2016-03-22 2017-09-28 Council Of Scientific & Industrial Research Indole derivatives, preparation and use thereof

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557142A (en) 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
US3776923A (en) 1970-01-06 1973-12-04 American Cyanamid Co 2-nitro-4-oxo-4,5,6,7-tetrahydroindole
US3997557A (en) 1974-04-23 1976-12-14 American Hoechst Corporation Substituted N-aminoalkylpyrroles
US4496742A (en) 1981-10-13 1985-01-29 The Upjohn Company Analogs of 5,6-dihydro PGI2
FR2537974A1 (fr) 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4529724A (en) 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
FR2565981B1 (fr) 1984-06-15 1986-09-19 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
WO1986000896A1 (en) 1984-07-30 1986-02-13 Schering Corporation NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE
US4675332A (en) 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
EP0189690B1 (en) 1984-12-12 1989-03-01 Merck & Co. Inc. Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4721725A (en) 1986-01-27 1988-01-26 E. R. Squibb & Sons, Inc. Aryl-cycloalkyl[b]pyrrole derivatives
IL84796A (en) 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
JPS63284177A (ja) 1987-05-14 1988-11-21 Sumitomo Chem Co Ltd ホルミルピロロピロ−ル類およびその製造方法
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
DE3907388A1 (de) 1989-03-08 1990-09-13 Kali Chemie Pharma Gmbh Verfahren zur herstellung von indolcarbonsaeurederivaten
NZ234883A (en) 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
US5272145A (en) 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
DE3943225A1 (de) 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5081145A (en) 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
WO1992004343A1 (en) 1990-09-04 1992-03-19 Yamanouchi Pharmaceutical Co., Ltd. Novel tetrahydrobenzazole derivative
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
JPH04273857A (ja) 1991-02-26 1992-09-30 Taisho Pharmaceut Co Ltd Ｎ−置換フェニルスルホニルインドール誘導体
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
CA2079374C (en) 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5273980A (en) 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5318985A (en) 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists
AU3488693A (en) 1992-02-13 1993-09-03 Merck Frosst Canada Inc. (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
ATE197051T1 (de) 1992-04-03 2000-11-15 Upjohn Co Pharmazeutisch wirksame bicyclisch heterocyclische amine
US5334719A (en) 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
US5288743A (en) 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
EP0639573A1 (de) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5399699A (en) 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
CA2196046A1 (en) 1994-07-27 1996-02-08 Nigel Birdsall Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5684032A (en) 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
EA199900808A1 (ru) 1995-04-04 2000-06-26 Тексаз Байотекнолоджи Корпорейшн Бифенилсульфонамиды и их производные, модулирующие активность эндотелина
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
US5639780A (en) 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
US5604253A (en) 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
DK0954305T3 (da) 1996-02-26 2003-08-25 Advanced Res & Tech Inst Anvendelse af carbonanhydraseinhibitorer til behandling af maculaødem
WO1997035572A1 (en) 1996-03-28 1997-10-02 Smithkline Beecham Corporation Carboxylic acid indole inhibitors of chemokines
EP0822185A1 (en) 1996-07-31 1998-02-04 Pfizer Inc. B-3-adrenergic agonists as antidiabetic and antiobesity agents
EP0927167A1 (en) 1996-08-14 1999-07-07 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716656D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
RU2225397C2 (ru) 1997-12-24 2004-03-10 Авентис Фарма Дойчланд Гмбх Производные индола как ингибиторы фактора Ха
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
KR20020064374A (ko) 2002-08-07
DE60117517T2 (de) 2006-09-21
NO20023381D0 (no) 2002-07-12
EP1268423B1 (en) 2006-03-01
JP2003519684A (ja) 2003-06-24
NO20023381L (no) 2002-09-09
EP1268423A1 (en) 2003-01-02
DE60117517D1 (de) 2006-04-27
AU779502B2 (en) 2005-01-27
MXPA02006612A (es) 2002-09-30
AU2387401A (en) 2001-07-24
CA2393597A1 (en) 2001-07-19
ATE318800T1 (de) 2006-03-15
US6984657B1 (en) 2006-01-10
WO2001051467A1 (en) 2001-07-19
CN1395564A (zh) 2003-02-05
GB0000625D0 (en) 2000-03-01
NZ519311A (en) 2004-05-28
ZA200204351B (en) 2003-09-01
IL150276A0 (en) 2002-12-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009.