NO20023381L - Indolderivater som MCP-1-reseptoragonister - Google Patents

Indolderivater som MCP-1-reseptoragonister

Info

Publication number
NO20023381L
NO20023381L NO20023381A NO20023381A NO20023381L NO 20023381 L NO20023381 L NO 20023381L NO 20023381 A NO20023381 A NO 20023381A NO 20023381 A NO20023381 A NO 20023381A NO 20023381 L NO20023381 L NO 20023381L
Authority
NO
Norway
Prior art keywords
sup
halo
hydrogen
methoxy
lower alkyl
Prior art date
Application number
NO20023381A
Other languages
English (en)
Other versions
NO20023381D0 (no
Inventor
Alan Faull
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20023381D0 publication Critical patent/NO20023381D0/no
Publication of NO20023381L publication Critical patent/NO20023381L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelse av formel (I), hvor: Rer hydrogen, halogen, metyl, etyl eller metoksy; Rer hydrogen, halogen, metyl, etyl eller metoksy; Rer en halogengruppe, lavere alkyl, lavere alkenyl, lavere alkynyl, alokoksy, trifluormetyl, nitro, cyano, trifluormetoksy, C(0)R, eller S(0)R, hvor n er 0, 1 eller 2 og Rer en alkylgruppe; Rer en halogen, trifluormetyl, metyltio, metoksy, trifluormetoksy eller lavere alkyl, lavere alkenyl eller lavere alkynyl; Rer en hydrogen, halogen, cyano, lavere alkyl, lavere alkenyl eller lavere alkynyl eller COR, hvor Rer lavere alkyl; Rer en hydrogen, halogen, lavere alkyl, lavere alkenyl eller lavere alkynyl eller COR, hvor Rer lavere alkyl; forutsatt at når Rer hydrogen, halogen eller metoksy, R2 er hydrogen, halogen, metyl, etyl eller metoksy, Rs og R6 begge er hydrogen, og én av Reller Rer klor, fluor eller trifluormetyl,så er den andre av R3 eller Rikke halogen eller trifluormetyl; eller et farmasøytisk akseptabelt salt eller prodrug derav. Disse forbindelsene har nyttig aktivitet for behandlingen av inflammatorisk sykdom, spesielt ved antagonisering av en MCP-1 -formidlet effekt i et varmblodig dyr slik som et menneske.
NO20023381A 2000-01-13 2002-07-12 Indolderivater som MCP-1-reseptoragonister NO20023381L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000625.4A GB0000625D0 (en) 2000-01-13 2000-01-13 Chemical compounds
PCT/GB2001/000074 WO2001051467A1 (en) 2000-01-13 2001-01-09 Indole derivatives as mcp-1 receptor antagonists

Publications (2)

Publication Number Publication Date
NO20023381D0 NO20023381D0 (no) 2002-07-12
NO20023381L true NO20023381L (no) 2002-09-09

Family

ID=9883550

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023381A NO20023381L (no) 2000-01-13 2002-07-12 Indolderivater som MCP-1-reseptoragonister

Country Status (17)

Country Link
US (1) US6984657B1 (no)
EP (1) EP1268423B1 (no)
JP (1) JP2003519684A (no)
KR (1) KR20020064374A (no)
CN (1) CN1395564A (no)
AT (1) ATE318800T1 (no)
AU (1) AU779502B2 (no)
BR (1) BR0107405A (no)
CA (1) CA2393597A1 (no)
DE (1) DE60117517T2 (no)
GB (1) GB0000625D0 (no)
IL (1) IL150276A0 (no)
MX (1) MXPA02006612A (no)
NO (1) NO20023381L (no)
NZ (1) NZ519311A (no)
WO (1) WO2001051467A1 (no)
ZA (1) ZA200204351B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2017163263A1 (en) 2016-03-22 2017-09-28 Council Of Scientific & Industrial Research Indole derivatives, preparation and use thereof

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GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
ZA200204351B (en) 2003-09-01
AU2387401A (en) 2001-07-24
EP1268423A1 (en) 2003-01-02
KR20020064374A (ko) 2002-08-07
CN1395564A (zh) 2003-02-05
JP2003519684A (ja) 2003-06-24
AU779502B2 (en) 2005-01-27
GB0000625D0 (en) 2000-03-01
ATE318800T1 (de) 2006-03-15
NO20023381D0 (no) 2002-07-12
EP1268423B1 (en) 2006-03-01
US6984657B1 (en) 2006-01-10
IL150276A0 (en) 2002-12-01
BR0107405A (pt) 2002-10-08
DE60117517T2 (de) 2006-09-21
MXPA02006612A (es) 2002-09-30
DE60117517D1 (de) 2006-04-27
NZ519311A (en) 2004-05-28
CA2393597A1 (en) 2001-07-19
WO2001051467A1 (en) 2001-07-19

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