ES2188722T3 - Agentes antifungicos peptidicos ciclicos. - Google Patents

Agentes antifungicos peptidicos ciclicos.

Info

Publication number
ES2188722T3
ES2188722T3 ES96303600T ES96303600T ES2188722T3 ES 2188722 T3 ES2188722 T3 ES 2188722T3 ES 96303600 T ES96303600 T ES 96303600T ES 96303600 T ES96303600 T ES 96303600T ES 2188722 T3 ES2188722 T3 ES 2188722T3
Authority
ES
Spain
Prior art keywords
sub
sup
rent
antifungic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96303600T
Other languages
English (en)
Inventor
James Andrew Jamison
Michael John Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2188722T3 publication Critical patent/ES2188722T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PROPORCIONAN FORMULACIONES FARMACEUTICAS Y METODOS PARA LA INHIBICION DE LA ACTIVIDAD FUNGAL Y PARASITARIA UTILIZANDO UN COMPUESTO DE FORMULA I EN DONDE R'', R", R"'', R{SUP,X1}, R{SUP,X2}, R{SUP,Y1}, R{SUP,Y2}, R{SUP,Y3}, R{SUP,Y4} Y R{SUP,0} SON COMO SE DEFINEN ANTERIORMENTE; Y R{SUP,2} ES R{SUP,3} ES O R{SUP,3A}, R{SUP,3B}, R{SUP,3C} Y R{SUP,3D} SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO C{SUB,1}-C{SUB,12}, ALQUINILO C{SUB,2}-C{SUB,12}, ALCOXI C{SUB,1}-C{SUB,12}, ALQUILTIO C{SUB,1}-C{SUB,12}, HALO, O -O-(CH{SUB,2}){SUB,M}-[O-(CH{SUB,2}){SUB,N}]{SUB,P}-O-(ALQUILO C{SUB,1}-C{SUB,12}) O -O-(CH{SUB,2}){SUB,Q}-X-R{SUP,4}; M ES 2, 3 O 4; N ES 2, 3 O 4; P ES O O 1; Q ES 2, 3 O 4; X ES PIRROLIDINO, PIPERIDINO O PIPERAZINO; Y R{SUP,4} ES HIDROGENO, ALQUILO C{SUB,1}-C{SUB,12}, CICLOALQUILO C{SUB,3}-C{SUB,12}, BENCILO O CICLOALQUILMETILO C{SUB,3}C{SUB,12}; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS
ES96303600T 1995-05-26 1996-05-21 Agentes antifungicos peptidicos ciclicos. Expired - Lifetime ES2188722T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45305095A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
ES2188722T3 true ES2188722T3 (es) 2003-07-01

Family

ID=23799012

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96303600T Expired - Lifetime ES2188722T3 (es) 1995-05-26 1996-05-21 Agentes antifungicos peptidicos ciclicos.

Country Status (13)

Country Link
US (1) US5618787A (es)
EP (1) EP0744404B1 (es)
JP (1) JPH11505847A (es)
AT (1) ATE233786T1 (es)
AU (1) AU5799496A (es)
CA (1) CA2220944A1 (es)
CO (1) CO4700479A1 (es)
DE (1) DE69626439T2 (es)
ES (1) ES2188722T3 (es)
IL (1) IL118333A0 (es)
PE (1) PE38697A1 (es)
WO (1) WO1996037512A1 (es)
ZA (1) ZA964013B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
EP1666587A1 (en) 1996-06-13 2006-06-07 Astellas Pharma Inc. Cyclic lipopeptide acylase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
CA2340676A1 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
JP2003511345A (ja) 1998-12-09 2003-03-25 イーライ リリー アンド カンパニー Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製
CA2362482A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
RU2250763C2 (ru) * 1999-03-03 2005-04-27 Эли Лилли Энд Компани Фармацевтические препараты эхинокандина, содержащие мицелообразующие поверхностно-активные вещества
IL145187A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Echinocandin/carbohydrate complexes
DK1155034T3 (da) 1999-03-03 2007-01-08 Lilly Co Eli Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP1874724A2 (en) * 2005-04-22 2008-01-09 Merck & Co., Inc. Phenyl ethyne compounds
US8064666B2 (en) * 2007-04-10 2011-11-22 Avantis Medical Systems, Inc. Method and device for examining or imaging an interior surface of a cavity

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
TW264477B (es) * 1992-03-19 1995-12-01 Lilly Co Eli

Also Published As

Publication number Publication date
ZA964013B (en) 1997-11-20
IL118333A0 (en) 1996-09-12
JPH11505847A (ja) 1999-05-25
EP0744404B1 (en) 2003-03-05
ATE233786T1 (de) 2003-03-15
DE69626439T2 (de) 2003-10-02
CA2220944A1 (en) 1996-11-28
EP0744404A3 (en) 1998-05-20
DE69626439D1 (de) 2003-04-10
WO1996037512A1 (en) 1996-11-28
EP0744404A2 (en) 1996-11-27
PE38697A1 (es) 1997-10-09
AU5799496A (en) 1996-12-11
CO4700479A1 (es) 1998-12-29
US5618787A (en) 1997-04-08

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