ES2186569B1 - Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma. - Google Patents

Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.

Info

Publication number
ES2186569B1
ES2186569B1 ES200102178A ES200102178A ES2186569B1 ES 2186569 B1 ES2186569 B1 ES 2186569B1 ES 200102178 A ES200102178 A ES 200102178A ES 200102178 A ES200102178 A ES 200102178A ES 2186569 B1 ES2186569 B1 ES 2186569B1
Authority
ES
Spain
Prior art keywords
compositions
components
relief
treatment
disorders associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200102178A
Other languages
English (en)
Spanish (es)
Other versions
ES2186569A1 (es
Inventor
Ana Rifa Piñol
Montserrat Mata Moliner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200102178A priority Critical patent/ES2186569B1/es
Application filed by Lacer SA filed Critical Lacer SA
Priority to JP2003532032A priority patent/JP4111916B2/ja
Priority to DE60212673T priority patent/DE60212673T2/de
Priority to ES02800148T priority patent/ES2263849T3/es
Priority to PCT/ES2002/000443 priority patent/WO2003028699A1/es
Priority to EP02800148A priority patent/EP1437126B1/en
Priority to US10/490,160 priority patent/US7198779B2/en
Priority to AT02800148T priority patent/ATE330584T1/de
Priority to PT02800148T priority patent/PT1437126E/pt
Publication of ES2186569A1 publication Critical patent/ES2186569A1/es
Application granted granted Critical
Publication of ES2186569B1 publication Critical patent/ES2186569B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Lubricants (AREA)
ES200102178A 2001-09-28 2001-09-28 Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma. Expired - Lifetime ES2186569B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES200102178A ES2186569B1 (es) 2001-09-28 2001-09-28 Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.
DE60212673T DE60212673T2 (de) 2001-09-28 2002-09-19 Zusammensetzungen zur linderung von xerostomie und zur behandlung von damit zusammenhängenden erkrankungen
ES02800148T ES2263849T3 (es) 2001-09-28 2002-09-19 Composiciones para el alivio de la xerostomia y el tratamiento de los transtornos asociados con la misma.
PCT/ES2002/000443 WO2003028699A1 (es) 2001-09-28 2002-09-19 Composiciones para el alivio de la xerostomia y el tratamiento delos trastornos asociados con la misma
JP2003532032A JP4111916B2 (ja) 2001-09-28 2002-09-19 口内乾燥症の軽減および関連疾病の治療のための組成物
EP02800148A EP1437126B1 (en) 2001-09-28 2002-09-19 Compositions used to alleviate xerostomia and to treat disorders associated with same
US10/490,160 US7198779B2 (en) 2001-09-28 2002-09-19 Compositions for the relief of xerostomia and the treatment of associated disorders
AT02800148T ATE330584T1 (de) 2001-09-28 2002-09-19 Zusammensetzungen zur linderung von xerostomie und zur behandlung von damit zusammenhängenden erkrankungen
PT02800148T PT1437126E (pt) 2001-09-28 2002-09-19 Composicoes utilizadas para aliviar xerostomia e para tratar afeccoes associadas com a mesma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200102178A ES2186569B1 (es) 2001-09-28 2001-09-28 Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.

Publications (2)

Publication Number Publication Date
ES2186569A1 ES2186569A1 (es) 2003-05-01
ES2186569B1 true ES2186569B1 (es) 2004-09-16

Family

ID=8499043

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200102178A Expired - Lifetime ES2186569B1 (es) 2001-09-28 2001-09-28 Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.
ES02800148T Expired - Lifetime ES2263849T3 (es) 2001-09-28 2002-09-19 Composiciones para el alivio de la xerostomia y el tratamiento de los transtornos asociados con la misma.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02800148T Expired - Lifetime ES2263849T3 (es) 2001-09-28 2002-09-19 Composiciones para el alivio de la xerostomia y el tratamiento de los transtornos asociados con la misma.

Country Status (8)

Country Link
US (1) US7198779B2 (enExample)
EP (1) EP1437126B1 (enExample)
JP (1) JP4111916B2 (enExample)
AT (1) ATE330584T1 (enExample)
DE (1) DE60212673T2 (enExample)
ES (2) ES2186569B1 (enExample)
PT (1) PT1437126E (enExample)
WO (1) WO2003028699A1 (enExample)

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US20050031550A1 (en) * 2003-08-07 2005-02-10 Busch Joseph B. Antigingival/anticalculus oral rinse composition and method of use
US20060120975A1 (en) * 2004-12-02 2006-06-08 Colgate-Palmolive Company Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
JP4732784B2 (ja) * 2005-04-21 2011-07-27 興和株式会社 パンテノール含有口腔内粘膜付着製剤
US10183076B2 (en) 2005-05-16 2019-01-22 Resdevco Research And Development Co. L Topical compositions for treatment of irritation of mucous membranes
IL168603A (en) † 2005-05-16 2011-05-31 Resdevco Res And Dev Co Pharmaceutical or cosmetic composition for the prevention and treatment of irritation of mucous cells or skin cells
US20060263414A1 (en) * 2005-05-19 2006-11-23 Pauline Pan Confectionery products for the treatment of dry mouth
CN100427061C (zh) * 2006-01-26 2008-10-22 陈荣勋 口腔清洁剂及其制备方法
US20070196625A1 (en) * 2006-02-21 2007-08-23 Anderson Daryl E Method and apparatus for secure object labeling
US20070194111A1 (en) * 2006-02-21 2007-08-23 Martin Eric T Energy activated retail receipt system
ES2304103B1 (es) * 2007-02-22 2009-08-07 Biocosmetics S.L. Composicion para tratamiento de la xerostomia o boca seca.
US20090053267A1 (en) * 2007-08-20 2009-02-26 Depierro Karen Dentifrice composition containing silicone oil beads
US20090053309A1 (en) * 2007-08-24 2009-02-26 Axiomedic Ltd., Gibraltar Adhesive compositions for the treatment of xerostomia
US9161909B2 (en) * 2007-08-24 2015-10-20 Axiomedic Ltd. Adhesive compositions for the treatment of xerostomia
US20090068122A1 (en) * 2007-09-06 2009-03-12 Shira Pilch Dentifrice Compositions for Treating Xerostomia
JP2009114125A (ja) * 2007-11-06 2009-05-28 Nippon Zettoc Co Ltd 口腔用組成物
US20090238769A1 (en) * 2008-03-21 2009-09-24 Colgate-Palmolive Company Compositions Comprising Nonionic And Zwittterionic Surfactants
US8568697B2 (en) 2008-03-21 2013-10-29 Colgate-Palmolive Company High fluoride ion recovery compositions
JP5233399B2 (ja) * 2008-05-13 2013-07-10 ライオン株式会社 口腔スプレー用組成物及び口腔用製剤
US20100022471A1 (en) * 2008-07-23 2010-01-28 Sage Products Inc. Oral Moisturizer for Alleviating Dry Mouth
ITMI20081529A1 (it) * 2008-08-21 2010-02-22 Biotrading Di Mannone Maurizio Gius Eppe Metodo per la fluoroprofilassi dei denti mediante l'uso di una composizione spray a base di fluoro
BRPI1007676A2 (pt) 2009-05-08 2020-10-13 3M Innovative Properties Company métodos para hidratação, kits para tratamento bucal e método para hidratação dos tecidos bucais
US20110104081A1 (en) * 2009-11-03 2011-05-05 Douglas Craig Scott Oral Compositions for Treatment of Dry Mouth
US20110104080A1 (en) * 2009-11-03 2011-05-05 David Salloum Salloum Oral Compositions for Treatment of Dry Mouth
FR2956583B1 (fr) * 2010-02-22 2012-12-21 Previzen Utilisation d'une composition neutralisante par ingestion pour traiter les aphtes
US20130078316A1 (en) * 2011-03-25 2013-03-28 Robert D. Christensen Methods and compositions for irrigation of mucosal tissues
WO2012158580A2 (en) 2011-05-16 2012-11-22 Colgate-Palmolive Company Oral care compositions
US9403040B1 (en) * 2012-04-27 2016-08-02 Karlinsey Enterprises Calcium-free composition for dental mineralization
ES2387487B1 (es) * 2012-07-12 2013-08-01 Nuria LLONCH BERGÉS Utilización de xilitol y composiciones del mismo
CA2930455A1 (en) * 2012-11-26 2014-05-30 Apollonia Health Inc. Compositions, uses and methods for treating or preventing dental caries
ES2593618T3 (es) * 2012-12-18 2016-12-12 Sunstar Suisse Sa Composición oral tópica para aliviar los síntomas de la boca seca y para el tratamiento de úlceras bucales
BR112016005528B1 (pt) 2013-09-13 2023-03-28 3M Innovative Properties Company Composição antisséptica compreendendo antisséptico catiônico multivalente
KR101636430B1 (ko) * 2014-07-10 2016-07-05 동아제약 주식회사 항염 및 살균력이 증진된 치주질환 예방 또는 개선용 조성물
EP3223780B1 (en) * 2014-12-26 2019-10-23 Colgate-Palmolive Company Oral care products and methods of use and manufacture thereof
WO2016116813A1 (en) * 2015-01-22 2016-07-28 Americo Fernandes Dental appliances
JP2016175875A (ja) * 2015-03-20 2016-10-06 サンスター株式会社 水系口腔用組成物
RU2607931C2 (ru) * 2015-04-23 2017-01-11 Елена Ароновна Картон Лечебно-профилактическая композиция для ухода за полостью рта гематоонкологических больных
WO2017087009A1 (en) 2015-11-19 2017-05-26 Fantarella & Harewood LLC Mouthwash composition
GB2545007A (en) * 2015-12-03 2017-06-07 Cosmetic Warriors Ltd Composition
NL2017656B1 (nl) * 2016-10-21 2018-04-30 Johan Wagenaar Louis Samenstelling voor slijmvliesherstel
EP3585361A4 (en) * 2017-02-22 2020-12-23 Smilesonica Inc. ARTIFICIAL SALIVA, RELATED PROCESSES AND USES
WO2019126703A1 (en) 2017-12-22 2019-06-27 Ecolab Usa Inc. Antimicrobial compositions with enhanced efficacy
CN109464302B (zh) * 2018-12-29 2021-11-23 上海家化联合股份有限公司 含甘草酸二钾的组合物
US12083209B2 (en) 2020-02-18 2024-09-10 Sunstar Americas, Inc. Oral care composition
CN116035958A (zh) * 2022-12-29 2023-05-02 中山市天图精细化工有限公司 一种具有清洁能力的冲牙喷雾气雾剂及其制备方法

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US5541165A (en) * 1994-09-27 1996-07-30 Turgeon; Jean A. Saliva substitute

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US4906455A (en) * 1988-04-15 1990-03-06 Wm. Wrigley Jr. Company Method for treating xerostomia employing chewing gum containing relatively insoluble, hydrophobic, food-grade organic acid
US5661171A (en) * 1992-07-02 1997-08-26 Oramed, Inc. Controlled release pilocarpine delivery system
US5658554A (en) * 1995-06-01 1997-08-19 Colgate-Palmolive Company Mouth moistener for the relief of dry mouth condition
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Also Published As

Publication number Publication date
JP4111916B2 (ja) 2008-07-02
EP1437126A1 (en) 2004-07-14
US20040247532A1 (en) 2004-12-09
DE60212673T2 (de) 2007-03-29
ES2263849T3 (es) 2006-12-16
ATE330584T1 (de) 2006-07-15
EP1437126B1 (en) 2006-06-21
US7198779B2 (en) 2007-04-03
DE60212673D1 (de) 2006-08-03
PT1437126E (pt) 2006-10-31
JP2005504109A (ja) 2005-02-10
WO2003028699A1 (es) 2003-04-10
ES2186569A1 (es) 2003-05-01

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