ES2182451T3 - Procedimiento para la obtencion de derivados de cromano substituidos. - Google Patents

Procedimiento para la obtencion de derivados de cromano substituidos.

Info

Publication number
ES2182451T3
ES2182451T3 ES99124191T ES99124191T ES2182451T3 ES 2182451 T3 ES2182451 T3 ES 2182451T3 ES 99124191 T ES99124191 T ES 99124191T ES 99124191 T ES99124191 T ES 99124191T ES 2182451 T3 ES2182451 T3 ES 2182451T3
Authority
ES
Spain
Prior art keywords
formula
alkyl
preparation
derivatives
acrolein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99124191T
Other languages
English (en)
Inventor
Rainer Dr Sturmer
Kai-Uwe Dr Baldenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2182451T3 publication Critical patent/ES2182451T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la obtención de derivados de cromano substituidos de la fórmula general VII **(Ver fórmula)** representando X el grupo -CN, -COOR3, -CHO, -CH2OR7 o -CH(OR8)2, R2 un resto alquilo con 1 a 23 átomos de carbono, alquenilo con 2 a 23 átomos de carbono, arilo con 6 a 18 átomos de carbono o aralquilo con 7 a 18 átomos de carbono, R3 hidrógeno, un resto alquilo con 1 a 4 átomos de carbono, un resto alquilo halogenado con 1 a 4 átomos de carbono, un resto hidroxialquilo con 1 a 4 átomos de carbono o un resto aminoalquilo con 1 a 4 átomos de carbono, R4, R5, R6 independientemente entre sí, hidrógeno o un resto alquilo con 1 a 4 átomos de carbono, 25 R7 hidrógeno o un resto alquilo con 1 a 4 átomos de carbono, R8 un resto alquilo con 1 a 4 átomos de carbono, o significando ambos restos un resto alquileno con 2 a 6 átomos de carbono, que puentea ambos átomos de oxígeno en el sentido de un acetal cíclico, y en caso dado está ramificado, o puede portar uno a dos grupos carboxilo, restos ciclohexilo o restos fenilo, caracterizado porque en un primer paso se hace reaccionar acroleínas substituidas de la fórmula general I ** (Ver fórmula I)** representando R1 un resto alquilo con 1 a 4 átomos de carbono, arilo con 6 a 18 átomos de carbono, aralquilo con 7 a 18 átomos de carbono, acilo con 1 a 4 átomos de carbono, un resto acilo con 1 a 4 átomos de carbono halogenado, u otro grupo protector de la función hidroxi lábil frente a ácidos, con acrilonitrilos, acrilatos, acroleínas, acetales de acroleína, alcoholes alílicos o éteres alílicos de la fórmula general II **(Ver fórmula II)** para dar los correspondientes 3, 4-dihidro-2H-piranos de la fórmula general III **(Ver fórmula III)** y en un segundo paso se hace reaccionar estos con un ácido para dar los correspondientes 5-oxotetrahidropiranos de la fórmula general IV **(Ver fórmula IV)** y en un tercer paso se hace reaccionar estos con vinilcetonas substituidas de la fórmula general V **(Ver fórmula V)** para dar los correspondientes derivados de cromen-6-ona de la fórmula general VI **(Ver fórmula VI)** y en un cuarto paso se deshidrogena estos para dar los derivados de cromano substituidos de la fórmula general VII.
ES99124191T 1998-12-22 1999-12-03 Procedimiento para la obtencion de derivados de cromano substituidos. Expired - Lifetime ES2182451T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19859251A DE19859251A1 (de) 1998-12-22 1998-12-22 Verfahren zur Herstellung von substituierten Chromanderivaten

Publications (1)

Publication Number Publication Date
ES2182451T3 true ES2182451T3 (es) 2003-03-01

Family

ID=7892106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99124191T Expired - Lifetime ES2182451T3 (es) 1998-12-22 1999-12-03 Procedimiento para la obtencion de derivados de cromano substituidos.

Country Status (7)

Country Link
US (1) US6136986A (es)
EP (1) EP1013652B1 (es)
JP (1) JP2000191655A (es)
CN (1) CN1134426C (es)
AT (1) ATE222249T1 (es)
DE (2) DE19859251A1 (es)
ES (1) ES2182451T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20013076A3 (cs) * 2000-08-29 2002-04-17 Kuraray Co., Ltd. Způsob výroby chromankarboxylové kyseliny
US20030114416A1 (en) * 2001-08-14 2003-06-19 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
US20050101563A1 (en) * 2001-08-14 2005-05-12 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation
JP5603041B2 (ja) * 2009-09-09 2014-10-08 東ソー・ファインケム株式会社 （ヘテロ）ディールス−アルダー反応用触媒、それを用いたおよびジヒドロピラン化合物およびディールス−アルダー反応付加物の製造方法
CN103420964A (zh) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 四氢吡喃-3-甲酸的制备方法
CN105693672A (zh) * 2016-04-14 2016-06-22 青岛科技大学 一种多取代2-亚胺-2h-苯并吡喃衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411969A (en) * 1938-03-31 1946-12-03 Hoffmann La Roche Process for the preparation of synthetic dl-tocopherols
US2514168A (en) * 1947-06-02 1950-07-04 Shell Dev Derivatives of dihydropyran and preparation of the same
ZA739471B (en) * 1972-12-22 1974-08-28 Hoffmann La Roche Chromane derivatives
US3947473A (en) * 1972-12-22 1976-03-30 Hoffman-La Roche Inc. Antioxidant chroman compounds
GB9618877D0 (en) * 1996-09-10 1996-10-23 Unilever Plc Process for preparing high bulk density detergent compositions

Also Published As

Publication number Publication date
US6136986A (en) 2000-10-24
CN1264705A (zh) 2000-08-30
JP2000191655A (ja) 2000-07-11
EP1013652A2 (de) 2000-06-28
DE19859251A1 (de) 2000-06-29
CN1134426C (zh) 2004-01-14
ATE222249T1 (de) 2002-08-15
EP1013652B1 (de) 2002-08-14
EP1013652A3 (de) 2000-10-25
DE59902329D1 (de) 2002-09-19

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