ES2182116T3 - Composiciones farmaceuticas que comprenden derivados del s-alquilisotiouronio. - Google Patents

Composiciones farmaceuticas que comprenden derivados del s-alquilisotiouronio.

Info

Publication number
ES2182116T3
ES2182116T3 ES97941178T ES97941178T ES2182116T3 ES 2182116 T3 ES2182116 T3 ES 2182116T3 ES 97941178 T ES97941178 T ES 97941178T ES 97941178 T ES97941178 T ES 97941178T ES 2182116 T3 ES2182116 T3 ES 2182116T3
Authority
ES
Spain
Prior art keywords
pct
alquilisotiouronio
pharmaceutical compositions
include derivatives
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97941178T
Other languages
English (en)
Inventor
I Lev Mizrakh
I Victor Gikavy
V Valentin Znamensky
V Evgeni Arzamastsev
B Lev Shagalov
Valeri Kovtun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meditor Pharmaceuticals Ltd
Original Assignee
Meditor Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU96119163A external-priority patent/RU2142796C1/ru
Priority claimed from RU97115433/14A external-priority patent/RU2187309C2/ru
Application filed by Meditor Pharmaceuticals Ltd filed Critical Meditor Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2182116T3 publication Critical patent/ES2182116T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A SALES DE S-ALQUILISOTIOURONIUM CON ACIDOS QUE CONTIENEN FOSFORO, QUE INCLUYEN ALGUNOS COMPUESTOS NUEVOS QUE SON UTILES PARA SU USO COMO MEDICAMENTOS PARA INCREMENTAR LA TENSION SANGUINEA O PARA PROTEGER CONTRA LA HIPEROXIA. ESTOS COMPUESTOS PUEDEN UTILIZARSE PARA EL TRATAMIENTO DE LA HIPOTENSION AGUDA, POR EJEMPLO CONDICIONES DE SOCK, LA HIPOTENSION ARTERIAL CRONICA O LA INTOXICACION POR OXIGENO.
ES97941178T 1996-09-26 1997-09-25 Composiciones farmaceuticas que comprenden derivados del s-alquilisotiouronio. Expired - Lifetime ES2182116T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU96119163A RU2142796C1 (ru) 1996-09-26 1996-09-26 Лекарственное противошоковое средство
RU97115433/14A RU2187309C2 (ru) 1997-09-19 1997-09-19 Средство, влияющее на артериальное давление

Publications (1)

Publication Number Publication Date
ES2182116T3 true ES2182116T3 (es) 2003-03-01

Family

ID=26653892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97941178T Expired - Lifetime ES2182116T3 (es) 1996-09-26 1997-09-25 Composiciones farmaceuticas que comprenden derivados del s-alquilisotiouronio.

Country Status (18)

Country Link
US (1) US6160008A (es)
EP (1) EP0928191B1 (es)
JP (1) JP4260888B2 (es)
KR (1) KR100575507B1 (es)
CN (1) CN1116871C (es)
AT (1) ATE222758T1 (es)
AU (1) AU717712B2 (es)
BR (1) BR9712851A (es)
CA (1) CA2266533C (es)
DE (1) DE69715013T2 (es)
DK (1) DK0928191T3 (es)
ES (1) ES2182116T3 (es)
HK (1) HK1022833A1 (es)
IL (1) IL129020A (es)
NO (1) NO326600B1 (es)
PT (1) PT928191E (es)
TR (1) TR199900783T2 (es)
WO (1) WO1998013036A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ524903A (en) 2000-09-05 2004-11-26 Meditor Pharmaceuticals Ltd Pharmaceutical compositions comprising S-alkylisothiouronium derivatives for headache, migraine, nausea and emesis
CA2621582A1 (en) * 2005-09-06 2007-03-15 Meditor Pharmaceuticals Ltd. Prevention of hypotension and stabilization of blood pressure in hemodialysis patients
WO2007108004A2 (en) * 2006-03-23 2007-09-27 Meditor Pharmaceuticals Ltd. S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
EA200901591A1 (ru) * 2007-06-13 2010-06-30 Медитор Фармасьютикалс Лтд. Фармацевтические композиции производных s-алкилизотиоурония с маскированным вкусом
MD3619G2 (ro) * 2007-11-06 2009-01-31 Рафаэль Баркан Remediu medicamentos nazal cu acţiune anticongestivă
EP2219447B1 (en) * 2007-11-06 2013-07-03 Barkan-Farma S.r.l. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
CN104140386A (zh) * 2014-02-12 2014-11-12 上海应用技术学院 一种2-苄基-异硫脲三氟乙酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123636A (en) * 1964-03-03 Thiuronium h alii
US3116327A (en) * 1960-07-22 1963-12-31 Baxter Laboratories Inc Upsilon-dimethylaminopropyl isothiourea and acid addition salts thereof
US3657337A (en) * 1967-12-04 1972-04-18 Sandoz Ag Benzylideneamino guanidines
FR2419675A1 (fr) * 1978-03-16 1979-10-12 Philagro Sa Compositions fongicides a base de phosphites d'isothiouronium
AT395012B (de) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen

Also Published As

Publication number Publication date
CA2266533A1 (en) 1998-04-02
BR9712851A (pt) 2000-01-18
NO991419L (no) 1999-05-21
WO1998013036A1 (en) 1998-04-02
CN1234737A (zh) 1999-11-10
ATE222758T1 (de) 2002-09-15
US6160008A (en) 2000-12-12
EP0928191A1 (en) 1999-07-14
AU4317897A (en) 1998-04-17
CN1116871C (zh) 2003-08-06
JP2001501928A (ja) 2001-02-13
TR199900783T2 (xx) 1999-07-21
IL129020A0 (en) 2000-02-17
NO326600B1 (no) 2009-01-19
JP4260888B2 (ja) 2009-04-30
DE69715013D1 (de) 2002-10-02
DK0928191T3 (da) 2002-12-30
DE69715013T2 (de) 2003-05-22
IL129020A (en) 2004-06-20
PT928191E (pt) 2003-01-31
KR20000048636A (ko) 2000-07-25
KR100575507B1 (ko) 2006-05-03
HK1022833A1 (en) 2000-08-25
AU717712B2 (en) 2000-03-30
EP0928191B1 (en) 2002-08-28
NO991419D0 (no) 1999-03-24
CA2266533C (en) 2007-08-07

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