ES2181771T3 - Composiciones de inhibina y metodo para el uso de la misma. - Google Patents
Composiciones de inhibina y metodo para el uso de la misma.Info
- Publication number
- ES2181771T3 ES2181771T3 ES95913576T ES95913576T ES2181771T3 ES 2181771 T3 ES2181771 T3 ES 2181771T3 ES 95913576 T ES95913576 T ES 95913576T ES 95913576 T ES95913576 T ES 95913576T ES 2181771 T3 ES2181771 T3 ES 2181771T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- heterologous protein
- inhibin
- heterologous
- fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 10
- 108090000623 proteins and genes Proteins 0.000 abstract 10
- 102000014914 Carrier Proteins Human genes 0.000 abstract 4
- 108010078791 Carrier Proteins Proteins 0.000 abstract 4
- 239000000893 inhibin Substances 0.000 abstract 4
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 3
- 241000271566 Aves Species 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 abstract 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 abstract 1
- 241000287530 Psittaciformes Species 0.000 abstract 1
- 229940098773 bovine serum albumin Drugs 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Confectionery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- General Preparation And Processing Of Foods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Dental Preparations (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN METODO PARA ACELERAR LA APARICION DE LA PUBERTAD EN AVIARES, ESPECIALMENTE EN RATITAS Y PSITACIFORMES, MEDIANTE LA ADMINISTRACION DE UNA PROTEINA HETEROLOGA QUE CONTENGA INHIBINA, O UN FRAGMENTO DE LA MISMA, Y UNA PROTEINA DE SOPORTE. LA PRESENTE INVENCION TAMBIEN SE REFIERE A UN METODO PARA AUMENTAR LA PRODUCCION DE HUEVOS EN ANIMALES, EN PARTICULAR PAJAROS, PARTICULARMENTE RATITAS, MEDIANTE LA ADMINISTRACION DE LA PROTEINA HETEROLOGA. ESTA INVENCION TAMBIEN SE REFIERE A LA PROTEINA HETEROLOGA Y A UN METODO PARA LA PRODUCCION DE LA PROTEINA HETEROLOGA. LA PROTEINA HETEROLOGA PUEDE SER BIEN INHIBINA CONJUGADA A LA PROTEINA DE SOPORTE O INHIBINA FUSIONADA A LA PROTEINA DE SOPORTE. EL METODO PARA LA PRODUCCION DE LA PROTEINA HETEROLOGA FUSIONADA CONSISTE EN INSERTAR UNA INHIBINA QUE CODIFICA UN CADN DE DOBLE CEPA, O UN FRAGMENTO DE LA MISMA, EN UN VECTOR QUE CODIFICA UNA PROTEINA DE SOPORTE TAL COMO UNA PROTEINA QUE SE ENLAZA A LA MALTOSA O ALBUMINA DEL SUERO BOVINO. TRAS INSERTAR EL VECTOR EN UN SISTEMA DE EXPRESION, EL SISTEMA EXPRESA LA PROTEINA HETEROLOGA FUSIONADA. TRAS PURIFICAR LA PROTEINA HETEROLOGA EXPRESADA, SE ADMINISTRA UNA CANTIDAD EFECTIVA DE LA PROTEINA A UN ANIMAL DE MODO QUE SE PRODUZCA UNA RESPUESTA INMUNOLOGICA EN EL ANIMAL CONTRA LA PROTEINA HETEROLOGA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20296494A | 1994-02-28 | 1994-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2181771T3 true ES2181771T3 (es) | 2003-03-01 |
Family
ID=22751927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95913576T Expired - Lifetime ES2181771T3 (es) | 1994-02-28 | 1995-02-28 | Composiciones de inhibina y metodo para el uso de la misma. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0804219B1 (es) |
| JP (1) | JPH09510702A (es) |
| CN (1) | CN1149258A (es) |
| AT (1) | ATE220554T1 (es) |
| AU (1) | AU704737B2 (es) |
| BR (1) | BR9507426A (es) |
| CA (1) | CA2184183C (es) |
| DE (1) | DE69527439T2 (es) |
| DK (1) | DK0804219T3 (es) |
| ES (1) | ES2181771T3 (es) |
| FI (1) | FI963325A (es) |
| MX (1) | MX9603702A (es) |
| NO (1) | NO963572L (es) |
| NZ (1) | NZ282981A (es) |
| PL (1) | PL184202B1 (es) |
| PT (1) | PT804219E (es) |
| RU (1) | RU2170100C2 (es) |
| WO (1) | WO1995022980A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747659A (en) * | 1994-02-28 | 1998-05-05 | Agritech Technologies, Ltd. | Fusion gene products encoding avian alpha subunit inhibin protein, or an immunogenic fragment thereof, and a carrier protein |
| US5786179A (en) * | 1994-02-28 | 1998-07-28 | Agritech Technologies Ltd. | Heterologous protein comprising avian alpha-subunit inhibin protein and methods of producing same |
| AU2003295420A1 (en) * | 2002-11-07 | 2004-06-03 | Agritech Technology, Ltd. | Novel inhibin-related multiple antigenic peptide compositions that enhance production performance in avians |
| EP3470072A1 (en) | 2005-06-23 | 2019-04-17 | Biogen MA Inc. | Compositions and methods for modulation of smn2 splicing |
| AU2006285850A1 (en) | 2005-08-29 | 2007-03-08 | Japan Science And Technology Agency | Antibody produced using ostrich and method for production thereof |
| CN116440150A (zh) | 2009-06-17 | 2023-07-18 | 冷泉港实验室 | 用于在对象中调节smn2剪接的组合物和方法 |
| US9926559B2 (en) | 2013-01-09 | 2018-03-27 | Biogen Ma Inc. | Compositions and methods for modulation of SMN2 splicing in a subject |
| BR102014005376A2 (pt) * | 2014-03-07 | 2016-02-10 | Ouro Fino Saúde Animal Ltda | antígeno de inibina alfa, gene codificante de inibina alfa, gene codificante de proteína de fusão, processo de obtenção do antígeno de inibina alfa, composição antigênica, uso do antígeno de inibina alfa e uso da composição antigênica |
| WO2015161170A2 (en) | 2014-04-17 | 2015-10-22 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of smn2 splicing in a subject |
| WO2016040748A1 (en) | 2014-09-12 | 2016-03-17 | Ionis Pharmaceuticals, Inc. | Compositions and methods for detection of smn protein in a subject and treatment of a subject |
| EP3471779A4 (en) | 2016-06-16 | 2020-07-08 | Ionis Pharmaceuticals, Inc. | COMBINATIONS FOR MODULATING THE SMN EXPRESSION |
| CN110551744A (zh) * | 2019-09-18 | 2019-12-10 | 普健生物（武汉）科技有限公司 | 一种人抑制素a的核苷酸序列及重组表达人抑制素a的方法 |
| US20220064638A1 (en) | 2020-02-28 | 2022-03-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating smn2 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US4864019A (en) * | 1985-11-08 | 1989-09-05 | The Salk Institute For Biological Studies | Antibodies to inhibin and conjugates produced therefrom |
-
1995
- 1995-02-28 MX MX9603702A patent/MX9603702A/es not_active IP Right Cessation
- 1995-02-28 DE DE69527439T patent/DE69527439T2/de not_active Expired - Fee Related
- 1995-02-28 AT AT95913576T patent/ATE220554T1/de not_active IP Right Cessation
- 1995-02-28 DK DK95913576T patent/DK0804219T3/da active
- 1995-02-28 CA CA002184183A patent/CA2184183C/en not_active Expired - Fee Related
- 1995-02-28 RU RU96119774/13A patent/RU2170100C2/ru not_active IP Right Cessation
- 1995-02-28 ES ES95913576T patent/ES2181771T3/es not_active Expired - Lifetime
- 1995-02-28 CN CN95192317A patent/CN1149258A/zh active Pending
- 1995-02-28 AU AU20959/95A patent/AU704737B2/en not_active Ceased
- 1995-02-28 PT PT95913576T patent/PT804219E/pt unknown
- 1995-02-28 BR BR9507426A patent/BR9507426A/pt not_active IP Right Cessation
- 1995-02-28 NZ NZ282981A patent/NZ282981A/en unknown
- 1995-02-28 EP EP95913576A patent/EP0804219B1/en not_active Expired - Lifetime
- 1995-02-28 WO PCT/US1995/002795 patent/WO1995022980A1/en active IP Right Grant
- 1995-02-28 JP JP7522532A patent/JPH09510702A/ja not_active Withdrawn
- 1995-02-28 PL PL95316628A patent/PL184202B1/pl not_active IP Right Cessation
-
1996
- 1996-08-27 NO NO963572A patent/NO963572L/no unknown
- 1996-08-27 FI FI963325A patent/FI963325A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI963325A (fi) | 1996-10-21 |
| PT804219E (pt) | 2002-12-31 |
| AU2095995A (en) | 1995-09-11 |
| RU2170100C2 (ru) | 2001-07-10 |
| PL184202B1 (pl) | 2002-09-30 |
| NO963572D0 (no) | 1996-08-27 |
| FI963325A0 (fi) | 1996-08-27 |
| EP0804219A1 (en) | 1997-11-05 |
| WO1995022980A1 (en) | 1995-08-31 |
| CA2184183C (en) | 2005-02-08 |
| BR9507426A (pt) | 1997-09-16 |
| NO963572L (no) | 1996-10-25 |
| JPH09510702A (ja) | 1997-10-28 |
| MX9603702A (es) | 1997-12-31 |
| EP0804219A4 (en) | 1999-02-24 |
| AU704737B2 (en) | 1999-05-06 |
| ATE220554T1 (de) | 2002-08-15 |
| DK0804219T3 (da) | 2002-11-11 |
| DE69527439D1 (de) | 2002-08-22 |
| DE69527439T2 (de) | 2003-02-20 |
| CA2184183A1 (en) | 1995-08-31 |
| EP0804219B1 (en) | 2002-07-17 |
| CN1149258A (zh) | 1997-05-07 |
| NZ282981A (en) | 1998-08-26 |
| PL316628A1 (en) | 1997-02-03 |
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