ES2181320T3 - Procedimiento para la produccion de formas solidas de dosificacion. - Google Patents
Procedimiento para la produccion de formas solidas de dosificacion.Info
- Publication number
- ES2181320T3 ES2181320T3 ES98965716T ES98965716T ES2181320T3 ES 2181320 T3 ES2181320 T3 ES 2181320T3 ES 98965716 T ES98965716 T ES 98965716T ES 98965716 T ES98965716 T ES 98965716T ES 2181320 T3 ES2181320 T3 ES 2181320T3
- Authority
- ES
- Spain
- Prior art keywords
- production
- mixture
- dosage forms
- solid dosage
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007909 solid dosage form Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002552 dosage form Substances 0.000 abstract 2
- 229920005596 polymer binder Polymers 0.000 abstract 2
- 239000002491 polymer binding agent Substances 0.000 abstract 2
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229920001567 vinyl ester resin Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/74—Fixation, conservation, or encapsulation of flavouring agents with a synthetic polymer matrix or excipient, e.g. vinylic, acrylic polymers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Procedimiento para la producción de formas farmacéuticas sólidas de dosificación a través de la mezcla de 10 a 99,9 % en peso, con respecto al peso total de la forma de dosificación, de al menos un aglutinante polímero, de 0,1 a 90 % en peso de al menos una substancia activa farmacéutica y, dado el caso, aditivos usuales, bajo la formación de una mezcla plástica y conformación, caracterizado porque como aglutinante polímero se emplea un copolímero de una N-vinillactama de la fórmula I: en la que n representa 1, 2 ó 3, y de 1 a 30 % mol de un monómero, copolimerizable con la N-vinillactama, con un resto hidrófobo, que está seleccionado entre un compuesto de la fórmula II: R1OCH2 == CCXR3 (II), en la que R1 representa un átomo de hidrógeno o un grupo metilo; X representa O, NH o NR2, R2 representa alquilo de C1-C30, y R3 representa alquilo C8-C30, cicloalquilo de C8-C30, o alquenilo de C8-C30, o un éster vinílico de un ácido carboxílico alifático de C8-C30, o una mezcla de ellos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19753298A DE19753298A1 (de) | 1997-12-01 | 1997-12-01 | Verfahren zur Herstellung von festen Dosierungsformen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2181320T3 true ES2181320T3 (es) | 2003-02-16 |
Family
ID=7850420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98965716T Expired - Lifetime ES2181320T3 (es) | 1997-12-01 | 1998-11-30 | Procedimiento para la produccion de formas solidas de dosificacion. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6528089B1 (es) |
| EP (1) | EP1035841B1 (es) |
| JP (1) | JP2001524515A (es) |
| CN (1) | CN1156270C (es) |
| AT (1) | ATE220897T1 (es) |
| CA (1) | CA2311308C (es) |
| DE (2) | DE19753298A1 (es) |
| DK (1) | DK1035841T3 (es) |
| ES (1) | ES2181320T3 (es) |
| PT (1) | PT1035841E (es) |
| WO (1) | WO1999027916A2 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003101217A1 (es) * | 2002-05-29 | 2003-12-11 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamación y/o dolor, en un colectivo de animales, de forma simultánea |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853985A1 (de) * | 1998-11-23 | 2000-05-25 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19929361A1 (de) * | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
| EP1204410B1 (en) | 1999-07-30 | 2012-09-12 | Capsugel Belgium NV | Multi-component pharmaceutical dosage form |
| EP1226138B1 (en) | 1999-10-08 | 2004-12-29 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
| GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| DK1560584T3 (da) * | 2001-04-06 | 2009-05-18 | Affinium Pharm Inc | Fab I inhibitorer |
| US6756449B2 (en) * | 2002-02-27 | 2004-06-29 | Medtronic, Inc. | AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods |
| US20030203027A1 (en) * | 2002-04-26 | 2003-10-30 | Ethicon, Inc. | Coating technique for deposition of drug substance on a substrate |
| DK1575951T3 (da) | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi |
| EP1608377B1 (en) * | 2003-03-17 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US7704528B2 (en) * | 2003-05-05 | 2010-04-27 | Isp Investments Inc. | Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability |
| TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| KR100573124B1 (ko) * | 2003-11-22 | 2006-04-24 | 삼성에스디아이 주식회사 | 플라즈마 디스플레이 패널 구동방법 및 장치 |
| PE20060003A1 (es) * | 2004-03-12 | 2006-03-01 | Smithkline Beecham Plc | Formulacion farmaceutica polimerica para moldear por inyeccion |
| DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| CA2632476A1 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| EP1991207A2 (en) * | 2006-01-21 | 2008-11-19 | Abbott GmbH & Co. KG | Dosage form and method for the delivery of drugs of abuse |
| US8173152B2 (en) | 2006-03-24 | 2012-05-08 | Auxilium Us Holdings, Llc | Stabilized compositions containing alkaline labile drugs |
| CA2647801C (en) * | 2006-03-24 | 2015-04-14 | Auxilium Pharmaceuticals, Inc. | Process for the preparation of a hot-melt extruded laminate |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| JP5323715B2 (ja) * | 2006-11-30 | 2013-10-23 | ビーエーエスエフ ソシエタス・ヨーロピア | １−ビニル−２−ピロリジノンコポリマーを含む農薬製剤 |
| EP2500015A1 (en) * | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
| WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| EP2219624A2 (en) | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| WO2009103760A2 (en) * | 2008-02-21 | 2009-08-27 | Basf Se | Coated inert granules |
| WO2009150228A2 (en) * | 2008-06-13 | 2009-12-17 | Glaxo Group Limited | Pharmaceutical formulations |
| EP2675434A1 (en) | 2011-02-17 | 2013-12-25 | F.Hoffmann-La Roche Ag | A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion |
| ES2731474T3 (es) | 2012-06-19 | 2019-11-15 | Debiopharm Int Sa | Derivados de profármaco de (E)-N-metil-N-((3-metilbenzofuran-2-il)metil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)acrilamida |
| WO2016137983A1 (en) | 2015-02-24 | 2016-09-01 | X-Spine Systems, Inc. | Modular interspinous fixation system with threaded component |
| EP3419628B1 (en) | 2016-02-26 | 2020-10-14 | Debiopharm International SA | Medicament for treatment of diabetic foot infections |
| JP7126971B2 (ja) * | 2019-03-13 | 2022-08-29 | 日産合成工業株式会社 | バイパスペレット飼料の製造方法及びバイパスペレット飼料 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1563390A (en) | 1975-08-27 | 1980-03-26 | Hydrophilics Int Inc | Pharmaceutical products |
| IL50250A (en) * | 1975-08-27 | 1980-01-31 | Hydrophilics Int Inc | Sustained release compositions comprising slats of pharmaceutically acitve bases with polymers containing acid groups |
| CH602916A5 (es) | 1975-09-10 | 1978-08-15 | Airwick Ag | |
| GB2087408B (en) * | 1980-11-04 | 1984-05-23 | Patel Pravin Gordhanbhai Da Co | Cross-linked hydrophilic polymers |
| US4693887A (en) | 1983-09-15 | 1987-09-15 | The Kendall Company | Microphase separated hydrogels for controlled release of bioactive materials |
| DE3612211A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Kontinuierliches verfahren zum tablettieren |
| DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| DE3812567A1 (de) | 1988-04-15 | 1989-10-26 | Basf Ag | Verfahren zur herstellung pharmazeutischer mischungen |
| DE3830353A1 (de) | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
| DE19719187A1 (de) * | 1997-05-07 | 1998-11-12 | Basf Ag | Verwendung von Copolymerisaten des N-Vinyl-pyrrolidons in Zubereitungen wasserunlöslicher Stoffe |
| JP4049411B2 (ja) * | 1997-06-27 | 2008-02-20 | 株式会社メニコン | 硬質コンタクトレンズ用リングおよびそれを用いた硬質コンタクトレンズ複合物 |
-
1997
- 1997-12-01 DE DE19753298A patent/DE19753298A1/de not_active Withdrawn
-
1998
- 1998-11-30 EP EP98965716A patent/EP1035841B1/de not_active Expired - Lifetime
- 1998-11-30 DK DK98965716T patent/DK1035841T3/da active
- 1998-11-30 DE DE59804928T patent/DE59804928D1/de not_active Expired - Fee Related
- 1998-11-30 AT AT98965716T patent/ATE220897T1/de not_active IP Right Cessation
- 1998-11-30 WO PCT/EP1998/007716 patent/WO1999027916A2/de active IP Right Grant
- 1998-11-30 PT PT98965716T patent/PT1035841E/pt unknown
- 1998-11-30 JP JP2000522902A patent/JP2001524515A/ja not_active Ceased
- 1998-11-30 ES ES98965716T patent/ES2181320T3/es not_active Expired - Lifetime
- 1998-11-30 CN CNB988134233A patent/CN1156270C/zh not_active Expired - Fee Related
- 1998-11-30 US US09/555,596 patent/US6528089B1/en not_active Expired - Fee Related
- 1998-11-30 CA CA002311308A patent/CA2311308C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003101217A1 (es) * | 2002-05-29 | 2003-12-11 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamación y/o dolor, en un colectivo de animales, de forma simultánea |
| ES2201908A1 (es) * | 2002-05-29 | 2004-03-16 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
| AU2003233814B2 (en) * | 2002-05-29 | 2009-03-05 | Laboratorios Del Dr. Esteve, S.A. | Ketoprofen-supplemented animal feed and use thereof in the simultaneous treatment of a group of animals for processes which are accompanied by fever, inflammation and/or pain |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999027916A3 (de) | 1999-08-12 |
| US6528089B1 (en) | 2003-03-04 |
| DE19753298A1 (de) | 1999-06-02 |
| CA2311308C (en) | 2008-01-22 |
| EP1035841B1 (de) | 2002-07-24 |
| CN1283993A (zh) | 2001-02-14 |
| DK1035841T3 (da) | 2002-09-02 |
| CA2311308A1 (en) | 1999-06-10 |
| JP2001524515A (ja) | 2001-12-04 |
| WO1999027916A2 (de) | 1999-06-10 |
| PT1035841E (pt) | 2002-11-29 |
| DE59804928D1 (de) | 2002-08-29 |
| EP1035841A1 (de) | 2000-09-20 |
| CN1156270C (zh) | 2004-07-07 |
| ATE220897T1 (de) | 2002-08-15 |
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