ES2180782T3 - Procedimiento para la identificacion o el aislamiento de una molecula y moleculas identificadas de ese modo. - Google Patents

Procedimiento para la identificacion o el aislamiento de una molecula y moleculas identificadas de ese modo.

Info

Publication number
ES2180782T3
ES2180782T3 ES96919266T ES96919266T ES2180782T3 ES 2180782 T3 ES2180782 T3 ES 2180782T3 ES 96919266 T ES96919266 T ES 96919266T ES 96919266 T ES96919266 T ES 96919266T ES 2180782 T3 ES2180782 T3 ES 2180782T3
Authority
ES
Spain
Prior art keywords
host cells
molecula
isolation
identification
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96919266T
Other languages
English (en)
Inventor
Michael Pfreundschuh
Hans-Georg Rammensee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research Ltd
Ludwig Institute for Cancer Research New York
Original Assignee
Ludwig Institute for Cancer Research Ltd
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/580,980 external-priority patent/US6025191A/en
Priority claimed from US08/644,116 external-priority patent/US6140464A/en
Application filed by Ludwig Institute for Cancer Research Ltd, Ludwig Institute for Cancer Research New York filed Critical Ludwig Institute for Cancer Research Ltd
Application granted granted Critical
Publication of ES2180782T3 publication Critical patent/ES2180782T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

LA INVENCION DESCRIBE METODOS PARA IDENTIFICAR UNA MOLECULA DE INTERES, ASI COMO MOLECULAS DE ACIDO NUCLEICO QUE LA CODIFICAN, Y LIGANTES QUE LA ACOMPAÑAN. SE PREPARA UN BANCO DE ADNC A PARTIR DE UNA CELULA QUE EXPRESA LA MOLECULA, Y SE EXPRESA EN CELULAS HUESPED. SE COTEJAN LOS LISADOS DE LAS CELULAS HUESPED CON UNA MUESTRA, TRATADA PARA ELIMINAR LIGANTES ACOMPAÑANTES QUE PUEDAN INTERFERIR. EL TRATAMIENTO INCLUYE PONER EN CONTACTO LA MUESTRA CON LOS LISADOS DE CELULAS HUESPED NO TRANSFECTADAS Y DE CELULAS HUESPED TRANSFECTEDAS O TRANSFORMADAS CON EL MISMO VECTOR UTILIZADO PARA FABRICAR EL BANCO DE ADNC. TAMBIEN SON PARTE DE LA INVENCION ANTIGENOS Y ADNC IDENTIFICADOS UTILIZANDO LA METODOLOGIA.
ES96919266T 1995-06-07 1996-06-07 Procedimiento para la identificacion o el aislamiento de una molecula y moleculas identificadas de ese modo. Expired - Lifetime ES2180782T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/479,328 US5698396A (en) 1995-06-07 1995-06-07 Method for identifying auto-immunoreactive substances from a subject
US08/580,980 US6025191A (en) 1995-06-07 1996-01-03 Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof
US08/644,116 US6140464A (en) 1995-06-07 1996-05-10 Nonapeptides that bind a HLA-A2.1 molecule

Publications (1)

Publication Number Publication Date
ES2180782T3 true ES2180782T3 (es) 2003-02-16

Family

ID=23903564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96919266T Expired - Lifetime ES2180782T3 (es) 1995-06-07 1996-06-07 Procedimiento para la identificacion o el aislamiento de una molecula y moleculas identificadas de ese modo.

Country Status (11)

Country Link
US (2) US5698396A (es)
EP (1) EP0831879B1 (es)
JP (1) JP2002502354A (es)
CN (1) CN1136914C (es)
AT (2) ATE222116T1 (es)
CA (1) CA2223566C (es)
DE (2) DE69623014T2 (es)
DK (1) DK0831879T3 (es)
ES (1) ES2180782T3 (es)
PT (1) PT831879E (es)
WO (1) WO1996040209A1 (es)

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DE69623014D1 (de) 2002-09-19
AU6165296A (en) 1996-12-30
DE69627056D1 (de) 2003-04-30
US5798264A (en) 1998-08-25
AU704109B2 (en) 1999-04-15
CN1136914C (zh) 2004-02-04
DE69623014T2 (de) 2003-05-08
CN1190894A (zh) 1998-08-19
DK0831879T3 (da) 2002-12-16
PT831879E (pt) 2002-12-31
ATE222116T1 (de) 2002-08-15
EP0831879A1 (en) 1998-04-01
JP2002502354A (ja) 2002-01-22
EP0831879B1 (en) 2002-08-14
DE69627056T2 (de) 2004-01-29
WO1996040209A1 (en) 1996-12-19
CA2223566A1 (en) 1996-12-19
EP0831879A4 (en) 2000-01-26
US5698396A (en) 1997-12-16
ATE235248T1 (de) 2003-04-15
CA2223566C (en) 2002-09-03

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