ES2180405A1 - Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multica pa de tamaño micro y nanometrico. - Google Patents
Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multica pa de tamaño micro y nanometrico.Info
- Publication number
- ES2180405A1 ES2180405A1 ES200100231A ES200100231A ES2180405A1 ES 2180405 A1 ES2180405 A1 ES 2180405A1 ES 200100231 A ES200100231 A ES 200100231A ES 200100231 A ES200100231 A ES 200100231A ES 2180405 A1 ES2180405 A1 ES 2180405A1
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- micrometric
- nanometric
- component liquid
- liquid capillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B05B5/0255—Discharge apparatus, e.g. electrostatic spray guns spraying and depositing by electrostatic forces only
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Mycology (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- General Preparation And Processing Of Foods (AREA)
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
- Electrostatic Spraying Apparatus (AREA)
Abstract
Esta invención describe un dispositivo y procedimiento para generar chorros líquidos capilares compuestos multi-componentes de líquidos inmiscibles cuyos diámetros pueden variar desde unas decenas de nanómetros hasta cientos de micras, así como un aerosol relativamente monodisperso de gotas multicomponentes, cargadas eléctricamente, generadas mediante la rotura por inestabilidades capilares de los chorros compuestos. Dichos líquidos inmiscibles fluyen, a caudales apropiados, a través de agujas metálicas conectadas a fuentes de alto voltaje, de tal modo que una de las agujas contiene en su interior a las demás, pudiendo o no situarse concéntricamente entre sí. Las fuerzas eléctricas extrusionan los chorros hasta conseguir diámetros en un rango desde 100 micras hasta pocos nanómetros. El dispositivo y procedimiento objetos de la presente invención son aplicables a campos como Ciencia de Materiales y Tecnología de Alimentos, donde la generación y manipulación controlada de chorros estructurados de tamaño micro o nanométrico sea parte esencial del proceso.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100231A ES2180405B1 (es) | 2001-01-31 | 2001-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico. |
EP02709252A EP1355537A4 (en) | 2001-01-31 | 2002-01-30 | PRODUCTION OF CAPSULES AND PARTICLES FOR ENHANCING FOOD PRODUCTS |
AT02711878T ATE375207T1 (de) | 2001-01-31 | 2002-01-31 | Vorrichtung und verfahren zur herstellung von stationären mehrkomponentenflüssigkeits- kapillarströmen und kapseln in mikrometer- und nanometergrösse |
JP2002560778A JP2004531365A (ja) | 2001-01-31 | 2002-01-31 | 安定した複数成分の液体毛管ストリームを生成するデバイスおよび方法、ならびにマイクロメートルおよびナノメートルサイズのカプセル |
EP02711878A EP1364718B1 (en) | 2001-01-31 | 2002-01-31 | Device and method for producing stationary multi-component liquid capillary streams and micrometric and nanometric sized capsules |
ES02711878T ES2292731T3 (es) | 2001-01-31 | 2002-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multi-componentes estacionarios y capsulas de tamaño micro y nanometrico. |
PCT/ES2002/000047 WO2002060591A1 (es) | 2001-01-31 | 2002-01-31 | Disposito y procedimiento para producir chorros líquidos compuestos multicomponentes estacionarios y cápsulas de tamaños micro y nanométrico |
DE60222858T DE60222858T2 (de) | 2001-01-31 | 2002-01-31 | Vorrichtung und verfahren zur herstellung von stationären mehrkomponentenflüssigkeits-kapillarströmen und kapseln in mikrometergrösse und nanometergrösse |
CA002436524A CA2436524C (en) | 2001-01-31 | 2002-01-31 | Device and procedure to generate steady compound jets of immiscible liquids and micro/nanometric sized capsules |
US10/631,496 US20040069632A1 (en) | 2001-01-31 | 2003-07-31 | Device and procedure to generate steady compound jets of immiscible liquids and micro/nanometric sized capsules |
US13/406,180 USRE44508E1 (en) | 2001-01-31 | 2012-02-27 | Production of capsules and particles for improvement of food products |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100231A ES2180405B1 (es) | 2001-01-31 | 2001-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2180405A1 true ES2180405A1 (es) | 2003-02-01 |
ES2180405B1 ES2180405B1 (es) | 2004-01-16 |
Family
ID=8496581
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100231A Expired - Fee Related ES2180405B1 (es) | 2001-01-31 | 2001-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico. |
ES02711878T Expired - Lifetime ES2292731T3 (es) | 2001-01-31 | 2002-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multi-componentes estacionarios y capsulas de tamaño micro y nanometrico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02711878T Expired - Lifetime ES2292731T3 (es) | 2001-01-31 | 2002-01-31 | Dispositivo y procedimiento para producir chorros liquidos compuestos multi-componentes estacionarios y capsulas de tamaño micro y nanometrico. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20040069632A1 (es) |
EP (1) | EP1364718B1 (es) |
JP (1) | JP2004531365A (es) |
AT (1) | ATE375207T1 (es) |
CA (1) | CA2436524C (es) |
DE (1) | DE60222858T2 (es) |
ES (2) | ES2180405B1 (es) |
WO (1) | WO2002060591A1 (es) |
Cited By (5)
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---|---|---|---|---|
WO2005089042A2 (es) * | 2004-03-22 | 2005-09-29 | Universidad De Sevilla | Procedimiento para generar nanotubos y nanofibras compuestas a partir de chorros coaxiales |
WO2008116950A1 (es) * | 2007-03-27 | 2008-10-02 | Universidad De Sevilla | Método de generación de gotas y burbujas micro y submicrométricas mediante coflujos viscosos |
US9642694B2 (en) | 2006-01-31 | 2017-05-09 | Regents Of The University Of Minnesota | Device with electrospray coating to deliver active ingredients |
US10252289B2 (en) | 2006-01-31 | 2019-04-09 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
US10369579B1 (en) | 2018-09-04 | 2019-08-06 | Zyxogen, Llc | Multi-orifice nozzle for droplet atomization |
Families Citing this family (49)
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---|---|---|---|---|
US6433154B1 (en) * | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
AU6162501A (en) | 2000-05-16 | 2001-11-26 | Univ Minnesota | High mass throughput particle generation using multiple nozzle spraying |
US7247338B2 (en) * | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
JP2006523142A (ja) * | 2003-04-10 | 2006-10-12 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体種の形成および制御 |
WO2004103510A2 (en) | 2003-05-14 | 2004-12-02 | The Regents Of The University Of Colorado | Methods and apparatus using electrostatic atomization to form liquid vesicles |
WO2005021151A1 (en) | 2003-08-27 | 2005-03-10 | President And Fellows Of Harvard College | Electronic control of fluidic species |
JP2008506547A (ja) * | 2004-06-21 | 2008-03-06 | スリーエム イノベイティブ プロパティズ カンパニー | 半導体ナノ粒子のパターン形成および配列 |
US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
US7655470B2 (en) | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
US7258428B2 (en) * | 2004-09-30 | 2007-08-21 | Kimberly-Clark Worldwide, Inc. | Multiple head concentric encapsulation system |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7575707B2 (en) * | 2005-03-29 | 2009-08-18 | University Of Washington | Electrospinning of fine hollow fibers |
ES2282009B1 (es) * | 2005-05-12 | 2008-09-01 | Universidad De Sevilla | Dispositivo y procedimiento para la generacion de nanoemulsiones y microemulsiones simples y dobles mediante chorros coaxiales electrificados en medios liquidos dielectricos. |
KR101396737B1 (ko) | 2005-10-31 | 2014-05-26 | 더 트러스티즈 오브 프린스턴 유니버시티 | 전기수력학적 인쇄 및 제조 |
CA2636855C (en) | 2006-01-11 | 2016-09-27 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
CA2641117C (en) | 2006-01-31 | 2018-01-02 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
US20080187487A1 (en) * | 2006-05-03 | 2008-08-07 | Gustavo Larsen | Methods for producing multilayered particles, fibers and sprays and methods for administering the same |
EP2021113A2 (en) | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9040816B2 (en) | 2006-12-08 | 2015-05-26 | Nanocopoeia, Inc. | Methods and apparatus for forming photovoltaic cells using electrospray |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
GB0712862D0 (en) | 2007-07-03 | 2007-08-08 | Eastman Kodak Co | A method of continuous ink jet printing |
GB0712861D0 (en) | 2007-07-03 | 2007-08-08 | Eastman Kodak Co | Continuous ink jet printing of encapsulated droplets |
EP2020261A1 (en) | 2007-07-20 | 2009-02-04 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Multi component particle generating system |
ES2320618B1 (es) | 2007-11-23 | 2010-02-26 | Nanobiomatters S.L. | Procedimiento para la fabricacion de envases pasivos con propiedades mejoradas, activos, inteligentes y bioactivos mediante la incorporacion de polimeros obtenidos por tecnicas de electroestirado. |
EP2172264A1 (en) * | 2008-01-02 | 2010-04-07 | Ziel Biopharma Ltd | Process and apparatus for the production of microcapsules |
JP2010169701A (ja) * | 2008-05-13 | 2010-08-05 | Sony Corp | マイクロチップ |
JP4661942B2 (ja) * | 2008-05-13 | 2011-03-30 | ソニー株式会社 | マイクロチップとその流路構造 |
EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
EP2202336A1 (en) | 2008-12-12 | 2010-06-30 | Eads Construcciones Aeronauticas S.A. | Method for producing nanofibres of epoxy resin for composite laminates of aeronautical structures to improve their electromagnetic characteristics |
EP2213366A1 (en) | 2009-02-03 | 2010-08-04 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Multi component particle generating system |
EP3415235A1 (en) | 2009-03-23 | 2018-12-19 | Raindance Technologies Inc. | Manipulation of microfluidic droplets |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
GB201102148D0 (en) | 2011-02-08 | 2011-03-23 | Ucl Business Plc | Layered bodies, compositions containing them and processes for producing them |
EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
US9556470B2 (en) | 2011-06-02 | 2017-01-31 | Raindance Technologies, Inc. | Enzyme quantification |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
RU2688586C1 (ru) * | 2017-12-08 | 2019-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" | Устройство для коаксиального электрогидродинамического формования полимерных микро- или субмикронных структур |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH563807A5 (en) * | 1973-02-14 | 1975-07-15 | Battelle Memorial Institute | Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets |
WO1999030832A1 (en) * | 1997-12-17 | 1999-06-24 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
FR2776538A1 (fr) * | 1998-03-27 | 1999-10-01 | Centre Nat Rech Scient | Moyens de pulverisation electrohydrodynamique |
Family Cites Families (10)
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GB8504254D0 (en) * | 1985-02-19 | 1985-03-20 | Ici Plc | Spraying apparatus |
US4748043A (en) * | 1986-08-29 | 1988-05-31 | Minnesota Mining And Manufacturing Company | Electrospray coating process |
US5170053A (en) * | 1990-08-30 | 1992-12-08 | Finnigan Corporation | Electrospray ion source and interface apparatus and method |
US5122670A (en) * | 1991-05-17 | 1992-06-16 | Finnigan Corporation | Multilayer flow electrospray ion source using improved sheath liquid |
GB9406255D0 (en) * | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
US5873523A (en) * | 1996-02-29 | 1999-02-23 | Yale University | Electrospray employing corona-assisted cone-jet mode |
EP0912251B1 (en) * | 1996-07-23 | 2004-04-07 | Battelle Memorial Institute | A dispensing device and method for forming material |
US6297499B1 (en) * | 1997-07-17 | 2001-10-02 | John B Fenn | Method and apparatus for electrospray ionization |
US6245227B1 (en) * | 1998-09-17 | 2001-06-12 | Kionix, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
WO2003031931A2 (en) * | 2001-10-05 | 2003-04-17 | Yale University | Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures |
-
2001
- 2001-01-31 ES ES200100231A patent/ES2180405B1/es not_active Expired - Fee Related
-
2002
- 2002-01-31 CA CA002436524A patent/CA2436524C/en not_active Expired - Fee Related
- 2002-01-31 DE DE60222858T patent/DE60222858T2/de not_active Expired - Lifetime
- 2002-01-31 JP JP2002560778A patent/JP2004531365A/ja active Pending
- 2002-01-31 AT AT02711878T patent/ATE375207T1/de not_active IP Right Cessation
- 2002-01-31 EP EP02711878A patent/EP1364718B1/en not_active Expired - Lifetime
- 2002-01-31 WO PCT/ES2002/000047 patent/WO2002060591A1/es active IP Right Grant
- 2002-01-31 ES ES02711878T patent/ES2292731T3/es not_active Expired - Lifetime
-
2003
- 2003-07-31 US US10/631,496 patent/US20040069632A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH563807A5 (en) * | 1973-02-14 | 1975-07-15 | Battelle Memorial Institute | Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets |
WO1999030832A1 (en) * | 1997-12-17 | 1999-06-24 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
FR2776538A1 (fr) * | 1998-03-27 | 1999-10-01 | Centre Nat Rech Scient | Moyens de pulverisation electrohydrodynamique |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005089042A2 (es) * | 2004-03-22 | 2005-09-29 | Universidad De Sevilla | Procedimiento para generar nanotubos y nanofibras compuestas a partir de chorros coaxiales |
WO2005089042A3 (es) * | 2004-03-22 | 2005-10-27 | Univ Sevilla | Procedimiento para generar nanotubos y nanofibras compuestas a partir de chorros coaxiales |
ES2245874A1 (es) * | 2004-03-22 | 2006-01-16 | Universidad De Sevilla | Procedimiento para generar nanotubos y nanofibras compuestas a partir de chorros coaxiales. |
ES2245874B1 (es) * | 2004-03-22 | 2007-08-01 | Universidad De Sevilla | Procedimiento para generar nanotubos y nanofibras compuestas a partir de chorros coaxiales. |
US9642694B2 (en) | 2006-01-31 | 2017-05-09 | Regents Of The University Of Minnesota | Device with electrospray coating to deliver active ingredients |
US10252289B2 (en) | 2006-01-31 | 2019-04-09 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
WO2008116950A1 (es) * | 2007-03-27 | 2008-10-02 | Universidad De Sevilla | Método de generación de gotas y burbujas micro y submicrométricas mediante coflujos viscosos |
US10369579B1 (en) | 2018-09-04 | 2019-08-06 | Zyxogen, Llc | Multi-orifice nozzle for droplet atomization |
Also Published As
Publication number | Publication date |
---|---|
CA2436524A1 (en) | 2002-08-08 |
ATE375207T1 (de) | 2007-10-15 |
WO2002060591A1 (es) | 2002-08-08 |
US20040069632A1 (en) | 2004-04-15 |
CA2436524C (en) | 2009-10-27 |
DE60222858T2 (de) | 2008-07-24 |
ES2180405B1 (es) | 2004-01-16 |
DE60222858D1 (de) | 2007-11-22 |
EP1364718B1 (en) | 2007-10-10 |
ES2292731T3 (es) | 2008-03-16 |
JP2004531365A (ja) | 2004-10-14 |
EP1364718A1 (en) | 2003-11-26 |
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