WO2003019154A3 - Verfahren zur bestimmung der aerosol-partikelgrössenverteilung und vorrichtung zur durchführung eines derartigen verfahrens - Google Patents

Verfahren zur bestimmung der aerosol-partikelgrössenverteilung und vorrichtung zur durchführung eines derartigen verfahrens Download PDF

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Publication number
WO2003019154A3
WO2003019154A3 PCT/EP2002/007673 EP0207673W WO03019154A3 WO 2003019154 A3 WO2003019154 A3 WO 2003019154A3 EP 0207673 W EP0207673 W EP 0207673W WO 03019154 A3 WO03019154 A3 WO 03019154A3
Authority
WO
WIPO (PCT)
Prior art keywords
carrying
particle size
type
size distribution
aerosol particle
Prior art date
Application number
PCT/EP2002/007673
Other languages
English (en)
French (fr)
Other versions
WO2003019154A2 (de
Inventor
Jochen Ziegler
Herbert Wachtel
Original Assignee
Boehringer Ingelheim Int
Jochen Ziegler
Herbert Wachtel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Jochen Ziegler, Herbert Wachtel filed Critical Boehringer Ingelheim Int
Priority to EP02767194A priority Critical patent/EP1412723A2/de
Publication of WO2003019154A2 publication Critical patent/WO2003019154A2/de
Publication of WO2003019154A3 publication Critical patent/WO2003019154A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0255—Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/02—Equipment for testing the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0255—Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections
    • G01N2015/0261—Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections using impactors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicinal Preparation (AREA)
  • Powder Metallurgy (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Mit der vorliegenden Erfindung wird zum ersten Mal für die Zwecke der Pharmaindustrie ein Verfahren vorgestellt, welches die Teilchengrösse von vemebelten Aerosolen gleichzeitig, bzw. einander nachgeschaltet, mittels der Laserbeugungsmethode (Laserdiffraction) und der in der Fachwelt anerkannten Kaskadenimpaktor-Methode misst. Dadurch wird es möglich, die Zuverlässigkeit der Ergebnisse des erfindungsgemassen Laserbeugungsverfahren auf die des Kaskadenimpaktors anzugleichen, und so ein Verfahren zu schaffen, welches die Vorteile des schnellen Laserbeugungsverfahrens mit der Genauigkeit der ansonsten zeitintensiven Kaskadenimpaktor-Methode verbindet. Neben dem Verfahren werden Vorrichtungen zur Durchführung des Verfahrens offenbart.
PCT/EP2002/007673 2001-07-27 2002-07-10 Verfahren zur bestimmung der aerosol-partikelgrössenverteilung und vorrichtung zur durchführung eines derartigen verfahrens WO2003019154A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02767194A EP1412723A2 (de) 2001-07-27 2002-07-10 Verfahren zur bestimmung der aerosol-partikelgrössenverteilung und vorrichtung zur durchführung eines derartigen verfahrens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10136554A DE10136554A1 (de) 2001-07-27 2001-07-27 Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung eines derartigen Verfahrens
DE10136554.3 2001-07-27

Publications (2)

Publication Number Publication Date
WO2003019154A2 WO2003019154A2 (de) 2003-03-06
WO2003019154A3 true WO2003019154A3 (de) 2003-11-27

Family

ID=7693255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007673 WO2003019154A2 (de) 2001-07-27 2002-07-10 Verfahren zur bestimmung der aerosol-partikelgrössenverteilung und vorrichtung zur durchführung eines derartigen verfahrens

Country Status (6)

Country Link
US (3) US20030034032A1 (de)
EP (1) EP1412723A2 (de)
AR (1) AR034905A1 (de)
DE (1) DE10136554A1 (de)
UY (1) UY27393A1 (de)
WO (1) WO2003019154A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10136555A1 (de) * 2001-07-27 2003-02-13 Boehringer Ingelheim Int Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren
GB2455571A (en) * 2007-12-15 2009-06-17 Westech Instr Holdings Plc Inter-connecting nozzle impactor component arrangement
WO2011050436A1 (en) * 2009-10-28 2011-05-05 Apotex Technologies Inc. Particle size distribution determination apparatus and method
EP2381237B1 (de) 2010-04-23 2019-06-19 Boehringer Ingelheim microParts GmbH Verfahren und Vorrichtung zur Bestimmung der Arbeitsweise einer Dosiervorrichtung
DE102013103152B3 (de) * 2013-03-27 2013-12-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Bestimmung der Aerosolabgabe und/oder der Aerosolabgaberate einer Aerosolerzeugereinrichtung
US11085861B1 (en) * 2014-03-03 2021-08-10 Msp Corporation Apparatus for real-time size-distributed measurement of aerosol mass concentration
CA2997649A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim Microparts Gmbh Fluid atomizer test system and test method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3205764A (en) * 1961-09-01 1965-09-14 Bausch & Lomb Absorption cell with removable windows
US3583817A (en) * 1970-02-11 1971-06-08 Technicon Instr Colorimeter including a flow cell having end windows
US5438408A (en) * 1991-06-07 1995-08-01 Sympatec Gmbh System-Partikel-Technik Measuring device and method for the determination of particle size distributions by scattered light measurements
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
GB2351155A (en) * 1999-06-11 2000-12-20 Msp Corp Cascade impactor for classifying particles
US6431014B1 (en) * 1999-07-23 2002-08-13 Msp Corporation High accuracy aerosol impactor and monitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5895922A (en) * 1996-03-19 1999-04-20 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Fluorescent biological particle detection system
US6653150B1 (en) * 1996-11-13 2003-11-25 The Administrators Of The Tulane Educational Fund Automatic mixing and dilution methods for online characterization of equilibrium and non-equilibrium properties of solutions containing polymers and/or colloids
US5932818A (en) * 1997-09-30 1999-08-03 The United States Of America As Represented By The United States Department Of Energy Near real time vapor detection and enhancement using aerosol adsorption
US6386015B1 (en) * 1999-08-30 2002-05-14 Sandia Corporation Apparatus to collect, classify, concentrate, and characterize gas-borne particles
DE10136555A1 (de) 2001-07-27 2003-02-13 Boehringer Ingelheim Int Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3205764A (en) * 1961-09-01 1965-09-14 Bausch & Lomb Absorption cell with removable windows
US3583817A (en) * 1970-02-11 1971-06-08 Technicon Instr Colorimeter including a flow cell having end windows
US5438408A (en) * 1991-06-07 1995-08-01 Sympatec Gmbh System-Partikel-Technik Measuring device and method for the determination of particle size distributions by scattered light measurements
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
GB2351155A (en) * 1999-06-11 2000-12-20 Msp Corp Cascade impactor for classifying particles
US6431014B1 (en) * 1999-07-23 2002-08-13 Msp Corporation High accuracy aerosol impactor and monitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOLOVICH M: "MEASUREMENT OF PARTICLE SIZE CHARACTERISTICS OF METERED DOSE INHALER (MDI) AEROSOLS", JOURNAL OF AEROSOL MEDICINE, MARY ANN LIEBERT, INC., NEW YORK, US, vol. 4, no. 3, 1991, pages 251 - 263, XP009002203, ISSN: 0894-2684 *
UMHAUER H: "ERMITTLUNG VON PARTIKELGROESSENVERTEILUNGEN IN AEROSOLSTROEMUNGEN HOHER KONZENTRATION MIT HILFE EINER STREULICHTMESSEINRICHTUNG", VDI BERICHTE, DUESSELDORF, DE, no. 232, 1975, pages 101 - 105, XP001090810, ISSN: 0083-5560 *

Also Published As

Publication number Publication date
AR034905A1 (es) 2004-03-24
US20050238588A1 (en) 2005-10-27
DE10136554A1 (de) 2003-02-13
US20060246010A1 (en) 2006-11-02
US7616310B2 (en) 2009-11-10
UY27393A1 (es) 2003-02-28
EP1412723A2 (de) 2004-04-28
WO2003019154A2 (de) 2003-03-06
US20030034032A1 (en) 2003-02-20

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