ES2178701T3 - Procedimiento para preparar derivados del acido azabiciclo naftriridina carboxilico que comprenden un dipeptido. - Google Patents

Procedimiento para preparar derivados del acido azabiciclo naftriridina carboxilico que comprenden un dipeptido.

Info

Publication number
ES2178701T3
ES2178701T3 ES96904996T ES96904996T ES2178701T3 ES 2178701 T3 ES2178701 T3 ES 2178701T3 ES 96904996 T ES96904996 T ES 96904996T ES 96904996 T ES96904996 T ES 96904996T ES 2178701 T3 ES2178701 T3 ES 2178701T3
Authority
ES
Spain
Prior art keywords
dipeptide
naftriridine
azabiciclo
carboxyl
understanding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96904996T
Other languages
English (en)
Inventor
Tamim F Braish
Michael J Castaldi
Harry A Watson Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2178701T3 publication Critical patent/ES2178701T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REVELA UN NUEVO PROCESO PARA PREPARAR UN PROFARMACO ACIDO, VIZ., ACIDO 7 AMINO) L (2, DINA BLE DE ADICION ACIDA, QUE IMPLICA (1) TRATAR UN C1 ESTER DEL ACIDO N ARNINO -3 AZABICICLO[ 3,1,0] HEX ,4 DIFLUOROFENIL) ILOXICARBONIL, C1 UN ACIDO FUERTEMENTE PROTICO PARA ELIMINAR SELECTIVAMENTE EL GRUPO N-PROTECTOR; (2) CONDENSANDO A CONTINUACION EL COMPUESTO RESULTANTE ESTER AMINO LIBRE CON UN COMPUESTO DIPEPTIDO PROTEGIDO L-ALANIL EL PREVIAMENTE DEFINIDO, EN PRESENCIA DE UN AGENTE DESHIDRATADOR ESTANDAR PARA FORMAR EL CORRESPONDIENTE PROFARMACO ESTER COMPUESTO N-PROTEGIDO COMO EL PRODUCTO DESEADO DE CONDENSACION; Y (3) HIDROLIZANDO A CONTINUACION EL PROFARMACO ESTER COMPUESTO N-PROTEGIDO EN PRESENCIA DE UN ACIDO FUERTE FARMACEUTICAMENTE ACEPTABLE PARA CONVERTIR DICHO PROFARMACO ESTER N-PROTEGIDO AL DESEADO PRODUCTO FINAL PROFARMACO ACIDO NAFTIRIDINONA L-ALA L-ALA EN FORMA DE LA CORRESPONDIENTE SAL FARMACEUTICAMENTE ACEPTABLE DE ADICION ACIDA, INDICADA MAS ARRIBA. EL ULTIMO PRODUCTO FINAL PROFARMACO ACIDO ES ESPECIALMENTE UTIL EN SU FORMA DE LA CORRESPONDIENTE SAL ACIDA DE ADICION METANOSULFONICA, QUE SIRVE COMO ACOMPAÑANTE PROFARMACO HIDROSOLUBLE AL CONOCIDO AGENTE ANTIBACTERIANO, VIZ., ACIDO 7 [(L AL}, 5 AL}, 6 AL}) AMINO (2,4 INA - 3 - CARBOXILICO.
ES96904996T 1995-06-15 1996-03-27 Procedimiento para preparar derivados del acido azabiciclo naftriridina carboxilico que comprenden un dipeptido. Expired - Lifetime ES2178701T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49082795A 1995-06-15 1995-06-15

Publications (1)

Publication Number Publication Date
ES2178701T3 true ES2178701T3 (es) 2003-01-01

Family

ID=23949631

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96904996T Expired - Lifetime ES2178701T3 (es) 1995-06-15 1996-03-27 Procedimiento para preparar derivados del acido azabiciclo naftriridina carboxilico que comprenden un dipeptido.

Country Status (10)

Country Link
US (1) US5939550A (es)
EP (1) EP0833837B1 (es)
JP (1) JP3029293B2 (es)
AT (1) ATE221544T1 (es)
CA (1) CA2224616C (es)
DE (1) DE69622715T2 (es)
DK (1) DK0833837T3 (es)
ES (1) ES2178701T3 (es)
PT (1) PT833837E (es)
WO (1) WO1997000268A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000106A (es) * 1997-08-01 1999-01-08 Pfizer Prod Inc Composiciones parenterales de alatroflaxacino
US7019142B2 (en) * 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB0310593D0 (en) * 2003-05-08 2003-06-11 Leuven K U Res & Dev Peptidic prodrugs
BRPI0708606A2 (pt) * 2006-03-07 2011-06-14 Wockhardt Ltd prà-fÁrmacos de Ácido benzoquinolizina-2-carboxÍlico
GB202104712D0 (en) 2021-04-01 2021-05-19 Riedewald Frank Process and system for the recycling of composite materials, mixed and pure waste plastics.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
WO1991002526A1 (en) * 1989-08-16 1991-03-07 Pfizer Inc. Azabicyclo quinolone carboxylic acids
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids

Also Published As

Publication number Publication date
EP0833837B1 (en) 2002-07-31
CA2224616C (en) 2000-05-02
EP0833837A1 (en) 1998-04-08
JPH10511983A (ja) 1998-11-17
DK0833837T3 (da) 2002-09-02
JP3029293B2 (ja) 2000-04-04
DE69622715T2 (de) 2002-11-14
DE69622715D1 (de) 2002-09-05
CA2224616A1 (en) 1997-01-03
WO1997000268A1 (en) 1997-01-03
ATE221544T1 (de) 2002-08-15
US5939550A (en) 1999-08-17
PT833837E (pt) 2002-11-29

Similar Documents

Publication Publication Date Title
WO1999019306A3 (en) 2,3-benzodiazepin-2-one derivatives, their preparation and their use as inhibitors of protein tyrosine kinases
AU1120599A (en) New heterocyclic compounds and their use in medicine, process for their reparation and pharmaceutical compositions containing them
NZ330816A (en) Quinazoline derivatives as antitumor agents
IT1206078B (it) Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
HU9403112D0 (en) Process for producing quinolin-4-amine-and 1h-imidazo[4,5-c]quinolin-4-amine derivatives as intermediates
AP9600817A0 (en) Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt.
ZA96101B (en) Imidazol[4,5-c]quinoline amines
RS20060484A (en) Process for preparing sildenafil
NO974967D0 (no) Fremgangsmåte for fremstilling av rene enantiomere av tropasyre-estere
UA19782A (uk) Спосіб одержаhhя біциклічhих складhих ефірів або їх фармацевтичhо прийhятhих солей
AR002753A1 (es) El acido 7-([1 alfa,5 alfa,6 alfa]-6-amino-3-azabiciclo[3.1.0]hex-3-il)-6- fluor-1-(2,4-difluorofenil)-1,4-didhiro-4-oxo-1,8-naftiridin-3-carboxilico, saldel acido metanosulfonico, un procedimiento para prepararla y una composicion farmaceutica con actividad bacteriana que la comprende
ES2178701T3 (es) Procedimiento para preparar derivados del acido azabiciclo naftriridina carboxilico que comprenden un dipeptido.
NO983864D0 (no) Morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksyltypen
NO20003784L (no) FremgangsmÕte for fremstilling av enansiomert rene cykloalkanoindolkarboksylsyre og azaindolkarboksylsyrer og pyrimido 1,2a indolkarboksylsyrer og derivater derav
PL328123A1 (en) Derivatives of banzo[c]quinolysine and method of obtaining them
MY130757A (en) Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
AU587680B2 (en) 2-benzimidazolylalkylthio (or-sulfinyl or -sulfonyl) derivatives, their preparations and their application as medicinal products
FI894506A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivisia pyrido/1,2-a/indolijohdannaisia
MX9710063A (es) Procedimiento para preparar derivados de acido azabiciclonaftiridincarboxilico que comprenden un dipeptido.
AU5500896A (en) Substituted phenylamidines, pharmaceutical compositions containing these compounds and processes for preparing them
UA18634A1 (uk) Спосіб одердаhhя похідhих l-алаhіл-l-пропіліhа або їх фармацевтичhо прийhятhих солей
CA2245758A1 (en) Benzo[c]quinolizine derivatives, their preparation and use as 5.alpha.-reductases inhibitors