ES2178641T3 - Factores neurotroficos que tienen especificidades modificadas de union a receptores. - Google Patents
Factores neurotroficos que tienen especificidades modificadas de union a receptores.Info
- Publication number
- ES2178641T3 ES2178641T3 ES93905743T ES93905743T ES2178641T3 ES 2178641 T3 ES2178641 T3 ES 2178641T3 ES 93905743 T ES93905743 T ES 93905743T ES 93905743 T ES93905743 T ES 93905743T ES 2178641 T3 ES2178641 T3 ES 2178641T3
- Authority
- ES
- Spain
- Prior art keywords
- neurotrophic factors
- receptors
- union
- link
- specificities
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010025020 Nerve Growth Factor Proteins 0.000 title abstract 5
- 102000007072 Nerve Growth Factors Human genes 0.000 title abstract 4
- 239000003900 neurotrophic factor Substances 0.000 title abstract 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Prostheses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PRESENTA UN METODO PARA ALTERAR LAS PROPIEDADES DE ENLACE AL RECEPTOR Y LA ESTABILIDAD DE FACTORES NEUROTROFICOS. SE DESCRIBEN LOS FACTORES NEUROTROFICOS MUTANTES CON ESPECIFICIDADES DE ENLACE AL RECEPTOR ALTERADAS. ENTRE LOS ASPECTOS ESPECIFICOS CABE INCLUIR LOS FACTORES NEUROTROFICOS QUE SE ENLAZAN A RECEPTORES TRK PERO QUE NO SE ENLAZAN AL RECEPTOR NGF DE POCA AFINIDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/847,369 US5349055A (en) | 1992-03-06 | 1992-03-06 | Nerve growth factor having altered receptor binding specificities |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2178641T3 true ES2178641T3 (es) | 2003-01-01 |
Family
ID=25300448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93905743T Expired - Lifetime ES2178641T3 (es) | 1992-03-06 | 1993-03-08 | Factores neurotroficos que tienen especificidades modificadas de union a receptores. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5349055A (es) |
EP (1) | EP0632817B1 (es) |
JP (1) | JP3694523B2 (es) |
CN (1) | CN1041831C (es) |
AT (1) | ATE219500T1 (es) |
AU (1) | AU674305B2 (es) |
CA (1) | CA2131552A1 (es) |
DE (1) | DE69332047T2 (es) |
DK (1) | DK0632817T3 (es) |
ES (1) | ES2178641T3 (es) |
IL (1) | IL104958A0 (es) |
WO (1) | WO1993018066A1 (es) |
ZA (1) | ZA931597B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011258A1 (en) * | 1993-10-18 | 1995-04-27 | Regeneron Pharmaceuticals, Inc. | Growth factor heterodimers |
US5753225A (en) * | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
US7144983B1 (en) | 1997-02-03 | 2006-12-05 | Genentech, Inc. | Pantropic neurotrophic factors |
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
US5958875A (en) * | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
GB9608335D0 (en) * | 1996-04-23 | 1996-06-26 | Univ Kingston | Method of enhancing ngf-mediated neurite growth with low molecular weight analoues of p.75 ngfr 367-379 |
SK1499A3 (en) * | 1996-07-19 | 1999-08-06 | Amgen Inc | Analogs of cationic proteins |
IL129851A0 (en) * | 1996-11-15 | 2000-02-29 | Genentech Inc | Purification of neurotrophins |
CN101260398B (zh) | 2007-03-07 | 2013-06-05 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子基因定位改造动物及其制备方法和应用 |
CN102898514B (zh) * | 2011-07-28 | 2015-04-29 | 中国人民解放军军事医学科学院生物工程研究所 | 重组人神经生长因子缺失突变体及其制备方法和用途 |
CN103880944B (zh) * | 2014-01-20 | 2017-03-29 | 未名生物医药有限公司 | 一种野生型rhNGF的制备方法 |
ES2966133T3 (es) * | 2016-03-18 | 2024-04-18 | Staidson Beijing Biopharmaceuticals Co Ltd | Proteína de fusión que comprende el factor de crecimiento nervioso y método de preparación y uso de la misma |
-
1992
- 1992-03-06 US US07/847,369 patent/US5349055A/en not_active Expired - Lifetime
-
1993
- 1993-03-05 IL IL104958A patent/IL104958A0/xx unknown
- 1993-03-05 ZA ZA931597A patent/ZA931597B/xx unknown
- 1993-03-06 CN CN93104050A patent/CN1041831C/zh not_active Expired - Fee Related
- 1993-03-08 JP JP51559493A patent/JP3694523B2/ja not_active Expired - Fee Related
- 1993-03-08 AU AU36550/93A patent/AU674305B2/en not_active Ceased
- 1993-03-08 EP EP93905743A patent/EP0632817B1/en not_active Expired - Lifetime
- 1993-03-08 DK DK93905743T patent/DK0632817T3/da active
- 1993-03-08 CA CA002131552A patent/CA2131552A1/en not_active Abandoned
- 1993-03-08 DE DE69332047T patent/DE69332047T2/de not_active Expired - Fee Related
- 1993-03-08 ES ES93905743T patent/ES2178641T3/es not_active Expired - Lifetime
- 1993-03-08 WO PCT/SE1993/000201 patent/WO1993018066A1/en active IP Right Grant
- 1993-03-08 AT AT93905743T patent/ATE219500T1/de not_active IP Right Cessation
-
1994
- 1994-09-02 US US08/300,044 patent/US5705617A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1079992A (zh) | 1993-12-29 |
EP0632817B1 (en) | 2002-06-19 |
ATE219500T1 (de) | 2002-07-15 |
DE69332047T2 (de) | 2003-01-23 |
EP0632817A1 (en) | 1995-01-11 |
AU3655093A (en) | 1993-10-05 |
CN1041831C (zh) | 1999-01-27 |
CA2131552A1 (en) | 1993-09-16 |
WO1993018066A1 (en) | 1993-09-16 |
US5705617A (en) | 1998-01-06 |
JP3694523B2 (ja) | 2005-09-14 |
US5349055A (en) | 1994-09-20 |
DE69332047D1 (de) | 2002-07-25 |
JPH08511675A (ja) | 1996-12-10 |
AU674305B2 (en) | 1996-12-19 |
DK0632817T3 (da) | 2002-12-23 |
ZA931597B (en) | 1993-09-27 |
IL104958A0 (en) | 1993-07-08 |
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