ES2176452T3 - Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion. - Google Patents
Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion.Info
- Publication number
- ES2176452T3 ES2176452T3 ES96912051T ES96912051T ES2176452T3 ES 2176452 T3 ES2176452 T3 ES 2176452T3 ES 96912051 T ES96912051 T ES 96912051T ES 96912051 T ES96912051 T ES 96912051T ES 2176452 T3 ES2176452 T3 ES 2176452T3
- Authority
- ES
- Spain
- Prior art keywords
- almidon
- dicarboxylate
- acetate
- composition
- controlled release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000013270 controlled release Methods 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- IPBVNPXQWQGGJP-UHFFFAOYSA-N phenyl acetate Chemical compound CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003890 succinate salts Chemical group 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/02—Esters
- C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION ESTA RELACIONADA CON UNA COMPOSICION PARA LA LIBERACION CONTROLADA DEPENDIENTE DEL PH O REGULADA POR EL PH DE PRINCIPIOS ACTIVOS, EN ESPECIAL FARMACOS. LA COMPOSICION CONSISTE EN UNA MEZCLA COMPACTABLE DEL PRINCIPIO ACTIVO Y MOLECULAS DE ALMIDON SUSTITUIDO CON RESTOS ACETATO Y DICARBOXILATO. EL DICARBOXILATO DE ACIDO PREFERIDO ES EL SUCCINATO. EL GRADO DE SUSTITUCION MEDIO DEL RESTO ACETATO ES DE AL MENOS 1, Y DE 0,2 - 1,2 PARA EL RESTO DICARBOXILATO. LAS MOLECULAS DE ALMIDON PUEDEN LLEVAR LOS RESTOS ACETATO Y DICARBOXILATO UNIDOS AL MISMO ESQUELETO MOLECULAR DEL ALMIDON, O UNIDOS A OTROS ESQUELETOS MOLECULARES DEL ALMIDON. LA PRESENTE INVENCION TAMBIEN DESCRIBE PROCEDIMIENTOS PARA PREPARAR DICHOS ACETATO DICARBOXILATO DE ALMIDON MEDIANTE LA TRANSESTERIFICACION O LA MEZCLA DE ACETATOS DE ALMIDON Y DICARBOXILATOS DE ALMIDON, RESPECTIVAMENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/498,341 US5656292A (en) | 1994-06-07 | 1995-07-05 | Composition for pH dependent controlled release of active ingredients and methods for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2176452T3 true ES2176452T3 (es) | 2002-12-01 |
Family
ID=23980671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96912051T Expired - Lifetime ES2176452T3 (es) | 1995-07-05 | 1996-04-29 | Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5656292A (es) |
| EP (1) | EP0850049B1 (es) |
| JP (1) | JPH11508581A (es) |
| AT (1) | ATE219663T1 (es) |
| AU (1) | AU703085B2 (es) |
| CA (1) | CA2222372A1 (es) |
| DE (1) | DE69622038T2 (es) |
| DK (1) | DK0850049T3 (es) |
| ES (1) | ES2176452T3 (es) |
| HU (1) | HUP9900304A3 (es) |
| PT (1) | PT850049E (es) |
| WO (1) | WO1997002018A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9724186D0 (en) | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
| WO2003048786A2 (en) * | 2001-11-30 | 2003-06-12 | Bristol-Myers Squibb Company | Pipette configurations and arrays thereof for measuring cellular electrical properties |
| US20040062778A1 (en) * | 2002-09-26 | 2004-04-01 | Adi Shefer | Surface dissolution and/or bulk erosion controlled release compositions and devices |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| CA2547843A1 (en) * | 2004-02-09 | 2005-08-18 | Transfert Plus Societe En Commandite | Composition comprising polymeric material and uses thereof |
| US20040224019A1 (en) * | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
| FR2951177B1 (fr) * | 2009-10-09 | 2012-12-21 | Roquette Freres | Procede de preparation de derives acetyles de matiere amylacee |
| EP2386297A1 (en) * | 2010-04-28 | 2011-11-16 | Roquette Frères | Indigestible polymer: starch acetate -based film coatings for colon targeting |
| TWI434706B (zh) | 2011-12-15 | 2014-04-21 | Ind Tech Res Inst | 腸溶及腸酵素可分解材料及其製備方法 |
| JP6529967B2 (ja) | 2013-10-10 | 2019-06-12 | ソルベイ アセトウ ゲーエムベーハー | アシル化方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011392A (en) * | 1975-09-02 | 1977-03-08 | The Sherwin-Williams Company | Mixed starch esters and the use thereof |
| CH678920A5 (es) * | 1989-11-14 | 1991-11-29 | Gergely Gerhard | |
| JPH0749378B2 (ja) * | 1990-12-27 | 1995-05-31 | ナショナル スターチ アンド ケミカル インベストメント ホールディング コーポレイション | タブレット賦形剤としての酵素的に枝切りされたデンプン |
| DE4123001A1 (de) * | 1991-07-11 | 1993-01-14 | Laevosan Gmbh & Co Kg | Pharmazeutische zusammensetzung fuer die peritonealdialyse |
| WO1993020140A1 (en) * | 1992-03-31 | 1993-10-14 | Parke-Davis & Company | Biodegradable polymer compositions |
| US5321132A (en) * | 1992-12-23 | 1994-06-14 | National Starch And Chemical Investment Holding Corporation | Method of preparing intermediate DS starch esters in aqueous solution |
| EP0638609B1 (de) * | 1993-08-04 | 2001-03-21 | Buna Sow Leuna Olefinverbund GmbH | Bioabbaubare, thermoplastisch verformbare Materialien aus Stärkeestern |
| FI942686A0 (fi) * | 1994-06-07 | 1994-06-07 | Alko Ab Oy | Komposition innehaollande staerkelseacetat med varierande egenskaper, foerfarande foer dess framstaellning och anvaendning |
-
1995
- 1995-07-05 US US08/498,341 patent/US5656292A/en not_active Expired - Fee Related
-
1996
- 1996-04-29 HU HU9900304A patent/HUP9900304A3/hu unknown
- 1996-04-29 WO PCT/FI1996/000233 patent/WO1997002018A1/en active IP Right Grant
- 1996-04-29 CA CA002222372A patent/CA2222372A1/en not_active Abandoned
- 1996-04-29 JP JP9504847A patent/JPH11508581A/ja not_active Ceased
- 1996-04-29 AT AT96912051T patent/ATE219663T1/de not_active IP Right Cessation
- 1996-04-29 AU AU55032/96A patent/AU703085B2/en not_active Ceased
- 1996-04-29 DK DK96912051T patent/DK0850049T3/da active
- 1996-04-29 DE DE69622038T patent/DE69622038T2/de not_active Expired - Fee Related
- 1996-04-29 EP EP96912051A patent/EP0850049B1/en not_active Expired - Lifetime
- 1996-04-29 PT PT96912051T patent/PT850049E/pt unknown
- 1996-04-29 ES ES96912051T patent/ES2176452T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69622038T2 (de) | 2003-02-13 |
| US5656292A (en) | 1997-08-12 |
| PT850049E (pt) | 2002-10-31 |
| EP0850049B1 (en) | 2002-06-26 |
| DE69622038D1 (de) | 2002-08-01 |
| WO1997002018A1 (en) | 1997-01-23 |
| EP0850049A1 (en) | 1998-07-01 |
| ATE219663T1 (de) | 2002-07-15 |
| AU703085B2 (en) | 1999-03-18 |
| JPH11508581A (ja) | 1999-07-27 |
| HUP9900304A3 (en) | 2001-04-28 |
| AU5503296A (en) | 1997-02-05 |
| CA2222372A1 (en) | 1997-01-23 |
| DK0850049T3 (da) | 2002-10-21 |
| HUP9900304A2 (hu) | 1999-06-28 |
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