ES2174887T3 - Procedimiento para la produccion de oxiindoles. - Google Patents
Procedimiento para la produccion de oxiindoles.Info
- Publication number
- ES2174887T3 ES2174887T3 ES95117344T ES95117344T ES2174887T3 ES 2174887 T3 ES2174887 T3 ES 2174887T3 ES 95117344 T ES95117344 T ES 95117344T ES 95117344 T ES95117344 T ES 95117344T ES 2174887 T3 ES2174887 T3 ES 2174887T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- salt
- reaction
- oxindols
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE PRESENTA UN METODO PARA LA PRODUCCION DE OXINDOLAS, QUE SE COMPONE DE LA FASES DE REACCIONAR UN ACIDO 2HALOGENOFENILIACETICO O SU SAL CON AMONIACO EN PRESENCIA DE UN CATALIZADOR DE UNA SAL DE COBRE, Y CALENTAR UNA MEZCLA DEL ACIDO 2-AMINOFENILIACETICO O SU SAL Y OXINDOLAS EN PRESENCIA DE UN CATALIZADOR ACIDO, SOMETER EL ACIDO 2-AMINOFENILACETICO O SU SAL A UNA REACCION DE CIERRE DE NUCLEOS. SEGUN ESTE METODO, ACIDOS 2-HALOGENOFENILACETICOS DE LOS QUE SE PUEDE DISPONER FACILMENTE SE UTILIZAN COMO MATERIA PRIMA INICIADORA PARA PRODUCIR DE FORMA INDUSTRIAL OXINDOLAS DE ELEVADA PUREZA EN ELEVADA CANTIDAD, EN UN SOLO RECIPIENTE SIN NECESIDAD DE LLEVAR A CABO PROCESOS COMPLICADOS. ADEMAS, PUESTO QUE LA AMINACION SE LLEVA A CABO A UNA TEMPERATURA MUY INFERIOR A LA UTILIZADA HABITUALMENTE, LA REDUCCION DEL PH DEL LIQUIDO OBTENIDO PUEDE SUPRIMIRSE. POR LO TANTO, LAS RESTRICCIONES EN LAS ESPECIFICACIONES DEL APARATO DE REACCION, COMO LA PREVENCION DE LA CORROSION Y LA RESISTENCIA A LA PRESION, PUEDEN MITIGARSE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29365494 | 1994-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174887T3 true ES2174887T3 (es) | 2002-11-16 |
Family
ID=17797521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95117344T Expired - Lifetime ES2174887T3 (es) | 1994-11-04 | 1995-11-03 | Procedimiento para la produccion de oxiindoles. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5679799A (es) |
EP (1) | EP0710648B1 (es) |
KR (1) | KR100391586B1 (es) |
DE (1) | DE69526173T2 (es) |
ES (1) | ES2174887T3 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6098945A (en) | 1998-03-19 | 2000-08-08 | Hubbell Incorporated | Mounting bracket and supporting brace |
CN102267934B (zh) * | 2010-06-02 | 2013-04-17 | 金凯美(大连)医药科技有限公司 | 一种6-甲氧羰基吲哚酮的制备方法 |
CN104744338A (zh) * | 2015-03-31 | 2015-07-01 | 天津维智精细化工有限公司 | 一种6-氯羟吲哚的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6228133A (ja) * | 1985-07-30 | 1987-02-06 | Seiatsu:Kk | ボルト・ナツト自動締結装置 |
US5166401A (en) * | 1991-06-25 | 1992-11-24 | Pfizer Inc | Intermediates for 5-fluoro-6-chlorooxindole |
AU658060B2 (en) * | 1992-05-13 | 1995-03-30 | Lonza Ltd | Process for the preparation of 5-chloroxindole |
JP3455315B2 (ja) * | 1994-12-15 | 2003-10-14 | 株式会社テイエルブイ | 蒸気加熱装置 |
-
1995
- 1995-11-03 KR KR1019950039557A patent/KR100391586B1/ko not_active IP Right Cessation
- 1995-11-03 DE DE69526173T patent/DE69526173T2/de not_active Expired - Lifetime
- 1995-11-03 EP EP95117344A patent/EP0710648B1/en not_active Expired - Lifetime
- 1995-11-03 US US08/553,022 patent/US5679799A/en not_active Expired - Lifetime
- 1995-11-03 ES ES95117344T patent/ES2174887T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR960017639A (ko) | 1996-06-17 |
DE69526173T2 (de) | 2002-09-26 |
EP0710648B1 (en) | 2002-04-03 |
US5679799A (en) | 1997-10-21 |
EP0710648A1 (en) | 1996-05-08 |
KR100391586B1 (ko) | 2004-02-11 |
DE69526173D1 (de) | 2002-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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