ES2174600T3 - Microcapsula humectante compuesta de un medicamento encapsulado por etilcelulosa. - Google Patents

Microcapsula humectante compuesta de un medicamento encapsulado por etilcelulosa.

Info

Publication number
ES2174600T3
ES2174600T3 ES99916911T ES99916911T ES2174600T3 ES 2174600 T3 ES2174600 T3 ES 2174600T3 ES 99916911 T ES99916911 T ES 99916911T ES 99916911 T ES99916911 T ES 99916911T ES 2174600 T3 ES2174600 T3 ES 2174600T3
Authority
ES
Spain
Prior art keywords
microcapsules
solvent
etilcellulose
humecting
microcapsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99916911T
Other languages
English (en)
Inventor
Massimo Maria Calanchi
Luigi Bruschi Stefano De
Leonardo Gentilini
Luigi Giovanni Mapelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Eurand International SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA filed Critical Eurand International SpA
Application granted granted Critical
Publication of ES2174600T3 publication Critical patent/ES2174600T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Microcápsula humectable compuesta de un medicamento encapsulado por etilcelulosa, con uno o más tensioactivos y opcionalmente un ligante depositados en dicha etilcelulosa, en la cual: la cantidad de tensioactivo, expresada como % w/w de los núcleos hidrofóbicos varía entre un 0,010% y un 2,000 %, y en el que dicho tensioactivo y el ligante opcional han sido depositados mediante el revestimiento por pulverización de las microcápsulas, en un lecho fluidizado, con una solución que contiene una concentración de tensioactivo junto con el ligante optativo de entre un 0,1 y un 10,0% por peso, en un disolvente en el que dicha etilcelulosa que conforma la membrana exterior de la microcápsula es insoluble y un proceso de secado, aplicándose dicha etilcelulosa en dicho medicamento mediante la separación de fases.
ES99916911T 1998-04-09 1999-04-09 Microcapsula humectante compuesta de un medicamento encapsulado por etilcelulosa. Expired - Lifetime ES2174600T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98106521 1998-04-09

Publications (1)

Publication Number Publication Date
ES2174600T3 true ES2174600T3 (es) 2002-11-01

Family

ID=8231743

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99916911T Expired - Lifetime ES2174600T3 (es) 1998-04-09 1999-04-09 Microcapsula humectante compuesta de un medicamento encapsulado por etilcelulosa.

Country Status (15)

Country Link
US (1) US6509034B1 (es)
EP (1) EP1069891B1 (es)
JP (1) JP4555980B2 (es)
KR (1) KR20010042547A (es)
AT (1) ATE213935T1 (es)
AU (1) AU742009B2 (es)
BR (1) BR9909434A (es)
CA (1) CA2328080C (es)
DE (1) DE69900977T2 (es)
DK (1) DK1069891T3 (es)
ES (1) ES2174600T3 (es)
NZ (1) NZ507951A (es)
PT (1) PT1069891E (es)
WO (1) WO1999052510A1 (es)
ZA (1) ZA200005875B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100537952B1 (ko) * 2001-04-13 2005-12-21 주식회사 태평양 중공형 소수성 고분자 마이크로캡슐 및 이의 제조방법, 및이 마이크로캡슐을 함유하는 화장료 조성물
KR100526998B1 (ko) * 2002-01-21 2005-11-08 임대우 홍삼 및 인삼 엑기스 분말을 함유한 마이크로캡슐
KR100466719B1 (ko) * 2002-02-04 2005-01-17 주식회사 일화 홍삼 또는 인삼정분을 함유하는 구형의 미세캡슐 제조방법
DE10227224B4 (de) * 2002-06-18 2005-11-24 Daimlerchrysler Ag Verwendung eines Granulates zum Herstellen eines Gegenstandes mit einem 3D-Binderdruck-Verfahren
BR0303954A (pt) * 2002-10-10 2004-09-08 Int Flavors & Fragrances Inc Composição, fragrância, método para divisão de uma quantidade efetiva olfativa de fragrância em um produto sem enxague e produto sem enxague
KR100963091B1 (ko) * 2003-08-25 2010-06-14 (주)아모레퍼시픽 자외선 흡수제를 함유하는 고분자 캡슐 및 그 제조 방법,및 이를 함유하는 화장료 조성물
US20050113282A1 (en) * 2003-11-20 2005-05-26 Parekh Prabodh P. Melamine-formaldehyde microcapsule slurries for fabric article freshening
US7105064B2 (en) * 2003-11-20 2006-09-12 International Flavors & Fragrances Inc. Particulate fragrance deposition on surfaces and malodour elimination from surfaces
US20050112152A1 (en) * 2003-11-20 2005-05-26 Popplewell Lewis M. Encapsulated materials
US7611630B2 (en) * 2004-03-30 2009-11-03 Bend Research, Inc. Method and device for evaluation of pharmaceutical compositions
US20050226900A1 (en) * 2004-04-13 2005-10-13 Winton Brooks Clint D Skin and hair treatment composition and process for using same resulting in controllably-releasable fragrance and/or malodour counteractant evolution
US20050227907A1 (en) * 2004-04-13 2005-10-13 Kaiping Lee Stable fragrance microcapsule suspension and process for using same
US7594594B2 (en) * 2004-11-17 2009-09-29 International Flavors & Fragrances Inc. Multi-compartment storage and delivery containers and delivery system for microencapsulated fragrances
US20070207174A1 (en) * 2005-05-06 2007-09-06 Pluyter Johan G L Encapsulated fragrance materials and methods for making same
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
DE102005062270A1 (de) * 2005-12-24 2007-06-28 Bayer Technology Services Gmbh Geschmacksmaskierung von Pulvern
US20100062073A1 (en) * 2006-11-29 2010-03-11 Ronald Arthur Beyerinck Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
WO2008135828A2 (en) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
EP2162120B1 (en) * 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
WO2009010842A2 (en) * 2007-07-13 2009-01-22 Pfizer Products Inc. Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
EP2231169B1 (en) * 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
KR100888380B1 (ko) * 2007-12-11 2009-03-13 한국생산기술연구원 계면 활성제를 이용한 유동성 입자의 제조방법 및 이로부터제조되는 유동성 입자
EP2440210A4 (en) * 2009-06-12 2014-01-29 Meritage Pharma Inc METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES
ES2668203T3 (es) 2009-12-02 2018-05-17 Adare Pharmaceuticals S.R.L. Microcápsulas de fexofenadina y composiciones que las contienen
AR105111A1 (es) * 2015-06-26 2017-09-06 Advanced Bionutrition Corp Composición para administración de agentes activos a un animal
KR101885365B1 (ko) * 2017-03-31 2018-08-06 서울대학교산학협력단 비용매 유도 상분리법을 이용한 초소수성직물 제조방법 및 이로부터 제조된 초소수성직물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3415758A (en) 1960-03-09 1968-12-10 Ncr Co Process of forming minute capsules en masse
US3748277A (en) 1965-10-14 1973-07-24 Ncr Co Process of forming minute capsules
JPS5524118A (en) * 1978-08-08 1980-02-21 Tetsuo Kato Microcapsulated preparation for mitomycinc
US4259315A (en) 1980-06-13 1981-03-31 A. H. Robins Company, Inc. Controlled release potassium dosage form
JPS57209223A (en) * 1981-06-19 1982-12-22 Tanabe Seiyaku Co Ltd Microcapsule for intracranial anti hypotension and its production
AU5356986A (en) * 1984-12-14 1986-07-22 Gergely, Gerhard Teilchen aus euner hydrophoben oder schwerloslichen substanz und verfahren zur ihrer hydrophilisierung
HU201869B (en) * 1988-12-30 1991-01-28 Egyt Gyogyszervegyeszeti Gyar Process for producing microcapsules of quick dissolving active component
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
US5192522A (en) * 1991-11-26 1993-03-09 Uop Zeolite LZ-277 and process for preparing same
US5972383A (en) * 1994-03-02 1999-10-26 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os

Also Published As

Publication number Publication date
CA2328080C (en) 2008-08-12
JP4555980B2 (ja) 2010-10-06
US6509034B1 (en) 2003-01-21
JP2002511402A (ja) 2002-04-16
AU3522799A (en) 1999-11-01
DE69900977D1 (de) 2002-04-11
PT1069891E (pt) 2002-08-30
KR20010042547A (ko) 2001-05-25
BR9909434A (pt) 2000-12-12
DE69900977T2 (de) 2002-11-14
NZ507951A (en) 2002-12-20
EP1069891B1 (en) 2002-03-06
EP1069891A1 (en) 2001-01-24
AU742009B2 (en) 2001-12-13
WO1999052510A1 (en) 1999-10-21
ZA200005875B (en) 2002-03-20
ATE213935T1 (de) 2002-03-15
DK1069891T3 (da) 2002-06-24
CA2328080A1 (en) 1999-10-21

Similar Documents

Publication Publication Date Title
ES2174600T3 (es) Microcapsula humectante compuesta de un medicamento encapsulado por etilcelulosa.
DE60332958D1 (de) Mikrokapseln mit mehrfachen hüllen und verfahren zu deren herstellung
WO1999047252A3 (de) Herstellung von nano- und mikrokapseln durch schichtweise polyelektrolyt-selbstassemblierung
DE60325709D1 (de) Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
EP1533364A3 (en) Encapsulated materials
DE60106666D1 (de) Kontinuierlicher Prozess für die Herstellung von Mikrokapseln mit verzögerten Freisetzung von wasserlöslichen Peptiden
DE50209688D1 (de) Mononuklear gefüllte mikrokapseln
IT1149471B (it) Procedimento di preparazione di microcapsule
AR048457A2 (es) Proceso para formar una composicion farmaceutica de topiramato
NO175286C (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat som omfatter dobbeltveggede mikrokapsler
ATE217804T1 (de) Verfahren zum einkapseln von aromastoffen und riechstoffen durch kontrollierte wassereinbringung in microkapseln
DE69602602D1 (de) Herstellung von bremsklötzen
ATE405629T1 (de) Wasserlöslich umhüllte bleichmittelteilchen
NO20015816L (no) Indanylsubstituerte benzenkarbonamider, fremgangsmåter for fremstilling derav, anvendelse derav som medikament ogfarmasöytiske preparater inneholdende disse
ATE113473T1 (de) Eine ölartige flüssigkeit enthaltende mikrokapseln.
NO20002443D0 (no) FremgangsmÕte for fremstilling av derivater av taxoidklassen
NO870890L (no) FremgangsmŸte for fremstilling av aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3-(2h)-on-1,1-dioxyd-derivater.
IT1317750B1 (it) Miscele di coloranti e loro impiego per la tintura o per la stampa dimateriali fibrosi contenenti acetato di cellulosa.
DK1028714T3 (da) Vitaminsammensætning
ES507779A0 (es) Procedimiento para producir una suspension de capsulas microscopicas conteniendo tinte, para la fabricacion de materia- les registradores.
NO993912D0 (no) Fremgangsmåte for fremstilling av eprosartan
NO993913D0 (no) Fremgangsmåte for fremstilling av eprosartan
DE69800901D1 (de) Verfahren zur Herstellung von Trans 1,4-Cyclohexan-bis-(methylamin)
FR2597478B1 (fr) Benzimidazoles et imidazopyridines sulfonamides, leur preparation et leur application en tant que medicaments.
NO994083D0 (no) Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 1069891

Country of ref document: ES