ES2173185T3 - Empleo de derivados de tetrahidropteridina como inhibidores de la no-sintasa. - Google Patents
Empleo de derivados de tetrahidropteridina como inhibidores de la no-sintasa.Info
- Publication number
- ES2173185T3 ES2173185T3 ES95921745T ES95921745T ES2173185T3 ES 2173185 T3 ES2173185 T3 ES 2173185T3 ES 95921745 T ES95921745 T ES 95921745T ES 95921745 T ES95921745 T ES 95921745T ES 2173185 T3 ES2173185 T3 ES 2173185T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- employment
- synthase
- radical
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE LA UTILIZACION DE DERIVADOS DE PTERIDINA DE FORMULA GENERAL (I), ENLA QUE X ES O O NH Y R{SUP,4} ES P. E. HIDROGENO, FENILO O EL RADICAL R{SUP,4A}-CH{SUB,2}- Y R{SUP,4A} ES P. E. HIDROGENO, MERCAPTOALQUILO DE C{SUB,1}C{SUB,4}, EL RADICAL -NR{SUP,11}R{SUP,12} O EL RADICAL OR{SUP,13}, Y R{SUP,1}, R{SUP,2}, R{SUP,3}, R{SUP,5}, R{SUP,6}, R{SUP,7}, R{SUP,11}, R{SUP,12} Y R{SUP,13} TIENEN LOS SIGNIFICADOS DADOS EN LA REIVINDICACION 1; SON INHIBIDORES DE LA SINTETASA DEL MONOXIDO DE NITROGENO, PAA EL TRATAMIENTO DE ENFERMEDADES, QUE ESTAN CAUSADAS POR UN ELEVADO NIVEL DE MONOXIDO DE NITROGENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4418097A DE4418097A1 (de) | 1994-05-24 | 1994-05-24 | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173185T3 true ES2173185T3 (es) | 2002-10-16 |
Family
ID=6518842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95921745T Expired - Lifetime ES2173185T3 (es) | 1994-05-24 | 1995-05-11 | Empleo de derivados de tetrahidropteridina como inhibidores de la no-sintasa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6858612B1 (es) |
EP (1) | EP0760818B1 (es) |
JP (1) | JP4287506B2 (es) |
AT (1) | ATE214068T1 (es) |
DE (2) | DE4418097A1 (es) |
ES (1) | ES2173185T3 (es) |
PT (1) | PT760818E (es) |
WO (1) | WO1995032203A2 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
DE4418097A1 (de) | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
WO1996033175A1 (en) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
ATE252385T1 (de) † | 1996-08-30 | 2003-11-15 | Daiichi Suntory Pharma Co Ltd | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind |
JP4842415B2 (ja) * | 1996-08-30 | 2011-12-21 | 第一三共株式会社 | Nosの機能低下が寄与する疾患の予防または治療剤 |
US5922713A (en) * | 1997-06-26 | 1999-07-13 | Werner; Ernst | Inhibition of nitric oxide synthase |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
EP0906913B1 (de) * | 1997-10-06 | 2001-05-23 | Ernst Werner | Pteridinderivate als NO Synthase-Hemmer |
US6489323B1 (en) | 1998-06-10 | 2002-12-03 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
DE59805976D1 (de) * | 1998-07-10 | 2002-11-21 | Ernst Werner | Herstellung eines die Transplantatabstossung unterdrückenden Mittels |
US7276506B2 (en) | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
JP2002533464A (ja) * | 1998-12-28 | 2002-10-08 | カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント | プテリジン誘導体の免疫抑制作用 |
EP1199078A1 (en) * | 1999-06-09 | 2002-04-24 | Ono Pharmaceutical Co., Ltd. | Analgesics |
DE19944767A1 (de) | 1999-09-17 | 2001-03-29 | Vasopharm Biotech Gmbh & Co Kg | N-substituierte 4-Aminopteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
JP4836388B2 (ja) * | 2002-03-22 | 2011-12-14 | 第一三共株式会社 | eNOS発現に起因する疾患の予防または治療薬 |
DE10260263A1 (de) * | 2002-12-20 | 2004-07-15 | Biocrates Life Sciences Gmbh | Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen |
WO2005037286A1 (en) * | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
AU2004285300A1 (en) * | 2003-10-31 | 2005-05-12 | Altana Pharma Ag | Use of BH4 for the treatment of respiratory diseases |
EP1699793A1 (en) * | 2003-12-30 | 2006-09-13 | Vasopharm Biotech GmbH | 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing them and their use for the treatment of diseases which are caused by an increased nitric oxide level |
US20060194800A1 (en) * | 2005-01-07 | 2006-08-31 | University Of Strathclyde | Pteridine derivatives as nitric oxide synthase activators |
US20090075992A1 (en) * | 2005-01-07 | 2009-03-19 | University Of Strathclyde | Pteridine Derivatives as Nitric Oxide Synthase Activators |
CN101171005A (zh) * | 2005-05-11 | 2008-04-30 | 尼科梅德有限责任公司 | Pde4抑制剂罗氟司特与四氢生物蝶呤衍生物的组合 |
WO2008009079A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
JP2010515747A (ja) * | 2007-01-12 | 2010-05-13 | ビオマリン プハルマセウトイカル インコーポレイテッド | テトラヒドロビオプテリンプロドラッグ |
JP5330401B2 (ja) | 2007-11-08 | 2013-10-30 | アリメラ・サイエンシーズ,インコーポレーテッド | 眼のための埋め込み装置、及びその装置を備えるキット |
AU2008347005B2 (en) * | 2008-01-03 | 2013-10-03 | Biomarin Pharmaceutical Inc. | Pterin analog for treating BH4 responsive condition |
KR101756050B1 (ko) | 2015-03-04 | 2017-07-07 | 길리애드 사이언시즈, 인코포레이티드 | 톨 유사 수용체 조정제 화합물 |
US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
CN114984019B (zh) * | 2022-07-15 | 2023-08-22 | 山东中医药大学 | 一种铁死亡抑制剂化合物及在肝损伤修复领域的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8318833D0 (en) | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
ZA836957B (en) | 1982-09-20 | 1985-04-24 | Wellcome Found | Neurologically active chemical compounds |
US5196533A (en) | 1983-04-11 | 1993-03-23 | South Alabama Medical Science Foundation, Usa | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines |
EP0318926B1 (en) | 1987-11-30 | 1995-05-03 | Kabushiki Kaisha Vitamin Kenkyusyo | Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives |
JPH0656669A (ja) * | 1992-06-11 | 1994-03-01 | Asahi Breweries Ltd | 活性酸素消去作用を持つプテリン誘導体製剤 |
WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
US5502050A (en) | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
DE4418097A1 (de) | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
ES2177654T3 (es) | 1994-08-05 | 2002-12-16 | Suntory Ltd | Remedio contra la degeneracion espinocerebelosa. |
-
1994
- 1994-05-24 DE DE4418097A patent/DE4418097A1/de not_active Withdrawn
-
1995
- 1995-05-11 JP JP53002295A patent/JP4287506B2/ja not_active Expired - Lifetime
- 1995-05-11 EP EP95921745A patent/EP0760818B1/de not_active Expired - Lifetime
- 1995-05-11 DE DE59510094T patent/DE59510094D1/de not_active Expired - Lifetime
- 1995-05-11 PT PT95921745T patent/PT760818E/pt unknown
- 1995-05-11 AT AT95921745T patent/ATE214068T1/de active
- 1995-05-11 WO PCT/EP1995/001785 patent/WO1995032203A2/de active IP Right Grant
- 1995-05-11 ES ES95921745T patent/ES2173185T3/es not_active Expired - Lifetime
-
1999
- 1999-07-20 US US09/357,212 patent/US6858612B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE59510094D1 (de) | 2002-04-11 |
JPH10500417A (ja) | 1998-01-13 |
WO1995032203A2 (de) | 1995-11-30 |
EP0760818B1 (de) | 2002-03-06 |
DE4418097A1 (de) | 1995-11-30 |
ATE214068T1 (de) | 2002-03-15 |
PT760818E (pt) | 2002-08-30 |
JP4287506B2 (ja) | 2009-07-01 |
WO1995032203A3 (de) | 1995-12-28 |
EP0760818A1 (de) | 1997-03-12 |
US6858612B1 (en) | 2005-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2173185T3 (es) | Empleo de derivados de tetrahidropteridina como inhibidores de la no-sintasa. | |
MX9206008A (es) | Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida. | |
ES2180633T3 (es) | Uso de derivados de pteridina como inhibidores de la no-sintasa. | |
TR199901905T2 (xx) | 2-(P�rin-9-il)-tetrahidrofuran-3,4-diol t�revleri. | |
ATE216360T1 (de) | Sulfinsäurederivate und deren herstellung und verwendung | |
TR200402157T2 (tr) | Heteroaril süksinamidler ve metalloproteinaz inhibitörü olarak kullanımları | |
MY120994A (en) | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives | |
TR200100411T2 (tr) | 2-(Pürin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
NZ505452A (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives and pharmaceuticals thereof, useful for inhibiting leukocyte function and treating inflammatory conditions | |
DE59903921D1 (de) | Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen | |
DE69912606D1 (de) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate | |
EA199900448A1 (ru) | Производные 6-фенилпиридил-2-амина, полезные в качестве ингибиторов nos | |
DE69723863D1 (de) | Chinoline und deren therapeutische verwendung | |
ATE220679T1 (de) | Porphyrine und ihre verwendung als photosensitizer | |
BR9712140A (pt) | Agentes e processos para inibir a produção de citoquina, a adesão de cédulas e a produção de tnf - alfa e uso de um composto. | |
ES2135769T3 (es) | Derivados de isotiourea como inhibidores de no-sintasa. | |
NO994330D0 (no) | Metode for behandling av en tumor | |
AP2000001761A0 (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. | |
TR199701013T1 (xx) | Nitrik oksit synthas'�n�n inhibit�rleri olarak mercapto ve seleno t�revleri. | |
ATE157660T1 (de) | Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen | |
ES8604853A1 (es) | Un metodo para la preparacion de un derivado de acetileno. | |
MX9701764A (es) | Derivados de imidoacidos. | |
BR9916154A (pt) | 1 3, 5 triazinas substituìdas | |
DE59509727D1 (de) | Uracilderivate | |
NO20010626D0 (no) | N-substituerte azabicykloheptanderivater, deres fremstilling og anvendelse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 760818 Country of ref document: ES |