ES2172882T3 - Procedimientos y productos intermedios para la preparacion de derivados indazol sustituidos. - Google Patents
Procedimientos y productos intermedios para la preparacion de derivados indazol sustituidos.Info
- Publication number
- ES2172882T3 ES2172882T3 ES98913997T ES98913997T ES2172882T3 ES 2172882 T3 ES2172882 T3 ES 2172882T3 ES 98913997 T ES98913997 T ES 98913997T ES 98913997 T ES98913997 T ES 98913997T ES 2172882 T3 ES2172882 T3 ES 2172882T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- compound
- preparation
- indazol
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de fórmula o una sal farmaceúticamente aceptable de dicho compuesto, en la que: R es alquilo (C1-C10) o -(CH2)n(fenilo), en el que n es un número entero que va de 0 a 2, y en el que dichos grupos R están opcionalmente sustituidos con 1 a 3 sustituyentes independientemente seleccionados entre cloro, fluoro, alcoxi (C1-C6) y trifluorometilo; R1 es alquilo (C1-C10), alquenilo (C2-C6) o fenilo, en el que dichos grupos R1 están opcionalmente sustituidos con 1 a 3 sustituyentes independientemente seleccionados entre trifluorometilo, cloro y fluoro; R2 es H, -C(Y)R4, -C(O)OR4, -C(Y)NR5R4, - C(Y)NR5OR4, o CN; R3 es H, alquilo (C1-C6) opcionalmente sustituido con hidroxi, -OR4, -CN, -C(Y)R4, -C(O)OR4, -C(Y)NR4R5, - C(Y)NR4OR5, -NR4OR5 o NR4R5; o R2 y R3 se unen formando =O; cada R4 y R5 es independientemente H o alquilo (C1- C6); y cada Y es independientemente O o S; el cual comprende el tratamiento de un compuesto de fórmula o una sal de dicho compuesto, en la que R, R1, R2 y R3 son lo definido anteriormente, con un ácido de Lewis y cianuro de tri-(aril C6-C10)sililo o cianuro de tri- (alquil C1-C6)sililo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4685897P | 1997-05-08 | 1997-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172882T3 true ES2172882T3 (es) | 2002-10-01 |
Family
ID=21945777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98913997T Expired - Lifetime ES2172882T3 (es) | 1997-05-08 | 1998-04-28 | Procedimientos y productos intermedios para la preparacion de derivados indazol sustituidos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6011159A (es) |
EP (1) | EP0983249B1 (es) |
JP (1) | JP3399546B2 (es) |
AR (2) | AR015648A1 (es) |
AT (1) | ATE214373T1 (es) |
AU (1) | AU6849798A (es) |
DE (1) | DE69804212T2 (es) |
DK (1) | DK0983249T3 (es) |
ES (1) | ES2172882T3 (es) |
PT (1) | PT983249E (es) |
WO (1) | WO1998050367A1 (es) |
ZA (1) | ZA983842B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
YU25400A (sh) * | 1997-11-04 | 2003-07-07 | Pfizer Products Inc. | Terapeutski aktivna jedinjenja sa indazolom |
JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
DE102004005172A1 (de) * | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
CN101528698A (zh) | 2006-05-09 | 2009-09-09 | 阿斯利康公司 | (2s)-(4e)-n-甲基-5-[3-(5-异丙氧基吡啶)基]-4-戊烯-2-胺的盐形式 |
TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ292991A (en) * | 1994-10-20 | 1999-02-25 | Pfizer | Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them |
AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
-
1998
- 1998-04-28 EP EP98913997A patent/EP0983249B1/en not_active Expired - Lifetime
- 1998-04-28 US US09/308,954 patent/US6011159A/en not_active Expired - Fee Related
- 1998-04-28 WO PCT/IB1998/000647 patent/WO1998050367A1/en active IP Right Grant
- 1998-04-28 DK DK98913997T patent/DK0983249T3/da active
- 1998-04-28 PT PT98913997T patent/PT983249E/pt unknown
- 1998-04-28 AU AU68497/98A patent/AU6849798A/en not_active Abandoned
- 1998-04-28 JP JP54786398A patent/JP3399546B2/ja not_active Expired - Fee Related
- 1998-04-28 AT AT98913997T patent/ATE214373T1/de not_active IP Right Cessation
- 1998-04-28 DE DE69804212T patent/DE69804212T2/de not_active Expired - Fee Related
- 1998-04-28 ES ES98913997T patent/ES2172882T3/es not_active Expired - Lifetime
- 1998-05-07 ZA ZA9803842A patent/ZA983842B/xx unknown
- 1998-05-07 AR ARP980102142A patent/AR015648A1/es unknown
-
1999
- 1999-08-03 AR ARP990103861A patent/AR016737A1/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69804212T2 (de) | 2002-07-25 |
ATE214373T1 (de) | 2002-03-15 |
JP2000513019A (ja) | 2000-10-03 |
EP0983249B1 (en) | 2002-03-13 |
EP0983249A1 (en) | 2000-03-08 |
DE69804212D1 (de) | 2002-04-18 |
US6011159A (en) | 2000-01-04 |
JP3399546B2 (ja) | 2003-04-21 |
ZA983842B (en) | 1999-11-08 |
DK0983249T3 (da) | 2002-07-08 |
AR016737A1 (es) | 2001-07-25 |
PT983249E (pt) | 2002-08-30 |
AU6849798A (en) | 1998-11-27 |
WO1998050367A1 (en) | 1998-11-12 |
AR015648A1 (es) | 2001-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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