ES2172535T3 - Antagonistas de los receptores de la endotelina. - Google Patents
Antagonistas de los receptores de la endotelina.Info
- Publication number
- ES2172535T3 ES2172535T3 ES94915903T ES94915903T ES2172535T3 ES 2172535 T3 ES2172535 T3 ES 2172535T3 ES 94915903 T ES94915903 T ES 94915903T ES 94915903 T ES94915903 T ES 94915903T ES 2172535 T3 ES2172535 T3 ES 2172535T3
- Authority
- ES
- Spain
- Prior art keywords
- antagonists
- endotheline
- receptors
- endotheline receptors
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS INDANOS Y NUEVOS DERIVADOS DEL INDENO QUE SON ANTAGONISTAS DEL RECEPTOR DE LA ENDOTELINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6681893A | 1993-04-27 | 1993-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172535T3 true ES2172535T3 (es) | 2002-10-01 |
Family
ID=22071916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94915903T Expired - Lifetime ES2172535T3 (es) | 1993-04-27 | 1994-04-26 | Antagonistas de los receptores de la endotelina. |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0699069B9 (es) |
JP (1) | JP3346571B2 (es) |
KR (1) | KR100331667B1 (es) |
CN (1) | CN1129428C (es) |
AP (1) | AP573A (es) |
AT (1) | ATE213156T1 (es) |
AU (1) | AU682038B2 (es) |
BR (1) | BR9406572A (es) |
CA (1) | CA2160914A1 (es) |
CZ (1) | CZ291189B6 (es) |
DE (1) | DE69429861T2 (es) |
DK (1) | DK0699069T3 (es) |
DZ (1) | DZ1773A1 (es) |
ES (1) | ES2172535T3 (es) |
FI (1) | FI955103A0 (es) |
HK (1) | HK1012252A1 (es) |
HU (2) | HUT73763A (es) |
IL (1) | IL109443A0 (es) |
MA (1) | MA23172A1 (es) |
NO (1) | NO313754B1 (es) |
NZ (1) | NZ266314A (es) |
PL (1) | PL175392B1 (es) |
PT (1) | PT699069E (es) |
RU (1) | RU2130920C1 (es) |
SG (1) | SG49667A1 (es) |
SI (1) | SI9400195B (es) |
SK (1) | SK130595A3 (es) |
TW (1) | TW330204B (es) |
WO (1) | WO1994025013A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6075037A (en) * | 1994-06-09 | 2000-06-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
JPH10501812A (ja) * | 1994-06-20 | 1998-02-17 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗薬 |
WO1996020193A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | Compounds and methods |
US6080862A (en) * | 1995-11-08 | 2000-06-27 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
US6162932A (en) * | 1995-11-08 | 2000-12-19 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
ZA969363B (en) | 1995-11-08 | 1997-11-18 | Smithkline Beecham Corp | An improved process for preparing aromatic ring-fused cyclopentane derivatives. |
AU7677496A (en) * | 1995-11-08 | 1997-05-29 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5932553A (en) | 1996-07-18 | 1999-08-03 | The Regents Of The University Of California | Illudin analogs useful as antitumor agents |
US5723632A (en) * | 1996-08-08 | 1998-03-03 | Mgi Pharma, Inc. | Total synthesis of antitumor acylfulvenes |
WO1998008836A1 (fr) | 1996-08-27 | 1998-03-05 | Shionogi & Co., Ltd. | Derives de chromene-3-carboxylate |
US5929106A (en) * | 1997-10-27 | 1999-07-27 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US7141603B2 (en) | 1999-02-19 | 2006-11-28 | The Regents Of The University California | Antitumor agents |
US6025328A (en) | 1998-02-20 | 2000-02-15 | The Regents Of The University Of California | Antitumor agents |
US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
CA2327928A1 (en) * | 1998-04-09 | 1999-10-21 | Merck & Co., Inc. | Phosphate-mediated cyclization |
AR022228A1 (es) | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
EP1977741A3 (en) | 2004-03-17 | 2009-10-14 | Novartis AG | Use of renin inhibitors in therapy |
US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
MX2007007482A (es) | 2004-12-21 | 2007-07-20 | Hoffmann La Roche | Derivados de tetralina e indano y usos de los mismos como antagonistas de 5-ht. |
US20100040666A1 (en) * | 2005-06-24 | 2010-02-18 | Hiroshi Azuma | Method for Control of Drug Elution Rate and Composition for Coating of Drug-Eluting Stent |
JP4989648B2 (ja) | 2005-08-03 | 2012-08-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗癌剤として有用なイルジン類似体 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2125980C1 (ru) * | 1991-11-05 | 1999-02-10 | Смитклайн Бичам Корпорейшн | Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов |
-
1994
- 1994-04-26 HU HU9501931A patent/HUT73763A/hu unknown
- 1994-04-26 AU AU67750/94A patent/AU682038B2/en not_active Ceased
- 1994-04-26 EP EP94915903A patent/EP0699069B9/en not_active Expired - Lifetime
- 1994-04-26 DK DK94915903T patent/DK0699069T3/da active
- 1994-04-26 CZ CZ19952835A patent/CZ291189B6/cs not_active IP Right Cessation
- 1994-04-26 WO PCT/US1994/004603 patent/WO1994025013A1/en active IP Right Grant
- 1994-04-26 IL IL10944394A patent/IL109443A0/xx unknown
- 1994-04-26 NZ NZ266314A patent/NZ266314A/xx not_active IP Right Cessation
- 1994-04-26 MA MA23478A patent/MA23172A1/fr unknown
- 1994-04-26 SG SG1996003492A patent/SG49667A1/en unknown
- 1994-04-26 BR BR9406572A patent/BR9406572A/pt not_active Application Discontinuation
- 1994-04-26 AP APAP/P/1994/000636A patent/AP573A/en active
- 1994-04-26 SI SI9400195A patent/SI9400195B/sl not_active IP Right Cessation
- 1994-04-26 HU HU9503067A patent/HU9503067D0/hu unknown
- 1994-04-26 JP JP52449694A patent/JP3346571B2/ja not_active Expired - Fee Related
- 1994-04-26 CN CN94192388A patent/CN1129428C/zh not_active Expired - Fee Related
- 1994-04-26 PT PT94915903T patent/PT699069E/pt unknown
- 1994-04-26 DZ DZ940038A patent/DZ1773A1/fr active
- 1994-04-26 KR KR1019950704682A patent/KR100331667B1/ko not_active IP Right Cessation
- 1994-04-26 DE DE69429861T patent/DE69429861T2/de not_active Expired - Fee Related
- 1994-04-26 AT AT94915903T patent/ATE213156T1/de not_active IP Right Cessation
- 1994-04-26 PL PL94311272A patent/PL175392B1/pl unknown
- 1994-04-26 CA CA002160914A patent/CA2160914A1/en not_active Abandoned
- 1994-04-26 SK SK1305-95A patent/SK130595A3/sk unknown
- 1994-04-26 RU RU95122388A patent/RU2130920C1/ru active
- 1994-04-26 ES ES94915903T patent/ES2172535T3/es not_active Expired - Lifetime
- 1994-07-01 TW TW083106015A patent/TW330204B/zh not_active IP Right Cessation
-
1995
- 1995-10-26 NO NO19954291A patent/NO313754B1/no unknown
- 1995-10-26 FI FI955103A patent/FI955103A0/fi not_active Application Discontinuation
-
1998
- 1998-12-15 HK HK98113510A patent/HK1012252A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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