ES2172222T3 - Derivados de tetrahidropiridopirimidona 3-substituidos, su obtencion y empleo. - Google Patents
Derivados de tetrahidropiridopirimidona 3-substituidos, su obtencion y empleo.Info
- Publication number
- ES2172222T3 ES2172222T3 ES98951491T ES98951491T ES2172222T3 ES 2172222 T3 ES2172222 T3 ES 2172222T3 ES 98951491 T ES98951491 T ES 98951491T ES 98951491 T ES98951491 T ES 98951491T ES 2172222 T3 ES2172222 T3 ES 2172222T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- branched
- substituted
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Structure And Mechanism Of Cameras (AREA)
Abstract
Derivados de tetrahidropiridopirimidona 3-substituidos de la fórmula I (I), donde uno de ambos restos X, Y representa CH2, y el otro representa NR 1 , R 1 representa hidrógeno, alquilo con 1 a 6 átomos de carbono ramifiado o no ramificado, CO-alquilo con 1a 4 átomos de carbono, CO2tBu, CO-arilo, y un resto fenilalquilo con 1 a 4 átomos de carbono, que puede estar substituido por su parte en el anillo aromático por F, Cl, Br, I, alquilo con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono, trifluormetilo, hidroxi, amino, ciano o nitro, A representa alquileno con 1 a 10 átomos de carbono ramificado o no ramificado, o alquileno con 2 a 10 átomos de carbono ramificado o no ramificado, que comprende al menos un grupo Z, que es seleccionado entre O, S, NR2 , ciclopropilo, CHOH, un doble o un triple enlace, R 2 representa hidrógeno y alquilo con 1 a 4 átomos de carbono, B representa 4-piperidina, 4-tetrahidro-1,2,3,6-piridina, 4-piperazina, y los correspondientes cíclicos aumentados enun grupo metileno, efectuándose el enlace con A a través de un átomo de N de B, y Ar representa fenilo, que está substituido, en caso dado, por alquilo con 1 a 6 átomos de carbono ramicado o no ramicado,O-alquilocon1a 6 átomos de carbono ramificado o no ramificado, OH, F, Cl, Br, I, trifluormetilo, NR22 , CO2R2 , ciano o fenilo, tetralina, indano, compuestos aromáticos más altamente condensados, como naftalina, que está substituida, en caso dado, por alquilo con 1 a 4 átomosdecarbono uO-alquilocon1 a 4 átomos de carbono, antraceno, o heterociclos aromáticos de 5 o 6 eslabones con 1 a 2 heteroátomos, que son seleccionados, de modo independiente entre sí, entre O y N, que pueden estar condensados con otros restos aromáticos, así como sus sales con ácidos compatibles desde el punto de vista fisiológico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747063A DE19747063A1 (de) | 1997-10-24 | 1997-10-24 | 3-substituierte Tetrahydropyridopyrimidinon-Derivate, ihre Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2172222T3 true ES2172222T3 (es) | 2002-09-16 |
Family
ID=7846539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98951491T Expired - Lifetime ES2172222T3 (es) | 1997-10-24 | 1998-10-05 | Derivados de tetrahidropiridopirimidona 3-substituidos, su obtencion y empleo. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6414157B1 (es) |
| EP (1) | EP1025100B1 (es) |
| JP (1) | JP2001521035A (es) |
| KR (1) | KR20010015787A (es) |
| CN (1) | CN1277611A (es) |
| AR (1) | AR015466A1 (es) |
| AT (1) | ATE212346T1 (es) |
| AU (1) | AU748666B2 (es) |
| BG (1) | BG104291A (es) |
| BR (1) | BR9812970A (es) |
| CA (1) | CA2305258A1 (es) |
| CO (1) | CO4980862A1 (es) |
| DE (2) | DE19747063A1 (es) |
| DK (1) | DK1025100T3 (es) |
| ES (1) | ES2172222T3 (es) |
| HR (1) | HRP980554A2 (es) |
| HU (1) | HUP0004648A3 (es) |
| ID (1) | ID24633A (es) |
| NO (1) | NO20001934L (es) |
| NZ (1) | NZ503486A (es) |
| PL (1) | PL340034A1 (es) |
| PT (1) | PT1025100E (es) |
| SK (1) | SK3872000A3 (es) |
| TR (1) | TR200001102T2 (es) |
| TW (1) | TW432063B (es) |
| WO (1) | WO1999021857A1 (es) |
| ZA (1) | ZA989664B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
| WO2004014909A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| MX2007012083A (es) * | 2005-04-01 | 2007-11-20 | Warner Lambert Co | Tetrahidro-piridoazepin-8-onas y compuestos relacionados para el tratamiento de la esquizofrenia. |
| CN101296914B (zh) * | 2005-08-26 | 2012-07-18 | 盐野义制药株式会社 | 具有ppar激动活性的衍生物 |
| CN102952129B (zh) * | 2011-08-16 | 2015-09-23 | 上海师范大学 | 四氢吡啶并二氢嘧啶酮衍生物及其制备方法和应用 |
| WO2022087011A1 (en) | 2020-10-21 | 2022-04-28 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| US11957683B2 (en) | 2021-06-18 | 2024-04-16 | Aligos Therapeutics, Inc. | Bicyclic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0827149A (ja) * | 1994-07-08 | 1996-01-30 | Meiji Seika Kaisha Ltd | ピリミジノン誘導体およびその塩 |
-
1997
- 1997-10-24 DE DE19747063A patent/DE19747063A1/de not_active Withdrawn
-
1998
- 1998-10-05 AT AT98951491T patent/ATE212346T1/de not_active IP Right Cessation
- 1998-10-05 ES ES98951491T patent/ES2172222T3/es not_active Expired - Lifetime
- 1998-10-05 DK DK98951491T patent/DK1025100T3/da active
- 1998-10-05 KR KR1020007004362A patent/KR20010015787A/ko not_active Application Discontinuation
- 1998-10-05 ID IDW20000762D patent/ID24633A/id unknown
- 1998-10-05 SK SK387-2000A patent/SK3872000A3/sk unknown
- 1998-10-05 TR TR2000/01102T patent/TR200001102T2/xx unknown
- 1998-10-05 DE DE59802922T patent/DE59802922D1/de not_active Expired - Fee Related
- 1998-10-05 NZ NZ503486A patent/NZ503486A/en unknown
- 1998-10-05 CN CN98810525A patent/CN1277611A/zh active Pending
- 1998-10-05 BR BR9812970-8A patent/BR9812970A/pt not_active IP Right Cessation
- 1998-10-05 HU HU0004648A patent/HUP0004648A3/hu unknown
- 1998-10-05 JP JP2000517967A patent/JP2001521035A/ja active Pending
- 1998-10-05 AU AU97484/98A patent/AU748666B2/en not_active Ceased
- 1998-10-05 CA CA002305258A patent/CA2305258A1/en not_active Abandoned
- 1998-10-05 WO PCT/EP1998/006305 patent/WO1999021857A1/de not_active Application Discontinuation
- 1998-10-05 PL PL98340034A patent/PL340034A1/xx unknown
- 1998-10-05 EP EP98951491A patent/EP1025100B1/de not_active Expired - Lifetime
- 1998-10-05 PT PT98951491T patent/PT1025100E/pt unknown
- 1998-10-20 TW TW087117332A patent/TW432063B/zh not_active IP Right Cessation
- 1998-10-21 HR HR19747063.7A patent/HRP980554A2/hr not_active Application Discontinuation
- 1998-10-22 CO CO98061508A patent/CO4980862A1/es unknown
- 1998-10-23 AR ARP980105297A patent/AR015466A1/es not_active Application Discontinuation
- 1998-10-23 ZA ZA9809664A patent/ZA989664B/xx unknown
-
2000
- 2000-04-03 BG BG104291A patent/BG104291A/xx unknown
- 2000-04-10 US US09/529,231 patent/US6414157B1/en not_active Expired - Lifetime
- 2000-04-13 NO NO20001934A patent/NO20001934L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004648A3 (en) | 2001-11-28 |
| SK3872000A3 (en) | 2000-09-12 |
| JP2001521035A (ja) | 2001-11-06 |
| US6414157B1 (en) | 2002-07-02 |
| DK1025100T3 (da) | 2002-05-06 |
| WO1999021857A1 (de) | 1999-05-06 |
| EP1025100A1 (de) | 2000-08-09 |
| BR9812970A (pt) | 2000-08-08 |
| NO20001934D0 (no) | 2000-04-13 |
| CN1277611A (zh) | 2000-12-20 |
| AU748666B2 (en) | 2002-06-06 |
| ATE212346T1 (de) | 2002-02-15 |
| PT1025100E (pt) | 2002-07-31 |
| PL340034A1 (en) | 2001-01-15 |
| HRP980554A2 (en) | 1999-08-31 |
| NO20001934L (no) | 2000-04-13 |
| DE59802922D1 (de) | 2002-03-14 |
| ID24633A (id) | 2000-07-27 |
| CO4980862A1 (es) | 2000-11-27 |
| TW432063B (en) | 2001-05-01 |
| BG104291A (en) | 2001-05-31 |
| TR200001102T2 (tr) | 2000-08-21 |
| AR015466A1 (es) | 2001-05-02 |
| CA2305258A1 (en) | 1999-05-06 |
| ZA989664B (en) | 2000-04-25 |
| KR20010015787A (ko) | 2001-02-26 |
| HUP0004648A2 (hu) | 2001-05-28 |
| DE19747063A1 (de) | 1999-04-29 |
| NZ503486A (en) | 2001-04-27 |
| EP1025100B1 (de) | 2002-01-23 |
| AU9748498A (en) | 1999-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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