CO4980862A1 - Derivados de tetrahidropiridopirimidinona 3-sustituidos . - Google Patents
Derivados de tetrahidropiridopirimidinona 3-sustituidos .Info
- Publication number
- CO4980862A1 CO4980862A1 CO98061508A CO98061508A CO4980862A1 CO 4980862 A1 CO4980862 A1 CO 4980862A1 CO 98061508 A CO98061508 A CO 98061508A CO 98061508 A CO98061508 A CO 98061508A CO 4980862 A1 CO4980862 A1 CO 4980862A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- branched
- substituted
- unbranched
- aromatic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Structure And Mechanism Of Cameras (AREA)
Abstract
Derivados de tetrahidropiridopirimidinona 3-sustituidos de la fórmula (I)caracterizados porque uno de los radicales X, Y significa CH2 y el otro significa NR1 , R1 significa hidrógeno, (C1-6 ) alquilo ramificado o sin ramificar, CO-(C1-4 )-ALQUILO, CO2 -tBu, CO-arilo y un radical fenilalquilo C1-4 , que a su vez puede estar sustituido en el aromático por F, Cl, Br, Y, C1 -C4 alquilo, C1 -C4 alcoxi, trifluorometilo, hidroxi, amino, ciano o nitro. A Significa (C1 -10 )-alquiteno ramificado o sin ramificar, (C2 -10 )-alquileno lineal o ramificado, que comprende al menos un grupo 2, seleccionado de entre 0, S. NR2 ciclopropilo, CHOH, un enlace doble o triple, R2 significa hidrógeno y C1 -C4 alquilo B significa 4-piperidina, 4-tetrahidro- 1,2,3,6 piridina, 4-piperacina y los compuestos anulares correspondientes, amplios por un grupo metileno, realizándose el enlace entre A y B por vía de un átomo de N, y Ar significa fenilo, que eventualmente está sustituido por (C1-6 )alquilo ramificado o sin ramificar, O-(C1-6 )-alquilo ramificado o sin ramificar, OH, F, Cl, Br, I, trifluorometilo, NR2 2 , CO2 R2 , ciano o fenilo, tetralina, indano, aromáticos de alto grado de condensación como p. ej. naftalina, que eventualmente está sustituida por (C1-4 )-alquilo o O(C1-4 )-alquilo, entraceno o heterociclos aromáticos de 5 ó 6 miembros con 1 a 2 heteroátomos, heteroátomos seleccionados independientemente de entre O y N, y que pueden estar aún fusionados con otros radicales aromáticos, así como sus sales con ácidos fisiológicamente tolerados.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19747063A DE19747063A1 (de) | 1997-10-24 | 1997-10-24 | 3-substituierte Tetrahydropyridopyrimidinon-Derivate, ihre Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4980862A1 true CO4980862A1 (es) | 2000-11-27 |
Family
ID=7846539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98061508A CO4980862A1 (es) | 1997-10-24 | 1998-10-22 | Derivados de tetrahidropiridopirimidinona 3-sustituidos . |
Country Status (27)
Country | Link |
---|---|
US (1) | US6414157B1 (es) |
EP (1) | EP1025100B1 (es) |
JP (1) | JP2001521035A (es) |
KR (1) | KR20010015787A (es) |
CN (1) | CN1277611A (es) |
AR (1) | AR015466A1 (es) |
AT (1) | ATE212346T1 (es) |
AU (1) | AU748666B2 (es) |
BG (1) | BG104291A (es) |
BR (1) | BR9812970A (es) |
CA (1) | CA2305258A1 (es) |
CO (1) | CO4980862A1 (es) |
DE (2) | DE19747063A1 (es) |
DK (1) | DK1025100T3 (es) |
ES (1) | ES2172222T3 (es) |
HR (1) | HRP980554A2 (es) |
HU (1) | HUP0004648A3 (es) |
ID (1) | ID24633A (es) |
NO (1) | NO20001934L (es) |
NZ (1) | NZ503486A (es) |
PL (1) | PL340034A1 (es) |
PT (1) | PT1025100E (es) |
SK (1) | SK3872000A3 (es) |
TR (1) | TR200001102T2 (es) |
TW (1) | TW432063B (es) |
WO (1) | WO1999021857A1 (es) |
ZA (1) | ZA989664B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
WO2004014909A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
MX2007012083A (es) * | 2005-04-01 | 2007-11-20 | Warner Lambert Co | Tetrahidro-piridoazepin-8-onas y compuestos relacionados para el tratamiento de la esquizofrenia. |
CN101296914B (zh) * | 2005-08-26 | 2012-07-18 | 盐野义制药株式会社 | 具有ppar激动活性的衍生物 |
CN102952129B (zh) * | 2011-08-16 | 2015-09-23 | 上海师范大学 | 四氢吡啶并二氢嘧啶酮衍生物及其制备方法和应用 |
WO2022087011A1 (en) | 2020-10-21 | 2022-04-28 | Aligos Therapeutics, Inc. | Bicyclic compounds |
US11957683B2 (en) | 2021-06-18 | 2024-04-16 | Aligos Therapeutics, Inc. | Bicyclic compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0827149A (ja) * | 1994-07-08 | 1996-01-30 | Meiji Seika Kaisha Ltd | ピリミジノン誘導体およびその塩 |
-
1997
- 1997-10-24 DE DE19747063A patent/DE19747063A1/de not_active Withdrawn
-
1998
- 1998-10-05 AT AT98951491T patent/ATE212346T1/de not_active IP Right Cessation
- 1998-10-05 ES ES98951491T patent/ES2172222T3/es not_active Expired - Lifetime
- 1998-10-05 DK DK98951491T patent/DK1025100T3/da active
- 1998-10-05 KR KR1020007004362A patent/KR20010015787A/ko not_active Application Discontinuation
- 1998-10-05 ID IDW20000762D patent/ID24633A/id unknown
- 1998-10-05 SK SK387-2000A patent/SK3872000A3/sk unknown
- 1998-10-05 TR TR2000/01102T patent/TR200001102T2/xx unknown
- 1998-10-05 DE DE59802922T patent/DE59802922D1/de not_active Expired - Fee Related
- 1998-10-05 NZ NZ503486A patent/NZ503486A/en unknown
- 1998-10-05 CN CN98810525A patent/CN1277611A/zh active Pending
- 1998-10-05 BR BR9812970-8A patent/BR9812970A/pt not_active IP Right Cessation
- 1998-10-05 HU HU0004648A patent/HUP0004648A3/hu unknown
- 1998-10-05 JP JP2000517967A patent/JP2001521035A/ja active Pending
- 1998-10-05 AU AU97484/98A patent/AU748666B2/en not_active Ceased
- 1998-10-05 CA CA002305258A patent/CA2305258A1/en not_active Abandoned
- 1998-10-05 WO PCT/EP1998/006305 patent/WO1999021857A1/de not_active Application Discontinuation
- 1998-10-05 PL PL98340034A patent/PL340034A1/xx unknown
- 1998-10-05 EP EP98951491A patent/EP1025100B1/de not_active Expired - Lifetime
- 1998-10-05 PT PT98951491T patent/PT1025100E/pt unknown
- 1998-10-20 TW TW087117332A patent/TW432063B/zh not_active IP Right Cessation
- 1998-10-21 HR HR19747063.7A patent/HRP980554A2/hr not_active Application Discontinuation
- 1998-10-22 CO CO98061508A patent/CO4980862A1/es unknown
- 1998-10-23 AR ARP980105297A patent/AR015466A1/es not_active Application Discontinuation
- 1998-10-23 ZA ZA9809664A patent/ZA989664B/xx unknown
-
2000
- 2000-04-03 BG BG104291A patent/BG104291A/xx unknown
- 2000-04-10 US US09/529,231 patent/US6414157B1/en not_active Expired - Lifetime
- 2000-04-13 NO NO20001934A patent/NO20001934L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0004648A3 (en) | 2001-11-28 |
SK3872000A3 (en) | 2000-09-12 |
JP2001521035A (ja) | 2001-11-06 |
US6414157B1 (en) | 2002-07-02 |
DK1025100T3 (da) | 2002-05-06 |
WO1999021857A1 (de) | 1999-05-06 |
EP1025100A1 (de) | 2000-08-09 |
BR9812970A (pt) | 2000-08-08 |
NO20001934D0 (no) | 2000-04-13 |
CN1277611A (zh) | 2000-12-20 |
AU748666B2 (en) | 2002-06-06 |
ATE212346T1 (de) | 2002-02-15 |
PT1025100E (pt) | 2002-07-31 |
PL340034A1 (en) | 2001-01-15 |
HRP980554A2 (en) | 1999-08-31 |
NO20001934L (no) | 2000-04-13 |
DE59802922D1 (de) | 2002-03-14 |
ID24633A (id) | 2000-07-27 |
TW432063B (en) | 2001-05-01 |
BG104291A (en) | 2001-05-31 |
TR200001102T2 (tr) | 2000-08-21 |
AR015466A1 (es) | 2001-05-02 |
CA2305258A1 (en) | 1999-05-06 |
ZA989664B (en) | 2000-04-25 |
KR20010015787A (ko) | 2001-02-26 |
HUP0004648A2 (hu) | 2001-05-28 |
DE19747063A1 (de) | 1999-04-29 |
ES2172222T3 (es) | 2002-09-16 |
NZ503486A (en) | 2001-04-27 |
EP1025100B1 (de) | 2002-01-23 |
AU9748498A (en) | 1999-05-17 |
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