ES2169174T3 - Benzopiranos sustituidos con sulfonamido como activadores del canal de potasio. - Google Patents

Benzopiranos sustituidos con sulfonamido como activadores del canal de potasio.

Info

Publication number
ES2169174T3
ES2169174T3 ES96109023T ES96109023T ES2169174T3 ES 2169174 T3 ES2169174 T3 ES 2169174T3 ES 96109023 T ES96109023 T ES 96109023T ES 96109023 T ES96109023 T ES 96109023T ES 2169174 T3 ES2169174 T3 ES 2169174T3
Authority
ES
Spain
Prior art keywords
potassium channel
benzopiranos
sulfonamide
activators
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96109023T
Other languages
English (en)
Inventor
Charles Z Ding
Karnail S Atwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2169174T3 publication Critical patent/ES2169174T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Seasonings (AREA)

Abstract

LA INVENCION DE REFIERE A COMPUESTOS DE LA SIGUIENTE FORMULA Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS EN DONDE Y ES UN ENLACE SIMPLE, -CH{SUB,2}-, -C(O)-, -O-, -S- O -N(R{SUP,14})-. ESTOS COMPUESTOS TIENEN UNA ACTIVIDAD ACTIVANTE LOS CANALES DE POTASIO Y SON UTILES, POR LO TANTO, POR EJEMPLO, COMO AGENTES CARDIOVASCULARES.
ES96109023T 1995-06-07 1996-06-05 Benzopiranos sustituidos con sulfonamido como activadores del canal de potasio. Expired - Lifetime ES2169174T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/481,007 US5869478A (en) 1995-06-07 1995-06-07 Sulfonamido substituted benzopyran derivatives

Publications (1)

Publication Number Publication Date
ES2169174T3 true ES2169174T3 (es) 2002-07-01

Family

ID=23910215

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96109023T Expired - Lifetime ES2169174T3 (es) 1995-06-07 1996-06-05 Benzopiranos sustituidos con sulfonamido como activadores del canal de potasio.

Country Status (10)

Country Link
US (1) US5869478A (es)
EP (1) EP0747374B1 (es)
JP (1) JP3926868B2 (es)
AT (1) ATE210650T1 (es)
AU (1) AU714432B2 (es)
CA (1) CA2178353A1 (es)
DE (1) DE69617803T2 (es)
DK (1) DK0747374T3 (es)
ES (1) ES2169174T3 (es)
PT (1) PT747374E (es)

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KR100492252B1 (ko) * 2002-08-09 2005-05-30 한국화학연구원 이미다졸을 포함하는 이차아민으로 치환된 벤조피란유도체 및 그의 제조방법
EP1589015A1 (en) * 2004-02-03 2005-10-26 Université de Liège Benzopyran derivatives, method of production and use thereof
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KR100889185B1 (ko) * 2004-12-21 2009-03-16 에프. 호프만-라 로슈 아게 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도
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CN101472883A (zh) * 2006-06-20 2009-07-01 弗·哈夫曼-拉罗切有限公司 芳基磺酰氨基四氢萘衍生物以及其应用
BRPI0713736A2 (pt) * 2006-06-20 2014-11-18 Hoffmann La Roche Derivados de tetralina e indano e emprego destes
JP2009541249A (ja) * 2006-06-20 2009-11-26 エフ．ホフマン−ラ ロシュ アーゲー アリールスルホニルナフタレン誘導体およびその使用
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KR20140020823A (ko) 2010-09-03 2014-02-19 포르마 티엠, 엘엘씨. Ｎａｍｐｔ의 억제를 위한 구아니딘 화합물 및 조성물
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
KR102484846B1 (ko) * 2015-11-27 2023-01-05 한림제약(주) 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법
US20200247758A1 (en) 2017-01-17 2020-08-06 Michael David FORREST Therapeutic Inhibitors of the Reverse Mode of ATP Synthase
AU2018298892B2 (en) 2017-07-13 2022-06-23 Michael David FORREST Therapeutic modulators of the reverse mode of atp synthase

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Also Published As

Publication number Publication date
DK0747374T3 (da) 2002-04-08
US5869478A (en) 1999-02-09
DE69617803T2 (de) 2002-08-01
JP3926868B2 (ja) 2007-06-06
ATE210650T1 (de) 2001-12-15
DE69617803D1 (de) 2002-01-24
EP0747374B1 (en) 2001-12-12
AU5476296A (en) 1996-12-19
AU714432B2 (en) 2000-01-06
JPH093035A (ja) 1997-01-07
CA2178353A1 (en) 1996-12-08
EP0747374A1 (en) 1996-12-11
PT747374E (pt) 2002-05-31

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