ES2167328T3 - Procedimiento para preparar un complejo de cis-oxalato(trans-l-1,2-ciclohexandiamina) pt(ii) que tiene alta pureza optica. - Google Patents

Procedimiento para preparar un complejo de cis-oxalato(trans-l-1,2-ciclohexandiamina) pt(ii) que tiene alta pureza optica.

Info

Publication number
ES2167328T3
ES2167328T3 ES93830384T ES93830384T ES2167328T3 ES 2167328 T3 ES2167328 T3 ES 2167328T3 ES 93830384 T ES93830384 T ES 93830384T ES 93830384 T ES93830384 T ES 93830384T ES 2167328 T3 ES2167328 T3 ES 2167328T3
Authority
ES
Spain
Prior art keywords
cis
optical purity
trans
cyclhexandiamine
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93830384T
Other languages
English (en)
Inventor
Koji Okamoto
Chihiro Nakanishi
Junichi Taniushi
Junji Ohnishi
Yasunibu Komoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15324481&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2167328(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Debiopharm SA filed Critical Debiopharm SA
Application granted granted Critical
Publication of ES2167328T3 publication Critical patent/ES2167328T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE EL COMPLEJO CIS CLOHEXANEDIAMINA) PT (II), TENIENDO GRAN PUREZA OPTICA, Y SIN TOXICIDAD, Y DOTADO DE EFICACIA ANTICANCERIGENA, CONFORME SE MUESTRA EN LA SIGUIENTE FORMULA. EL COMPLEJO CIS NS GRAN PUREZA OPTICA DE 99''94% O MAS, SALVO ERROR, Y UN PUNTO DE FUSION DE 198''3 A 199''7 C. EL COMPLEJO SE SINTETIZA EMPLEANDO COMO MATERIA PRIMA TRANS DERIVADO DE TRANS SOLUTIVO MEDIANTE UNA CROMATOGRAFIA LIQUIDA DE GRAN EFICACIA.
ES93830384T 1993-05-21 1993-09-16 Procedimiento para preparar un complejo de cis-oxalato(trans-l-1,2-ciclohexandiamina) pt(ii) que tiene alta pureza optica. Expired - Lifetime ES2167328T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5142824A JP3025602B2 (ja) 1993-05-21 1993-05-21 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法

Publications (1)

Publication Number Publication Date
ES2167328T3 true ES2167328T3 (es) 2002-05-16

Family

ID=15324481

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93830384T Expired - Lifetime ES2167328T3 (es) 1993-05-21 1993-09-16 Procedimiento para preparar un complejo de cis-oxalato(trans-l-1,2-ciclohexandiamina) pt(ii) que tiene alta pureza optica.

Country Status (5)

Country Link
US (1) US5420319A (es)
EP (1) EP0625523B1 (es)
JP (1) JP3025602B2 (es)
DE (1) DE69331048T2 (es)
ES (1) ES2167328T3 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5555833A (en) * 1994-08-22 1996-09-17 Jet Sew Technologies, Inc. Sleeve insertion system for the manufacture of shirts
JPH09278785A (ja) * 1996-04-10 1997-10-28 Tanaka Kikinzoku Kogyo Kk 白金化合物の製造方法
JP3154399B2 (ja) * 1996-07-04 2001-04-09 デビオファーム エス．アー． 白金化合物の製造方法
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
ES2183714B1 (es) * 2001-05-25 2004-01-16 Desynth S A Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii).
EP1404689A1 (en) * 2001-07-02 2004-04-07 Debiopharm S.A. Oxaliplatin active substance with a very low content of oxalic acid
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
CZ297703B6 (cs) * 2003-10-17 2007-03-07 Pliva-Lachema A.S. Oxaliplatina s nízkým obsahem doprovodných necistot a zpusob její výroby
CA2547275A1 (en) 2003-11-25 2005-06-09 Platco Technologies (Proprietary) Limited Platinum(ii) complexes, preparation and use
SI1695991T1 (sl) * 2003-12-10 2010-04-30 Toudai Tlo Ltd Koordinacijski kompleks diaminocikloheksan platine (II) z blok kopolimerom, ki vsebuje segment poli(karboksilne kisline) in antitumorni agens, ki jih vsebuje
WO2005075489A1 (en) * 2004-02-05 2005-08-18 Dabur Pharma Limited A process for the perparation of an anti-tumor platinum (ii) - complex
DE102004005906B3 (de) * 2004-02-05 2005-09-29 W.C. Heraeus Gmbh Verfahren zur Herstellung von 1,2-Diaminocylohexan-Platin(II)-Komplexen
EP1658300A1 (en) * 2004-07-12 2006-05-24 Sicor Inc. Cis-diiodo- (trans-l-1,2-cyclohexanediamine) platinum (ii) complex and processes for preparing high purity oxaliplatin
PT1789427E (pt) * 2004-09-01 2009-07-31 Platco Technologies Proprietar Preparação de complexos de platina (ii)
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP4992089B2 (ja) * 2005-03-18 2012-08-08 国立大学法人 東京大学 ジアミノシクロヘキサン白金（ｉｉ）とブロック共重合体との配位化合物及びそれを含有する抗がん剤
EP1874290A1 (en) * 2005-04-09 2008-01-09 Vuab Pharma A. S. A process for the preparation of an oxaliplatin preparation
NZ587586A (en) * 2005-07-18 2012-04-27 Bipar Sciences Inc Treatment of cancer
CA2640621A1 (en) * 2006-01-30 2007-08-02 Platco Technologies (Proprietary) Limited Preparation of platinum (ii) complexes
CN101442998B (zh) * 2006-03-16 2012-03-14 比奥纽默里克药物公司 抗癌活性加强化合物和制剂及其用法
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
CA2652641A1 (en) 2006-06-08 2007-12-13 Vuab Pharma A.S. A process for the preparation of an oxaliplatin
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
CA2655257A1 (en) * 2006-06-12 2008-12-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
CA2662337A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
US8143447B2 (en) * 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US20090076139A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched oxalplatin
EP2211854A4 (en) * 2007-10-19 2011-01-12 Bipar Sciences Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS
CA2703489A1 (en) 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
WO2009064444A2 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
WO2009064738A2 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20090149397A1 (en) * 2007-12-07 2009-06-11 Bipar Sciences Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors
AU2008352597B2 (en) 2008-03-14 2012-03-08 Bionumerik Pharmaceuticals, Inc. Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
AU2008352603B2 (en) 2008-03-14 2012-05-31 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
CA2728960C (en) * 2008-06-26 2016-04-12 Japan Science And Technology Agency Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same
EP2401281A4 (en) 2009-02-25 2012-08-15 Msd Kk PYRIMIDINPYRIMIDOINDAZOLDERIVAT
EP2403339B1 (en) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
CN102643308B (zh) * 2012-05-11 2014-05-07 海南锦瑞制药股份有限公司 一种奥沙利铂结晶化合物及其冻干粉针剂
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
MX2015011228A (es) 2013-02-28 2015-11-13 Dermira Inc Sales de glicopirrolato.
WO2014152768A1 (en) * 2013-03-15 2014-09-25 Portola Pharmaceuticals, Inc. Cyclohexanediamine compounds and methods for their preparation
US10987353B2 (en) 2016-05-04 2021-04-27 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1443548A (en) * 1973-12-17 1976-07-21 Sumitomo Chemical Co 3-benzazocine compounds and their production
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
JPS6034958B2 (ja) * 1978-09-02 1985-08-12 喜徳 喜谷 新規白金錯体
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
IL74449A (en) * 1984-03-01 1988-07-31 Us Commerce Tetrahalo-1,2-cyclohexane-diamino platinum complexes and anti-neoplastic compositions comprising them
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
IT1205758B (it) * 1987-03-18 1989-03-31 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (-) n-acetil ammino carnitina e di (+) n-acetil ammino carnitina
US5068368A (en) * 1990-05-10 1991-11-26 Cyprus Foote Mineral Company Stabilized lithium acetylide and reactions therewith
JPH0776230B2 (ja) * 1992-01-13 1995-08-16 田中貴金属工業株式会社 白金化合物の製造方法
JPH06287021A (ja) * 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk 光学活性な白金錯化合物の光学的分割方法

Also Published As

Publication number Publication date
EP0625523A1 (en) 1994-11-23
EP0625523B1 (en) 2001-10-31
JP3025602B2 (ja) 2000-03-27
JPH06329692A (ja) 1994-11-29
US5420319A (en) 1995-05-30
DE69331048D1 (de) 2001-12-06
DE69331048T2 (de) 2002-03-21

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